LOCUS       NM_001401937            5013 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus iduronate 2-sulfatase (Ids), transcript variant 12,
            mRNA.
ACCESSION   NM_001401937
VERSION     NM_001401937.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5013)
  AUTHORS   Imakiire,A., Morimoto,H., Suzuki,H., Masuda,T., Yoden,E., Inoue,A.,
            Morioka,H., Konaka,T., Mori,A., Shirasaka,R., Kato,R., Hirato,T.,
            Sonoda,H. and Minami,K.
  TITLE     Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the
            Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice
  JOURNAL   Mol Pharm 20 (11), 5901-5909 (2023)
   PUBMED   37860991
  REMARK    GeneRIF: Transferrin Receptor-Targeted Iduronate-2-sulfatase
            Penetrates the Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice.
REFERENCE   2  (bases 1 to 5013)
  AUTHORS   Mashima,R., Ohira,M., Okuyama,T., Onodera,M. and Takada,S.
  TITLE     A novel mucopolysaccharidosis type II mouse model with an
            iduronate-2-sulfatase-P88L mutation
  JOURNAL   Sci Rep 13 (1), 7865 (2023)
   PUBMED   37188686
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5013)
  AUTHORS   Maccari,F., Rigon,L., Mantovani,V., Galeotti,F., Salvalaio,M.,
            D'Avanzo,F., Zanetti,A., Capitani,F., Gabrielli,O., Tomanin,R. and
            Volpi,N.
  TITLE     Glycosaminoglycan signatures in body fluids of
            mucopolysaccharidosis type II mouse model under long-term enzyme
            replacement therapy
  JOURNAL   J Mol Med (Berl) 100 (8), 1169-1179 (2022)
   PUBMED   35816218
REFERENCE   4  (bases 1 to 5013)
  AUTHORS   Lobo-Menendez,F., Bowman,L.H. and Dewey,M.J.
  TITLE     Inverted Gcg/CGC trinucleotide microsatellites in the 5'-region of
            Mus IDS mRNA: recurrent induction of aberrant reverse transcripts
  JOURNAL   Mol Biol Rep 31 (2), 107-112 (2004)
   PUBMED   15293786
REFERENCE   5  (bases 1 to 5013)
  AUTHORS   Daniele,A., Russo,T., Ballabio,A. and Di Natale,P.
  TITLE     The mouse iduronate sulfatase gene: identification of a novel
            transcript
  JOURNAL   Biochem Biophys Res Commun 194 (3), 1030-1037 (1993)
   PUBMED   8352760
REFERENCE   6  (bases 1 to 5013)
  AUTHORS   Daniele,A., Faust,C.J., Herman,G.E., Di Natale,P. and Ballabio,A.
  TITLE     Cloning and characterization of the cDNA for the murine iduronate
            sulfatase gene
  JOURNAL   Genomics 16 (3), 755-757 (1993)
   PUBMED   8325651
REFERENCE   7  (bases 1 to 5013)
  AUTHORS   Angel,T.A., Faust,C.J., Gonzales,J.C., Kenwrick,S., Lewis,R.A. and
            Herman,G.E.
  TITLE     Genetic mapping of the X-linked dominant mutations striated (Str)
            and bare patches (Bpa) to a 600-kb region of the mouse X
            chromosome: implications for mapping human disorders in Xq28
  JOURNAL   Mamm Genome 4 (3), 171-176 (1993)
   PUBMED   8439729
REFERENCE   8  (bases 1 to 5013)
  AUTHORS   Chatterjee,A., Faust,C.J. and Herman,G.E.
  TITLE     Genetic and physical mapping of the biglycan gene on the mouse X
            chromosome
  JOURNAL   Mamm Genome 4 (1), 33-36 (1993)
   PUBMED   8093671
REFERENCE   9  (bases 1 to 5013)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (bases 1 to 5013)
  AUTHORS   Habara-Ohkubo,A., Takikawa,O. and Yoshida,R.
