LOCUS       NM_145360               2883 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus isopentenyl-diphosphate delta isomerase (Idi1), mRNA.
ACCESSION   NM_145360 NM_177960 XM_975208 XM_975239
VERSION     NM_145360.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2883)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   3  (bases 1 to 2883)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   4  (bases 1 to 2883)
  AUTHORS   Kim,M., Wende,H., Walcher,J., Kuhnemund,J., Cheret,C., Kempa,S.,
            McShane,E., Selbach,M., Lewin,G.R. and Birchmeier,C.
  TITLE     Maf links Neuregulin1 signaling to cholesterol synthesis in
            myelinating Schwann cells
  JOURNAL   Genes Dev 32 (9-10), 645-657 (2018)
   PUBMED   29748249
  REMARK    Erratum:[Genes Dev. 2018 Aug 1;32(15-16):1101. doi:
            10.1101/gad.318477.118.. PMID: 30068704]
REFERENCE   5  (bases 1 to 2883)
  AUTHORS   Munkacsi,A.B., Hammond,N., Schneider,R.T., Senanayake,D.S.,
            Higaki,K., Lagutin,K., Bloor,S.J., Ory,D.S., Maue,R.A., Chen,F.W.,
            Hernandez-Ono,A., Dahlson,N., Repa,J.J., Ginsberg,H.N.,
            Ioannou,Y.A. and Sturley,S.L.
  TITLE     Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model
            of Niemann-Pick Type C Disease Treated with the Histone Deacetylase
            Inhibitor Vorinostat
  JOURNAL   J Biol Chem 292 (11), 4395-4410 (2017)
   PUBMED   28031458
REFERENCE   6  (bases 1 to 2883)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   7  (bases 1 to 2883)
  AUTHORS   Pfister,S., Jones,V.J., Power,M., Truisi,G.L., Khoo,P.L.,
            Steiner,K.A., Kanai-Azuma,M., Kanai,Y., Tam,P.P. and Loebel,D.A.
  TITLE     Sox17-dependent gene expression and early heart and gut development
            in Sox17-deficient mouse embryos
  JOURNAL   Int J Dev Biol 55 (1), 45-58 (2011)
   PUBMED   21305474
REFERENCE   8  (bases 1 to 2883)
  AUTHORS   Clizbe,D.B., Owens,M.L., Masuda,K.R., Shackelford,J.E. and
            Krisans,S.K.
  TITLE     IDI2, a second isopentenyl diphosphate isomerase in mammals
  JOURNAL   J Biol Chem 282 (9), 6668-6676 (2007)
   PUBMED   17202134
REFERENCE   9  (bases 1 to 2883)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   10 (bases 1 to 2883)
  AUTHORS   Breitling,R., Laubner,D., Clizbe,D., Adamski,J. and Krisans,S.K.
  TITLE     Isopentenyl-diphosphate isomerases in human and mouse: evolutionary
            analysis of a mammalian gene duplication
  JOURNAL   J Mol Evol 57 (3), 282-291 (2003)
   PUBMED   14629038
  REMARK    GeneRIF: only one of the two isoforms (IDI1) is highly conserved,
            ubiquitously expressed and most likely responsible for housekeeping
            isomerase activity
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124732.5, AK160832.1 and BE953932.1.
            
            On Dec 24, 2009 this sequence version replaced NM_145360.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream start codon would result in a
            protein that is 56 aa longer.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110313.1, AK160832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               AC124732.5         93702-94092         c
            392-2839            AK160832.1         26-2473
            2840-2883           BE953932.1         1-44                c
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.62 cM"
     gene            1..2883
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /note="isopentenyl-diphosphate delta isomerase"
                     /db_xref="GeneID:319554"
                     /db_xref="MGI:MGI:2442264"
     exon            1..391
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1106
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /EC_number="5.3.3.2"
                     /note="IPP isomerase 1; isopentenyl pyrophosphate
                     isomerase 1"
                     /codon_start=1
                     /product="isopentenyl-diphosphate Delta-isomerase 1"
                     /protein_id="NP_663335.2"
                     /db_xref="CCDS:CCDS26233.2"
                     /db_xref="GeneID:319554"
                     /db_xref="MGI:MGI:2442264"
                     /translation="MWRGRTLARAIGYAVRGRGLEAEHAAERIEVQLSAQLLSTCSRN
                     LCVLGQIRHSVTMPEINTSHLDEKQVQLLAEMCILIDENDNKIGADTKKNCHLNENID
                     KGLLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNSCCSHPLSNPGELEENNAIGV
