LOCUS       NM_010499               1541 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus immediate early response 2 (Ier2), mRNA.
ACCESSION   NM_010499
VERSION     NM_010499.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Kyjacova,L., Saup,R., Ronsch,K., Wallbaum,S., Dukowic-Schulze,S.,
            Foss,A., Scherer,S.D., Rothley,M., Neeb,A., Grau,N., Thiele,W.,
            Thaler,S., Cremers,N., Sticht,C., Gretz,N., Garvalov,B.K.,
            Utikal,J. and Sleeman,J.P.
  TITLE     IER2-induced senescence drives melanoma invasion through
            osteopontin
  JOURNAL   Oncogene 40 (47), 6494-6512 (2021)
   PUBMED   34611309
  REMARK    GeneRIF: IER2-induced senescence drives melanoma invasion through
            osteopontin.
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Neeb,A., Wallbaum,S., Novac,N., Dukovic-Schulze,S., Scholl,I.,
            Schreiber,C., Schlag,P., Moll,J., Stein,U. and Sleeman,J.P.
  TITLE     The immediate early gene Ier2 promotes tumor cell motility and
            metastasis, and predicts poor survival of colorectal cancer
            patients
  JOURNAL   Oncogene 31 (33), 3796-3806 (2012)
   PUBMED   22120713
  REMARK    GeneRIF: Relief of contact inhibition was associated with
            translocation of the Ier2 protein from the cytoplasm to the nucleus
            in both 3T3 fibroblasts and 1AS tumor cells
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Lopez-Rios,J., Speziale,D., Robay,D., Scotti,M., Osterwalder,M.,
            Nusspaumer,G., Galli,A., Hollander,G.A., Kmita,M. and Zeller,R.
  TITLE     GLI3 constrains digit number by controlling both progenitor
            proliferation and BMP-dependent exit to chondrogenesis
  JOURNAL   Dev Cell 22 (4), 837-848 (2012)
   PUBMED   22465667
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Schneider,A., Fischer,A., Weber,D., von Ahsen,O., Scheek,S.,
            Kruger,C., Rossner,M., Klaussner,B., Faucheron,N., Kammandel,B.,
            Goetz,B., Herrmann,O., Bach,A. and Schwaninger,M.
  TITLE     Restriction-mediated differential display (RMDD) identifies pip92
            as a pro-apoptotic gene product induced during focal cerebral
            ischemia
  JOURNAL   J Cereb Blood Flow Metab 24 (2), 224-236 (2004)
   PUBMED   14747749
  REMARK    GeneRIF: shows a rapid and long-lasting induction after cerebral
            ischemia; induces cell death in primary neurons and displays
            several hallmarks of pro-apoptotic activity upon overexpression
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Latinkic,B.V. and Lau,L.F.
  TITLE     Transcriptional activation of the immediate early gene pip92 by
            serum growth factors requires both Ets and CArG-like elements
  JOURNAL   J Biol Chem 269 (37), 23163-23170 (1994)
   PUBMED   8083220
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Charles,C.H., Simske,J.S., O'Brien,T.P. and Lau,L.F.
  TITLE     Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3
            and PC12 cells
  JOURNAL   Mol Cell Biol 10 (12), 6769-6774 (1990)
   PUBMED   2247083
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Coleclough,C., Kuhn,L. and Lefkovits,I.
  TITLE     Regulation of mRNA abundance in activated T lymphocytes:
            identification of mRNA species affected by the inhibition of
            protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 87 (5), 1753-1757 (1990)
   PUBMED   2308934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU604538.1, AK144601.1 and BP770574.1.
