LOCUS       NM_145949               3014 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus indoleamine 2,3-dioxygenase 2 (Ido2), mRNA.
ACCESSION   NM_145949 XM_982907 XM_982942
VERSION     NM_145949.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Ishikawa,M., Yamamoto,Y., Wulaer,B., Kunisawa,K., Fujigaki,H.,
            Ando,T., Kimura,H., Kushima,I., Arioka,Y., Torii,Y., Mouri,A.,
            Ozaki,N., Nabeshima,T. and Saito,K.
  TITLE     Indoleamine 2,3-dioxygenase 2 deficiency associates with
            autism-like behavior via dopaminergic neuronal dysfunction
  JOURNAL   FEBS J 291 (5), 945-964 (2024)
   PUBMED   38037233
  REMARK    GeneRIF: Indoleamine 2,3-dioxygenase 2 deficiency associates with
            autism-like behavior via dopaminergic neuronal dysfunction.
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Ando,T., Hoshi,M., Tezuka,H., Ito,H., Nakamoto,K., Yamamoto,Y. and
            Saito,K.
  TITLE     Absence of indoleamine 2,3-dioxygenase 2 promotes liver
            regeneration after partial hepatectomy in mice
  JOURNAL   Mol Med Rep 27 (2) (2023)
   PUBMED   36484383
  REMARK    GeneRIF: Absence of indoleamine 2,3dioxygenase 2 promotes liver
            regeneration after partial hepatectomy in mice.
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Merlo,L.M.F., Peng,W., DuHadaway,J.B., Montgomery,J.D.,
            Prendergast,G.C., Muller,A.J. and Mandik-Nayak,L.
  TITLE     The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis
            through a Nonenzymatic Mechanism
  JOURNAL   J Immunol 208 (3), 571-581 (2022)
   PUBMED   34965962
  REMARK    GeneRIF: The Immunomodulatory Enzyme IDO2 Mediates Autoimmune
            Arthritis through a Nonenzymatic Mechanism.
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Divanovic,S., Sawtell,N.M., Trompette,A., Warning,J.I., Dias,A.,
            Cooper,A.M., Yap,G.S., Arditi,M., Shimada,K., Duhadaway,J.B.,
            Prendergast,G.C., Basaraba,R.J., Mellor,A.L., Munn,D.H.,
            Aliberti,J. and Karp,C.L.
  TITLE     Opposing biological functions of tryptophan catabolizing enzymes
            during intracellular infection
  JOURNAL   J Infect Dis 205 (1), 152-161 (2012)
   PUBMED   21990421
  REMARK    GeneRIF: IDO-1 and IDO-2 play biologically important, contradictory
            roles during intracellular protozoal infection - facilitating
            (Toxoplasma gondii) or suppressing (Leishmania major) microbial
            clearance in a pathogen-specific manner.
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Ball,H.J., Yuasa,H.J., Austin,C.J., Weiser,S. and Hunt,N.H.
  TITLE     Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine
            pathway
  JOURNAL   Int J Biochem Cell Biol 41 (3), 467-471 (2009)
   PUBMED   18282734
  REMARK    GeneRIF: role in the inhibition of immune responses to tumours
            Review article
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Katz,J.B., Muller,A.J. and Prendergast,G.C.
  TITLE     Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune
            escape
  JOURNAL   Immunol Rev 222, 206-221 (2008)
   PUBMED   18364004
  REMARK    GeneRIF: A second tryptophan catabolic enzyme inducible by IFNg,
            implicated in transcriptional immune regulation (IFNg-driven
            negative feedback), may limit the pro-inflammatory and
            anti-proliferative functions(Review)
            Review article
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Metz,R., Duhadaway,J.B., Kamasani,U., Laury-Kleintop,L.,
            Muller,A.J. and Prendergast,G.C.
  TITLE     Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical
            target of the antitumor indoleamine 2,3-dioxygenase inhibitory
            compound D-1-methyl-tryptophan
  JOURNAL   Cancer Res 67 (15), 7082-7087 (2007)
   PUBMED   17671174
  REMARK    GeneRIF: Findings implicate novel IDO related enzyme IDO2 in cancer
            as a result of its preferential inhibition by the D racemer of
            1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as
            an IDO inhibitor including as an anticancer agent
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Ball,H.J., Sanchez-Perez,A., Weiser,S., Austin,C.J., Astelbauer,F.,
            Miu,J., McQuillan,J.A., Stocker,R., Jermiin,L.S. and Hunt,N.H.
