LOCUS       NM_001302651            3497 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus interferon activated gene 203 (Ifi203), transcript
            variant 3, mRNA.
ACCESSION   NM_001302651 XM_006496673
VERSION     NM_001302651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3497)
  AUTHORS   Norheim,F., Chella Krishnan,K., Bjellaas,T., Vergnes,L., Pan,C.,
            Parks,B.W., Meng,Y., Lang,J., Ward,J.A., Reue,K., Mehrabian,M.,
            Gundersen,T.E., Peterfy,M., Dalen,K.T., Drevon,C.A., Hui,S.T.,
            Lusis,A.J. and Seldin,M.M.
  TITLE     Genetic regulation of liver lipids in a mouse model of insulin
            resistance and hepatic steatosis
  JOURNAL   Mol Syst Biol 17 (1), e9684 (2021)
   PUBMED   33417276
  REMARK    GeneRIF: Genetic regulation of liver lipids in a mouse model of
            insulin resistance and hepatic steatosis.
REFERENCE   2  (bases 1 to 3497)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3497)
  AUTHORS   Brunette,R.L., Young,J.M., Whitley,D.G., Brodsky,I.E., Malik,H.S.
            and Stetson,D.B.
  TITLE     Extensive evolutionary and functional diversity among mammalian
            AIM2-like receptors
  JOURNAL   J Exp Med 209 (11), 1969-1983 (2012)
   PUBMED   23045604
REFERENCE   4  (bases 1 to 3497)
  AUTHORS   Zhang,K., Kagan,D., DuBois,W., Robinson,R., Bliskovsky,V.,
            Vass,W.C., Zhang,S. and Mock,B.A.
  TITLE     Mndal, a new interferon-inducible family member, is highly
            polymorphic, suppresses cell growth, and may modify plasmacytoma
            susceptibility
  JOURNAL   Blood 114 (14), 2952-2960 (2009)
   PUBMED   19654412
REFERENCE   5  (bases 1 to 3497)
  AUTHORS   Kurey,I., Kobets,T., Havelkova,H., Slapnickova,M., Quan,L.,
            Trtkova,K., Grekov,I., Svobodova,M., Stassen,A.P., Hutson,A.,
            Demant,P. and Lipoldova,M.
  TITLE     Distinct genetic control of parasite elimination, dissemination,
            and disease after Leishmania major infection
  JOURNAL   Immunogenetics 61 (9), 619-633 (2009)
   PUBMED   19705113
REFERENCE   6  (bases 1 to 3497)
  AUTHORS   Brownstein,D.G. and Gras,L.
  TITLE     Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host
            resistance to mousepox
  JOURNAL   J Virol 69 (11), 6958-6964 (1995)
   PUBMED   7474114
REFERENCE   7  (bases 1 to 3497)
  AUTHORS   Kingsmore,S.F., Watson,M.L., Howard,T.A. and Seldin,M.F.
  TITLE     A 6000 kb segment of chromosome 1 is conserved in human and mouse
  JOURNAL   EMBO J 8 (13), 4073-4080 (1989)
   PUBMED   2591369
REFERENCE   8  (bases 1 to 3497)
  AUTHORS   Opdenakker,G., Snoddy,J., Choubey,D., Toniato,E., Pravtcheva,D.D.,
            Seldin,M.F., Ruddle,F.H. and Lengyel,P.
  TITLE     Interferons as gene activators: a cluster of six
            interferon-activatable genes is linked to the erythroid
            alpha-spectrin locus on murine chromosome 1
  JOURNAL   Virology 171 (2), 568-578 (1989)
   PUBMED   2474894
REFERENCE   9  (bases 1 to 3497)
  AUTHORS   Kingsmore,S.F., Snoddy,J., Choubey,D., Lengyel,P. and Seldin,M.F.
  TITLE     Physical mapping of a family of interferon-activated genes, serum
            amyloid P-component, and alpha-spectrin on mouse chromosome 1
  JOURNAL   Immunogenetics 30 (3), 169-174 (1989)
   PUBMED   2476388
REFERENCE   10 (bases 1 to 3497)
  AUTHORS   Engel,D.A., Snoddy,J., Toniato,E. and Lengyel,P.
  TITLE     Interferons as gene activators: close linkage of two
            interferon-activatable murine genes
  JOURNAL   Virology 166 (1), 24-29 (1988)
   PUBMED   2457983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040214.1, AK144663.1 and BE691222.1.
            
            On Nov 5, 2014 this sequence version replaced XM_006496673.1.
