LOCUS       NM_001401935            4995 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus iduronate 2-sulfatase (Ids), transcript variant 10,
            mRNA.
ACCESSION   NM_001401935
VERSION     NM_001401935.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4995)
  AUTHORS   Imakiire,A., Morimoto,H., Suzuki,H., Masuda,T., Yoden,E., Inoue,A.,
            Morioka,H., Konaka,T., Mori,A., Shirasaka,R., Kato,R., Hirato,T.,
            Sonoda,H. and Minami,K.
  TITLE     Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the
            Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice
  JOURNAL   Mol Pharm 20 (11), 5901-5909 (2023)
   PUBMED   37860991
  REMARK    GeneRIF: Transferrin Receptor-Targeted Iduronate-2-sulfatase
            Penetrates the Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice.
REFERENCE   2  (bases 1 to 4995)
  AUTHORS   Mashima,R., Ohira,M., Okuyama,T., Onodera,M. and Takada,S.
  TITLE     A novel mucopolysaccharidosis type II mouse model with an
            iduronate-2-sulfatase-P88L mutation
  JOURNAL   Sci Rep 13 (1), 7865 (2023)
   PUBMED   37188686
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4995)
  AUTHORS   Maccari,F., Rigon,L., Mantovani,V., Galeotti,F., Salvalaio,M.,
            D'Avanzo,F., Zanetti,A., Capitani,F., Gabrielli,O., Tomanin,R. and
            Volpi,N.
  TITLE     Glycosaminoglycan signatures in body fluids of
            mucopolysaccharidosis type II mouse model under long-term enzyme
            replacement therapy
  JOURNAL   J Mol Med (Berl) 100 (8), 1169-1179 (2022)
   PUBMED   35816218
REFERENCE   4  (bases 1 to 4995)
  AUTHORS   Lobo-Menendez,F., Bowman,L.H. and Dewey,M.J.
  TITLE     Inverted Gcg/CGC trinucleotide microsatellites in the 5'-region of
            Mus IDS mRNA: recurrent induction of aberrant reverse transcripts
  JOURNAL   Mol Biol Rep 31 (2), 107-112 (2004)
   PUBMED   15293786
REFERENCE   5  (bases 1 to 4995)
  AUTHORS   Daniele,A., Russo,T., Ballabio,A. and Di Natale,P.
  TITLE     The mouse iduronate sulfatase gene: identification of a novel
            transcript
  JOURNAL   Biochem Biophys Res Commun 194 (3), 1030-1037 (1993)
   PUBMED   8352760
REFERENCE   6  (bases 1 to 4995)
  AUTHORS   Daniele,A., Faust,C.J., Herman,G.E., Di Natale,P. and Ballabio,A.
  TITLE     Cloning and characterization of the cDNA for the murine iduronate
            sulfatase gene
  JOURNAL   Genomics 16 (3), 755-757 (1993)
   PUBMED   8325651
REFERENCE   7  (bases 1 to 4995)
  AUTHORS   Angel,T.A., Faust,C.J., Gonzales,J.C., Kenwrick,S., Lewis,R.A. and
            Herman,G.E.
  TITLE     Genetic mapping of the X-linked dominant mutations striated (Str)
            and bare patches (Bpa) to a 600-kb region of the mouse X
            chromosome: implications for mapping human disorders in Xq28
  JOURNAL   Mamm Genome 4 (3), 171-176 (1993)
   PUBMED   8439729
REFERENCE   8  (bases 1 to 4995)
  AUTHORS   Chatterjee,A., Faust,C.J. and Herman,G.E.
  TITLE     Genetic and physical mapping of the biglycan gene on the mouse X
            chromosome
  JOURNAL   Mamm Genome 4 (1), 33-36 (1993)
   PUBMED   8093671
REFERENCE   9  (bases 1 to 4995)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (bases 1 to 4995)
  AUTHORS   Habara-Ohkubo,A., Takikawa,O. and Yoshida,R.
