LOCUS       NM_001033450            1789 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus interferon activated gene 211 (Ifi211), transcript
            variant 1, mRNA.
ACCESSION   NM_001033450 XM_001003076
VERSION     NM_001033450.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Brunette,R.L., Young,J.M., Whitley,D.G., Brodsky,I.E., Malik,H.S.
            and Stetson,D.B.
  TITLE     Extensive evolutionary and functional diversity among mammalian
            AIM2-like receptors
  JOURNAL   J Exp Med 209 (11), 1969-1983 (2012)
   PUBMED   23045604
REFERENCE   2  (bases 1 to 1789)
  AUTHORS   Cridland,J.A., Curley,E.Z., Wykes,M.N., Schroder,K., Sweet,M.J.,
            Roberts,T.L., Ragan,M.A., Kassahn,K.S. and Stacey,K.J.
  TITLE     The mammalian PYHIN gene family: phylogeny, evolution and
            expression
  JOURNAL   BMC Evol Biol 12, 140 (2012)
   PUBMED   22871040
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1789)
  AUTHORS   Khromov,T., Dressel,R., Siamishi,I., Nolte,J., Opitz,L., Engel,W.
            and Pantakani,D.V.
  TITLE     Apoptosis-related gene expression profiles of mouse ESCs and
            maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to
            genotoxicity
  JOURNAL   PLoS One 7 (11), e48869 (2012)
   PUBMED   23145002
  REMARK    GeneRIF: The role of Mnda in response to apoptosis and genotoxic
            stress is discussed.
REFERENCE   4  (bases 1 to 1789)
  AUTHORS   Burckstummer,T., Baumann,C., Bluml,S., Dixit,E., Durnberger,G.,
            Jahn,H., Planyavsky,M., Bilban,M., Colinge,J., Bennett,K.L. and
            Superti-Furga,G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
REFERENCE   5  (bases 1 to 1789)
  AUTHORS   Asefa,B., Dermott,J.M., Kaldis,P., Stefanisko,K., Garfinkel,D.J.
            and Keller,J.R.
  TITLE     p205, a potential tumor suppressor, inhibits cell proliferation via
            multiple pathways of cell cycle regulation
  JOURNAL   FEBS Lett 580 (5), 1205-1214 (2006)
   PUBMED   16458891
REFERENCE   6  (bases 1 to 1789)
  AUTHORS   Tannenbaum,C.S., Major,J., Ohmori,Y. and Hamilton,T.A.
  TITLE     A lipopolysaccharide-inducible macrophage gene (D3) is a new member
            of an interferon-inducible gene cluster and is selectively
            expressed in mononuclear phagocytes
  JOURNAL   J Leukoc Biol 53 (5), 563-568 (1993)
   PUBMED   7684766
REFERENCE   7  (bases 1 to 1789)
  AUTHORS   Samanta,H., Engel,D.A., Chao,H.M., Thakur,A., Garcia-Blanco,M.A.
            and Lengyel,P.
  TITLE     Interferons as gene activators. Cloning of the 5' terminus and the
            control segment of an interferon activated gene
  JOURNAL   J Biol Chem 261 (25), 11849-11858 (1986)
   PUBMED   3017948
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK166217.1, AC170584.4,
            CJ067068.1, AK152683.1 and AV250999.1.
            
            On Sep 12, 2014 this sequence version replaced NM_001033450.3.