  TITLE     Cloning and expression of a cDNA encoding mouse indoleamine
            2,3-dioxygenase
  JOURNAL   Gene 105 (2), 221-227 (1991)
   PUBMED   1937018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672026.11 and BX294168.13.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.2348787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL672026.11        5958-6012           c
            56-132              BX294168.13        222755-222831       c
            133-331             BX294168.13        220962-221160       c
            332-468             BX294168.13        211539-211675       c
            469-646             BX294168.13        210714-210891       c
            647-735             BX294168.13        208780-208868       c
            736-936             BX294168.13        207686-207886       c
            937-1107            BX294168.13        206004-206174       c
            1108-1234           BX294168.13        200881-201007       c
            1235-1408           BX294168.13        198664-198837       c
            1409-5013           BX294168.13        190806-194410       c
FEATURES             Location/Qualifiers
     source          1..5013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.01 cM"
     gene            1..5013
                     /gene="Ids"
                     /note="iduronate 2-sulfatase"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
     exon            1..55
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            56..132
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            133..331
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            332..468
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            469..646
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     CDS             619..1881
                     /gene="Ids"
                     /EC_number="3.1.6.13"
                     /note="isoform 5 is encoded by transcript variant 12;
                     iduronate sulfatase; alpha-L-iduronate sulfate sulfatase"
                     /codon_start=1
                     /product="iduronate 2-sulfatase isoform 5"
                     /protein_id="NP_001388866.1"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
                     /translation="MSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQ
                     DGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASPFFLAVGYHKPHIPF
                     RYPKEFQKLYPLENITLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPE
                     DFQRKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAKY
                     SNFDVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVSL
                     FPTLAGLAGLPVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAYS
                     QYPRPADFPQWNSDKPSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGEL
                     YFVDSDPLQDHNVYNDSQHGGLLHSLRP"
     exon            647..735
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            736..936
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1107
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1234
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1408
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..5013
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4906..4911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      4932
                     /gene="Ids"
                     /note="major polyA site"
     regulatory      4989..4994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      5013
                     /gene="Ids"
                     /note="major polyA site"
ORIGIN      
        1 gaaggaaggg ctgtgcaagc tgaagtggtg gaccagactg tcagtactca gcaagtgcac
       61 ttcctaggcg atgcttccac tggccccttg tgcattagtc tcctgtctgg atggtaatta
      121 cccccatcca tgctggaatc ctgtgacacc accacatcag agggaagagg agaggcgcta
      181 atccccgagt gaatggagag tctccatctt catctgcctt gcttgatttc cacaaatgcc
      241 tcggtcacag ggaaacttca tgtgatttct catcaaggat ggaacgtggg attctgagca
      301 ggactgcatt gttgccttct ggcctgggaa gatgctctga acatccttct gatcattgtg
      361 gatgatctcc gcccctccct gggctgttat ggagacaagc tagtgaggtc cccgaacatt
      421 gaccagctgg catcccatag cgttctcttt cagaatgcct ttgctcagca agcagtgtgc
      481 gcaccaagtc gagtgtcctt cctcaccggg aggaggcctg acaccacccg cctgtatgac
      541 ttcaattcct actggagggt acattctgga aatttttcca ccatccccca atacttcaag
      601 gagaatggct acgtgaccat gtcggttggg aaagtctttc accctggtat atcttccaat
      661 cacagtgatg attatccata tagctggtct tttccacctt atcatccatc ctcagagaaa
      721 tatgaaaaca ctaagacgtg taagggacaa gatggaaaac tccacgccaa tctgctttgt
      781 cctgtcgatg tggcagatgt gcctgaaggt accttgcctg acaaacagag cacagaagaa
      841 gccatcaggt tgttggaaaa gatgaagaca tcagctagtc ctttcttcct ggcagttggg
      901 taccacaagc cgcatatccc cttcagatac cccaaggaat ttcagaagtt gtatcccttg
      961 gaaaacataa ccctggctcc tgatccccat gttcctgata gcctaccacc tgtagcctac
     1021 aacccctgga tggatatcag ggagagggaa gatgtccaag ccttaaacat cagtgttccc