  TITLE     Characterization of an indoleamine 2,3-dioxygenase-like protein
            found in humans and mice
  JOURNAL   Gene 396 (1), 203-213 (2007)
   PUBMED   17499941
  REMARK    GeneRIF: This article describes the evolutionary relationships
            between the INDO and INDOL1 genes. The INDOL1 protein has a
            distinct expression pattern compared to INDO and both have the
            ability to catabolise tryptophan.
            Erratum:[Gene. 2010 Oct 1;465(1-2):66]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EF137182.1, AC114602.16 and BX637885.1.
            
            On Mar 25, 2008 this sequence version replaced NM_145949.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF137182.1, BC026393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1462              EF137182.1         1-1462
            1463-2700           AC114602.16        105066-106303       c
            2701-3014           BX637885.1         4-317               c
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 12.58 cM"
     gene            1..3014
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /note="indoleamine 2,3-dioxygenase 2"
                     /db_xref="GeneID:209176"
                     /db_xref="MGI:MGI:2142489"
     exon            1..184
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1303
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /EC_number="1.13.11.52"
                     /note="indoleamine 2,3-dioxygenase-like protein 1;
                     indoleamine-pyrrole 2,3 dioxygenase-like 1"
                     /codon_start=1
                     /product="indoleamine 2,3-dioxygenase 2"
                     /protein_id="NP_666061.3"
                     /db_xref="CCDS:CCDS40298.2"
                     /db_xref="GeneID:209176"
                     /db_xref="MGI:MGI:2142489"
                     /translation="MEPQSQSMTLEVPLSLGRYHISEEYGFLLPNPLEALPDHYKPWM
                     EIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQ
                     PQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTNWTKRNPEGPLEISNLETIISFPG
                     GESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRAL
                     AQMHDYVDPDIFYSVIRIFLSGWKDNPAMPVGLVYEGVATEPLKYSGGSAAQSSVLHA
                     FDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLMAYN
                     QCVEALGELRSYHINVVARYIISAATRARSRGLTNPSPHALEDRGTGGTAMLSFLKSV
                     REKTMEALLCPGA"
     exon            185..280
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..400
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..519
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..534
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..634
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..752
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..804
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..953
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..3014
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2991..2996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /note="hexamer: AATAAA"
     polyA_site      3014
                     /gene="Ido2"
                     /gene_synonym="C230043N17Rik; Ido-2; Indol1"
                     /note="major polyA site"
ORIGIN      
        1 cgcacaagta caaccacaca gaagacacag ctggaaagct ccctggcctg ggcattcctc
       61 tggggcagag acctcacgcg aaaatatgga gcctcaaagt cagagcatga cgctggaggt
      121 gccgttgtcc ttggggagat accacatttc tgaggaatat ggctttctcc ttccaaatcc
      181 tctggaagca cttccagatc attacaagcc ttggatggaa attgccctca gacttcctca
