LOCUS       NM_001401931            5179 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus iduronate 2-sulfatase (Ids), transcript variant 6,
            mRNA.
ACCESSION   NM_001401931 XM_030251231
VERSION     NM_001401931.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5179)
  AUTHORS   Imakiire,A., Morimoto,H., Suzuki,H., Masuda,T., Yoden,E., Inoue,A.,
            Morioka,H., Konaka,T., Mori,A., Shirasaka,R., Kato,R., Hirato,T.,
            Sonoda,H. and Minami,K.
  TITLE     Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the
            Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice
  JOURNAL   Mol Pharm 20 (11), 5901-5909 (2023)
   PUBMED   37860991
  REMARK    GeneRIF: Transferrin Receptor-Targeted Iduronate-2-sulfatase
            Penetrates the Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice.
REFERENCE   2  (bases 1 to 5179)
  AUTHORS   Mashima,R., Ohira,M., Okuyama,T., Onodera,M. and Takada,S.
  TITLE     A novel mucopolysaccharidosis type II mouse model with an
            iduronate-2-sulfatase-P88L mutation
  JOURNAL   Sci Rep 13 (1), 7865 (2023)
   PUBMED   37188686
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5179)
  AUTHORS   Maccari,F., Rigon,L., Mantovani,V., Galeotti,F., Salvalaio,M.,
            D'Avanzo,F., Zanetti,A., Capitani,F., Gabrielli,O., Tomanin,R. and
            Volpi,N.
  TITLE     Glycosaminoglycan signatures in body fluids of
            mucopolysaccharidosis type II mouse model under long-term enzyme
            replacement therapy
  JOURNAL   J Mol Med (Berl) 100 (8), 1169-1179 (2022)
   PUBMED   35816218
REFERENCE   4  (bases 1 to 5179)
  AUTHORS   Lobo-Menendez,F., Bowman,L.H. and Dewey,M.J.
  TITLE     Inverted Gcg/CGC trinucleotide microsatellites in the 5'-region of
            Mus IDS mRNA: recurrent induction of aberrant reverse transcripts
  JOURNAL   Mol Biol Rep 31 (2), 107-112 (2004)
   PUBMED   15293786
REFERENCE   5  (bases 1 to 5179)
  AUTHORS   Daniele,A., Russo,T., Ballabio,A. and Di Natale,P.
  TITLE     The mouse iduronate sulfatase gene: identification of a novel
            transcript
  JOURNAL   Biochem Biophys Res Commun 194 (3), 1030-1037 (1993)
   PUBMED   8352760
REFERENCE   6  (bases 1 to 5179)
  AUTHORS   Daniele,A., Faust,C.J., Herman,G.E., Di Natale,P. and Ballabio,A.
  TITLE     Cloning and characterization of the cDNA for the murine iduronate
            sulfatase gene
  JOURNAL   Genomics 16 (3), 755-757 (1993)
   PUBMED   8325651
REFERENCE   7  (bases 1 to 5179)
  AUTHORS   Angel,T.A., Faust,C.J., Gonzales,J.C., Kenwrick,S., Lewis,R.A. and
            Herman,G.E.
  TITLE     Genetic mapping of the X-linked dominant mutations striated (Str)
            and bare patches (Bpa) to a 600-kb region of the mouse X
            chromosome: implications for mapping human disorders in Xq28
  JOURNAL   Mamm Genome 4 (3), 171-176 (1993)
   PUBMED   8439729
REFERENCE   8  (bases 1 to 5179)
  AUTHORS   Chatterjee,A., Faust,C.J. and Herman,G.E.
  TITLE     Genetic and physical mapping of the biglycan gene on the mouse X
            chromosome
  JOURNAL   Mamm Genome 4 (1), 33-36 (1993)
   PUBMED   8093671
REFERENCE   9  (bases 1 to 5179)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (bases 1 to 5179)
  AUTHORS   Habara-Ohkubo,A., Takikawa,O. and Yoshida,R.