  TITLE     Cloning and expression of a cDNA encoding mouse indoleamine
            2,3-dioxygenase
  JOURNAL   Gene 105 (2), 221-227 (1991)
   PUBMED   1937018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672026.11 and BX294168.13.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.1363778.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL672026.11        5839-6012           c
            175-251             BX294168.13        222755-222831       c
            252-450             BX294168.13        220962-221160       c
            451-628             BX294168.13        210714-210891       c
            629-717             BX294168.13        208780-208868       c
            718-918             BX294168.13        207686-207886       c
            919-1089            BX294168.13        206004-206174       c
            1090-1216           BX294168.13        200881-201007       c
            1217-1390           BX294168.13        198664-198837       c
            1391-4995           BX294168.13        190806-194410       c
FEATURES             Location/Qualifiers
     source          1..4995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.01 cM"
     gene            1..4995
                     /gene="Ids"
                     /note="iduronate 2-sulfatase"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
     exon            1..174
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            175..251
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            252..450
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            451..628
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..1863
                     /gene="Ids"
                     /EC_number="3.1.6.13"
                     /note="isoform 5 is encoded by transcript variant 10;
                     iduronate sulfatase; alpha-L-iduronate sulfate sulfatase"
                     /codon_start=1
                     /product="iduronate 2-sulfatase isoform 5"
                     /protein_id="NP_001388864.1"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
                     /translation="MSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQ
                     DGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASPFFLAVGYHKPHIPF
                     RYPKEFQKLYPLENITLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPE
                     DFQRKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAKY
                     SNFDVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVSL
                     FPTLAGLAGLPVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAYS
                     QYPRPADFPQWNSDKPSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGEL
                     YFVDSDPLQDHNVYNDSQHGGLLHSLRP"
     exon            629..717
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            718..918
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1089
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1216
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1390
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..4995
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4888..4893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      4914
                     /gene="Ids"
                     /note="major polyA site"
     regulatory      4971..4976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      4995
                     /gene="Ids"
                     /note="major polyA site"
ORIGIN      
        1 gaaggaaggg ctgtgcaagc tgaagtggtg gaccagactg tcagtactca gcaaggtggt
       61 tagggcctca agagtaccag ccagggctat gtgtggtgag attttgttga cagagctgag
      121 ctttggatgc tggctttact tgctggaggg atacagggga aggagggcgt gccttgcact
      181 tcctaggcga tgcttccact ggccccttgt gcattagtct cctgtctgga tggtaattac
      241 ccccatccat gctggaatcc tgtgacacca ccacatcaga gggaagagga gaggcgctaa
      301 tccccgagtg aatggagagt ctccatcttc atctgccttg cttgatttcc acaaatgcct
      361 cggtcacagg gaaacttcat gtgatttctc atcaaggatg gaacgtggga ttctgagcag
      421 gactgcattg ttgccttctg gcctgggaag caagcagtgt gcgcaccaag tcgagtgtcc
      481 ttcctcaccg ggaggaggcc tgacaccacc cgcctgtatg acttcaattc ctactggagg
      541 gtacattctg gaaatttttc caccatcccc caatacttca aggagaatgg ctacgtgacc
      601 atgtcggttg ggaaagtctt tcaccctggt atatcttcca atcacagtga tgattatcca
      661 tatagctggt cttttccacc ttatcatcca tcctcagaga aatatgaaaa cactaagacg
      721 tgtaagggac aagatggaaa actccacgcc aatctgcttt gtcctgtcga tgtggcagat
      781 gtgcctgaag gtaccttgcc tgacaaacag agcacagaag aagccatcag gttgttggaa
      841 aagatgaaga catcagctag tcctttcttc ctggcagttg ggtaccacaa gccgcatatc
      901 cccttcagat accccaagga atttcagaag ttgtatccct tggaaaacat aaccctggct
      961 cctgatcccc atgttcctga tagcctacca cctgtagcct acaacccctg gatggatatc
     1021 agggagaggg aagatgtcca agccttaaac atcagtgttc cctatggacc aattcctgag
     1081 gattttcagc ggaaaatccg ccagagctac tttgcttctg tgtcctattt ggatactcag
