LOCUS       NM_023065                997 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus interferon gamma inducible protein 30 (Ifi30), mRNA.
ACCESSION   NM_023065
VERSION     NM_023065.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 997)
  AUTHORS   Broxmeyer,H.E., Cooper,S. and Blum,J.S.
  TITLE     Expression of gilt acts as a positive regulator of mouse
            hematopoietic progenitor cells
  JOURNAL   Blood Cells Mol Dis 90, 102574 (2021)
   PUBMED   34015674
  REMARK    GeneRIF: Expression of gilt acts as a positive regulator of mouse
            hematopoietic progenitor cells.
REFERENCE   2  (bases 1 to 997)
  AUTHORS   Ewanchuk,B.W., Arnold,C.R., Balce,D.R., Premnath,P., Orsetti,T.L.,
            Warren,A.L., Olsen,A., Krawetz,R.J. and Yates,R.M.
  TITLE     A non-immunological role for gamma-interferon-inducible lysosomal
            thiol reductase (GILT) in osteoclastic bone resorption
  JOURNAL   Sci Adv 7 (17) (2021)
   PUBMED   33893096
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 997)
  AUTHORS   Rausch,M.P., Meador,L.R., Metzger,T.C., Li,H., Qiu,S.,
            Anderson,M.S. and Hastings,K.T.
  TITLE     GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell
            Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen
  JOURNAL   J Immunol 204 (11), 2877-2886 (2020)
   PUBMED   32269095
  REMARK    GeneRIF: GILT in Thymic Epithelial Cells Facilitates Central CD4 T
            Cell Tolerance to a Tissue-Restricted, Melanoma-Associated
            Self-Antigen.
REFERENCE   4  (bases 1 to 997)
  AUTHORS   Merino,K.M., Bansal,G.P. and Kumar,N.
  TITLE     Reduced immunogenicity of Plasmodium falciparum gamete surface
            antigen (Pfs48/45) in mice after disruption of disulphide bonds -
            evaluating effect of interferon-gamma-inducible lysosomal thiol
            reductase
  JOURNAL   Immunology 148 (4), 433-447 (2016)
   PUBMED   27177843
REFERENCE   5  (bases 1 to 997)
  AUTHORS   Miller,M.A., Ganesan,A.P., Luckashenak,N., Mendonca,M. and
            Eisenlohr,L.C.
  TITLE     Endogenous antigen processing drives the primary CD4+ T cell
            response to influenza
  JOURNAL   Nat Med 21 (10), 1216-1222 (2015)
   PUBMED   26413780
REFERENCE   6  (bases 1 to 997)
  AUTHORS   Barjaktarevic,I., Rahman,A., Radoja,S., Bogunovic,B., Vollmer,A.,
            Vukmanovic,S. and Maric,M.
  TITLE     Inhibitory role of IFN-gamma-inducible lysosomal thiol reductase in
            T cell activation
  JOURNAL   J Immunol 177 (7), 4369-4375 (2006)
   PUBMED   16982871
REFERENCE   7  (bases 1 to 997)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 997)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   9  (bases 1 to 997)
  AUTHORS   Maric,M., Arunachalam,B., Phan,U.T., Dong,C., Garrett,W.S.,
            Cannon,K.S., Alfonso,C., Karlsson,L., Flavell,R.A. and Cresswell,P.
  TITLE     Defective antigen processing in GILT-free mice
  JOURNAL   Science 294 (5545), 1361-1365 (2001)
   PUBMED   11701933
  REMARK    GeneRIF: GILT facilitated the processing and presentation to
            antigen-specific T cells of protein antigens containing disulfide
            bonds.
REFERENCE   10 (bases 1 to 997)
  AUTHORS   Phan,U.T., Maric,M., Dick,T.P. and Cresswell,P.
  TITLE     Multiple species express thiol oxidoreductases related to GILT
  JOURNAL   Immunogenetics 53 (4), 342-346 (2001)
   PUBMED   11491538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY774497.1, AF309649.1, BQ746455.1 and BE951500.1.
