LOCUS       NM_175026               3497 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus interferon activated gene 209 (Ifi209), mRNA.
ACCESSION   NM_175026 XM_908369
VERSION     NM_175026.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3497)
  AUTHORS   Haque,A., Koide,N., Odkhuu,E., Tsolmongyn,B., Naiki,Y., Komatsu,T.,
            Yoshida,T. and Yokochi,T.
  TITLE     Mouse pyrin and HIN domain family member 1 (pyhin1) protein
            positively regulates LPS-induced IFN-beta and NO production in
            macrophages
  JOURNAL   Innate Immun 20 (1), 40-48 (2014)
   PUBMED   23606517
  REMARK    GeneRIF: promotes LPS-induced IFN-beta and NO production in
            macrophages
REFERENCE   2  (bases 1 to 3497)
  AUTHORS   Brunette,R.L., Young,J.M., Whitley,D.G., Brodsky,I.E., Malik,H.S.
            and Stetson,D.B.
  TITLE     Extensive evolutionary and functional diversity among mammalian
            AIM2-like receptors
  JOURNAL   J Exp Med 209 (11), 1969-1983 (2012)
   PUBMED   23045604
REFERENCE   3  (bases 1 to 3497)
  AUTHORS   Cridland,J.A., Curley,E.Z., Wykes,M.N., Schroder,K., Sweet,M.J.,
            Roberts,T.L., Ragan,M.A., Kassahn,K.S. and Stacey,K.J.
  TITLE     The mammalian PYHIN gene family: phylogeny, evolution and
            expression
  JOURNAL   BMC Evol Biol 12, 140 (2012)
   PUBMED   22871040
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3497)
  AUTHORS   Burckstummer,T., Baumann,C., Bluml,S., Dixit,E., Durnberger,G.,
            Jahn,H., Planyavsky,M., Bilban,M., Colinge,J., Bennett,K.L. and
            Superti-Furga,G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
REFERENCE   5  (bases 1 to 3497)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056097.1, AK080371.1 and AC117682.11.
            
            On May 16, 2009 this sequence version replaced NM_175026.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150817.1, BC096384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               CJ056097.1         3-267
            266-1825            AK080371.1         256-1815
            1826-3497           AC117682.11        108247-109918       c
FEATURES             Location/Qualifiers
     source          1..3497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.54 cM"
     gene            1..3497
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /note="interferon activated gene 209"
                     /db_xref="GeneID:236312"
                     /db_xref="MGI:MGI:2138243"
     exon            1..297
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..579
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1580
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /note="ifi-209; interferon-inducible protein X;
                     interferon-inducible protein 209; interferon-inducible
                     protein p209; pyrin and HIN domain family, member 1"
                     /codon_start=1
                     /product="pyrin and HIN domain-containing protein 1"
                     /protein_id="NP_778191.1"
                     /db_xref="CCDS:CCDS35791.1"
                     /db_xref="GeneID:236312"
                     /db_xref="MGI:MGI:2138243"
                     /translation="MVNEYKRIVLLTGLMGINDHDFRMVKSLLSKELKLNRMQDQYDR
                     VKIADLMEDKFPKDAGVDQLIKLYKQIPGLGDIANKLKNEKAKAKRTRTGKRKTAAKR
                     QRQEEPSTSQPMSTTNEDAEPESGRSTPDTQVAQLSLPTASRRNQAIQISPTIASSSG
                     QTSSRSSETLQSIIQSPKTPKRPSSSILDPPVSSGTASSSAQALGVPLATIAKRQRLK
                     NVPKEPSEENGHQQGSKKVMVLKVTEPFSYDVTEEKMFHATVATETEFFRVKVFDIVL
                     KEKFIPNKVLTISNYVGCNGFINIYSASSVSEVNDGEPMNIPLSLRKSANRTPKINYL
                     CSKKRGIFVNGVFTVCKKEEKWNYICYEIGDDTGMMEVEVYGRLTNIACNPGDKLRLI
                     CFKLIPDEEKAQLRSTTHSNMQVIKAKN"
     exon            580..716
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..956
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1370
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1559
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..3497
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /note="major polyA site"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /note="hexamer: AATAAA"
     polyA_site      3493
                     /gene="Ifi209"
                     /gene_synonym="4930422C14; Ifix; Pyhin-1; Pyhin1"
                     /note="major polyA site"
ORIGIN      
