LOCUS       NM_008329               2302 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus interferon activated gene 204 (Ifi204), mRNA.
ACCESSION   NM_008329 XM_001002287
VERSION     NM_008329.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Moran,E.A., Salas-Briceno,K., Zhao,W., Enya,T., Aguilera,A.N.,
            Acosta,I., Alonzo,F., Kiani,D., Behnsen,J., Alvarez,C., Keane,T.M.,
            Adams,D.J., Lilue,J. and Ross,S.R.
  TITLE     IFI207, a young and fast-evolving protein, controls retroviral
            replication via the STING pathway
  JOURNAL   mBio 15 (7), e0120924 (2024)
   PUBMED   38860764
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Zhang,J.G., Chen,W., Zhou,C.K., Ma,K., Liu,Z.Z., Gao,Y., Lin,X.Q.
            and Yang,Y.J.
  TITLE     IFI204 protects host defense against Staphylococcus aureus-induced
            pneumonia by promoting extracellular traps formation
  JOURNAL   Exp Cell Res 422 (1), 113415 (2023)
   PUBMED   36379277
  REMARK    GeneRIF: IFI204 protects host defense against Staphylococcus
            aureus-induced pneumonia by promoting extracellular traps
            formation.
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Pucinelli,C.M., Lima,R.B., Almeida,L.K.Y., Lucisano,M.P.,
            Cordoba,A.Z., Marchesan,J.T., da Silva,L.A.B. and da Silva,R.A.B.
  TITLE     Interferon-gamma inducible protein 16 and type I interferon
            receptors expression in experimental apical periodontitis induced
            in wild-type mice
  JOURNAL   Int Endod J 55 (10), 1042-1052 (2022)
   PUBMED   35869806
  REMARK    GeneRIF: Interferon-gamma inducible protein 16 and type I
            interferon receptors expression in experimental apical
            periodontitis induced in wild-type mice.
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Ka,N.L., Lim,G.Y., Kim,S.S., Hwang,S., Han,J., Lee,Y.H. and
            Lee,M.O.
  TITLE     Type I IFN stimulates IFI16-mediated aromatase expression in
            adipocytes that promotes E2-dependent growth of ER-positive breast
            cancer
  JOURNAL   Cell Mol Life Sci 79 (6), 306 (2022)
   PUBMED   35593921
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Choubey,D. and Lengyel,P.
  TITLE     Interferon action: nucleolar and nucleoplasmic localization of the
            interferon-inducible 72-kD protein that is encoded by the Ifi 204
            gene from the gene 200 cluster
  JOURNAL   J Cell Biol 116 (6), 1333-1341 (1992)
   PUBMED   1541632
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Kingsmore,S.F., Watson,M.L., Howard,T.A. and Seldin,M.F.
  TITLE     A 6000 kb segment of chromosome 1 is conserved in human and mouse
  JOURNAL   EMBO J 8 (13), 4073-4080 (1989)
   PUBMED   2591369
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Choubey,D., Snoddy,J., Chaturvedi,V., Toniato,E., Opdenakker,G.,
            Thakur,A., Samanta,H., Engel,D.A. and Lengyel,P.
  TITLE     Interferons as gene activators. Indications for repeated gene
            duplication during the evolution of a cluster of
            interferon-activatable genes on murine chromosome 1
  JOURNAL   J Biol Chem 264 (29), 17182-17189 (1989)
   PUBMED   2477366
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Opdenakker,G., Snoddy,J., Choubey,D., Toniato,E., Pravtcheva,D.D.,
            Seldin,M.F., Ruddle,F.H. and Lengyel,P.
  TITLE     Interferons as gene activators: a cluster of six
            interferon-activatable genes is linked to the erythroid
            alpha-spectrin locus on murine chromosome 1
  JOURNAL   Virology 171 (2), 568-578 (1989)
   PUBMED   2474894
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Kingsmore,S.F., Snoddy,J., Choubey,D., Lengyel,P. and Seldin,M.F.
  TITLE     Physical mapping of a family of interferon-activated genes, serum
            amyloid P-component, and alpha-spectrin on mouse chromosome 1
  JOURNAL   Immunogenetics 30 (3), 169-174 (1989)
   PUBMED   2476388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150522.1, AC119230.16, AC117682.11, BU694586.1, CT010351.1 and
            BE686930.1.
