LOCUS       NM_001401926            5660 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus iduronate 2-sulfatase (Ids), transcript variant 2,
            mRNA.
ACCESSION   NM_001401926 XM_006527845
VERSION     NM_001401926.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5660)
  AUTHORS   Imakiire,A., Morimoto,H., Suzuki,H., Masuda,T., Yoden,E., Inoue,A.,
            Morioka,H., Konaka,T., Mori,A., Shirasaka,R., Kato,R., Hirato,T.,
            Sonoda,H. and Minami,K.
  TITLE     Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the
            Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice
  JOURNAL   Mol Pharm 20 (11), 5901-5909 (2023)
   PUBMED   37860991
  REMARK    GeneRIF: Transferrin Receptor-Targeted Iduronate-2-sulfatase
            Penetrates the Blood-Retinal Barrier and Improves Retinopathy in
            Mucopolysaccharidosis II Mice.
REFERENCE   2  (bases 1 to 5660)
  AUTHORS   Mashima,R., Ohira,M., Okuyama,T., Onodera,M. and Takada,S.
  TITLE     A novel mucopolysaccharidosis type II mouse model with an
            iduronate-2-sulfatase-P88L mutation
  JOURNAL   Sci Rep 13 (1), 7865 (2023)
   PUBMED   37188686
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5660)
  AUTHORS   Maccari,F., Rigon,L., Mantovani,V., Galeotti,F., Salvalaio,M.,
            D'Avanzo,F., Zanetti,A., Capitani,F., Gabrielli,O., Tomanin,R. and
            Volpi,N.
  TITLE     Glycosaminoglycan signatures in body fluids of
            mucopolysaccharidosis type II mouse model under long-term enzyme
            replacement therapy
  JOURNAL   J Mol Med (Berl) 100 (8), 1169-1179 (2022)
   PUBMED   35816218
REFERENCE   4  (bases 1 to 5660)
  AUTHORS   Lobo-Menendez,F., Bowman,L.H. and Dewey,M.J.
  TITLE     Inverted Gcg/CGC trinucleotide microsatellites in the 5'-region of
            Mus IDS mRNA: recurrent induction of aberrant reverse transcripts
  JOURNAL   Mol Biol Rep 31 (2), 107-112 (2004)
   PUBMED   15293786
REFERENCE   5  (bases 1 to 5660)
  AUTHORS   Daniele,A., Russo,T., Ballabio,A. and Di Natale,P.
  TITLE     The mouse iduronate sulfatase gene: identification of a novel
            transcript
  JOURNAL   Biochem Biophys Res Commun 194 (3), 1030-1037 (1993)
   PUBMED   8352760
REFERENCE   6  (bases 1 to 5660)
  AUTHORS   Daniele,A., Faust,C.J., Herman,G.E., Di Natale,P. and Ballabio,A.
  TITLE     Cloning and characterization of the cDNA for the murine iduronate
            sulfatase gene
  JOURNAL   Genomics 16 (3), 755-757 (1993)
   PUBMED   8325651
REFERENCE   7  (bases 1 to 5660)
  AUTHORS   Angel,T.A., Faust,C.J., Gonzales,J.C., Kenwrick,S., Lewis,R.A. and
            Herman,G.E.
  TITLE     Genetic mapping of the X-linked dominant mutations striated (Str)
            and bare patches (Bpa) to a 600-kb region of the mouse X
            chromosome: implications for mapping human disorders in Xq28
  JOURNAL   Mamm Genome 4 (3), 171-176 (1993)
   PUBMED   8439729
REFERENCE   8  (bases 1 to 5660)
  AUTHORS   Chatterjee,A., Faust,C.J. and Herman,G.E.
  TITLE     Genetic and physical mapping of the biglycan gene on the mouse X
            chromosome
  JOURNAL   Mamm Genome 4 (1), 33-36 (1993)
   PUBMED   8093671
REFERENCE   9  (bases 1 to 5660)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (bases 1 to 5660)
  AUTHORS   Habara-Ohkubo,A., Takikawa,O. and Yoshida,R.
  TITLE     Cloning and expression of a cDNA encoding mouse indoleamine
            2,3-dioxygenase
  JOURNAL   Gene 105 (2), 221-227 (1991)
   PUBMED   1937018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672026.11 and BX294168.13.