      241 cttaatcgag aaccgccagc tccgagctca cgtgtacagg atgcctctcc tggactgcag
      301 attcctaaag agttaccgtg agcagcgcct ggcacacatg gcgctggccg ctatcaccat
      361 gggattcgtc tggcaggagg gggaaggcca accccaaaag gtgctgccaa gatctcttgc
      421 cattcctttt gttgaggtat ccaggaactt gggactcccg cctatcctgg tccactctga
      481 cctggtgctg acaaactgga ccaaaaggaa cccagaagga ccgttggaaa tcagtaacct
      541 ggaaaccatc atctcatttc cggggggaga gagcctgcgg ggcttcatcc tagtgacagt
      601 cttggtggag aaggcagcag tgcccggcct taaggccctg gttcagggaa tggaggccat
      661 tcggcaacac agtcaggaca ccctgctaga agccctgcag cagctgagac tctccatcca
      721 ggatatcacc agagccttgg cccaaatgca tgattatgtg gacccagaca tattttactc
      781 ggtcatccgg atcttcctct ctgggtggaa ggacaatcca gccatgcctg tggggctggt
      841 ctatgaaggt gttgccacag agcctctgaa gtactctgga ggaagtgcag cccagagctc
      901 cgtgcttcat gccttcgatg agttcctggg cattgagcat tgcaaggaaa gtgttggctt
      961 tctacacaga atgagggact acatgccgcc ttcccataag gctttcctgg aagatctcca
     1021 cgtagctcct tctctgagag actacatact ggcctctggt cctggggact gcctgatggc
     1081 ctataaccag tgtgtggagg ccctgggaga gctgcgcagt taccacatca atgtcgtggc
     1141 cagatacatt atctccgctg ccaccagggc caggagcagg gggctaacta atccctcacc
     1201 ccatgccttg gaagacaggg gcactggggg tactgccatg ctgagcttct tgaagagtgt
     1261 cagggagaag accatggagg ccctcctgtg tcctggtgct tagcagtcat gtcctgcacc
     1321 ctaacactta gatgttctca tcctgcatcc cagcgttaga ggttcacatc ctgcatccta
     1381 gtgcttagct gttcttgtgc tatatcccag cgcttagcag tcatgtcctg catcctagtg
     1441 cttagcattt tatatccagc atcttagtgc ttagagattc acatcctgca tcctagagct
     1501 tagcatttta tatccagcat ccttgtgcgt atcagctatg ttttgtatcc tgcttagcag
     1561 ttaacatcct gcatcctagt acttatctgt tctcatcctg catcctagag cttagcagtc
     1621 aggtcccgtg ggagcaagaa ccagggtctg agctctgtct gagcccaagc atggctttac
     1681 tgctttgtta attgtggctc ccacctccac cccaccccag ccagtttgct tgctagaagc
     1741 ctttctgcac tgcctaatcc ccctgcctca cagcagagag ctgcagccat gacctcctca
     1801 ttcagtatta ggtggacaag tcggagatac ccaaactcaa ttttaaaaga atcaagttgc
     1861 ttttggggca tgttacttca tcttttctta ccctgggcct cttcccttct tccctacctc
     1921 cctcgtccct tagtctttca cccctctctc tttctccttt tgtcaccctc cccctcccct
     1981 gcttactctc ttttcccttc ccccctctcc tcatccctcc ttcctttctt ccttcccttt
     2041 ttgtctgtga agcaccaggt ctgatgggcc tcaaactgtg atcttcctgt ctcacccttc
     2101 aaaggttatg tgtatgtgac gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2161 tcgtttcttt tgtttttccc tagtggagat gacacccaaa gatttgcaca taccaggcaa
     2221 ttgctccacc acctgactac agtcccagct ctctgtattc ctgaaggaaa gtcttgatga
     2281 gttgcctagg ctggtattga gctctttagc ccaggcaggc cttagtctga gtagctggga
     2341 tgtacaggga tgagccactg agccatgctg ctgctgctaa cgatgatgac gatgatgatg
     2401 atgaagatta tgataactac agtcactgca ataatgacgg caaagataat gatggctgtc
     2461 tcttcccttt tttgttattt tattttttat tttaatttac tttaagacag tatcctacta
     2521 tgctttagtc caggttgcct tgaactacct cagcctcccc agtgcttaga ttatactcat
     2581 gaaccaccaa ggctggctct agattctttc aattcactaa gccctactgt gctcttgtct
     2641 gtgacctggg acagccttcc cctccatgcc caggctgaat tcagcactgg gggtgggggt
     2701 ggggttagat gctgagtgga gatttgtggg gttaaagatg ctgtccatgc agacctggaa
     2761 gtcaccagca cgggagctat cagctactga ctaggaaccc gatgcgactc ccccacagag
     2821 ggtagacatt gtcggttcta ttttaactct ctctgttcta tttttaggac cgtgtttttc
     2881 tttctcctag tgacactgga aatttgtatg tgaaaaatgc tttaactgac cccttgaaag
     2941 ccagtaagcc aaaataagaa taaatagtaa gtccacatgt ttaggataaa aataaatatg
     3001 gcttttatat ccga
//
