LOCUS       NM_008325               4430 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus iduronidase, alpha-L (Idua), transcript variant 1,
            mRNA.
ACCESSION   NM_008325
VERSION     NM_008325.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4430)
  AUTHORS   Malinowska,M., Nowicka,W., Kloska,A., Wegrzyn,G. and
            Jakobkiewicz-Banecka,J.
  TITLE     Efficacy of a Combination Therapy with Laronidase and Genistein in
            Treating Mucopolysaccharidosis Type I in a Mouse Model
  JOURNAL   Int J Mol Sci 25 (4), 2371 (2024)
   PUBMED   38397051
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4430)
  AUTHORS   Tuyaa-Boustugue,P., Jantzen,I., Zhang,H., Young,S.P., Broqua,P.,
            Tallandier,M. and Entchev,E.
  TITLE     Reduction of lysosome abundance and GAG accumulation after
            odiparcil treatment in MPS I and MPS VI models
  JOURNAL   Mol Genet Metab Rep 37, 101011 (2023)
   PUBMED   38053941
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4430)
  AUTHORS   Zhu,W., Ou,L., Zhang,L., Clark,I.H., Zhang,Y., Zhu,X.H.,
            Whitley,C.B., Hackett,P.B., Low,W.C. and Chen,W.
  TITLE     Mapping brain networks in MPS I mice and their restoration
            following gene therapy
  JOURNAL   Sci Rep 13 (1), 12716 (2023)
   PUBMED   37543633
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4430)
  AUTHORS   Gaffke,L., Pierzynowska,K., Cyske,Z., Podlacha,M. and Wegrzyn,G.
  TITLE     Contribution of vesicle trafficking dysregulation to the
            pathomechanism of mucopolysaccharidosis
  JOURNAL   Biochem Biophys Res Commun 665, 107-117 (2023)
   PUBMED   37149983
REFERENCE   5  (bases 1 to 4430)
  AUTHORS   Gaffke,L., Rintz,E., Pierzynowska,K. and Wegrzyn,G.
  TITLE     Actin Cytoskeleton Polymerization and Focal Adhesion as Important
            Factors in the Pathomechanism and Potential Targets of
            Mucopolysaccharidosis Treatment
  JOURNAL   Cells 12 (13), 1782 (2023)
   PUBMED   37443816
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4430)
  AUTHORS   Clarke,L.A., Nasir,J., Zhang,H., McDonald,H., Applegarth,D.A.,
            Hayden,M.R. and Toone,J.
  TITLE     Murine alpha-L-iduronidase: cDNA isolation and expression
  JOURNAL   Genomics 24 (2), 311-316 (1994)
   PUBMED   7698753
REFERENCE   7  (bases 1 to 4430)
  AUTHORS   Nasir,J., Lin,B., Bucan,M., Koizumi,T., Nadeau,J.H. and Hayden,M.R.
  TITLE     The murine homologues of the Huntington disease gene (Hdh) and the
            alpha-adducin gene (Add1) map to mouse chromosome 5 within a region
            of conserved synteny with human chromosome 4p16.3
  JOURNAL   Genomics 22 (1), 198-201 (1994)
   PUBMED   7959767
REFERENCE   8  (bases 1 to 4430)
  AUTHORS   Grosson,C.L., MacDonald,M.E., Duyao,M.P., Ambrose,C.M.,
            Roffler-Tarlov,S. and Gusella,J.F.
  TITLE     Synteny conservation of the Huntington's disease gene and
            surrounding loci on mouse Chromosome 5
  JOURNAL   Mamm Genome 5 (7), 424-428 (1994)
   PUBMED   7919654
REFERENCE   9  (bases 1 to 4430)
  AUTHORS   Koizumi,T., MacDonald,M., Bucan,M., Hopwood,J.J., Morris,C.P.,
            Scott,H.S., Gusella,J.F. and Nadeau,J.H.