            
            On Mar 3, 2022 this sequence version replaced XM_006527845.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2292557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL672026.11        6514-6547           c
            35-111              BX294168.13        222755-222831       c
            112-238             BX294168.13        222247-222373       c
            239-461             BX294168.13        220962-221184       c
            462-849             BX294168.13        212532-212919       c
            850-986             BX294168.13        211539-211675       c
            987-1164            BX294168.13        210714-210891       c
            1165-1253           BX294168.13        208780-208868       c
            1254-1454           BX294168.13        207686-207886       c
            1455-1625           BX294168.13        206004-206174       c
            1626-1754           BX294168.13        203856-203984       c
            1755-1881           BX294168.13        200881-201007       c
            1882-2055           BX294168.13        198664-198837       c
            2056-5660           BX294168.13        190806-194410       c
FEATURES             Location/Qualifiers
     source          1..5660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.01 cM"
     gene            1..5660
                     /gene="Ids"
                     /note="iduronate 2-sulfatase"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
     exon            1..34
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            35..111
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            112..238
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            239..461
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            462..849
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     CDS             741..2528
                     /gene="Ids"
                     /EC_number="3.1.6.13"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; iduronate sulfatase; alpha-L-iduronate sulfate
                     sulfatase"
                     /codon_start=1
                     /product="iduronate 2-sulfatase isoform 2 precursor"
                     /protein_id="NP_001388855.1"
                     /db_xref="GeneID:15931"
                     /db_xref="MGI:MGI:96417"
                     /translation="MSPPPPPPIWRQLSFSLLLGSFCIALESAAQGNSATDALNILLI
                     IVDDLRPSLGCYGDKLVRSPNIDQLASHSVLFQNAFAQQAVCAPSRVSFLTGRRPDTT
                     RLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDYPYSWSFPPY
                     HPSSEKYENTKTCKGQDGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSA
                     SPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPHVPDSLPPVAYNPWMDIRERE
                     DVQALNISVPYGPIPEDFQHRCSICSILILRQSSCESSWKEHLLLLSRGFQLPSEVLC
                     LFAERKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAK
                     YSNFDVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVS
                     LFPTLAGLAGLPVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAY
                     SQYPRPADFPQWNSDKPSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGE
                     LYFVDSDPLQDHNVYNDSQHGGLLHSLRP"
     exon            850..986
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1164
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1253
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1454
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1625
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1754
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1881
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2055
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..5660