            
            On Dec 13, 2007 this sequence version replaced NM_010499.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BU604538.1         4-7
            5-1515              AK144601.1         2-1512
            1516-1541           BP770574.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..1541
                     /gene="Ier2"
                     /gene_synonym="Ch1; Pip92"
                     /note="immediate early response 2"
                     /db_xref="GeneID:15936"
                     /db_xref="MGI:MGI:104815"
     exon            1..1522
                     /gene="Ier2"
                     /gene_synonym="Ch1; Pip92"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..767
                     /gene="Ier2"
                     /gene_synonym="Ch1; Pip92"
                     /note="CHX1; T-lymphocyte-activated protein;
                     proline-rich-induced protein 92; cycloheximide-induced
                     gene protein; growth factor-inducible immediate early
                     protein"
                     /codon_start=1
                     /product="immediate early response gene 2 protein"
                     /protein_id="NP_034629.3"
                     /db_xref="CCDS:CCDS22474.1"
                     /db_xref="GeneID:15936"
                     /db_xref="MGI:MGI:104815"
                     /translation="MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSAR
                     EVYLSAKVEAHQPEFPPSRRALDPRLHPPREAEVAVEVASPEAVQPPEPMDTQEEVLR
                     VQETPALCDPPPARVSRKRRSSSDLSDGSDAGLVPSKKARLEEVEGEATSEVPDRLQL
                     PPAQSEGAFPNLARVLQRRFSSLLNCGPAVPPPTPPTCEAKPACRPADNMLNVLVRAV
                     VAF"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ier2"
                     /gene_synonym="Ch1; Pip92"
                     /note="hexamer: AATAAA"
     polyA_site      1519
                     /gene="Ier2"
                     /gene_synonym="Ch1; Pip92"
                     /note="major polyA site"
ORIGIN      
        1 gcccgaacgt ctagcagagt acctgctgct gtaagcttgt cgtctgggct gcaccgcccg
       61 tcttaaccca ttctcgactt aactactctc gtcgaacaag catggaagta cagaaagaag
      121 cgcagcgcat catgactctg tcggtatgga agatgtacca ctctcgcatg cagcgaggtg
      181 gcttgcgact ccaccggagt ctgcagctgt ccctcgttat gcgcagcgct cgagaggtct
      241 acctctcagc caaggtagaa gcccaccagc ccgagttccc gccatcccgc agggctcttg
      301 accctcgcct gcacccgccg cgggaagccg aagttgcagt ggaagtagcg tcccccgaag
      361 ccgtgcagcc tccggagccc atggatacgc aagaggaagt gctgcgagtc caggagaccc
      421 ctgcgctctg tgacccgccc cccgctagag tcagccgcaa gcgccggagc agcagcgatt
      481 tgagcgacgg tagtgatgcc ggactggtac caagcaagaa ggcccgtcta gaagaggtgg
      541 agggggaggc gacgtcggag gttcccgatc gcctgcagct tcctccggca caaagcgaag
      601 gtgccttccc taacctcgcc cgcgtcctcc aaaggcgctt ctccagtctc ctgaactgtg
      661 gacccgccgt gcccccgccg acgcccccca cgtgcgaggc caagccagcc tgccgcccgg
      721 ccgacaatat gctcaacgtg ctggtgcgag ctgtggtggc cttctgagag ctctggtggc
      781 ttctttcgag cggcgccacc ggagcggaga acgcacaccc gaggcgaagg ccggcggggg
      841 ccgtgaagaa gagccgcggc ccgagctgcc gagaggccag gggaaggact gaggagcgag
      901 gggcgcgggc gccttctccc agacgtgcgt ccataggtgc tattaaagga ctgtcccttc
      961 cttggcttgg agaagggaca cctagatctt gaatctcagg gtcgaactct ctaggggcca
     1021 ggctgccctt tcaaggccgt ttcactacca ttcgcgtttc ggcccctaca agtgggcacg
     1081 cttgtgcaag cggtcagagt tgcgtcatgg gacagacgcg ggtgcttcct gttgccttgc
     1141 gtgggtgtgg ggcctgggag gaggccaggg tgtggacccg ccctagggac tgggaagtga
     1201 cttgagtcac ctcgccccca caggctgctg tgggtgagcc tgaactgaac caatcaaatc
     1261 tgcgatcaga gttgaagtgg ctggagaccc cgggactggt caacctagat gatcgcctgg
     1321 cgtggaccac cgcgggacgg gtgggccgct ggtcgtagtt gctgccgtag acacagcttc
     1381 ttcgggcagg aaagaaaatt ttttttttac cagcgtgttt aagaaagtct gtttactttt
     1441 cccacggtgg gttgtttaat tagcaactac ctggagtttt acaatgtcag ctaggaaaat
     1501 aaagaccatc ggtgtaaaac gcaaaaaaaa aaaaaaaaaa a
//