  TITLE     Cloning and expression of a cDNA encoding mouse indoleamine
            2,3-dioxygenase
  JOURNAL   Gene 105 (2), 221-227 (1991)
   PUBMED   1937018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672026.11 and BX294168.13.
            
            On Mar 3, 2022 this sequence version replaced XM_030251231.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1127938.1,
                                           SRR7345562.1429395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL672026.11        6514-6547           c
            35-111              BX294168.13        222755-222831       c
            112-238             BX294168.13        222247-222373       c
            239-437             BX294168.13        220962-221160       c
            438-497             BX294168.13        213317-213376       c
            498-634             BX294168.13        211539-211675       c
            635-812             BX294168.13        210714-210891       c
            813-901             BX294168.13        208780-208868       c
            902-1102            BX294168.13        207686-207886       c
            1103-1273           BX294168.13        206004-206174       c
            1274-1400           BX294168.13        200881-201007       c
            1401-1574           BX294168.13        198664-198837       c
            1575-5179           BX294168.13        190806-194410       c
FEATURES             Location/Qualifiers
     source          1..5179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.01 cM"
     gene            1..5179
                     /gene="Ids"
                     /note="iduronate 2-sulfatase"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
     exon            1..34
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            35..111
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            112..238
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            239..437
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            438..497
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            498..634
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            635..812
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     CDS             785..2047
                     /gene="Ids"
                     /EC_number="3.1.6.13"
                     /note="isoform 5 is encoded by transcript variant 6;
                     iduronate sulfatase; alpha-L-iduronate sulfate sulfatase"
                     /codon_start=1
                     /product="iduronate 2-sulfatase isoform 5"
                     /protein_id="NP_001388860.1"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
                     /translation="MSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQ
                     DGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASPFFLAVGYHKPHIPF
                     RYPKEFQKLYPLENITLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPE
                     DFQRKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAKY
                     SNFDVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVSL
                     FPTLAGLAGLPVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAYS
                     QYPRPADFPQWNSDKPSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGEL
                     YFVDSDPLQDHNVYNDSQHGGLLHSLRP"
     exon            813..901
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1102
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1273
