LOCUS       NM_177197               2253 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus isopentenyl-diphosphate delta isomerase 2 (Idi2),
            mRNA.
ACCESSION   NM_177197
VERSION     NM_177197.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2253)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   2  (bases 1 to 2253)
  AUTHORS   Clizbe,D.B., Owens,M.L., Masuda,K.R., Shackelford,J.E. and
            Krisans,S.K.
  TITLE     IDI2, a second isopentenyl diphosphate isomerase in mammals
  JOURNAL   J Biol Chem 282 (9), 6668-6676 (2007)
   PUBMED   17202134
REFERENCE   3  (bases 1 to 2253)
  AUTHORS   Breitling,R., Laubner,D., Clizbe,D., Adamski,J. and Krisans,S.K.
  TITLE     Isopentenyl-diphosphate isomerases in human and mouse: evolutionary
            analysis of a mammalian gene duplication
  JOURNAL   J Mol Evol 57 (3), 282-291 (2003)
   PUBMED   14629038
  REMARK    GeneRIF: significant positive fitness effect of IDI2, revealed by
            the pattern of sequence conservation, as well as its specific
            expression pattern underscores the importance of the IDI gene
            duplication
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124732.5.
            
            On Oct 25, 2022 this sequence version replaced NM_177197.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029364.1, AK081319.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC124732.5         26782-26835         c
            55-198              AC124732.5         22746-22889         c
            199-291             AC124732.5         21809-21901         c
            292-422             AC124732.5         21125-21255         c
            423-2253            AC124732.5         18753-20583         c
FEATURES             Location/Qualifiers
     source          1..2253
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.63 cM"
     gene            1..2253
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /note="isopentenyl-diphosphate delta isomerase 2"
                     /db_xref="GeneID:320581"
                     /db_xref="MGI:MGI:2444315"
     exon            1..54
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..198
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..740
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /EC_number="5.3.3.2"
                     /note="isopentenyl diphosphate delta-isomerase type 2; IPP
                     isomerase 2; isopentenyl pyrophosphate isomerase 2"
                     /codon_start=1
                     /product="isopentenyl-diphosphate delta-isomerase 2"
                     /protein_id="NP_796171.1"
                     /db_xref="CCDS:CCDS26235.1"
                     /db_xref="GeneID:320581"
                     /db_xref="MGI:MGI:2444315"
                     /translation="MFQASKTHLDELQLKRLEEMCIVIDKQDQIIGADTKKNCHLMEN
                     INKGLLHRAFSVVLFNMKNELLVQQRADAKYTFPGHFTDSCSSHPLYVPEELEEKDAL
                     GVRRAALRRLQAELGISQDQISIKDIIFMTRKYHKCQSDAIWGEHEIGYLLLVRKDLM
                     LNPDTREVRRCCYMSQKDVQELLDREARGEEKITPWFRSMVEDFLFSWWPHLEDVSSF
                     VEPDKIYGL"
     exon            199..291
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..422
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..2253
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2160..2165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /note="major polyA site"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
                     /note="hexamer: AATAAA"
     polyA_site      2253
                     /gene="Idi2"
                     /gene_synonym="4833405L16Rik; IPPI2"
ORIGIN      
        1 atctccattc actcccaggt ttcagaggct gcacaagact gatcttcaga ggaggtatgt
       61 tccaggcaag caaaactcac cttgatgaac tccagctcaa acgtctggag gagatgtgca
      121 ttgtcattga caagcaggat cagatcattg gggctgacac caagaagaac tgtcacctca
      181 tggaaaacat caacaagggt ctgctacaca gagccttcag tgtggtcctt ttcaacatga
      241 aaaacgagct cttggtccag cagagagcag atgccaagta cacatttcca ggacatttta
      301 cagactcctg ttctagtcac cctctgtatg tgcctgagga gctggaagag aaggatgcct
      361 tgggagtgag gagggcagcc ctaagacgtc tgcaggctga gctgggcatc tcccaggacc
      421 agatttccat aaaggacata atcttcatga cccgaaaata ccacaagtgt cagtcagatg
      481 ctatctgggg agaacatgag attggctacc ttctgttggt gagaaaagat cttatgctaa
      541 acccagatac cagggaagtg agacgctgct gctacatgag ccagaaggac gtgcaggagc
      601 tactggacag ggaggcccga ggagaagaaa agatcacccc ttggttcaga agcatggtag
      661 aggatttcct gttctcttgg tggcctcatt tagaggatgt gtcttcattc gtggagcctg
      721 acaagatata tggactgtga gttgggagaa gtacagtcta tagctgaggt cagctccaag
      781 gcaggatttg aattgcttgc acaagggtga ggggagttat agaagttgaa tgctgaaatc
      841 cttcagtcac cttgccagct aaaatccagc ctgcgagttt taaccaattg ttcccttgat
      901 tcttctagct cttaaaaagt tttccgctgc agtctacaga aatatcactt tcctccctaa
      961 cagttctctg cggagcatct gctctcctta gtctcatgga cagcagaggc tcagacaagg
     1021 accacagctg tcatctctgc tatgtcatca gctgtgactg cagacccccc caggatgtgt
     1081 ggtgcatgat gataacaatg tacatgagga attcatagct ggtcggtggt ggcacacacg
     1141 tttagtccga gcactcaaag acagaggtag atggatctct gagtttgagg ccagcctggt
     1201 ctacatagtg agttccaaaa cagcctgggc tacacagaaa accctacctc agaaaccaaa
     1261 aataaataca taggtagata aatagatgca tagctacagt aaactaaaag agccagagac
     1321 ttacactgta accagacaca ttaacttcac agaagcagtc acccatttgg taaactaaac
     1381 agcagagtaa cagttgcttt ccgtgctatc agtaccctac ctagtagtga caacaacaga
     1441 acataccaga gtgctttgta caaatgtaat gagaaatcaa actttcattt ccttcaaaat
     1501 gagtaagggc agaatacttt tggcaaaatg ctatgtctac attatataaa caaataatgt
     1561 ctatttcaaa ctatctttaa tacataaata tcatgaaaac actgaatgca aatacttgag
     1621 tcattgactt gttagtcagc ctcctagaac tgtgacaaaa cacctgggga atagacttag
     1681 aaaaggaaga aagagtgtat caaagtctca actgggattg tgtgactcaa ttccttcagg
     1741 cctaaggtca gagagaaacc agtgaggcag aagctggagc taagaatgct acctacctcc
     1801 cagcagaaag aggaaacaga gaggcagaga aaagatcatg ttggcaagga agcagagagg
     1861 gggagagaga tgcagagaga aatatatcct cacaggcata acccacatag gtgccacctc
     1921 cttagagcca attaactatg aattcaatag atttgcccac tattactaca ctagagccct
     1981 gatgatctag tcacctaaac tatctaccat ctctcctgca tcggggtcaa cacttggact
     2041 tcgggacagt tccaaaataa ttataatcag atttaaaaaa caaaaacaaa aaacagctac
     2101 tttgatttct ctaattttcc tttgactaat gagaaaactc ctttaatttc ttgttactaa
     2161 ataaattgct ttttaaatcc tttgccgttt gctaccatat tgcattaggt cattttctca
     2221 gcaataaata aaaaccaagc gccaattacc taa
//