     1081 tatggaccaa ttcctgagga ttttcagcgg aaaatccgcc agagctactt tgcttctgtg
     1141 tcctatttgg atactcaggt tggacatgtt ttgagtgctt tggatgatct tcgtctagcc
     1201 cacaacacaa ttattgcttt cacatctgat cacggatggg ccctaggtga acacggagaa
     1261 tgggccaagt acagcaactt tgatgttgct acccgtgtgc ccctgatgct ctatgtccct
     1321 ggaaggacgg ccccacttcc tgcggcaggc cagaagctct ttccataccg ggaccccttt
     1381 gatccggcct cggattggat ggatgcaggc aggcacaccg aggacctcgt agaacttgta
     1441 tctctcttcc ccacgctcgc tggacttgca ggactgccag ttcctcctcg gtgccccatc
     1501 ccttcttttc atgttgagct ttgcagagaa ggccagaatc ttcagaagca tttgcagctc
     1561 catgacttgg aagaggagcc agacttgttt ggtaatcccc gggagttgat cgcctatagc
     1621 cagtaccccc ggcctgcaga tttccctcag tggaattctg acaagccaag cttaaatgat
     1681 ataaaggtca tgggatattc tatacgcact gtagactaca ggtacactgt gtgggttggc
     1741 ttcgatccta gtgaatttct ggctaacttt tctgatatcc atgccgggga actctatttt
     1801 gtcgattctg acccactgca ggatcacaat gtatataatg actcccaaca tggaggtctt
     1861 ctccactcac tgaggccttg agttctgcca gcctcagtgg gcacatatgt gtccccttcc
     1921 ccccctaccc attgtattag atataacctg agtgggaaac agtggaaaca tgcatcagca
     1981 atctggcctc ggactaggtg gcagatggcc ctttttatgt agtccttctt aagttagaat
     2041 ttgccattgg atttgggcta agctgaaact tttattttaa aagctcccat agcttcgtta
     2101 ctacacaagt acaaagtgaa ctaaggtata atcttatctt tatatctaaa gaccatgcta
     2161 gccagacata atactgtact taagaaatca tttgcttgtt gaatttagtg catttcagat
     2221 agtaaccata tgtcttacgt agcccagagt gtcaagcatg ttaacatggg atttatttct
     2281 ttctcaaatg tgaaattcaa gttgcttcta gagttattgc ttctaagact acagatttag
     2341 aatcaaaggt aaaataccca tgtgatgatc aatgtggtgt ttcttcatta aataataaat
     2401 aatgcttagt aaagtatagt taaagttagg aaattcagtt aagtatttca atactctctg
     2461 gcccaaataa taatttgtta gtaaatacta caattcttga actcagtggc tatctgttaa
     2521 aaattctgtt attcacaatg aaatcatctc aaatggaact attcccatga tttgaatcat
     2581 tccagattgt attcatatgc ctatttagaa aactgcagat atccatgtat cctggaggca
     2641 ggaggtattc tactttttgc taaaacaaaa caaaacaaaa catgtttatg aaatgtaaat
     2701 tatcttgagg gttgtggata ctttttatta atagggtata agtaattttc agaatgtagt
     2761 tctgtgttcc ctaagtacga aggtaactag aatatgggca tgtagtaagg attaggttat
     2821 ttcattactg tcaccagaca gaagtccttc ctctaacatt gtgaaaactg ttcaattacc
     2881 aggagtcaac agctttctaa ataaacattc tatgtatttt gttttgtatt taaatgagta
     2941 atttcaataa tttcattaaa aatgattcag tgtctcaagg taaatgtttt taaaacaaaa
     3001 actatagtaa atagctgatt agattaagtt actgtcatgt attaaattgt aaccaaaaag
     3061 tcaagacact actttgaagt gtgtaaaatt tcaaagagag attgttgatt ttaccagctg
     3121 gcctatagta gagtagattt gtctgttgtt ctgaaactga cttttgcaaa ggctttgctc
     3181 ccatctttcc ttgttcttga tctttactgc tctcctgatg tctactcagt gtcattttac
     3241 aatttagttt agaaactcct cacagcatgt tttctttttt tttttagctt catctccttc
     3301 atagagggac agattttgac acaagtgttt atttgacatc tatttattgt tcctgtttgg
     3361 ccatagtgtg tgtgtatgtg tgtgtgtgta tgtatgtgta tgtatgtgtg tgtatgtgta
     3421 tatatacata tacatacaca tacatacaca tacatatata catatataca tatatacata
     3481 tatatatata tatatatata tatatattta atcttccaaa gtacagtttt agtttaaacc
     3541 cctctgaatt ctgcttccaa tgacatatgt ggctatttaa atttaaattc attaacacaa
     3601 aataacattt taaaaaattt ctgttttact tcgcacttag aaccttccca tcctagcaga
     3661 ctggacggag atgccctgga ttcgatctag atgtgttcac cctgattggc aggtccctac
     3721 tgtcctgcac ttgcccacaa tgagcaaact atatttggtt taggcataga gtagggagtt
     3781 tgctgtggcc atcagcttct tccttccact ctcatcacca ttgcctctgt ccttctttct
     3841 ttccttccca agaaatttcc ttcccctcct tttccctccc ctgttcctta aagaatccat
     3901 gtgtcttcct aaaatccctc ttgacccctg ccctttaaga acaccgtcag tgcctactaa
     3961 gggtctagaa agacctccgt tgagcagtca gagtcttccc tggctccaca ataccccttc
     4021 ccttggctga ctctccttgc caatccttac ctccctggtc cttcaagcct ttgtcccctc
     4081 ttctttgctc caaccccttc acagccattc ttcatagcct ggctccccta cccccctgct
     4141 tagaagctga ggctgtcagg actctctaga gtgtattatg ggggaaaatg aacacatctt
     4201 aaaaatctgt tatttgctac atttttttag aaggcatttt tcctcatgag tttgatatgt
     4261 taattataca gaaattggaa agcagaaatg cattttaaaa ggcaagaaaa tgtctgagtg
     4321 ctttatacta agattgccat agtttgttct ttttggggta tgaatgtttt acatttcttg
     4381 atcctctatg ttgtttataa tacaacttct gctctttctt tctgaacatt atgtatggtt
     4441 ggttattagt gaattttgca gatattttat attgctggta atatgtgtta ttgcatagat
     4501 ttattgtaat tttctcagcc ttctttcagt tgttagaaat ttagattatt tccaaatttt
     4561 cagtgttaca aataatgctg tgatcaattt tgtgaatata gtgtttttac gtatttcaaa
     4621 gtattcccat aggctagttt ctcagtgcca agtcatcaaa aacagctccg ttttctcttc
     4681 actcttgcta tgatagcata ttaaacttag aaaagaaact caaaaggcct atattaaaaa
     4741 ccataatacc aaaaaggaaa gtctgtagtc ctataataat agatgagagt tgtattctgc
     4801 tttaatatct gattctttgc tgattaacga catgaaccat tatgctctct gtatgacagt
     4861 tgtgtgactt tgtgtggtca tgttatggat cttacctttt aatgtaataa agtaaattgc
     4921 tcttttcctg tgtgacagtt tttcctgtat atttgttcta agcgtagaac aactctattt
     4981 gggacctgaa taaatactca ttttcctttg aaa
//