     1141 gttggacatg ttttgagtgc tttggatgat cttcgtctag cccacaacac aattattgct
     1201 ttcacatctg atcacggatg ggccctaggt gaacacggag aatgggccaa gtacagcaac
     1261 tttgatgttg ctacccgtgt gcccctgatg ctctatgtcc ctggaaggac ggccccactt
     1321 cctgcggcag gccagaagct ctttccatac cgggacccct ttgatccggc ctcggattgg
     1381 atggatgcag gcaggcacac cgaggacctc gtagaacttg tatctctctt ccccacgctc
     1441 gctggacttg caggactgcc agttcctcct cggtgcccca tcccttcttt tcatgttgag
     1501 ctttgcagag aaggccagaa tcttcagaag catttgcagc tccatgactt ggaagaggag
     1561 ccagacttgt ttggtaatcc ccgggagttg atcgcctata gccagtaccc ccggcctgca
     1621 gatttccctc agtggaattc tgacaagcca agcttaaatg atataaaggt catgggatat
     1681 tctatacgca ctgtagacta caggtacact gtgtgggttg gcttcgatcc tagtgaattt
     1741 ctggctaact tttctgatat ccatgccggg gaactctatt ttgtcgattc tgacccactg
     1801 caggatcaca atgtatataa tgactcccaa catggaggtc ttctccactc actgaggcct
     1861 tgagttctgc cagcctcagt gggcacatat gtgtcccctt ccccccctac ccattgtatt
     1921 agatataacc tgagtgggaa acagtggaaa catgcatcag caatctggcc tcggactagg
     1981 tggcagatgg ccctttttat gtagtccttc ttaagttaga atttgccatt ggatttgggc
     2041 taagctgaaa cttttatttt aaaagctccc atagcttcgt tactacacaa gtacaaagtg
     2101 aactaaggta taatcttatc tttatatcta aagaccatgc tagccagaca taatactgta
     2161 cttaagaaat catttgcttg ttgaatttag tgcatttcag atagtaacca tatgtcttac
     2221 gtagcccaga gtgtcaagca tgttaacatg ggatttattt ctttctcaaa tgtgaaattc
     2281 aagttgcttc tagagttatt gcttctaaga ctacagattt agaatcaaag gtaaaatacc
     2341 catgtgatga tcaatgtggt gtttcttcat taaataataa ataatgctta gtaaagtata
     2401 gttaaagtta ggaaattcag ttaagtattt caatactctc tggcccaaat aataatttgt
     2461 tagtaaatac tacaattctt gaactcagtg gctatctgtt aaaaattctg ttattcacaa
     2521 tgaaatcatc tcaaatggaa ctattcccat gatttgaatc attccagatt gtattcatat
     2581 gcctatttag aaaactgcag atatccatgt atcctggagg caggaggtat tctacttttt
     2641 gctaaaacaa aacaaaacaa aacatgttta tgaaatgtaa attatcttga gggttgtgga
     2701 tactttttat taatagggta taagtaattt tcagaatgta gttctgtgtt ccctaagtac
     2761 gaaggtaact agaatatggg catgtagtaa ggattaggtt atttcattac tgtcaccaga
     2821 cagaagtcct tcctctaaca ttgtgaaaac tgttcaatta ccaggagtca acagctttct
     2881 aaataaacat tctatgtatt ttgttttgta tttaaatgag taatttcaat aatttcatta
     2941 aaaatgattc agtgtctcaa ggtaaatgtt tttaaaacaa aaactatagt aaatagctga
     3001 ttagattaag ttactgtcat gtattaaatt gtaaccaaaa agtcaagaca ctactttgaa
     3061 gtgtgtaaaa tttcaaagag agattgttga ttttaccagc tggcctatag tagagtagat
     3121 ttgtctgttg ttctgaaact gacttttgca aaggctttgc tcccatcttt ccttgttctt
     3181 gatctttact gctctcctga tgtctactca gtgtcatttt acaatttagt ttagaaactc
     3241 ctcacagcat gttttctttt tttttttagc ttcatctcct tcatagaggg acagattttg
     3301 acacaagtgt ttatttgaca tctatttatt gttcctgttt ggccatagtg tgtgtgtatg
     3361 tgtgtgtgtg tatgtatgtg tatgtatgtg tgtgtatgtg tatatataca tatacataca
     3421 catacataca catacatata tacatatata catatataca tatatatata tatatatata
     3481 tatatatatt taatcttcca aagtacagtt ttagtttaaa cccctctgaa ttctgcttcc
     3541 aatgacatat gtggctattt aaatttaaat tcattaacac aaaataacat tttaaaaaat
     3601 ttctgtttta cttcgcactt agaaccttcc catcctagca gactggacgg agatgccctg
     3661 gattcgatct agatgtgttc accctgattg gcaggtccct actgtcctgc acttgcccac
     3721 aatgagcaaa ctatatttgg tttaggcata gagtagggag tttgctgtgg ccatcagctt
     3781 cttccttcca ctctcatcac cattgcctct gtccttcttt ctttccttcc caagaaattt
     3841 ccttcccctc cttttccctc ccctgttcct taaagaatcc atgtgtcttc ctaaaatccc
     3901 tcttgacccc tgccctttaa gaacaccgtc agtgcctact aagggtctag aaagacctcc
     3961 gttgagcagt cagagtcttc cctggctcca caatacccct tcccttggct gactctcctt
     4021 gccaatcctt acctccctgg tccttcaagc ctttgtcccc tcttctttgc tccaacccct
     4081 tcacagccat tcttcatagc ctggctcccc tacccccctg cttagaagct gaggctgtca
     4141 ggactctcta gagtgtatta tgggggaaaa tgaacacatc ttaaaaatct gttatttgct
     4201 acattttttt agaaggcatt tttcctcatg agtttgatat gttaattata cagaaattgg
     4261 aaagcagaaa tgcattttaa aaggcaagaa aatgtctgag tgctttatac taagattgcc
     4321 atagtttgtt ctttttgggg tatgaatgtt ttacatttct tgatcctcta tgttgtttat
     4381 aatacaactt ctgctctttc tttctgaaca ttatgtatgg ttggttatta gtgaattttg
     4441 cagatatttt atattgctgg taatatgtgt tattgcatag atttattgta attttctcag
     4501 ccttctttca gttgttagaa atttagatta tttccaaatt ttcagtgtta caaataatgc
     4561 tgtgatcaat tttgtgaata tagtgttttt acgtatttca aagtattccc ataggctagt
     4621 ttctcagtgc caagtcatca aaaacagctc cgttttctct tcactcttgc tatgatagca
     4681 tattaaactt agaaaagaaa ctcaaaaggc ctatattaaa aaccataata ccaaaaagga
     4741 aagtctgtag tcctataata atagatgaga gttgtattct gctttaatat ctgattcttt
     4801 gctgattaac gacatgaacc attatgctct ctgtatgaca gttgtgtgac tttgtgtggt
     4861 catgttatgg atcttacctt ttaatgtaat aaagtaaatt gctcttttcc tgtgtgacag
     4921 tttttcctgt atatttgttc taagcgtaga acaactctat ttgggacctg aataaatact
     4981 cattttcctt tgaaa
//