  TITLE     Linkage, but not gene order, of homologous loci, including
            alpha-L-iduronidase (Idua), is conserved in the Huntington disease
            region of the mouse and human genomes
  JOURNAL   Mamm Genome 3 (1), 23-27 (1992)
   PUBMED   1533802
REFERENCE   10 (bases 1 to 4430)
  AUTHORS   Scott,H.S., Ashton,L.J., Eyre,H.J., Baker,E., Brooks,D.A.,
            Callen,D.F., Sutherland,G.R., Morris,C.P. and Hopwood,J.J.
  TITLE     Chromosomal localization of the human alpha-L-iduronidase gene
            (IDUA) to 4p16.3
  JOURNAL   Am J Hum Genet 47 (5), 802-807 (1990)
   PUBMED   2220820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155627.1, AK031414.1, AK045330.1 and AC161813.2.
            
            On Jan 22, 2014 this sequence version replaced NM_008325.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AK155627.1         2-350
            350-2500            AK031414.1         4-2154
            2501-3536           AK045330.1         1988-3023
            3537-4430           AC161813.2         1034-1927           c
FEATURES             Location/Qualifiers
     source          1..4430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.24 cM"
     gene            1..4430
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /note="iduronidase, alpha-L"
                     /db_xref="GeneID:15932"
                     /db_xref="MGI:MGI:96418"
     exon            1..168
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            169..580
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..2357
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /EC_number="3.2.1.76"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alpha-L-iduronidase"
                     /codon_start=1
                     /product="alpha-L-iduronidase isoform 1 precursor"
                     /protein_id="NP_032351.2"
                     /db_xref="CCDS:CCDS19516.2"
                     /db_xref="GeneID:15932"
                     /db_xref="MGI:MGI:96418"
                     /translation="MRPPRPSSAMLTFFAAFLAAPLALAESPYLVRVDAARPLRPLLP
                     FWRSTGFCPPLPHDQADQYDLSWDQQLNLAYIGAVPHSGIEQVRIHWLLDLITARKSP
                     GQGLMYNFTHLDAFLDLLMENQLLPGFELMGSPSGYFTDFDDKQQVFEWKDLVSLLAR
                     RYIGRYGLTHVSKWNFETWNEPDHHDFDNVSMTTQGFLNYYDACSEGLRIASPTLKLG
                     GPGDSFHPLPRSPMCWSLLGHCANGTNFFTGEVGVRLDYISLHKKGAGSSIAILEQEM
                     AVVEQVQQLFPEFKDTPIYNDEADPLVGWSLPQPWRADVTYAALVVKVIAQHQNLLFA
                     NSSSSMRYVLLSNDNAFLSYHPYPFSQRTLTARFQVNNTHPPHVQLLRKPVLTVMGLM
                     ALLDGEQLWAEVSKAGAVLDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSDDTHAHPN
                     HSIPVTLRLRGVPPGLDLVYIVLYLDNQLSSPYSAWQHMGQPVFPSAEQFRRMRMVED
                     PVAEAPRPFPARGRLTLHRKLPVPSLLLVHVCTRPLKPPGQVSRLRALPLTHGQLILV
                     WSDERVGSKCLWTYEIQFSQKGEEYAPINRRPSTFNLFVFSPDTAVVSGSYRVRALDY
                     WARPGPFSDPVTYLDVPAS"
     exon            581..721
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            722..807
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            808..915
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1011