        1 gagacattca gcaagcctca gtccatggag tgagtctaac ctgagaattt ctgtagatta
       61 cattttccag ttcccaagag atttattggt ttatcttctt acacacatac acatacacac
      121 acacacacac acacacacac acacacacac acacacacac accaactcct ccctgtcccc
      181 aacaaacttt aagaagaaga aggacaaaag agaagaggag gaagaggagt ggagaagcct
      241 ctagtcctgc cctgtagaag atctcagctt tacatcccta gagaaacatc cagcaaggtt
      301 cacacataat ttgaaagatg gtgaatgaat acaagagaat tgttcttctg acaggattaa
      361 tgggtattaa tgaccatgat tttagaatgg ttaagtcctt gttgagcaaa gaactaaaac
      421 taaatagaat gcaagatcag tacgacagag ttaagattgc tgatttgatg gaagacaagt
      481 tcccaaaaga tgctggagtg gaccaactga taaaactata taagcagatt ccaggacttg
      541 gagacattgc taataaactc aaaaatgaga aggcaaaagc taaaaggaca cggacaggga
      601 aacggaaaac cgcagcaaaa agacaaaggc aagaagaacc cagtacttcc caacctatgt
      661 ccaccacaaa tgaagatgca gaaccagaat cagggaggag tacacctgac acacaggttg
      721 ctcagttatc tttaccaact gcttcccgaa ggaaccaagc cattcaaatt tctccaacaa
      781 tagcatccag cagtggtcag accagcagca gatcttcaga aacattacaa agcatcattc
      841 agtcccccaa aactccaaaa agaccgtcca gcagtattct ggaccctcca gtgtcttcag
      901 gaacagcatc cagcagtgcc caggcactag gagttcctct agcaacaata gccaagagac
      961 agagactgaa aaatgtaccc aaagaacctt ctgaggaaaa tggtcaccag caaggttcca
     1021 aaaaagtgat ggtgttaaaa gtaacagaac cattttcata tgacgtgaca gaagagaaga
     1081 tgttccatgc caccgtggct acggaaacag aattctttag agtaaaggtg tttgacattg
     1141 tcctgaagga gaagttcata ccaaataagg tccttaccat ctcaaactat gttggctgca
     1201 atgggttcat aaatatatac agtgcatcta gtgtgtcaga ggtaaatgat ggcgaaccaa
     1261 tgaatatccc actttcactg aggaaaagtg ccaatcgaac acctaaaatc aactatcttt
     1321 gctcgaagaa aagaggaata tttgtgaatg gagtgtttac tgtatgtaag aaagaagaaa
     1381 agtggaacta catttgctat gagataggag atgatacagg gatgatggaa gtggaggtct
     1441 acggacgact gaccaatatt gcttgtaatc ctggagataa acttagactc atatgcttta
     1501 aactgatccc agatgaagaa aaagcacagc tgagatctac aacacacagt aacatgcagg
     1561 ttatcaaagc taagaattga gaaacaacca ctcagtcctg cttcctttat gaaactgcat
     1621 taattcttgt tttgcggact tggacatcac tgatgtttat aaagataaga tcctgttcca
     1681 actaaagaaa aatgtcattc aactgataaa agcaagctct ttggtttagg aaatggcact
     1741 tattctttct acagttttag cattttatta catattttga ttttatagtg tttatacttt
     1801 gaatgaaaaa aacttcaggt acttcacaag tttcttgcat ttgtcagttg ctttaaaact
     1861 gggtttgcag accaaggagg aataaacatg tttcatgaaa tattttcatt tatgttttgg
     1921 gtgagctatt taaagacaaa gccttactca taaaggaaca gctgtgtcat cctcagaaac
     1981 atcaagccat caataaaaag gatgtggagg ctgaaatgca ggctgaatgc agttgtggag
     2041 actaatgtct tcagaagtga tgcagtcctt cctatgcatt tccatgagtc aatgtgagta
     2101 cattgtagag tttagtcatt tgaaatatga atttccagaa gtggatgatc agagtacatt
     2161 ttactgcttg caacagtaaa gaatctcacc tctgaatata gggtgaaata atgtcaagga
     2221 aatcttgaga ccatgaggaa gctgtcctaa aacaaatgag tctcagtcaa ggcttcctgc
     2281 agtgttaatt acctctctca ttgttatgac tgtatatcta gaaacagaaa ctgagagaga
     2341 tgctttacat tggctcacag tttaatggta gatgagagtg ctgtggctga tcacattgta
     2401 tcagcagagc agaaagcaga gagcaattgt atgctcttga ggagagctct ctttcttttt
     2461 atattcagtt cacaaacttt gccagtagaa tgttgtcacc cacatttagg ctgaattccc
     2521 aaattgattt atggaaaaaa aaattcctca caaacatgcc cagggtgttg cctcctaagt
     2581 ggatctatat cctgttacct ttataatcag tatcaataac gacaatgggc aatgatgacc
     2641 aatcatggag aaaaggagca aaggaaaggt agaaatagca gccataacaa gataagtaca
     2701 agatatgtgt ttctgacccc ttgggagatt tgtgtaggca aagacctcag tagacagaca
     2761 ttaggaaatg ggattaatag ggatgtacga aggtcataag ggttttacca gttctcataa
     2821 gtagattgat atcactacaa agaaatgggt tgaggactga tttcttggat tttattatat
     2881 tactcccacg tgagaagaag tcaatcaagc atagggtata gtttagcaac ctggaactcc
     2941 acttggcttg gggcatataa ccaacccctt ctaacaatgc actggaagct tcagagactt
     3001 actttcaaac actaggcaaa caaaccctct atgaacaatg tacctacaaa ccaactgaca
     3061 acctagaacg ctcaagtgca tcaggcttca ggtatatgtt tccaacatgg acgtagatta
     3121 ttcttttagc aattctttag tgatatatat cccagaacac accttgatgc tacaagagat
     3181 agcctaatcc agcctagact tgtttgagtg cataaatgag acaaactgtc tcctatttgc
     3241 cattttatgc ctatatatta ttgtatgtgc tactgattaa cattagatga cctatgcaat
     3301 aaacaaaatc ctatggtacc caagttggtc agtcaacctc ctacttctct tgaagtccat
     3361 aatgtcaaca ccacagtaat tgctatgctt ccgtatcttc atttatgtgg cctgttattc
     3421 tccttgactt catatttctt cctaacctgc gatattccac ggctttaaat aaatgtccgc
     3481 acctactttg aaagttg
//