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1400
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1574
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..5179
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5072..5077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      5098
                     /gene="Ids"
                     /note="major polyA site"
     regulatory      5155..5160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      5179
                     /gene="Ids"
                     /note="major polyA site"
ORIGIN      
        1 agaactacag gcactatgct acccggatag gaagtgcact tcctaggcga tgcttccact
       61 ggccccttgt gcattagtct cctgtctgga tggtaattac ccccatccat gtgccatctg
      121 ctggcccatt cctccaactt cactgggaac tgaagatgaa aggtgatcag aagcaggggc
      181 ggtaagcaag caccttccat ggtggaagtt ctgtcctgct gagggagcag gagtggagct
      241 ggaatcctgt gacaccacca catcagaggg aagaggagag gcgctaatcc ccgagtgaat
      301 ggagagtctc catcttcatc tgccttgctt gatttccaca aatgcctcgg tcacagggaa
      361 acttcatgtg atttctcatc aaggatggaa cgtgggattc tgagcaggac tgcattgttg
      421 ccttctggcc tgggaagacg tcaggtggat tgcttcttcc cttctaatat ttgttcaaca
      481 atcacttcac cagtgagatg ctctgaacat ccttctgatc attgtggatg atctccgccc
      541 ctccctgggc tgttatggag acaagctagt gaggtccccg aacattgacc agctggcatc
      601 ccatagcgtt ctctttcaga atgcctttgc tcagcaagca gtgtgcgcac caagtcgagt
      661 gtccttcctc accgggagga ggcctgacac cacccgcctg tatgacttca attcctactg
      721 gagggtacat tctggaaatt tttccaccat cccccaatac ttcaaggaga atggctacgt
      781 gaccatgtcg gttgggaaag tctttcaccc tggtatatct tccaatcaca gtgatgatta
      841 tccatatagc tggtcttttc caccttatca tccatcctca gagaaatatg aaaacactaa
      901 gacgtgtaag ggacaagatg gaaaactcca cgccaatctg ctttgtcctg tcgatgtggc
      961 agatgtgcct gaaggtacct tgcctgacaa acagagcaca gaagaagcca tcaggttgtt
     1021 ggaaaagatg aagacatcag ctagtccttt cttcctggca gttgggtacc acaagccgca
     1081 tatccccttc agatacccca aggaatttca gaagttgtat cccttggaaa acataaccct
     1141 ggctcctgat ccccatgttc ctgatagcct accacctgta gcctacaacc cctggatgga
     1201 tatcagggag agggaagatg tccaagcctt aaacatcagt gttccctatg gaccaattcc
     1261 tgaggatttt cagcggaaaa tccgccagag ctactttgct tctgtgtcct atttggatac
     1321 tcaggttgga catgttttga gtgctttgga tgatcttcgt ctagcccaca acacaattat
     1381 tgctttcaca tctgatcacg gatgggccct aggtgaacac ggagaatggg ccaagtacag
     1441 caactttgat gttgctaccc gtgtgcccct gatgctctat gtccctggaa ggacggcccc
     1501 acttcctgcg gcaggccaga agctctttcc ataccgggac ccctttgatc cggcctcgga
     1561 ttggatggat gcaggcaggc acaccgagga cctcgtagaa cttgtatctc tcttccccac
     1621 gctcgctgga cttgcaggac tgccagttcc tcctcggtgc cccatccctt cttttcatgt
     1681 tgagctttgc agagaaggcc agaatcttca gaagcatttg cagctccatg acttggaaga
     1741 ggagccagac ttgtttggta atccccggga gttgatcgcc tatagccagt acccccggcc
     1801 tgcagatttc cctcagtgga attctgacaa gccaagctta aatgatataa aggtcatggg
     1861 atattctata cgcactgtag actacaggta cactgtgtgg gttggcttcg atcctagtga
     1921 atttctggct aacttttctg atatccatgc cggggaactc tattttgtcg attctgaccc
     1981 actgcaggat cacaatgtat ataatgactc ccaacatgga ggtcttctcc actcactgag
     2041 gccttgagtt ctgccagcct cagtgggcac atatgtgtcc ccttcccccc ctacccattg
     2101 tattagatat aacctgagtg ggaaacagtg gaaacatgca tcagcaatct ggcctcggac
     2161 taggtggcag atggcccttt ttatgtagtc cttcttaagt tagaatttgc cattggattt
     2221 gggctaagct gaaactttta ttttaaaagc tcccatagct tcgttactac acaagtacaa
     2281 agtgaactaa ggtataatct tatctttata tctaaagacc atgctagcca gacataatac
     2341 tgtacttaag aaatcatttg cttgttgaat ttagtgcatt tcagatagta accatatgtc
