LOCUS       NM_001162938            3003 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interferon activated gene 208 (Ifi208), transcript
            variant 1, mRNA.
ACCESSION   NM_001162938 XR_035320 XR_035462
VERSION     NM_001162938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3003)
  AUTHORS   Ding,X., Wu,Y., Vainshtein,A., Rodriguez,V., Ricco,E., Okoh,J.T.,
            Liu,Y., Kraushaar,D.C., Peles,E. and Rasband,M.N.
  TITLE     Age-dependent regulation of axoglial interactions and behavior by
            oligodendrocyte AnkyrinG
  JOURNAL   Nat Commun 15 (1), 10865 (2024)
   PUBMED   39738113
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3003)
  AUTHORS   Zhang,M., Zhi,N., Feng,J., Liu,Y., Zhang,M., Liu,D., Yuan,J.,
            Dong,Y., Jiang,S., Ge,J., Wu,S. and Zhao,X.
  TITLE     ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is Essential
            for Myelination and Involved in Depressive-Like Behavior in
            Adolescent Mice
  JOURNAL   Adv Sci (Weinh) 11 (20), e2306498 (2024)
   PUBMED   38476116
REFERENCE   3  (bases 1 to 3003)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3003)
  AUTHORS   Rojo,D., Dal Cengio,L., Badner,A., Kim,S., Sakai,N., Greene,J.,
            Dierckx,T., Mehl,L.C., Eisinger,E., Ransom,J., Arellano-Garcia,C.,
            Gumma,M.E., Soyk,R.L., Lewis,C.M., Lam,M., Weigel,M.K.,
            Damonte,V.M., Yalcin,B., Jones,S.E., Ollila,H.M., Nishino,S. and
            Gibson,E.M.
  TITLE     BMAL1 loss in oligodendroglia contributes to abnormal myelination
            and sleep
  JOURNAL   Neuron 111 (22), 3604-3618 (2023)
   PUBMED   37657440
REFERENCE   5  (bases 1 to 3003)
  AUTHORS   Tong,L., Han,S., Xue,Y., Chen,M., Chen,F., Ke,W., Shu,Y., Ding,N.,
            Bewersdorf,J., Zhou,Z.J., Yuan,P. and Grutzendler,J.
  TITLE     Single cell in vivo optogenetic stimulation by two-photon
            excitation fluorescence transfer
  JOURNAL   iScience 26 (10), 107857 (2023)
   PUBMED   37752954
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3003)
  AUTHORS   Liu,C., Sage,J.C., Miller,M.R., Verhaak,R.G., Hippenmeyer,S.,
            Vogel,H., Foreman,O., Bronson,R.T., Nishiyama,A., Luo,L. and
            Zong,H.
  TITLE     Mosaic analysis with double markers reveals tumor cell of origin in
            glioma
  JOURNAL   Cell 146 (2), 209-221 (2011)
   PUBMED   21737130
REFERENCE   7  (bases 1 to 3003)
  AUTHORS   Komitova,M., Serwanski,D.R., Lu,Q.R. and Nishiyama,A.
  TITLE     NG2 cells are not a major source of reactive astrocytes after
            neocortical stab wound injury
  JOURNAL   Glia 59 (5), 800-809 (2011)
   PUBMED   21351161
REFERENCE   8  (bases 1 to 3003)
  AUTHORS   Feng,J., Mantesso,A., De Bari,C., Nishiyama,A. and Sharpe,P.T.
  TITLE     Dual origin of mesenchymal stem cells contributing to organ growth
            and repair
  JOURNAL   Proc Natl Acad Sci U S A 108 (16), 6503-6508 (2011)
   PUBMED   21464310
REFERENCE   9  (bases 1 to 3003)
  AUTHORS   Fyffe-Maricich,S.L., Karlo,J.C., Landreth,G.E. and Miller,R.H.
  TITLE     The ERK2 mitogen-activated protein kinase regulates the timing of
            oligodendrocyte differentiation
  JOURNAL   J Neurosci 31 (3), 843-850 (2011)
   PUBMED   21248107
REFERENCE   10 (bases 1 to 3003)
  AUTHORS   Zhu,X., Bergles,D.E. and Nishiyama,A.
  TITLE     NG2 cells generate both oligodendrocytes and gray matter astrocytes
  JOURNAL   Development 135 (1), 145-157 (2008)
   PUBMED   18045844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117682.11.
