LOCUS       NM_008327               1796 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus interferon activated gene 202B (Ifi202b), transcript
            variant 1, mRNA.
ACCESSION   NM_008327 XM_001006087
VERSION     NM_008327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Moran,E.A., Salas-Briceno,K., Zhao,W., Enya,T., Aguilera,A.N.,
            Acosta,I., Alonzo,F., Kiani,D., Behnsen,J., Alvarez,C., Keane,T.M.,
            Adams,D.J., Lilue,J. and Ross,S.R.
  TITLE     IFI207, a young and fast-evolving protein, controls retroviral
            replication via the STING pathway
  JOURNAL   mBio 15 (7), e0120924 (2024)
   PUBMED   38860764
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Lim,G.Y., Cho,S.W., Ka,N.L., Lee,K.H., Im,S.A., Kim,S.S., Hwang,S.
            and Lee,M.O.
  TITLE     IFI16/Ifi202 released from breast cancer induces secretion of
            inflammatory cytokines from macrophages and promotes tumor growth
  JOURNAL   J Cell Physiol 238 (7), 1507-1519 (2023)
   PUBMED   37062941
  REMARK    GeneRIF: IFI16/Ifi202 released from breast cancer induces secretion
            of inflammatory cytokines from macrophages and promotes tumor
            growth.
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Wang,P.H., Ye,Z.W., Deng,J.J., Siu,K.L., Gao,W.W., Chaudhary,V.,
            Cheng,Y., Fung,S.Y., Yuen,K.S., Ho,T.H., Chan,C.P., Zhang,Y.,
            Kok,K.H., Yang,W., Chan,C.P. and Jin,D.Y.
  TITLE     Inhibition of AIM2 inflammasome activation by a novel transcript
            isoform of IFI16
  JOURNAL   EMBO Rep 19 (10) (2018)
   PUBMED   30104205
  REMARK    GeneRIF: Enforced expression of IFI16-b inhibits the activation of
            AIM2 inflammasome, whereas knockdown of IFI16-b augments
            interleukin-1b secretion triggered by dsDNA but not dsRNA Thus,
            cytoplasm-localized IFI16-b is functionally equivalent to mouse
            p202 that exerts an inhibitory effect on AIM2 inflammasome. .
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Cao,Y., Wang,L., Wang,C.Y., Ye,J., Wang,Y., Li,T., Garcia-Godoy,F.,
            Sun,D., Gu,W. and Postlethwaite,A.E.
  TITLE     Sex Differences in Correlation with Gene Expression Levels between
            Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes
  JOURNAL   J Immunol Res 2018, 1290814 (2018)
   PUBMED   30246031
  REMARK    GeneRIF: the expression level of Ifi202b showed the most sex
            difference in correlation with known immune-related genes
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Zhang,L., Wang,C., Zhang,X. and Li,H.
  TITLE     The interferon-inducible protein p202 promotes osteogenesis in
            mouse bone marrow stromal cells
  JOURNAL   Biosci Rep 38 (3) (2018)
   PUBMED   29853536
  REMARK    GeneRIF: p202 promotes osteogenesis in mouse bone marrow stromal
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Wang,H., Ding,B., Liu,C.J., Ma,X.Y., Deschamps,S., Roe,B.A. and
            Lengyel,P.
  TITLE     The increase in levels of interferon-inducible proteins p202a and
            p202b and RNA-dependent protein kinase (PKR) during myoblast
            differentiation is due to transactivation by MyoD: their tissue
            distribution in uninfected mice does not depend on interferons
  JOURNAL   J Interferon Cytokine Res 22 (6), 729-737 (2002)
   PUBMED   12162885
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Wang,H., Chatterjee,G., Meyer,J.J., Liu,C.J., Manjunath,N.A.,
            Bray-Ward,P. and Lengyel,P.
  TITLE     Characteristics of three homologous 202 genes (Ifi202a, Ifi202b,
            and Ifi202c) from the murine interferon-activatable gene 200
            cluster
  JOURNAL   Genomics 60 (3), 281-294 (1999)
   PUBMED   10493828
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Datta,B., Li,B., Choubey,D., Nallur,G. and Lengyel,P.
  TITLE     p202, an interferon-inducible modulator of transcription, inhibits
            transcriptional activation by the p53 tumor suppressor protein, and
            a segment from the p53-binding protein 1 that binds to p202
            overcomes this inhibition
  JOURNAL   J Biol Chem 271 (44), 27544-27555 (1996)
   PUBMED   8910340
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Choubey,D. and Lengyel,P.
  TITLE     Binding of an interferon-inducible protein (p202) to the
            retinoblastoma protein
  JOURNAL   J Biol Chem 270 (11), 6134-6140 (1995)
   PUBMED   7890747
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Choubey,D., Snoddy,J., Chaturvedi,V., Toniato,E., Opdenakker,G.,
            Thakur,A., Samanta,H., Engel,D.A. and Lengyel,P.
  TITLE     Interferons as gene activators. Indications for repeated gene
            duplication during the evolution of a cluster of
            interferon-activatable genes on murine chromosome 1
  JOURNAL   J Biol Chem 264 (29), 17182-17189 (1989)
   PUBMED   2477366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056241.1, AC170584.4, M31418.1 and EL957871.1.