            
            On Feb 10, 2007 this sequence version replaced NM_023065.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054852.1, AK077725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY774497.1         2-33
            33-156              AF309649.1         1-124
            157-316             BQ746455.1         112-271
            317-779             AF309649.1         285-747
            780-997             BE951500.1         1-218               c
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..997
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /note="interferon gamma inducible protein 30"
                     /db_xref="GeneID:65972"
                     /db_xref="MGI:MGI:2137648"
     exon            1..155
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..779
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /note="gamma-interferon-inducible lysosomal thiol
                     reductase; gamma-interferon-inducible protein IP-30;
                     lysosomal thio reductase IP30; lysosomal thiol reductase
                     IP30"
                     /codon_start=1
                     /product="gamma-interferon-inducible lysosomal thiol
                     reductase precursor"
                     /protein_id="NP_075552.2"
                     /db_xref="GeneID:65972"
                     /db_xref="MGI:MGI:2137648"
                     /translation="MSWSPILPFLSLLLLLFPLEVPRAATASLSQASSEGTTTCKAHD
                     VCLLGPRPLPPSPPVRVSLYYESLCGACRYFLVRDLFPTWLMVMEIMNITLVPYGNAQ
                     ERNVSGTWEFTCQHGELECRLNMVEACLLDKLEKEAAFLTIVCMEEMDDMEKKLGPCL
                     QVYAPEVSPESIMECATGKRGTQLMHENAQLTDALHPPHEYVPWVLVNEKPLKDPSEL
                     LSIVCQLYQGTEKPDICSSIADSPRKVCYK"
     exon            156..338
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            339..413
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            414..506
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            507..659
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            660..713
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     exon            714..981
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /note="hexamer: AATAAA"
     polyA_site      981
                     /gene="Ifi30"
                     /gene_synonym="GILT; IP30"
                     /note="major polyA site"
ORIGIN      
        1 aagcagtcct gccagctttt tcctccgcag ccatgtcctg gtctccgatc ctaccatttt
       61 tgtcccttct gcttctgctg ttcccactcg aggttcccag agcagccact gcgtcccttt
      121 cgcaagcatc ctccgaaggc acaaccacct gcaaggccca cgatgtgtgc ctcttggggc
      181 cacgcccatt gcccccttca ccacctgtca gagtcagcct gtattatgag tccctgtgtg
      241 gagcttgtcg ctacttcctc gtccgggatt tgttcccaac ctggctgatg gtgatggaaa
      301 tcatgaacat caccctggtg ccctacggga atgcacagga gagaaatgtc agcggtacgt
      361 gggagttcac gtgccagcac ggggagctgg agtgtagact gaacatggtg gaggcctgtc
      421 tgctggataa gctggaaaag gaggcagcgt tcctaaccat cgtctgtatg gaggagatgg
      481 atgatatgga gaagaaactg ggaccgtgcc tgcaggtgta tgctcctgag gtgtcaccag
      541 agagtatcat ggagtgcgcc acaggaaaac ggggcacaca gctcatgcat gagaatgccc
      601 agctcacaga tgccctacac ccaccccacg agtatgtgcc ctgggtgctg gtcaatgaga
      661 aacctttgaa ggaccccagc gagctcctga gcatagtctg tcagctgtac cagggaacgg
      721 agaagccaga catctgctcc tccattgccg actcccccag gaaggtctgc tataagtaaa
      781 ggcataacct caaactcgtc ccaggaaaaa ctgcccagct tcttcaaatt gccaacctgc
      841 aagagctgct gcctcgctat gaaaaccttg cacatgtccc acaaagccca gactccagac
      901 ttctcagaga caaggatctt gccttatttt caaatggtgc taaatttaaa ttcatagaat
      961 aaatcatcta tactcctgtg aaaaaaaaaa aaaaaaa
//