            
            On Apr 6, 2020 this sequence version replaced NM_001162938.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036671.1, SRR4048178.3381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC117682.11        82209-82510         c
            303-587             AC117682.11        78213-78497         c
            588-694             AC117682.11        77139-77245         c
            695-1648            AC117682.11        72557-73510         c
            1649-1716           AC117682.11        65441-65508         c
            1717-2014           AC117682.11        60306-60603         c
            2015-3003           AC117682.11        57782-58770         c
FEATURES             Location/Qualifiers
     source          1..3003
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.57 cM"
     gene            1..3003
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /note="interferon activated gene 208"
                     /db_xref="GeneID:100033459"
                     /db_xref="MGI:MGI:2442822"
     exon            1..302
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..587
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2077
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /note="isoform 1 is encoded by transcript variant 1; pyrin
                     domain-containing protein 3; pyrin domain containing 3;
                     inteferon-activable protein 208; interferon-activable
                     protein 208"
                     /codon_start=1
                     /product="interferon-activable protein 208 isoform 1"
                     /protein_id="NP_001156410.1"
                     /db_xref="CCDS:CCDS48451.1"
                     /db_xref="GeneID:100033459"
                     /db_xref="MGI:MGI:2442822"
                     /translation="MTGEMVNYYKQIVLLSGLEYMNDYNFRALKSLLNHDLKLTKNMQ
                     DDYDRIKIADLMEEKFPEDAGLSKLIEVCEDIPELAARVDILRKEMEKVKNKTKIKSE
                     SSPLPLTSSLMEAWEVEPAMVTASSEESKDTIPESPDTMTTQFLEEKPKFPLLSATST
                     SQAEGEPLTPQRFPTTASSSLQTPLEPTEILSTILATSQGSSAPYSTCDKSSRVPPVT
                     VSSSLQTIQTCQATSTLPCSHHTSLESPKTEPSSVQATQMTQAIKASGHNCPQVPASA
                     VSSSFIKPQVTPAMLLSGVQTPLMPQATVPSRAQTFQLTPAKMTSGCNSPQMSAATVY
                     SSYSNPQVTPVHSSVQILQMNLAAMTIGCNSPHVSAATVSSPYNNPWVTPATFPRNAQ
                     TLQLYPAAMAHACNSPQVSAATISSSYNNTPQVSSVTVPRSFPAMSLSPAKPLKAKIG
                     SHLGATDQLVKDHQFEDNEMQNPQSGLGTGLSDQPRLSRTQSRTEKRRRKQEEQPLAT
                     KMKRLSLSPPQTTARRVNPMPTWGQLKKLTREAEGLVQRTGNKLSSETMFLAMLALIA
                     MQSSSEICNYDKGGHSGTSSEK"
     exon            588..694
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1648
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1716
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..2014
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..3003
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2957..2962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /note="hexamer: TATAAA"
     polyA_site      3003
                     /gene="Ifi208"
                     /gene_synonym="9830148g24rik; E430029J22Rik; NG2creBAC;
                     Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik"
                     /note="major polyA site"
ORIGIN      
        1 agttcccctc agtctgagca gctgtgcagt gactctaccc agtgtcagct ttccatctct
       61 ctctgaaaac acttcattgt ctcagaattt caggagatta caaaatcctc tggatcacct
      121 tctgagagat ttactatttg ctcttcacac acacactcac acacagacac agacacacac