                     /gene="Ids"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5553..5558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      5579
                     /gene="Ids"
                     /note="major polyA site"
     regulatory      5636..5641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ids"
                     /note="hexamer: AATAAA"
     polyA_site      5660
                     /gene="Ids"
                     /note="major polyA site"
ORIGIN      
        1 agaactacag gcactatgct acccggatag gaagtgcact tcctaggcga tgcttccact
       61 ggccccttgt gcattagtct cctgtctgga tggtaattac ccccatccat gtgccatctg
      121 ctggcccatt cctccaactt cactgggaac tgaagatgaa aggtgatcag aagcaggggc
      181 ggtaagcaag caccttccat ggtggaagtt ctgtcctgct gagggagcag gagtggagtg
      241 ccttatttaa actgtgctgt agctggaatc ctgtgacacc accacatcag agggaagagg
      301 agaggcgcta atccccgagt gaatggagag tctccatctt catctgcctt gcttgatttc
      361 cacaaatgcc tcggtcacag ggaaacttca tgtgatttct catcaaggat ggaacgtggg
      421 attctgagca ggactgcatt gttgccttct ggcctgggaa ggttctgccc accttgactg
      481 atcgtgctca gacgtccggc gccatcaggc tccacccccg acagggaggg gacagaagag
      541 agttgcgcaa gcgcattcgt gctcgggcca gcgcccgggc ctttgggccc gaggcagagg
      601 tgtcgcgcag ttttctcaga gactttggtg gtgacagcgg ctgcagcggc ggcggcggcg
      661 gcggcggcgg cggccactgc tacgtaatgg tcccgctgta gcctcacgcc accttcttgc
      721 aagactgcgc cgaggcagaa atgtcgccgc cgccgccgcc gcctatctgg cggcagctta
      781 gcttcagctt gttgctaggc tccttctgca tcgccctgga gtccgcagcg caaggcaact
      841 ctgctacaga tgctctgaac atccttctga tcattgtgga tgatctccgc ccctccctgg
      901 gctgttatgg agacaagcta gtgaggtccc cgaacattga ccagctggca tcccatagcg
      961 ttctctttca gaatgccttt gctcagcaag cagtgtgcgc accaagtcga gtgtccttcc
     1021 tcaccgggag gaggcctgac accacccgcc tgtatgactt caattcctac tggagggtac
     1081 attctggaaa tttttccacc atcccccaat acttcaagga gaatggctac gtgaccatgt
     1141 cggttgggaa agtctttcac cctggtatat cttccaatca cagtgatgat tatccatata
     1201 gctggtcttt tccaccttat catccatcct cagagaaata tgaaaacact aagacgtgta
     1261 agggacaaga tggaaaactc cacgccaatc tgctttgtcc tgtcgatgtg gcagatgtgc
     1321 ctgaaggtac cttgcctgac aaacagagca cagaagaagc catcaggttg ttggaaaaga
     1381 tgaagacatc agctagtcct ttcttcctgg cagttgggta ccacaagccg catatcccct
     1441 tcagataccc caaggaattt cagaagttgt atcccttgga aaacataacc ctggctcctg
     1501 atccccatgt tcctgatagc ctaccacctg tagcctacaa cccctggatg gatatcaggg
     1561 agagggaaga tgtccaagcc ttaaacatca gtgttcccta tggaccaatt cctgaggatt
     1621 ttcagcacag atgttccatt tgcagtatcc tgatcctgag gcagtctagc tgtgagagct
     1681 cctggaaaga acacctgttg ctgctaagca gaggttttca gctacctagc gaagttcttt
     1741 gcttgtttgc tgagcggaaa atccgccaga gctactttgc ttctgtgtcc tatttggata
     1801 ctcaggttgg acatgttttg agtgctttgg atgatcttcg tctagcccac aacacaatta
     1861 ttgctttcac atctgatcac ggatgggccc taggtgaaca cggagaatgg gccaagtaca
     1921 gcaactttga tgttgctacc cgtgtgcccc tgatgctcta tgtccctgga aggacggccc
     1981 cacttcctgc ggcaggccag aagctctttc cataccggga cccctttgat ccggcctcgg
     2041 attggatgga tgcaggcagg cacaccgagg acctcgtaga acttgtatct ctcttcccca
     2101 cgctcgctgg acttgcagga ctgccagttc ctcctcggtg ccccatccct tcttttcatg
     2161 ttgagctttg cagagaaggc cagaatcttc agaagcattt gcagctccat gacttggaag
     2221 aggagccaga cttgtttggt aatccccggg agttgatcgc ctatagccag tacccccggc
     2281 ctgcagattt ccctcagtgg aattctgaca agccaagctt aaatgatata aaggtcatgg
     2341 gatattctat acgcactgta gactacaggt acactgtgtg ggttggcttc gatcctagtg
     2401 aatttctggc taacttttct gatatccatg ccggggaact ctattttgtc gattctgacc
     2461 cactgcagga tcacaatgta tataatgact cccaacatgg aggtcttctc cactcactga
     2521 ggccttgagt tctgccagcc tcagtgggca catatgtgtc cccttccccc cctacccatt
     2581 gtattagata taacctgagt gggaaacagt ggaaacatgc atcagcaatc tggcctcgga
