LOCUS       NM_029803                464 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus interferon, alpha-inducible protein 27 like 2A
            (Ifi27l2a), transcript variant 1, mRNA.
ACCESSION   NM_029803 XM_127107
VERSION     NM_029803.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 464)
  AUTHORS   Lucas,T.M., Richner,J.M. and Diamond,M.S.
  TITLE     The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus
            Infection and Pathogenesis in a Cell-Type- and Region-Specific
            Manner
  JOURNAL   J Virol 90 (5), 2600-2615 (2015)
   PUBMED   26699642
  REMARK    GeneRIF: Collectively, these findings suggest that Ifi27l2a has an
            antiviral phenotype in subsets of cells and that at least some
            interferon-stimulated genes have specific inhibitory functions in
            restricted tissues in West Nile virus infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 464)
  AUTHORS   Mannion,N.M., Greenwood,S.M., Young,R., Cox,S., Brindle,J.,
            Read,D., Nellaker,C., Vesely,C., Ponting,C.P., McLaughlin,P.J.,
            Jantsch,M.F., Dorin,J., Adams,I.R., Scadden,A.D., Ohman,M.,
            Keegan,L.P. and O'Connell,M.A.
  TITLE     The RNA-editing enzyme ADAR1 controls innate immune responses to
            RNA
  JOURNAL   Cell Rep 9 (4), 1482-1494 (2014)
   PUBMED   25456137
REFERENCE   5  (bases 1 to 464)
  AUTHORS   Tantawy,M.A., Hatesuer,B., Wilk,E., Dengler,L., Kasnitz,N.,
            Weiss,S. and Schughart,K.
  TITLE     The interferon-induced gene Ifi27l2a is active in lung macrophages
            and lymphocytes after influenza A infection but deletion of
            Ifi27l2a in mice does not increase susceptibility to infection
  JOURNAL   PLoS One 9 (9), e106392 (2014)
   PUBMED   25184786
  REMARK    GeneRIF: up-regulation of Ifi27l2a in infected lungs is mainly due
            to the infiltration of macrophages and lymphocytes. Most
            surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not
            result in increased susceptibility to infections
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 464)
  AUTHORS   Papac-Milicevic,N., Breuss,J.M., Zaujec,J., Ryban,L., Plyushch,T.,
            Wagner,G.A., Fenzl,S., Dremsek,P., Cabaravdic,M., Steiner,M.,
            Glass,C.K., Binder,C.J., Uhrin,P. and Binder,B.R.
  TITLE     The interferon stimulated gene 12 inactivates vasculoprotective
            functions of NR4A nuclear receptors
  JOURNAL   Circ Res 110 (8), e50-e63 (2012)
   PUBMED   22427340
  REMARK    GeneRIF: Identify a feedback loop activated by interferons via
            interferon stimulated gene 12 that inhibits the vasculoprotective
            functions of NR4A1 nuclear receptors.
REFERENCE   7  (bases 1 to 464)
  AUTHORS   Li,B., Shin,J. and Lee,K.
  TITLE     Interferon-stimulated gene ISG12b1 inhibits adipogenic
            differentiation and mitochondrial biogenesis in 3T3-L1 cells
  JOURNAL   Endocrinology 150 (3), 1217-1224 (2009)
   PUBMED   18948406
  REMARK    GeneRIF: Mitochondrial-localized ISG12b1 protein inhibits adipocyte
            differentiation and mitochondrial biogenesis and function.
REFERENCE   8  (bases 1 to 464)
  AUTHORS   Ohgaki,S., Iida,K., Yokoo,T., Watanabe,K., Kihara,R., Suzuki,H.,
            Shimano,H., Toyoshima,H. and Yamada,N.
  TITLE     Identification of ISG12b as a putative interferon-inducible
            adipocytokine which is highly expressed in white adipose tissue
  JOURNAL   J Atheroscler Thromb 14 (4), 179-184 (2007)
   PUBMED   17704618
  REMARK    GeneRIF: ISG12b is an additional candidate for a adipocytokine
            induced to express in adipose tissue by interferon
REFERENCE   9  (bases 1 to 464)
  AUTHORS   Parker,N. and Porter,A.C.
  TITLE     Identification of a novel gene family that includes the
            interferon-inducible human genes 6-16 and ISG12
  JOURNAL   BMC Genomics 5 (1), 8 (2004)
   PUBMED   14728724
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 464)
  AUTHORS   Labrada,L., Liang,X.H., Zheng,W., Johnston,C. and Levine,B.
  TITLE     Age-dependent resistance to lethal alphavirus encephalitis in mice:
            analysis of gene expression in the central nervous system and
            identification of a novel interferon-inducible protective gene,
            mouse ISG12
  JOURNAL   J Virol 76 (22), 11688-11703 (2002)
   PUBMED   12388728
  REMARK    GeneRIF: induced by Sindbis virus encephalitis to greater levels in
            brains of weanling mice than neonatal mice and significantly
            delayed death in the neonatal mice (interferon- inducible
            protective protein, ISG12).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154347.2 and AK160503.1.
            
            On Aug 8, 2013 this sequence version replaced NM_029803.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100588.1, BN000231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC154347.2         77382-77401         c
            21-460              AK160503.1         2-441
            461-464             AC154347.2         75887-75890         c
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.93 cM"
     gene            1..464
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /note="interferon, alpha-inducible protein 27 like 2A"
                     /db_xref="GeneID:76933"
                     /db_xref="MGI:MGI:1924183"
     exon            1..54
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..320
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interferon stimulated gene 12(b1);
                     interferon-stimulated gene 12 protein; interferon
                     alpha-inducible protein 27-like protein 2A"
                     /codon_start=1
                     /product="interferon alpha-inducible protein 27-like
                     protein 2A isoform 1 precursor"
                     /protein_id="NP_084079.1"
                     /db_xref="CCDS:CCDS49153.1"
                     /db_xref="GeneID:76933"
                     /db_xref="MGI:MGI:1924183"
                     /translation="MLGTLFGSAIGGALAVAGAPVALAAMGFTGTGIAAASIAAKMMS
                     AAAIANGGGVAAGSLVATLQSAGVLGLSTSTNAILGAAGAAVGALL"
     exon            55..84
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /inference="alignment:Splign:2.1.0"
     exon            85..246
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /inference="alignment:Splign:2.1.0"
     exon            247..464
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      436..441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /note="hexamer: AACAAA"
     polyA_site      463
                     /gene="Ifi27l2a"
                     /gene_synonym="2310061N23Rik; Ifi27; Isg12; Isg12(b1)"
                     /note="major polyA site"
ORIGIN      
        1 actccctaag ttcttcctat gctctgctgc taccaggagg actcaacatg ttgggaacac
       61 tgtttggctc tgccatagga ggagctctgg ctgtggcagg ggcacctgtg gccctggctg
      121 ccatgggctt cactgggaca ggcattgcag ctgcctccat agcagccaag atgatgtctg
      181 ctgcagcaat tgccaatgga ggtggagttg cagcaggaag cctggtagcc acactccaat
      241 cagcaggggt ccttggactc tccacatcaa caaatgccat cctaggggct gctggggcag
      301 ctgttggagc cttgctctga gcttaggaga tgacacttct atcagctcaa ctcaaagcct
      361 gtacagacta cgcaggagat gaagttccaa aaggcacctt cagaaccctc actgatgtca
      421 aagaatgatg aaaacaacaa agtatatggg ctggtgttcc taac
//
