LOCUS       NM_194067                918 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus interferon, alpha-inducible protein 27 (Ifi27),
            transcript variant 3, mRNA.
ACCESSION   NM_194067
VERSION     NM_194067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Cui,X., Liu,H., Shi,T., Zhao,Q., Li,F., Lv,W., Yu,C., Huang,H.,
            Tang,Q.Q. and Pan,D.
  TITLE     IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote
            Adipocyte Thermogenic Adaption
  JOURNAL   Adv Sci (Weinh) 10 (28), e2301855 (2023)
   PUBMED   37544897
  REMARK    GeneRIF: IFI27 Integrates Succinate and Fatty Acid Oxidation to
            Promote Adipocyte Thermogenic Adaption.
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Fan,K., Zan,X., Zhi,Y., Yang,Y., Hu,K., Zhang,X., Zhang,X.,
            Zhao,S., Chen,K., Gong,X., Tian,R. and Zhang,L.
  TITLE     Immune response gene 1 deficiency impairs Nrf2 activation and
            aggravates liver fibrosis in mice
  JOURNAL   Biochem Biophys Res Commun 607, 103-109 (2022)
   PUBMED   35367821
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Geng,X., Zhang,C., Li,M., Wang,J., Ji,F., Feng,H., Xing,M., Li,F.,
            Zhang,L., Li,W., Chen,Z., Hickson,I.D., Shen,H. and Ying,S.
  TITLE     PICH Supports Embryonic Hematopoiesis by Suppressing a
            cGAS-STING-Mediated Interferon Response
  JOURNAL   Adv Sci (Weinh) 9 (7), e2103837 (2022)
   PUBMED   35037428
REFERENCE   6  (bases 1 to 918)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 918)
  AUTHORS   Jin,W., Jin,W. and Pan,D.
  TITLE     Ifi27 is indispensable for mitochondrial function and browning in
            adipocytes
  JOURNAL   Biochem Biophys Res Commun 501 (1), 273-279 (2018)
   PUBMED   29730295
  REMARK    GeneRIF: Ifi27 protein localizes to mitochondria, and the
            expression of Ifi27 can be induced by beta3-adrenergic activation
            in adipose tissues. Knockdown of Ifi27 leads to reduced expression
            of key enzymes of tricarboxylic acid cycle, the subunits of
            electron transport chain, and uncoupling protein 1 (Ucp1) in brown
            and beige adipocytes.
REFERENCE   8  (bases 1 to 918)
  AUTHORS   Uhrin,P., Perkmann,T., Binder,B. and Schabbauer,G.
  TITLE     ISG12 is a critical modulator of innate immune responses in murine
            models of sepsis
  JOURNAL   Immunobiology 218 (9), 1207-1216 (2013)
   PUBMED   23747037
REFERENCE   9  (bases 1 to 918)
  AUTHORS   Papac-Milicevic,N., Breuss,J.M., Zaujec,J., Ryban,L., Plyushch,T.,
            Wagner,G.A., Fenzl,S., Dremsek,P., Cabaravdic,M., Steiner,M.,
            Glass,C.K., Binder,C.J., Uhrin,P. and Binder,B.R.
  TITLE     The interferon stimulated gene 12 inactivates vasculoprotective
            functions of NR4A nuclear receptors
  JOURNAL   Circ Res 110 (8), e50-e63 (2012)
   PUBMED   22427340
REFERENCE   10 (bases 1 to 918)
  AUTHORS   Parker,N. and Porter,A.C.
  TITLE     Identification of a novel gene family that includes the
            interferon-inducible human genes 6-16 and ISG12
  JOURNAL   BMC Genomics 5 (1), 8 (2004)
   PUBMED   14728724
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY130471.1, AK003665.1, AK075797.2 and BY443016.1.
            
            On Nov 17, 2009 this sequence version replaced NM_194067.1.
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            CDS, as compared to variant 1. The resulting isoform (3) lacks an
            internal segment, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146231.1, AJ566113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY130471.1         14-75
            63-459              AK003665.1         2-398
            460-912             AK075797.2         534-986
            913-918             BY443016.1         420-425
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.93 cM"
     gene            1..918
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /note="interferon, alpha-inducible protein 27"
                     /db_xref="GeneID:52668"
                     /db_xref="MGI:MGI:1277180"
     exon            1..162
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /inference="alignment:Splign:2.1.0"
     exon            163..314
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..844
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /note="isoform 3 is encoded by transcript variant 3;
                     interferon, alpha-inducible protein 27 like 1"
                     /codon_start=1
                     /product="interferon, alpha-inducible protein 27 like 1
                     isoform 3"
                     /protein_id="NP_919043.1"
                     /db_xref="CCDS:CCDS26130.1"
                     /db_xref="GeneID:52668"
                     /db_xref="MGI:MGI:1277180"
                     /translation="MAFSGTGTLVASIVSKMTSSAAMVKAGGAVSGTILAGSKGLILL
                     TQSALGSATSALGALKVGTILSGFSASTLAASPIGAKAVVAVLGGAMTVAAVPPALSA
                     VGFTASGIAASSLAAKMMSLSAIANGGGVPAGGLVAILQSAGAAGLSVPSTVIVGSAG
                     SAVVASVMNICESFYPFLMGSEVADMATEVADMAIEVADISTEEALPNLSNTEKD"
     exon            315..434
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /inference="alignment:Splign:2.1.0"
     exon            435..464
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /inference="alignment:Splign:2.1.0"
     exon            465..626
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /inference="alignment:Splign:2.1.0"
     exon            627..918
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      889..894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /note="hexamer: AATAAA"
     polyA_site      913
                     /gene="Ifi27"
                     /gene_synonym="1110013J02Rik; 2900026P10Rik; D12Ertd647e;
                     Ifi27l1; ISG12a"
                     /note="major polyA site"
ORIGIN      
        1 agtggatttg tcgggcctgg agagagctgg ggaaatcgaa acttatttca gcagctgtct
       61 tcagtcactg ggtgtgtctt cctgcacagt ggacttgacg ggcctggagg gaggagagga
      121 aattgaaacc tatctcatcc tctagtttat ttacatcatt ggattcggtt cctgtttgga
      181 aacttaactg gtcctcatgg cgttttcggg cacagggaca ctggtggctt ccattgtctc
      241 caagatgaca tcttcagcag ccatggtcaa agctggaggg gcagtctctg gcaccattct
      301 agctggttcg aaggggctca tcctgttaac acagagtgcc ctgggctctg caacatctgc
      361 acttggagca ctgaaggttg gcaccatttt atctgggttc tctgcctcca ccttggctgc
      421 ttcccccatt ggagccaagg ctgttgtggc tgtgcttggg ggagccatga cagtagctgc
      481 tgtaccacct gcgctgagtg ctgtgggctt caccgcctca ggaattgcag cctcctctct
      541 agcagctaag atgatgtcct tgtcagctat tgctaatggg ggtggagtcc cagctggtgg
      601 cctggtggcc attctgcagt ctgctggagc tgctggactc tccgtgccat ctactgtcat
      661 cgtgggctct gcagggtctg ccgttgtggc cagtgtcatg aacatctgtg agagtttcta
      721 cccttttctc atgggatcag aggtggcaga catggcgaca gaggtggcag atatggcgat
      781 agaggtggca gacatttcaa cagaagaggc actgcccaac ttgtctaaca cagagaagga
      841 ttaattaccc ccaggcgaca atctcctaac acatattgcc taggtggaaa taaattaaac
      901 cgagttcttg ccagtctc
//