            
            On Jan 9, 2008 this sequence version replaced NM_008327.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome sequence was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055888.1, AF140672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               CJ056241.1         2-389
            389-648             AC170584.4         27242-27501
            649-833             M31418.1           718-902
            834-834             EL957871.1         5-5
            835-1114            M31418.1           904-1183
            1115-1326           AC170584.4         30754-30965
            1327-1358           M31418.1           1396-1427
            1359-1518           AC170584.4         38368-38527
            1519-1563           M31418.1           1588-1632
            1564-1796           AC170584.4         39543-39775
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1796
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /note="interferon activated gene 202B"
                     /db_xref="GeneID:26388"
                     /db_xref="MGI:MGI:1347083"
     exon            1..171
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
     exon            172..344
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1562
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /note="lupus susceptibility protein p202; ifi-202;
                     interferon-inducible protein p202; interferon activated
                     gene 202A; Interferon-activatable protein 202a (Ifi-202a)
                     (Interferon-inducible protein p202a)"
                     /codon_start=1
                     /product="interferon-activable protein 202"
                     /protein_id="NP_032353.2"
                     /db_xref="CCDS:CCDS35794.1"
                     /db_xref="GeneID:26388"
                     /db_xref="MGI:MGI:1347083"
                     /translation="MSNRNLRSSTNSEFSEGQHQTPSSDSSGHGEDQPQASPGPNKKS
                     HTPKKNISKGAVLHEKPMTVMVLTATEPFNYKEGKENMFHATVATESQYYRVKVFNMD
                     LKEKFTENKFITISKYFNSSGILEINETATVSEAAPNQIIEVPKNIIRSAKETLKISK
                     IKELDSGTLIYGVFAVEKKKVNDKSITFKIKDNEDNIKVVWDKKQHNINYEKGDKLQL
                     FSFHLRKGNGKPILHSGNHSFIKGEKLLKESFEGDGYHKGPKQVVALKATKLFTYDSI
                     KSKKMFHATVATDTEFFRVMVFEENLEKKFIPGNTIALSDYFGMYGSLAIHEYSSVSE
                     VKSQNKEDSSSSDERLIEHLKICDLHLQTKERLVDGEFKVYRKSTGNNCICYGIWDDT
                     GAMKVVVSGQLTSVNCEIGNTIRLVCFELTSNADEWFLRSTRYSYMEVIMPEK"
     exon            345..758
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
     exon            759..947
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1352
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1541
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1796
                     /gene="Ifi202b"
                     /gene_synonym="Ifbip-1; Ifi202; Ifi202a; Ifi202c; p202"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataccgagaa gagtatttaa ccggtgtcat tttcttacca tttttataaa ttcttaattt
       61 gctgtacatc tgataacacc ttcatttatt ttccttctta aagctgacac actctgcctt
      121 gttggagatc taggacccgg aacaggagtc actgaagaag ttcccggctt gaagaactca
      181 atcaaaaagt ctgtatctac agaaagagac atctgtccca ggcaatgtcc aaccgtaact
      241 taaggtcatc taccaactca gaattttctg agggtcaaca tcagacccct tccagtgatt
      301 catctggcca tggggaggat caacctcaag cctctcctgg acctaacaaa aagtcacaca
      361 ccccaaaaaa gaacattagc aaaggtgctg ttcttcatga gaaacccatg acagtgatgg
      421 tactcactgc aacagaacca tttaattata aagagggaaa agagaacatg tttcatgcta
      481 cagtggctac agagagccaa tattaccgtg tgaaagtttt caacatggac ttgaaagaga
      541 agttcacaga aaataaattt attaccattt ccaaatactt caacagcagt ggcatcctag
      601 agatcaatga aactgccact gtgtcagagg ctgctcctaa ccaaattatt gaagtgccca
      661 aaaatattat cagaagtgca aaagaaactc ttaagatctc taaaattaaa gaacttgatt
      721 ctggaacact gatttatggt gtgtttgcag tagagaagaa aaaagtgaat gataaaagta
      781 taaccttcaa aataaaagat aatgaagata atataaaagt ggtgtgggat aaaaaacagc
      841 acaatatcaa ctatgagaaa ggagataaac tccaactctt ctcctttcac ctgagaaaag
      901 gaaatgggaa accaatatta cactctggaa atcacagttt catcaaggga gaaaagctac
      961 taaaagaatc ttttgaaggg gatggttacc acaaaggtcc caaacaagtg gtggcattga
     1021 aagcaacaaa actatttact tatgatagta taaaaagtaa aaagatgttc catgccacag
     1081 tggctactga tacagaattc ttcagagtga tggtcttcga ggaaaaccta gagaaaaagt
     1141 ttatcccggg aaacaccatt gctttatcag attattttgg tatgtatggg tctctggcaa
     1201 tacatgaata ttccagcgtg tctgaggtga agagccaaaa taaggaagac tcaagttcat
     1261 cagatgaaag actcatagaa catcttaaaa tttgtgatct tcacttgcaa acaaaagaaa
     1321 ggctggttga tggagagttt aaagtataca ggaaaagtac cggaaataat tgtatatgct
     1381 atggaatttg ggatgataca ggagcaatga aagtggtggt atctggacaa ctgaccagtg
     1441 tcaactgtga gattggtaat acaattagac ttgtctgctt tgaattgacc tcaaatgcag
     1501 atgagtggtt tctgagatct acgaggtaca gttacatgga ggtcatcatg cctgaaaaat
     1561 gaagaacagt gagtgatgta accccaattc aatggtgaaa atttccttat gaaacatgta
     1621 cactgaaaat ggaaaagaaa tgtatacctg ctcaaatata atacatacaa catccagctc
     1681 ttagttgtgg gaacaatact ttagcttatt ctttataaaa aaattttatg aactttcata
     1741 gtctgcatgc ttaagttcca taatatgaaa aaaataaatg ctgtacatta agcaat
//
