LOCUS       NM_133662               1090 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus immediate early response 3 (Ier3), mRNA.
ACCESSION   NM_133662
VERSION     NM_133662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1090)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1090)
  AUTHORS   Katano,W., Mori,S., Sasaki,S., Tajika,Y., Tomita,K., Takeuchi,J.K.
            and Koshiba-Takeuchi,K.
  TITLE     Sall1 and Sall4 cooperatively interact with Myocd and SRF to
            promote cardiomyocyte proliferation by regulating CDK and cyclin
            genes
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38014633
REFERENCE   3  (bases 1 to 1090)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1090)
  AUTHORS   Zhang,Q., Steensma,D.P., Yang,J., Dong,T. and Wu,M.X.
  TITLE     Uncoupling of CD71 shedding with mitochondrial clearance in
            reticulocytes in a subset of myelodysplastic syndromes
  JOURNAL   Leukemia 33 (1), 217-229 (2019)
   PUBMED   30050123
REFERENCE   5  (bases 1 to 1090)
  AUTHORS   Shahid,M., Hermes,E.L., Chandra,D., Tauseef,M., Siddiqui,M.R.,
            Faridi,M.H. and Wu,M.X.
  TITLE     Emerging Potential of Immediate Early Response Gene X-1 in
            Cardiovascular and Metabolic Diseases
  JOURNAL   J Am Heart Assoc 7 (21), e009261 (2018)
   PUBMED   30373431
  REMARK    GeneRIF: In this article, we reviewed the findings in IEX-1
            knockout mice from our laboratory and others and primarily focused
            on the roles of IEX-1 in cardiovascular and metabolic dis
REFERENCE   6  (bases 1 to 1090)
  AUTHORS   Zhang,Y., Schlossman,S.F., Edwards,R.A., Ou,C.N., Gu,J. and Wu,M.X.
  TITLE     Impaired apoptosis, extended duration of immune responses, and a
            lupus-like autoimmune disease in IEX-1-transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 878-883 (2002)
   PUBMED   11782530
REFERENCE   7  (bases 1 to 1090)
  AUTHORS   Schilling,D., Pittelkow,M.R. and Kumar,R.
  TITLE     IEX-1, an immediate early gene, increases the rate of apoptosis in
            keratinocytes
  JOURNAL   Oncogene 20 (55), 7992-7997 (2001)
   PUBMED   11753682
REFERENCE   8  (bases 1 to 1090)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   9  (bases 1 to 1090)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
REFERENCE   10 (bases 1 to 1090)
  AUTHORS   Charles,C.H., Yoon,J.K., Simske,J.S. and Lau,L.F.
  TITLE     Genomic structure, cDNA sequence, and expression of gly96, a growth
            factor-inducible immediate-early gene encoding a short-lived
            glycosylated protein
  JOURNAL   Oncogene 8 (3), 797-801 (1993)
   PUBMED   8437864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974451.9.
            
            On Nov 17, 2006 this sequence version replaced NM_133662.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006950.1, AK051003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               CR974451.9         46108-46323
            217-1090            CR974451.9         46433-47306
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.7 cM"
     gene            1..1090
                     /gene="Ier3"
                     /gene_synonym="cI-3; gly96; IEX-1"
                     /note="immediate early response 3"
                     /db_xref="GeneID:15937"
                     /db_xref="MGI:MGI:104814"
     exon            1..216
                     /gene="Ier3"
                     /gene_synonym="cI-3; gly96; IEX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..489
                     /gene="Ier3"
                     /gene_synonym="cI-3; gly96; IEX-1"
                     /note="immediate early protein GLY96; immediate early
                     response 3 protein; cAMP inducible gene 3"
                     /codon_start=1
                     /product="radiation-inducible immediate-early gene IEX-1"
                     /protein_id="NP_598423.1"
                     /db_xref="CCDS:CCDS28704.1"
                     /db_xref="GeneID:15937"
                     /db_xref="MGI:MGI:104814"
                     /translation="MCHSRNHLHTMTGLRAPSPAPSTGPELRRGSGPEIFTFDPLPER
                     AVVSTARLNTSRGHRKRSRRVLYPRVVRRQLPTEEPNIAKRVLFLLFAIIFCQILMAE
                     EGVSQPLAPEDATSAVTPEPISAPITAPPVLEPLNLTSESSDYALDLKAFLQQHPAAF
                     "
     exon            217..1090
                     /gene="Ier3"
                     /gene_synonym="cI-3; gly96; IEX-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaattatgt gccactcgcg caaccatctc cacaccatga ctggcctgag ggccccttct
       61 ccagctccct ccaccggccc ggaactccgg cggggctctg gtcccgaaat tttcaccttc
      121 gaccctctcc cggagcgggc cgtggtgtcc accgcgcgtt tgaacacttc tcgcgggcac
      181 cgaaaacgca gccgaagggt gctctaccct cgagtggtcc ggcgccagct accaaccgag
      241 gaacccaaca ttgccaagag ggtcctcttt ctcctgttcg ccatcatctt ctgccagatt
      301 ttgatggctg aagagggtgt gtcgcagccc ctggctccgg aggatgctac cagcgccgtg
      361 acacctgagc ccatttctgc gcccattact gcgcccccgg tcctcgagcc tttgaacctg
      421 acctcggagt cctcggacta tgcgctggat cttaaagctt ttctccagca acatccggcg
      481 gccttctaaa cgcgatgggt cacagtccga agaaacaaag gcaccatgga tgggtacctg
      541 gtgcgagaga acgtatccca aactgggatt tctaaggcaa cgctaactca gaacactacc
      601 gccaagagac accgcgggtc ctggctaggc ccactgggga cggacagaga ctttctccgt
      661 gtctaattaa tatttatgta tttatgtata tcctcctagg tgaaggaggg gtgtatgtaa
      721 tatttattct aacttatgca ggggtgcgag atatgcctcc ctgctgtaac acagatattt
      781 attacgattt atagggtcgg taagacagag ttgtgggagg gaggacccgg gtggtaggac
      841 tcccagcttg gggattagtc tggggggggt gtaataagat taggggtaac actccgtctt
      901 ccagcacttc aactctgtag tctgttgtaa ggctttggaa gacccttggg aatccggcct
      961 ttgatgtctt ctggttgctt ctcaggggca gctgcaggag tcttgggtcc atggattgtc
     1021 agagggcggc tgtctggggt cgcctagtat gtatgttctg tgaacacgaa taaacttgat
     1081 ttgcctgtca
//