     2641 ctaggtggca gatggccctt tttatgtagt ccttcttaag ttagaatttg ccattggatt
     2701 tgggctaagc tgaaactttt attttaaaag ctcccatagc ttcgttacta cacaagtaca
     2761 aagtgaacta aggtataatc ttatctttat atctaaagac catgctagcc agacataata
     2821 ctgtacttaa gaaatcattt gcttgttgaa tttagtgcat ttcagatagt aaccatatgt
     2881 cttacgtagc ccagagtgtc aagcatgtta acatgggatt tatttctttc tcaaatgtga
     2941 aattcaagtt gcttctagag ttattgcttc taagactaca gatttagaat caaaggtaaa
     3001 atacccatgt gatgatcaat gtggtgtttc ttcattaaat aataaataat gcttagtaaa
     3061 gtatagttaa agttaggaaa ttcagttaag tatttcaata ctctctggcc caaataataa
     3121 tttgttagta aatactacaa ttcttgaact cagtggctat ctgttaaaaa ttctgttatt
     3181 cacaatgaaa tcatctcaaa tggaactatt cccatgattt gaatcattcc agattgtatt
     3241 catatgccta tttagaaaac tgcagatatc catgtatcct ggaggcagga ggtattctac
     3301 tttttgctaa aacaaaacaa aacaaaacat gtttatgaaa tgtaaattat cttgagggtt
     3361 gtggatactt tttattaata gggtataagt aattttcaga atgtagttct gtgttcccta
     3421 agtacgaagg taactagaat atgggcatgt agtaaggatt aggttatttc attactgtca
     3481 ccagacagaa gtccttcctc taacattgtg aaaactgttc aattaccagg agtcaacagc
     3541 tttctaaata aacattctat gtattttgtt ttgtatttaa atgagtaatt tcaataattt
     3601 cattaaaaat gattcagtgt ctcaaggtaa atgtttttaa aacaaaaact atagtaaata
     3661 gctgattaga ttaagttact gtcatgtatt aaattgtaac caaaaagtca agacactact
     3721 ttgaagtgtg taaaatttca aagagagatt gttgatttta ccagctggcc tatagtagag
     3781 tagatttgtc tgttgttctg aaactgactt ttgcaaaggc tttgctccca tctttccttg
     3841 ttcttgatct ttactgctct cctgatgtct actcagtgtc attttacaat ttagtttaga
     3901 aactcctcac agcatgtttt cttttttttt ttagcttcat ctccttcata gagggacaga
     3961 ttttgacaca agtgtttatt tgacatctat ttattgttcc tgtttggcca tagtgtgtgt
     4021 gtatgtgtgt gtgtgtatgt atgtgtatgt atgtgtgtgt atgtgtatat atacatatac
     4081 atacacatac atacacatac atatatacat atatacatat atacatatat atatatatat
     4141 atatatatat atatttaatc ttccaaagta cagttttagt ttaaacccct ctgaattctg
     4201 cttccaatga catatgtggc tatttaaatt taaattcatt aacacaaaat aacattttaa
     4261 aaaatttctg ttttacttcg cacttagaac cttcccatcc tagcagactg gacggagatg
     4321 ccctggattc gatctagatg tgttcaccct gattggcagg tccctactgt cctgcacttg
     4381 cccacaatga gcaaactata tttggtttag gcatagagta gggagtttgc tgtggccatc
     4441 agcttcttcc ttccactctc atcaccattg cctctgtcct tctttctttc cttcccaaga
     4501 aatttccttc ccctcctttt ccctcccctg ttccttaaag aatccatgtg tcttcctaaa
     4561 atccctcttg acccctgccc tttaagaaca ccgtcagtgc ctactaaggg tctagaaaga
     4621 cctccgttga gcagtcagag tcttccctgg ctccacaata ccccttccct tggctgactc
     4681 tccttgccaa tccttacctc cctggtcctt caagcctttg tcccctcttc tttgctccaa
     4741 ccccttcaca gccattcttc atagcctggc tcccctaccc ccctgcttag aagctgaggc
     4801 tgtcaggact ctctagagtg tattatgggg gaaaatgaac acatcttaaa aatctgttat
     4861 ttgctacatt tttttagaag gcatttttcc tcatgagttt gatatgttaa ttatacagaa
     4921 attggaaagc agaaatgcat tttaaaaggc aagaaaatgt ctgagtgctt tatactaaga
     4981 ttgccatagt ttgttctttt tggggtatga atgttttaca tttcttgatc ctctatgttg
     5041 tttataatac aacttctgct ctttctttct gaacattatg tatggttggt tattagtgaa
     5101 ttttgcagat attttatatt gctggtaata tgtgttattg catagattta ttgtaatttt
     5161 ctcagccttc tttcagttgt tagaaattta gattatttcc aaattttcag tgttacaaat
     5221 aatgctgtga tcaattttgt gaatatagtg tttttacgta tttcaaagta ttcccatagg
     5281 ctagtttctc agtgccaagt catcaaaaac agctccgttt tctcttcact cttgctatga
     5341 tagcatatta aacttagaaa agaaactcaa aaggcctata ttaaaaacca taataccaaa
     5401 aaggaaagtc tgtagtccta taataataga tgagagttgt attctgcttt aatatctgat
     5461 tctttgctga ttaacgacat gaaccattat gctctctgta tgacagttgt gtgactttgt
     5521 gtggtcatgt tatggatctt accttttaat gtaataaagt aaattgctct tttcctgtgt
     5581 gacagttttt cctgtatatt tgttctaagc gtagaacaac tctatttggg acctgaataa
     5641 atactcattt tcctttgaaa
//
