LOCUS       NM_008330               1742 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus interferon gamma inducible protein 47 (Ifi47),
            transcript variant 1, mRNA.
ACCESSION   NM_008330
VERSION     NM_008330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Zuo B, Du X, Zhao J, Yang H, Wang C, Wu Y, Lu J, Wang Y and Chen Z.
  TITLE     Analysis of microsatellite polymorphism in inbred knockout mice
  JOURNAL   PLoS One 7 (4), e34555 (2012)
   PUBMED   22509320
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Henry SC, Daniell X, Indaram M, Whitesides JF, Sempowski GD, Howell
            D, Oliver T and Taylor GA.
  TITLE     Impaired macrophage function underscores susceptibility to
            Salmonella in mice lacking Irgm1 (LRG-47)
  JOURNAL   J Immunol 179 (10), 6963-6972 (2007)
   PUBMED   17982087
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Butcher BA, Greene RI, Henry SC, Annecharico KL, Weinberg JB,
            Denkers EY, Sher A and Taylor GA.
  TITLE     p47 GTPases regulate Toxoplasma gondii survival in activated
            macrophages
  JOURNAL   Infect Immun 73 (6), 3278-3286 (2005)
   PUBMED   15908352
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Collazo CM, Yap GS, Sempowski GD, Lusby KC, Tessarollo L, Vande
            Woude GF, Sher A and Taylor GA.
  TITLE     Inactivation of LRG-47 and IRG-47 reveals a family of interferon
            gamma-inducible genes with essential, pathogen-specific roles in
            resistance to infection
  JOURNAL   J Exp Med 194 (2), 181-188 (2001)
   PUBMED   11457893
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK,
            Moore KA, Overton GC and Lemischka IR.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Gilly M, Damore MA and Wall R.
  TITLE     A promoter ISRE and dual 5' YY1 motifs control IFN-gamma induction
            of the IRG-47 G-protein gene
  JOURNAL   Gene 179 (2), 237-244 (1996)
   PUBMED   8972906
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Gilly M and Wall R.
  TITLE     The IRG-47 gene is IFN-gamma induced in B cells and encodes a
            protein with GTP-binding motifs
  JOURNAL   J Immunol 148 (10), 3275-3281 (1992)
   PUBMED   1578148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159742.1, M63630.1 and CD742161.1.
            
            On Nov 7, 2012 this sequence version replaced NM_008330.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009131.1, AK156785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY159742.1         2-39
            39-1711             M63630.1           1-1673
            1712-1742           CD742161.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.08 cM"
     gene            1..1742
                     /gene="Ifi47"
                     /gene_synonym="47kDa; Ifggc1; Igrd; Iigp4; Iipg4; IRG-47;
                     Irgd"
                     /note="interferon gamma inducible protein 47"
                     /db_xref="GeneID:15953"
                     /db_xref="MGI:MGI:99448"
     exon            1..128
                     /gene="Ifi47"
                     /gene_synonym="47kDa; Ifggc1; Igrd; Iigp4; Iipg4; IRG-47;
                     Irgd"
                     /inference="alignment:Splign:2.1.0"
     exon            129..1727
                     /gene="Ifi47"
                     /gene_synonym="47kDa; Ifggc1; Igrd; Iigp4; Iipg4; IRG-47;
                     Irgd"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1410
