LOCUS       NM_027320               1360 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus interferon-induced protein 35 (Ifi35), mRNA.
ACCESSION   NM_027320
VERSION     NM_027320.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Dai,M., Ouyang,W., Yu,Y., Wang,T., Wang,Y., Cen,M., Yang,L.,
            Han,Y., Yao,Y. and Xu,F.
  TITLE     IFP35 aggravates Staphylococcus aureus infection by promoting
            Nrf2-regulated ferroptosis
  JOURNAL   J Adv Res 62, 143-154 (2024)
   PUBMED   37777065
  REMARK    GeneRIF: IFP35 aggravates Staphylococcus aureus infection by
            promoting Nrf2-regulated ferroptosis.
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Mao,X., Wu,D., Xu,N., Wang,J., Zeng,J., Jiang,Z., Liu,Y. and
            Liang,H.
  TITLE     The danger signal interferon-induced protein 35 (IFP35) mediates
            acetaminophen-induced liver injury
  JOURNAL   Biochem Biophys Res Commun 621, 25-31 (2022)
   PUBMED   35809344
  REMARK    GeneRIF: The danger signal interferon-induced protein 35 (IFP35)
            mediates acetaminophen-induced liver injury.
REFERENCE   3  (bases 1 to 1360)
  AUTHORS   Jing,X., Yao,Y., Wu,D., Hong,H., Feng,X., Xu,N., Liu,Y. and
            Liang,H.
  TITLE     IFP35 family proteins promote neuroinflammation and multiple
            sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34362845
  REMARK    GeneRIF: IFP35 family proteins promote neuroinflammation and
            multiple sclerosis.
REFERENCE   4  (bases 1 to 1360)
  AUTHORS   Gounder,A.P., Yokoyama,C.C., Jarjour,N.N., Bricker,T.L.,
            Edelson,B.T. and Boon,A.C.M.
  TITLE     Interferon induced protein 35 exacerbates H5N1 influenza disease
            through the expression of IL-12p40 homodimer
  JOURNAL   PLoS Pathog 14 (4), e1007001 (2018)
   PUBMED   29698474
  REMARK    GeneRIF: High Expression of Ifi35 is associated with exacerbates
            lung inflammation and H5N1 influenza disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1360)
  AUTHORS   Xiahou,Z., Wang,X., Shen,J., Zhu,X., Xu,F., Hu,R., Guo,D., Li,H.,
            Tian,Y., Liu,Y. and Liang,H.
  TITLE     NMI and IFP35 serve as proinflammatory DAMPs during cellular
            infection and injury
  JOURNAL   Nat Commun 8 (1), 950 (2017)
   PUBMED   29038465
  REMARK    GeneRIF: Damage-associated molecular patterns (DAMP) are important
            mediators of innate immunity. Here the authors show that N-myc and
            STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act
            as DAMPs to promote inflammation by activating macrophages via the
            Toll-like receptor 4 and NF-kappaB pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1360)
  AUTHORS   Torre,S., Polyak,M.J., Langlais,D., Fodil,N., Kennedy,J.M.,
            Radovanovic,I., Berghout,J., Leiva-Torres,G.A., Krawczyk,C.M.,
            Ilangumaran,S., Mossman,K., Liang,C., Knobeloch,K.P., Healy,L.M.,
            Antel,J., Arbour,N., Prat,A., Majewski,J., Lathrop,M., Vidal,S.M.
            and Gros,P.
  TITLE     USP15 regulates type I interferon response and is required for
            pathogenesis of neuroinflammation
  JOURNAL   Nat Immunol 18 (1), 54-63 (2017)
   PUBMED   27721430
  REMARK    Erratum:[Nat Immunol. 2016 Nov 16;17(12):1479. doi:
            10.1038/ni1216-1479c. PMID: 27849203]
REFERENCE   7  (bases 1 to 1360)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL590996.12.
            
            On Apr 30, 2007 this sequence version replaced NM_027320.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131884.1, AK008161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL590996.12        27150-27360
            212-310             AL590996.12        35304-35402
            311-458             AL590996.12        35928-36075
            459-565             AL590996.12        36154-36260
            566-752             AL590996.12        36358-36544
            753-859             AL590996.12        36629-36735
            860-1360            AL590996.12        36939-37439
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.07 cM"
     gene            1..1360
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /note="interferon-induced protein 35"
                     /db_xref="GeneID:70110"
                     /db_xref="MGI:MGI:1917360"
     exon            1..211
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            212..310
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            311..458
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            459..565
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            566..752
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            753..859
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1360
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1123
                     /gene="Ifi35"
                     /gene_synonym="2010008K16Rik; ifi-35; IFP35"
                     /note="major polyA site"
ORIGIN      
        1 agcagaattc acagaaatga aagtggaagt gaggccggca agcaagcaac agcagtggaa
       61 gtgtgtttca gacgctgctg gaggctgagg agaccagagc cacctctgag gggtcaaaga
      121 gtttagtcct tcagaactct tcactgccaa ccctgctctg aagccccagc ttctgccaga
      181 cgtgagagcc atgtctgtga ccctgcaaac tgtcctctac agtcttcagg aggagcaagc
      241 caggctcaag atgaggctgc aggagctgca gcagctcaaa agggagcgca caggctctcc
      301 cggagccaag atcccattct cagtacctga agttcctctg gtattccaag gccaaactaa
      361 gcagggcagg caagtgccca agtttgtagt ttctaacttg aaggtctgct gccctctgcc
      421 tgaaggttct gctctggtca cctttgagga ccccaaagtg gttgatcggt tgctacaaca
      481 aaaggaacac agagttaact tagaggactg ccggctgcgg gtgcaggtcc agcccttgga
      541 gctgcctgtg gtgaccaaca ttcaggtgtc cagccagcca gataaccaca gggtgctcgt
      601 tagtggtttt cctgctggac ttaggctgag tgaagaggaa ctgttggaca agctggagat
      661 cttctttggc aaggccaaga atggaggtgg ggatgtagag acccgggaga tgctgcaagg
      721 gaccgtcatg ctagggtttg ctgatgaaga agtggcccag cacttatgcc agattggcca
      781 gttcagagtc ccactggacc ggcagcaggt cctcctgagg gtctctccct atgtgagtgg
      841 tgagatccag aaagccgaga tcaaattcca gcaagcccct cattcagtgc tggtgacaaa
      901 tattcctgat gtcatggatg cccaggaact gcatgacatc cttgagatcc acttccagaa
      961 gcccactcgt gggggcgggg aggtggaggc cctgacagtt gtgccttcag ggcagcaggg
     1021 cctggctatc ttcacttccg agtcaagcta ggcctgcatg tccacctgct ggggactagg
     1081 atcacttact gcctaatgct accaagaacg gtcaaagtgc caacctggtg tgatggtctt
     1141 ctttacttca agatagctga gagagagggc agaacgcaga ccttgacact ggctttccca
     1201 tggctcgctc gtgcacgcgc gcgctctctc tctctctttc atttgagact agatttctct
     1261 gtatattcca gacgttccct ctgtagacca ggctggcctg taactccaag ctgcctgtct
     1321 ctgcctccaa ctgctgagat taaaggtgcg catcactacc
//