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1214
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1394
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1611
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1824
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1946
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2072
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2149
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2250
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..4430
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3502..3507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /note="hexamer: AATAAA"
     polyA_site      3539
                     /gene="Idua"
                     /gene_synonym="6030426D08"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtgccc acccactgcc aagagggaca ggtctcaaag gtcagggcag tgtcccggga
       61 aggagggcat cggctcctgg gagcggcctt aggacgcggg gtggactctc accatcgcac
      121 aggaagccag ccagtcccca gatgaagtcc gagcagaggt ggcagaagag cacctacagg
      181 cctccagcga gaccgagaca gccgcaagaa taatggccgc tctgagacac ccaagcactg
      241 ctaatgttgg ttccattttt ggagcgcctg ggacgcagcg gaactcgcca gcacggggcg
      301 gcgcgtgact gggttccttt ttgtcccggc ctggcgagag gtcacgtggg gcgttacgca
      361 gaggcggaac actgcgaccg ccgcctaaaa agcttgctgt ttaggggcac ctggatatcc
      421 caaccatgcg acccccgcgt ccctcctcag ctatgctgac gttttttgct gcgttcttgg
      481 ccgcgccctt ggcgctggct gagtcaccgt acctggtgcg tgtggacgca gcccgcccgc
      541 tgaggcctct gttgcccttc tggaggagca ccggcttctg ccccccactg cctcacgacc
      601 aggctgacca gtacgacctt agttgggacc agcaactgaa ccttgcctac ataggtgccg
      661 tacctcacag tggcattgag caggtccgga tacactggct gctggatctc atcacagcca
      721 ggaagtcacc tgggcaggga cttatgtaca acttcaccca cttggatgca ttcttggacc
      781 ttctcatgga gaaccagctt ctccctggat ttgagctcat gggcagtcct tctgggtact
      841 tcacggactt tgatgacaag cagcaggtgt ttgaatggaa ggacctggtt tctctcttgg
      901 ccaggagata cattggtagg tatgggctga cacacgtttc caagtggaac tttgagactt
      961 ggaatgaacc agaccaccat gactttgaca acgtgtccat gaccacacaa ggcttcctga
     1021 attactatga tgcctgctct gaggggctgc gcattgccag ccccactttg aagttgggtg
     1081 gtcctgggga ttccttccac cccctgccaa ggtcaccaat gtgctggagc ctcctgggtc
     1141 actgtgccaa tggaaccaac ttcttcactg gcgaggtggg cgtgcgtctg gattacatct
     1201 ccctgcacaa gaagggtgca ggtagctcca tcgccatcct ggagcaggag atggcagttg
     1261 tggagcaggt ccagcagctc ttccctgagt tcaaggatac ccctatttac aatgacgagg
     1321 cagaccctct ggtgggctgg tccctgccac aaccttggag agctgatgtg acttatgcgg
     1381 ccctggtggt gaaggtcatt gcacagcacc agaacctgct gtttgccaac agcagttcct
     1441 ccatgcgcta tgtgctcctc agcaatgaca atgccttcct gagctaccac ccgtaccctt
     1501 tctcccagcg cacacttact gctcgattcc aggtcaacaa tactcaccca ccccacgtgc
     1561 agttgctgcg aaagccagta ctcacagtca tggggctcat ggccctgttg gatggagaac
     1621 aactctgggc agaggtctca aaggctgggg ctgtgttgga cagcaatcat acagtgggtg
     1681 tcctggccag cacccatcac cctgaaggct ccgcagcggc ctggagtacc acagtcctca
     1741 tctacactag tgatgacacc cacgcacacc ccaaccacag tatccctgtg actcttcgcc
     1801 tgcgtggggt acctcctggc ttggatcttg tctacatagt actctactta gacaatcaac
     1861 tcagcagccc ctacagtgcg tggcagcaca tgggccagcc agtcttcccc tctgcagagc