            
            Transcript Variant: This variant (3) lacks two in-frame exons in
            the coding region compared to variant 1. The encoded isoform (3) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040214.1, SRR13422598.1030054.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1462              AK040214.1         2-1463
            1463-3482           AK144663.1         1589-3608
            3483-3497           BE691222.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.76 cM"
     gene            1..3497
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="interferon activated gene 203"
                     /db_xref="GeneID:15950"
                     /db_xref="MGI:MGI:96428"
     exon            1..38
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     exon            39..103
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     exon            104..388
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1353
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="isoform 3 is encoded by transcript variant 3;
                     interferon-activable protein 203; interferon-inducible
                     protein p203"
                     /codon_start=1
                     /product="interferon-activable protein 203 isoform 3"
                     /protein_id="NP_001289580.1"
                     /db_xref="CCDS:CCDS35793.1"
                     /db_xref="GeneID:15950"
                     /db_xref="MGI:MGI:96428"
                     /translation="MMAEYKNIVLLKGLENMEDYQFRTVKSLLRKELKLTKKMQEDYD
                     RIQLADWIEDKFPKDAGLDKLIKVCEHIKDLKDLAKKLKTEKAKVQKKKEGKCKTAGK
                     KKGQDELSSSESLFNNKESNKSVPSSKKKRKQITKTEGGKKKKLTQEQAQLPETSGTN
                     IKKEEDCLQNPHKSPPTPSSSSSNKAPRRGTVPKEPSREEGHHQGPKQVMVLKVTEPF
                     TYDFEETKRMFHATVATETEFFRVKVFDTALMSKFIPGKIIAISHYIGCNGFLEIYRA
                     SCVSDVNINPTMIISNTLSESAIATPKISYLLSQAKGTFVNGEFVVFKKSERHECICY
                     GIGDDTGKMAVVVYGRLTNVRCEPGSKLRLVCFELTSTKDVCLLRSVRHSYMQVINEG
                     KPLNPDSVRRNSLEPYF"
     exon            389..510
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     exon            511..678
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1095
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1284
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..3489
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="major polyA site"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="hexamer: AATAAA"
     polyA_site      1670
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="hexamer: AATAAA"
     polyA_site      2008
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
     regulatory      2392..2397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="hexamer: ATTAAA"
     polyA_site      2414
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
     regulatory      3241..3246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="hexamer: AGTAAA"
     polyA_site      3264
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
     regulatory      3311..3316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
                     /note="hexamer: AATAAA"
     polyA_site      3333
                     /gene="Ifi203"
                     /gene_synonym="Ifi203a; Ifi203b; Mndal"
ORIGIN      
        1 caatttcatc ttaagtctcc ccaggaagac agcacactag aaaccccatt tcctgacttg
       61 ctgaagattt atcatctgaa cattgctgag aaatttcact gaggttaatc tataatttga
      121 gagatgatgg ctgaatacaa gaatattgtt cttctaaaag gattagagaa catggaggac
      181 tatcagttta ggacagtcaa gtccttacta agaaaagaac taaaacttac taaaaaaatg
      241 caagaagatt atgataggat tcagctggcg gactggattg aggacaagtt ccccaaagat
      301 gctggactag acaaactgat aaaagtgtgt gagcacataa aagatcttaa agaccttgct
      361 aaaaaactta aaacagagaa ggcaaaagtt caaaagaaaa aggaaggaaa atgcaaaacg