     2401 ttacgtagcc cagagtgtca agcatgttaa catgggattt atttctttct caaatgtgaa
     2461 attcaagttg cttctagagt tattgcttct aagactacag atttagaatc aaaggtaaaa
     2521 tacccatgtg atgatcaatg tggtgtttct tcattaaata ataaataatg cttagtaaag
     2581 tatagttaaa gttaggaaat tcagttaagt atttcaatac tctctggccc aaataataat
     2641 ttgttagtaa atactacaat tcttgaactc agtggctatc tgttaaaaat tctgttattc
     2701 acaatgaaat catctcaaat ggaactattc ccatgatttg aatcattcca gattgtattc
     2761 atatgcctat ttagaaaact gcagatatcc atgtatcctg gaggcaggag gtattctact
     2821 ttttgctaaa acaaaacaaa acaaaacatg tttatgaaat gtaaattatc ttgagggttg
     2881 tggatacttt ttattaatag ggtataagta attttcagaa tgtagttctg tgttccctaa
     2941 gtacgaaggt aactagaata tgggcatgta gtaaggatta ggttatttca ttactgtcac
     3001 cagacagaag tccttcctct aacattgtga aaactgttca attaccagga gtcaacagct
     3061 ttctaaataa acattctatg tattttgttt tgtatttaaa tgagtaattt caataatttc
     3121 attaaaaatg attcagtgtc tcaaggtaaa tgtttttaaa acaaaaacta tagtaaatag
     3181 ctgattagat taagttactg tcatgtatta aattgtaacc aaaaagtcaa gacactactt
     3241 tgaagtgtgt aaaatttcaa agagagattg ttgattttac cagctggcct atagtagagt
     3301 agatttgtct gttgttctga aactgacttt tgcaaaggct ttgctcccat ctttccttgt
     3361 tcttgatctt tactgctctc ctgatgtcta ctcagtgtca ttttacaatt tagtttagaa
     3421 actcctcaca gcatgttttc tttttttttt tagcttcatc tccttcatag agggacagat
     3481 tttgacacaa gtgtttattt gacatctatt tattgttcct gtttggccat agtgtgtgtg
     3541 tatgtgtgtg tgtgtatgta tgtgtatgta tgtgtgtgta tgtgtatata tacatataca
     3601 tacacataca tacacataca tatatacata tatacatata tacatatata tatatatata
     3661 tatatatata tatttaatct tccaaagtac agttttagtt taaacccctc tgaattctgc
     3721 ttccaatgac atatgtggct atttaaattt aaattcatta acacaaaata acattttaaa
     3781 aaatttctgt tttacttcgc acttagaacc ttcccatcct agcagactgg acggagatgc
     3841 cctggattcg atctagatgt gttcaccctg attggcaggt ccctactgtc ctgcacttgc
     3901 ccacaatgag caaactatat ttggtttagg catagagtag ggagtttgct gtggccatca
     3961 gcttcttcct tccactctca tcaccattgc ctctgtcctt ctttctttcc ttcccaagaa
     4021 atttccttcc cctccttttc cctcccctgt tccttaaaga atccatgtgt cttcctaaaa
     4081 tccctcttga cccctgccct ttaagaacac cgtcagtgcc tactaagggt ctagaaagac
     4141 ctccgttgag cagtcagagt cttccctggc tccacaatac cccttccctt ggctgactct
     4201 ccttgccaat ccttacctcc ctggtccttc aagcctttgt cccctcttct ttgctccaac
     4261 cccttcacag ccattcttca tagcctggct cccctacccc cctgcttaga agctgaggct
     4321 gtcaggactc tctagagtgt attatggggg aaaatgaaca catcttaaaa atctgttatt
     4381 tgctacattt ttttagaagg catttttcct catgagtttg atatgttaat tatacagaaa
     4441 ttggaaagca gaaatgcatt ttaaaaggca agaaaatgtc tgagtgcttt atactaagat
     4501 tgccatagtt tgttcttttt ggggtatgaa tgttttacat ttcttgatcc tctatgttgt
     4561 ttataataca acttctgctc tttctttctg aacattatgt atggttggtt attagtgaat
     4621 tttgcagata ttttatattg ctggtaatat gtgttattgc atagatttat tgtaattttc
     4681 tcagccttct ttcagttgtt agaaatttag attatttcca aattttcagt gttacaaata
     4741 atgctgtgat caattttgtg aatatagtgt ttttacgtat ttcaaagtat tcccataggc
     4801 tagtttctca gtgccaagtc atcaaaaaca gctccgtttt ctcttcactc ttgctatgat
     4861 agcatattaa acttagaaaa gaaactcaaa aggcctatat taaaaaccat aataccaaaa
     4921 aggaaagtct gtagtcctat aataatagat gagagttgta ttctgcttta atatctgatt
     4981 ctttgctgat taacgacatg aaccattatg ctctctgtat gacagttgtg tgactttgtg
     5041 tggtcatgtt atggatctta ccttttaatg taataaagta aattgctctt ttcctgtgtg
     5101 acagtttttc ctgtatattt gttctaagcg tagaacaact ctatttggga cctgaataaa
     5161 tactcatttt cctttgaaa
//