            
            On Nov 17, 2006 this sequence version replaced NM_008329.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-647               AK150522.1         2-648
            648-750             AC119230.16        72378-72480         c
            751-1104            AC117682.11        146-499
            1105-1572           BU694586.1         27-494
            1573-1987           CT010351.1         1465-1879
            1988-2302           BE686930.1         1-315               c
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.63 cM"
     gene            1..2302
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /note="interferon activated gene 204"
                     /db_xref="GeneID:15951"
                     /db_xref="MGI:MGI:96429"
     exon            1..109
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            110..394
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1989
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /note="interferon, gamma-inducible protein 16; interferon,
                     gamma-inducible gene 204; ifi-204; interferon-inducible
                     protein p204"
                     /codon_start=1
                     /product="interferon-activable protein 204"
                     /protein_id="NP_032355.2"
                     /db_xref="CCDS:CCDS35792.1"
                     /db_xref="GeneID:15951"
                     /db_xref="MGI:MGI:96429"
                     /translation="MVNEYKRIVLLRGLECINKHYFSLFKSLLARDLNLERDNQEQYT
                     TIQIANMMEEKFPADSGLGKLIAFCEEVPALRKRAEILKKERSEVTGETSLEKNGQEA
                     GPATPTSTTSHMLASERGETSATQEETSTAQAGTSTAQARTSTAQAGTSTAQKRKIMR
                     EEETGVKKSKAAKEPDQPPCCEEPTARCQSPILHSSSSASSNIPSAKNQKSQPQNQNI
                     PRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMLHATVATVSQYFHVKVFNINLKEK
                     FTKKNFIIISNYFESKGILEINETSSVLEAAPDQMIEVPNSIIRNANASPKICDIQKG
                     TSGAVFYGVFTLHKKTVNRKNTIYEIKDGSGSIEVVGSGKWHNINCKEGDKLHLFCFH
                     LKTIDRQPKLVCGEHSFIKISKRGNVPKEPAKEEDHHHGPKQVMVLKVTEPFTYDLKE
                     DKRMFHATVATETEFFRVKVFDTALKSKFIPRNIIAISDYFGCNGFLEIYRASCVSDV
                     NVNPTMVISNTLRQRANATPKISYLFSQARGTFVSGEYLVNKKTERNKFIYYGIGDDT
                     GKMEVVVYGRLTNVRCEPGSKLRLVCFELTSTEDGWQLRSVRHSYMQVINARK"
     exon            395..591
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            592..750
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1173
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1362
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1779
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1968
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2296
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /note="hexamer: AATAAA"
     polyA_site      2296
                     /gene="Ifi204"
                     /gene_synonym="Ifi16; p204"
                     /note="major polyA site"
ORIGIN      
        1 agtttcttat ttactgactt agctgcctac ctactcaagc caagcaggcc acttcttgac
       61 ccggtgaagg tctcaggatc tgtacatcac tgcagaaata tccaggaagg ctcagcaaca
      121 acttcaaaga tggtgaatga atacaagaga attgttctgc tgagaggact tgaatgtatc
      181 aataagcatt attttagctt atttaagtca ttgctggcca gagatttaaa tctggaaaga
      241 gacaaccaag agcaatacac cacgattcag attgctaaca tgatggaaga gaaatttcca
      301 gctgattctg gattgggcaa actgattgcg ttttgtgaag aagtaccagc tcttagaaaa
      361 cgagctgaaa ttcttaaaaa agagagatca gaagtaacag gagaaacatc actggaaaaa
      421 aatggtcaag aagcaggtcc tgcaacacct acatcaacta caagccacat gttagcatct
      481 gaaagaggcg agacttctgc aacccaggaa gagacttcca cagctcaggc ggggacttcc
      541 acagctcagg cgaggacttc cacagctcag gcggggactt ctacagccca gaaaagaaaa
      601 attatgagag aagaagagac tggagtgaaa aagagcaagg cggctaagga accagatcag
      661 cctccctgtt gtgaagaacc cacagccagg tgccagtcac caatactcca cagctcatct
      721 tcagcttcat ctaacattcc ttcggctaag aaccaaaaat cacaacccca gaatcagaac
      781 attcccagag gtgctgttct ccactcagag cccctgacag tgatggtgct cactgcaaca
      841 gacccatttg aatatgaatc accagaacat gaagtaaaga acatgcttca tgctacagtg
      901 gctacagtga gccagtattt ccatgtgaaa gttttcaaca tcaacttgaa agaaaagttc
      961 acaaaaaaga attttatcat catatccaat tactttgaga gcaaaggcat cctggagatc
     1021 aatgagactt cctctgtgtt agaggctgct cctgaccaaa tgattgaagt gcccaacagt
     1081 attatcagaa atgcaaatgc cagccctaag atctgtgata ttcaaaaggg tacttctgga
     1141 gcagtgttct atggagtgtt tacattacac aagaaaacag tgaaccgaaa gaacacaatc
     1201 tatgaaataa aagatggttc aggaagcata gaagtggtgg ggagtggaaa atggcacaac
     1261 atcaactgca aggaaggaga taaactccac ctcttctgct ttcacctgaa aacaattgac
     1321 aggcaaccaa agttagtgtg tggagaacac agtttcatca agatatcaaa gagaggaaat
     1381 gtaccaaagg agcctgctaa ggaagaagat caccatcatg gtcccaaaca agtgatggtg
     1441 ctgaaagtaa cagaaccatt tacatatgac ctgaaagagg ataaaagaat gtttcatgct
     1501 accgtggcta ctgaaactga gttcttcaga gtgaaggttt ttgacacggc tctaaagagc
     1561 aagttcatcc caagaaatat cattgccata tcagattatt ttgggtgcaa tgggtttctg
     1621 gagatataca gagcttcctg tgtctctgat gtgaacgtta atccaacaat ggttatctca
     1681 aatacactga gacaaagagc taatgcaact cctaaaattt cttatctttt ctcacaagca
     1741 agggggacat ttgtgagtgg agagtactta gtaaataaga aaacggagag gaataaattc
     1801 atttactatg gaattggaga tgatacaggg aaaatggaag tggtggttta tggaagactc
     1861 accaatgtca ggtgtgaacc aggcagtaaa ctaagacttg tctgctttga attgacttcc
     1921 actgaagatg ggtggcagct gaggtctgta aggcacagtt acatgcaggt catcaatgct
     1981 agaaagtgaa ggaaagccac tcaacccaga ctcagtcggg agaacctctc tggaaccata
     2041 cttctgaaaa cctgaatgcc aatgatattt ttttgtggag ataagattca attacagaaa
     2101 ataaatgtgt ataagcctat tgaaatatca gtcctataaa gaccatctct taattctagg
     2161 aaatggtgtt ttcttatatt ctttacacat tttctatatc taaattcatt tgttgtctct
     2221 ataacttcta taactgttca atttgcaatt tttatgccta aaacttataa aaataaattc
     2281 acacaatttc tgtaaaaaaa aa
//