                     KRAAKRRLKAELGIPLEEVDLNEMDYLTRIYYKAQSDGIWGEHEVDYILFLRKNVTLN
                     PDPNEIKSYCYVSKEEVREILKKAASGEIKLTPWFKIIADTFLFKWWDNLNHLSPFVD
                     HEKIHRL"
     exon            392..564
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..657
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..788
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..2867
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2827..2832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /note="hexamer: AATAAA"
     polyA_site      2859
                     /gene="Idi1"
                     /gene_synonym="4832416K17Rik; IPPI1"
                     /note="major polyA site"
ORIGIN      
        1 gacaggtcga accctcctca agaagcctcc ccagaaagga agcttcccca ccgcggagca
       61 gctagacgtg cgggccgtct cagctgtcca ctgggagtcg ccaacaccct cgctcgggtc
      121 ccagggccgc aatcactcct ggagacctcc agcgcttctt tcagagccac acgcagggca
      181 agtggtgcca ccgcgcgcta acctggcgcg gccgtgacgt caggcttgtg ctagattggc
      241 aattggctgg aggcatgtgg cgcggacgga cactggcgcg agcgattgga tatgctgtta
      301 gagggcgggg cctggaggcg gagcatgctg cggagaggat tgaagtacag ctctccgcac
      361 agcttctcag cacctgcagc cggaatctct gtgttctagg tcagatcaga cattctgtca
      421 caatgcctga aataaatacc agccatcttg atgaaaaaca ggttcagctt ctagcggaga
      481 tgtgtattct tattgatgaa aatgacaata aaattggggc tgacaccaag aaaaactgtc
      541 accttaatga aaacatcgac aaaggattat tacatcgagc ttttagtgtc ttcttgttta
      601 atactgaaaa taagctcctg ttacagcaga gatcagatgc taaaattacc tttccaggtt
      661 gtttcaccaa tagttgctgt agtcatccat taagtaaccc aggcgagctg gaagagaaca
      721 acgccattgg tgtgaagcga gcagcaaagc ggcgcttgaa agccgagttg ggaataccct
      781 tggaagaggt tgatctaaat gaaatggatt atctaacaag aatttactac aaggcccaat
      841 ctgatggtat ctggggtgaa catgaagttg attacattct gtttctgagg aagaatgtaa
      901 ccttgaatcc agatcccaac gagattaaaa gctattgcta tgtatcaaag gaagaagtca
      961 gagaaatttt gaagaaggca gccagtggtg aaattaagtt aactccgtgg tttaagataa
     1021 ttgcagatac tttcctcttc aaatggtggg ataacttaaa ccatttgagt ccatttgttg
     1081 accatgagaa aatacataga ttgtgaatgt gtaaatgatt tgaaaaattt tctacctggt
     1141 aagaatggtt tggtttggtt ttaaattggg ccctcttata tgatacatag gtattttaca
     1201 accagaattt gttttgagaa aagaaaaact caactagctt acagttttat atcatatatc
     1261 ccatatatat gcactgatgt ctgtaaaaga tatttaggtg aggttattgc aaaattatgc
     1321 cataagtaaa acttaattta gcctgtccaa atacctggct atgacaagat tgaggaagta
     1381 actagaactc atattttaca tttgatagac actttcagaa ctctttgcta attgtcaagt
     1441 gttgtttata tctttagatt tttatcatac atcagaaaat tgagcagctg ctttgaaaca
     1501 gcactaagag gttaaatggg cagggctcag gagacagctc agtgtaccat gattgccttg
     1561 caggcatgat gtcatgggtt gttgagtccc taaccctaaa gataattgta acaacagcag
     1621 caacaggcag agcaggttca gagggaagta tatggcgctc tctctctctc tctctctctc
     1681 tctctctctc tctctctcgg tcttcagaca ggatgattaa tctcaggaac cctgtataac
     1741 caatactgga tgctcaagtc gatagaaggt atcgtatttg catattactg actacacttc
     1801 acctcgtctc tggcgtggcc atgacactca acccagcgta aatgctcctg taaatgatag
     1861 ttgtactatg ctttatgata aggagacgtc tgcatgtgcg gcacagatca aatattaata
     1921 gacagttgct tgagcccttg gatgtttggc ccacagattt aaaaggccag ttctgtatac
     1981 taatttttgt cattctcact tgattttgtg ctttaaccat cctgaaatta ttattttact
     2041 acttaaaggt aactgttact tttggtagta atggtaactg attagctatt cagcaaaatc
     2101 tgtttatagt cctagtgaaa aagatggtta gtcataatgt gtgagtgagt tctactttaa
     2161 aaagttgaga aaacctttga ctctaccatg gctggccctg gatcctcttg ttgtaggggg
     2221 tctggcttga gttagataat ttagtagcat tagcacccct ttttaagaca acaacaacaa
     2281 aagaaaatct agggaagagt gggggcgtgt ttctttctct gtgtagctct ggctattcta
     2341 gaactcaatt tgtagactag gctagcctca aaacccagag atccaccttc ctctgactcc
     2401 caggtactgg gattaaagga gtgtaccaca tggccagcaa caaccagaat ttgaatgggt
     2461 gataatcaag agtcccgtaa cgggctcgct gttctatgat cagggcttat tttagaggtg
     2521 gaagtgggaa ggagtagggc tgaggaaaca tacagtgact agactgatgt cccagaatag
     2581 gcatatatta agattttgag gttatagaat aggcatatat tgatactgtg ttttgattga
     2641 tgttctttta aaacttgcca caggtgtgtc acatttgagc tctttagaca gctttattct
     2701 taagtgctgc ataatggata cattttttct tataaaaatt ttataaacct aatttcttgc
     2761 taactctgaa cagttgattt atcattgggg atatgactat gttgcaagaa tttattgaaa
     2821 attaaaaata aattatttta atattgtctg gcttgttaat atctggaaaa aaaaaaaaaa
     2881 aaa
//