      421 gctgggaaaa aaaaagggca agatgaactc agttcttctg aatctctttt caacaataaa
      481 gaatcaaaca agagtgtacc gtcttcaaag aaaaagagaa aacagatcac aaaaactgaa
      541 ggtggaaaga aaaagaagct cacccaggag caggctcagc ttccagaaac ttcaggaacc
      601 aacataaaaa aagaggaaga ttgcctccag aatcctcata agtctccacc aacaccatcc
      661 agcagttcct caaacaaggc accaaggaga ggaactgtac caaaggagcc ttctagagaa
      721 gaaggtcacc atcaaggtcc caaacaagtg atggtgttga aagtaacaga accatttaca
      781 tatgactttg aagaaacgaa aaggatgttt catgctacag tggctactga aactgagttc
      841 ttcagagtga aggtttttga cacagctcta atgagcaagt tcatcccagg aaagatcatt
      901 gccatatcac attatattgg gtgcaatggg tttctggaga tatacagagc ttcctgtgtg
      961 tccgatgtga acattaaccc aacaatgatt atctcaaata cactgagtga aagtgctatt
     1021 gcaactccaa aaatttctta tcttctctca caagcaaagg ggacatttgt aaatggagaa
     1081 tttgtagtat ttaagaaaag tgagaggcat gagtgcattt gctatggaat tggagatgat
     1141 acaggaaaaa tggcagtggt ggtttatgga cgactcacca atgtcaggtg tgaaccaggc
     1201 agtaaactta gacttgtctg ctttgaattg acttccacta aagatgtgtg cctcctgagg
     1261 tctgtaaggc acagttacat gcaggtcatc aatgaaggaa agccactcaa cccagactca
     1321 gtcaggagaa actctctgga accatacttc tgataacctg gatgccaatg acactgtttg
     1381 tggagataag attcaagtac agaaaataaa tgtgcacagg cctgttgaaa taccagtctt
     1441 ataaagacca gctcttaatt ctaagaaatg gtgctttctc atattcttta tacattctat
     1501 tatctaaatt tcataggttg tctctataac tcctttaact gttggtttgt aatttttata
     1561 cctaaaactt aaaaaataaa atccacacaa tttctgttaa gcagtgtgcc tttggcacta
     1621 tcctttaacc atttgagatg tgctttaaaa taaaaactta gtgaccctta cataaagctg
     1681 gagaatacag gcttcaaatg tgatgtgtca ggacaaagca tgttcagaaa caaatagact
     1741 gtgttttctg cccatgaagt caaggtatta ataagatgtg gggaaatgtt gaactcagcc
     1801 ttgagtgtag tttccaaaac taatatgctg agaacaggat caagttttca cctccactat
     1861 gcttagtaat gtgactgcat tacagagttt aggtattgga aaaaaacttc cccagaatga
     1921 ggtgtttagg gcggggcgta ctattttcaa ctataaggaa tcccatcttc aattccagaa
     1981 tcaaataaaa tcactgcaaa cttttaaagc aagatgaaga aggcttatga taaaggaaat
     2041 caaagaaatt aagaaattag tattctcaca gaggcctttc tagattattt ctcacttctc
     2101 tcactgatgg taagacttac ttgataaagc aactgaagga acaatgggtt cattttgccc
     2161 atatttgaat ggtagagaag ggtgaggtga ctgaccatgt acctgcagga ggaagcagag
     2221 agaagtgagt tctagagtcg atctctctct ctctctcttt ctgtctctgt ttctctgtct
     2281 ctgtctctct gtctctctgt ctctctgtct ctctgtctct ctctctgtct ctctctctct
     2341 ctctctctct ctctccctcc ctccctccct ccctccctct ctccctcttt tattaaagac
     2401 atgaacctat tcaatgatac tctccacatt tatgatgagt gtttgcaaat tccttaacac
     2461 agtctagaaa cttcctcttg cacagcataa aaggattctc acaagtaatt ccagatcctg
     2521 tcaggtttac aatcagtatt tacagtcaca tgaggcaatg atgtgaaata gaggtaagga
     2581 gcatacatag ggatttggac agctgaaatg taggcaagaa gaggcaagag ctaaggatgg
     2641 gtaactctct catcttctaa atccatgtgt tatcccccat tctaatgata ctggaatttt
     2701 gagcttaatg ggatttgttt aattctaaat cacttctcac caatagatta atgtccctaa
     2761 aaacatttgt ggaaggaaat tctatttgtt tttagtattt gttttgcttt aacatgatca
     2821 tccagtatgt gagagtggga cagaatattg tttagcacct tgaaactcca cttttctttt
     2881 cctataatca cagtgcacct tccagagaga gatcattatc cacatctact gtgtacacac
     2941 aacattcttc aaacaataca cctgaaacct attatcaaag taggcaccca tatacaacag
     3001 attgcaaata tatatgctat gaaccttgaa aatgattact gtctctagaa ataccttcat
     3061 taaaacctta tttatagtca aatatgtcaa cttttcaata ccatgaacaa tggactgatc
     3121 cagcctagac tagtttgagt aaatgtacat ccagacaaac tatttcttta aagtgaactt
     3181 ttatgatgga tattctgttt accacctcct tcctatgtat acttgtgtgt gtataatcaa
     3241 agtaaagtgc tctatggaaa gggacatgca ggaggaagaa atgcctacct aatctatgct
     3301 gatccaccga aataaagact cacttgtatt acatcccttc agcaaaacaa caactcctct
     3361 tgaactccat gaaagaaact tcaaggaaaa cctggagcct gtaaatacat ttacttataa
     3421 ggcccacaat tgctttctga tctgtactga cagtttgcat ctaataaagt ttcactggtt
     3481 ctataaaaaa aaaaaaa
//