     1921 agttccgacg tatgcgcatg gtggaggacc ccgtggctga ggcaccacgc ccctttcctg
     1981 ctaggggccg cctgacccta caccggaagc ttccggtgcc atcactcctg ctggtgcatg
     2041 tatgcacacg ccccttgaag ccacctgggc aggtcagccg gctccgtgca ctgcccctga
     2101 cacatggaca gctgattttg gtctggtcag atgagcgtgt gggctccaag tgcctgtgga
     2161 catatgagat ccagttttcc cagaaaggtg aagagtatgc cccaatcaac aggaggccgt
     2221 ctacttttaa cctctttgtg ttcagcccag acacagctgt ggtctctggc tcctaccgag
     2281 ttcgagcatt ggattactgg gcccggccag gccccttctc cgaccctgtg acttacctgg
     2341 atgtccctgc ctcatgagag ccactggctc ctagtgactt gtgaatctgt gctgactggt
     2401 gaatggagtc aaccagtatg agctagactg ccattagcta ggcagctgac tgtcagcttc
     2461 tattgttctt cccctatttc cctttaaagt gtctttctct acctcagact tagggtcagt
     2521 ctttgtggct aagcacttta taggcccagt tggagtgacc tttgcccacc ttcctcccca
     2581 tgcccagctg ttcaaaaagt ttaaatgtgg gactggaaag atggctcagt agataaagtg
     2641 cttgctgtgc aggcccaggg acttgtgttc agatatctag cactcatgta taggctgggc
     2701 atggcaatat atgcctattg tcctagtgtt ggtggaaggg acagagacag gccagggttc
     2761 cctggccttc cagtctacct gaaactgcaa gctccaggtt cagtaagaaa ccctgtttta
     2821 gaaaaatcaa gtagagtgct tggtacacac acacacacac acacacacac acacacagag
     2881 tctaaattta gtttcttgag cttctgtaat atcaaaaatg aagttatgta cttctgaaat
     2941 acaatactgc acagagtaag catcttcatt ccaacaggaa aaagaaatga cagggaagga
     3001 tttaagtgaa acaagaccaa agcatagcaa gacaaacgtt aaatcctgca gctccattct
     3061 cagcatcggg gcccatgatc ctgtgatgtg ctggacagtc tgtgtctgtg gtgttgccat
     3121 ttccagccgc catgaccttt ctcctaggct ggtgtcttgg gcttcctatt gattcgataa
     3181 accgcgatga atgagcagaa gcatctgggt agggaagcgt tgacttcact tgtattccta
     3241 cattacagtc tatcatcgaa ggcagtcagg caggcacctg gaggcaggaa gtcatggaga
     3301 ggccatggag gggtgctgct tactcagact atgatcttac acatcccggg atcaccagcc
     3361 aaagggtggg cccccaccca caacggtctg gaccctccca catcaatcac tagtttaaga
     3421 aaacaggctt atctataggt caatcttgtt ggggcatttt tctcaattga ggttccttct
     3481 tcccaaatga ctctagcttg taataaactg aaataaagcc accccaatct tgccacacat
     3541 tacctggcct cccaagtctt cctttgaaat ctgggtggaa gccaacataa ccctgtcact
     3601 gtaactctga tattctacct tctaagccag catcctgtgg atcacagcct actatcagct
     3661 tgagtggtag ttgaggactc ctgggtcatc catggctaca ataagcatga agtgcctgag
     3721 gcttagtccc atgcatttgt ggagaatatt atgatgatga tatctagtag aggggggagg
     3781 ctgttcacct caaagggaac aggaagtaga gtggggatag aattaagcta aatacttctt
     3841 cactgacccg ctttgtttaa ctcagccctg catcctaaag tttctagaat ctccccaaac
     3901 agacctatta cctggaaact acctttaagg tgtaagcctg ggctgatctt aataggctga
     3961 tgttcctacc ttggttctgg ccacgggaag aaccctctct cctttagtac aaacccctgg
     4021 tgtgccccac cagagagcct gttggacaca cgtgtcctta attcattctg cacatttttc
     4081 ttctctccat cagcacacag aagttcagca tacagaggtt tgtgctgaaa tgtaggcgta
     4141 ctcccaagct ctccccagag tactatcacc tactgtccag gaaatgagtc tgagtgcagt
     4201 gctcatatac actgcatggc tacatccaaa gtcagagttc ctctgccctc atgcctcttg
     4261 aagtgaacga aatgtgatga ccttctgcag ggtgtttttt agtcctctgt ggaccctagg
     4321 ctggccttgg catcttggct cacctgtccc agagttacta ctattaagat tacaggtgtg
     4381 taccaccatg cctgccaatt acctctcact ttaaataaaa tatgacattt
//