            
            Summary: The protein encoded by this gene is a member of the
            interferon-regulated 200 family of proteins, which contain an
            N-terminal pyrin domain that is proposed to function in cell death
            and a partially conserved 220 amino acid domain. Expression of this
            protein in embryonic stem cells is critical for the DNA damage
            response and regulation of cell survival. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166217.1, AK152683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK166217.1         1-4
            5-5                 AC170584.4         89302-89302
            6-9                 AK166217.1         6-9
            10-233              CJ067068.1         2-225
            234-1078            AK152683.1         102-946
            1079-1079           AC170584.4         100506-100506
            1080-1775           AK152683.1         948-1643
            1776-1789           AV250999.1         223-236
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.74 cM"
     gene            1..1789
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /note="interferon activated gene 211"
                     /db_xref="GeneID:381308"
                     /db_xref="MGI:MGI:3041120"
     exon            1..233
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
     exon            234..518
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1531
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon-activable protein 205-B;
                     lipopolysaccharide-inducible; protein D3;
                     interferon-inducible protein p205-B; myeloid cell nuclear
                     differentiation antigen; interferon-activable protein 211"
                     /codon_start=1
                     /product="interferon-activable protein 211 isoform 1"
                     /protein_id="NP_001028622.1"
                     /db_xref="CCDS:CCDS15532.1"
                     /db_xref="GeneID:381308"
                     /db_xref="MGI:MGI:3041120"
                     /translation="MVNEYKRIVLLRGLECINKHYFSLFKSLLARDLNLERDNQEQYT
                     TIQIANMMEEKFPADSGLGKLIEFCEEVPALRKRAEILKKERSEVTGETSLEKNGQEA
                     GPATPTSTTSHMLASERGETSATQEETSTAQAGTSTAQAGTSTAQAGTSTAQKRKSMR
                     EEETGVKKSKAAKEPDQPPCCEEPTAMCQSPILHSSSSASSNILSAKNQKSQPQNQNI
                     PRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMFHATVATVSQYFHVKVFNIDLKEK
                     FTKNNFITISNYFESKGILEINETSSVLEAAPKQMIEVPNCITRNANASPKICDIQKG
                     TSGTVFYGVFTLHKKKVKTQNTSYEIKDGSGSIEVVGSGQWHNINCKEGDKLHLFCFH
                     LKRERGQPKLVCGDHSFVKVTKAGKKKEASTVQ"
     exon            519..715
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
     exon            716..874
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1297
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1486
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1789
                     /gene="Ifi211"
                     /gene_synonym="A730048F03; ifi-205-B; Ifi205b; Mnda"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctatttca gcactcctca cccgagggag acagcacagg gagagacagc cagtgctgct
       61 caagaaatga aacaactctg agagttttgt aatcactacc ctcttccttt acacccaact
      121 gttcagtttc tcatttactg acttatctgc ctacctactc aagccaagca ggccacttct
      181 tgacccggtg aaggtctcag gatctgtaca tcactgcaga aatatccagg aaggctcagc
      241 aacaacttca aagatggtga atgaatacaa gagaattgtt ctgctgagag gacttgaatg
      301 tatcaataag cattatttta gcttatttaa gtcattgctg gccagagatt taaatctgga
      361 aagagacaac caagagcaat acaccacgat tcagattgct aacatgatgg aagagaaatt
      421 tccagctgat tctggattgg gcaaactgat tgagttttgt gaagaagtac cagctcttag
      481 aaaacgagct gaaattctta aaaaagagag atcagaagta acaggagaaa catcactgga
      541 aaaaaatggt caagaagcag gtcctgcaac acctacatca actacaagcc acatgttagc
      601 atctgaaaga ggcgagactt ctgcaaccca ggaagagact tccacagctc aggcggggac
      661 ttccacagct caggcgggga cttccacagc tcaggcgggg acttccacag cccagaaaag
      721 aaaaagtatg agagaagaag agactggagt gaaaaagagc aaggcggcta aggaaccaga
      781 tcagcctccc tgttgtgaag aacccacagc catgtgccag tcaccaatac tccacagctc
      841 atcttcggct tcatctaaca ttctttcggc taagaaccaa aaatcacaac cccagaacca
      901 gaacattccc agaggtgctg ttctccactc agagcccctg acagtgatgg tgctcactgc
      961 aacagacccg tttgaatatg aatcaccaga acatgaagta aagaacatgt ttcatgctac
     1021 agtggctaca gtgagccagt atttccatgt gaaagttttc aacatcgatt tgaaagagaa
     1081 gttcacaaaa aataatttta tcaccatatc caattacttt gagagcaaag gcatcctgga
     1141 gatcaatgag acttcctctg tgttagaggc tgctcctaaa caaatgattg aagtgcccaa
     1201 ctgtattacc agaaatgcaa atgccagtcc taagatctgt gatattcaaa agggtacttc
     1261 tggaacagtg ttctatggag tgtttacatt acacaagaaa aaagtgaaaa cacagaacac
     1321 aagctatgaa ataaaagatg gttcaggaag catagaagtt gtggggagtg gacaatggca
     1381 caacatcaac tgtaaggaag gagataagct ccacctcttc tgctttcacc tgaaaagaga
     1441 aagaggacaa ccaaagttag tgtgtggaga ccacagtttc gtcaaggtca ccaaggctgg
     1501 gaaaaaaaaa gaagcatcaa ctgtccagtg aagcacaaaa aatgaagaag aaaatgatta
     1561 cccaaaagtt ggaattaagg tagagatgcc aaaatagaaa tgtcacctct aaatgacagc
     1621 tttagtagta tatccaacca ttgattaatc ttcatacctg atttctgatt ttgtgttttc
     1681 atttgaaaaa attcttattg ttctgttttt ctatgaaaat aaaatttgat ttcatttctc
     1741 tactgtaaaa ataataaaca tgtcttttta aagggacatc attacaaag
//