      181 agacacacac acatacacag acacagacac agacacacac tcactcactc actcacttgc
      241 tcactcactc actgcttcct gccctgcaaa ggctggatac cactgaagaa ttttctgaag
      301 aggcttatcc atgactggag agatggtgaa ttactacaag caaattgttc ttctgtctgg
      361 attagaatat atgaatgact ataactttag agcacttaag tccttactga accatgacct
      421 aaaactgact aagaacatgc aagatgatta tgacagaatt aagattgctg acttaatgga
      481 agaaaagttc ccagaggatg ctggattgag caaactgata gaagtatgtg aagacattcc
      541 agaacttgca gctcgtgttg atatacttag aaaagagatg gagaaagtta aaaataaaac
      601 caaaataaaa tcggaatcca gtcctctccc acttacctcc agcctgatgg aagcttggga
      661 agtagaacca gctatggtga cagcttcatc agaggaaagc aaagatacta tccctgaatc
      721 acctgatacc atgacaacac agtttttgga ggaaaagcct aagtttccat tactttcagc
      781 aaccagcaca agccaggctg agggtgaacc actgactccc cagaggtttc caacaacagc
      841 ctccagcagt ctccagacac ccctggagcc tacagaaata ttgtccacca tattggcaac
      901 atctcagggt tcttcagcac catattccac ctgtgacaaa tcttctcggg tgcctccagt
      961 gacagtctcc agcagcctcc agaccatcca gacctgtcag gcaacctcaa cacttccttg
     1021 tagtcaccac acttctctgg agtctccaaa aacagagccc agcagtgtcc aggccactca
     1081 gatgactcaa gcaataaagg caagtggtca taattgtcct caggtgcctg catcagcagt
     1141 atccagcagt ttcattaaac ctcaggtgac cccagcaatg ttactcagcg gtgtccaaac
     1201 tcctttgatg cctcaagcaa cagtgcccag ccgtgcccag acctttcaac taaccccagc
     1261 aaaaatgacc agtggttgta atagtcctca gatgtctgca gcaacagtat acagcagtta
     1321 cagtaaccct caggtgactc cagtgcacag cagtgtccag atcttgcaaa tgaacctagc
     1381 agcaatgacc attggttgta atagtcctca tgtatctgca gcaacagtat ccagccctta
     1441 caataaccct tgggtgactc cagcaacatt tccccgaaat gcccagacct tgcaactcta
     1501 cccagcagcc atggcccatg cctgtaatag tcctcaggtg tctgcagcaa caatatccag
     1561 cagttacaat aatacccctc aggtgtcttc tgtaacagtg cccaggagtt ttcctgccat
     1621 gtctctgtct ccagcaaagc cactcaaggc aaagatagga tctcatctgg gtgctacaga
     1681 ccagctggta aaggatcacc agtttgagga caatgaaatg cagaatcccc agtctggatt
     1741 agggacaggc ttatcagatc agccccgcct gtcccgaaca caaagccgca cagagaagag
     1801 aaggagaaag caggaagaac agccgcttgc aaccaaaatg aagagactct ccctatctcc
     1861 accacagaca acagcaagga gagtcaaccc gatgccaacc tggggacaac taaagaagct
     1921 gactcgtgag gcggagggac tagtacagag aacgggcaac aagctttcat cagagacaat
     1981 gtttttggcc atgcttgctt taatagctat gcagagttct tctgagattt gtaactacga
     2041 caagggagga cattctggaa cttcatctga aaaataagaa agagggaatg ctacacaaac
     2101 tccagtgaag actgcatggc aggcccaaga gcttggacac agtgctgagg caaaaagttt
     2161 catggaaact taatgtcctg gagacttggc atccctgtag catgaatgct ccaaacttgt
     2221 tcttgtgtta gttggtgaat ggatctgtat gttttctttc agtattgttt tattaatagg
     2281 tgcctctaag taatgatttt actaatacct aaatcaggtt gaattttgct tcctggcctt
     2341 caccaatgtc ctaggcagtc ctggagctga ccctgggctt ggaatttcat aagaatgtta
     2401 ctcattcaga cgaaatgccc cagtgttgac agttagtaat ctggcatctc acagtttgcc
     2461 agataggagc tagaaatctc aggactagtt caaaatagta aacttagaat cctcattaca
     2521 gtcaggtatg gcagactaca ttgcatatta gaagaaagtt gagttctact gaccaatgga
     2581 gatttcccta cagacactta aaagagcagc caggttactc ccatatgaaa gaatttacaa
     2641 tggcctagga ataaggaggg ttgtagttta aggaagaact agagtattgc attattcatg
     2701 aaaaggtcag caagagcaga acccccctgg tgcaagcttt cacaaggctc agaggaatag
     2761 cataaattgt gactagggtg tgaaatcctc acctggctcc tgtcaatagc tgcctttaga
     2821 taggtctgat cttatctcaa ttgtaaacat tgcctggttt ctgccagtct ttatgtatgc
     2881 atcttttgtt ttgtgtcaga ttacttcaat gtaccttggc tgatgtgtca cctaacttct
     2941 ctgttttctt ctgtaatata aatctgatat tcagtttgag aaattacatt tagagataca
     3001 gca
//