                     /gene="Ifi47"
                     /gene_synonym="47kDa; Ifggc1; Igrd; Iigp4; Iipg4; IRG-47;
                     Irgd"
                     /note="interferon gamma inducible protein, 47 kDa;
                     interferon-gamma-inducible GTPase Ifggc1 protein; Immunity
                     related GTPase family D"
                     /codon_start=1
                     /product="interferon gamma inducible protein 47"
                     /protein_id="NP_032356.1"
                     /db_xref="CCDS:CCDS24595.1"
                     /db_xref="GeneID:15953"
                     /db_xref="MGI:MGI:99448"
                     /translation="MDQFISAFLKGASENSFQQLAKEFLPQYSALISKAGGMLSPETL
                     TGIHKALQEGNLSDVMIQIQKAISAAENAILEVAVIGQSGTGKSSFINALRGLGHEAD
                     ESADVGTVETTMCKTPYQHPKYPKVIFWDLPGTGTPNFHADAYLDQVGFANYDFFIII
                     SSSRFSLNDALLAQKIKDAGKKFYFVRTKVDSDLYNEQKAKPIAFKKEKVLQQIRDYC
                     VTNLIKTGVTEPCIFLISNLDLGAFDFPKLEETLLKELPGHKRHMFALLLPNISDASI
                     ELKKHFLREKIWLEALKSAAVSFIPFMTFFKGFDLPEQEQCLKDYRSYFGLDDQSIKE
                     IAEKLGAPLADIKGELKCLDFWSLVKDNSIIAQATSAAEAFCAVKGGPESSAFQALKV
                     YYRRTQFLNIVVDDAKHLLRKIETVNVA"
ORIGIN      
        1 ttttttctct ctgctagggc tcattgcttc agactttcct gaaggagggc agacccgtgc
       61 cgttggtggt ggctgtgctg tgggctgcag tgagaaacag acccggtatt ttctacttct
      121 tggatctgag cttccctggt aactgccatg gatcagttca tctcagcctt cctgaagggt
      181 gcttcagaaa atagtttcca acaattagct aaggagtttc tgcctcagta ctctgcatta
      241 atcagtaagg caggaggcat gctctctcca gaaaccctca ctggtattca caaagccctc
      301 caggagggaa atctctctga tgtcatgatc cagattcaga aagcaattag tgctgcagag
      361 aatgctatcc tggaggtggc tgtgatcggg cagtctggga ctggcaagtc cagttttata
      421 aatgcccttc gagggctggg ccacgaagca gatgaatccg ctgatgttgg gactgtggag
      481 accactatgt gtaaaacccc ctatcaacat ccaaaatatc ccaaagtgat cttctgggac
      541 ctgcctggga ctgggacacc caatttccac gcagacgctt atctagacca agtgggattt
      601 gccaactatg acttcttcat catcatttct tcttcccgct tcagcctcaa tgatgctctc
      661 ctggctcaga aaataaagga tgctgggaag aagttctact ttgttagaac caaggtggat
      721 agtgacttat ataatgaaca gaaagccaaa cccatagctt tcaagaagga gaaagtcctt
      781 cagcagattc gagactactg tgtgactaat ctcatcaaaa ctggggtgac tgaaccatgc
      841 atcttcctga tctccaactt ggatctgggt gcgtttgatt tccccaagct ggaggagact
      901 ctgctaaagg agctccctgg gcacaagcgt catatgtttg ccctgctctt gcccaatatc
      961 tcggatgctt ccattgagct aaagaaacat tttcttcggg agaagatctg gctggaggcc
     1021 ttgaagtcag cagctgtgag cttcatcccc ttcatgactt tctttaaggg ctttgatttg
     1081 cctgaacaag aacagtgctt gaaggattac cgaagctatt ttggcttgga tgatcaatcg
     1141 attaaagaga ttgctgaaaa attgggcgca cccttggcag acatcaaggg ggaacttaag
     1201 tgcttggatt tctggtccct tgtaaaggat aacagcataa tagcgcaagc tacgagtgct
     1261 gctgaagctt tttgtgctgt gaaaggaggc cctgaatctt ctgccttcca ggctttaaaa
     1321 gtctattata ggcgcacaca gttccttaac atagtggttg acgatgctaa acatctcttg
     1381 agaaagatag aaacagtaaa tgttgcctag ctaaacagtg aatggatttc aaattgtgtg
     1441 tccaaattgg caatggggtt ggttgtcctt ccaccaaact cccaggccag ctcttcccta
     1501 agctccacag aagtgtatcc catgaaggaa gtccattgct tccctctaga gattactacc
     1561 atgcatgaat tgttttttgc tcataccctg tttcctgtgt tcattgattt attattcttg
     1621 ataatagtca gcaataacat accacctgcc tctgtgttaa gagataacct gtttctgatc
     1681 catttgtacc aataaaaaaa gtttgtaata acaagatgag acttagaaaa aaaaaaaaaa
     1741 aa
//
