LOCUS       NM_008323               1299 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus isocitrate dehydrogenase 3 (NAD+), gamma (Idh3g),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_008323
VERSION     NM_008323.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Wang,M., He,T., Meng,D., Lv,W., Ye,J., Cheng,L. and Hu,J.
  TITLE     BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification
  JOURNAL   J Proteome Res 22 (12), 3854-3865 (2023)
   PUBMED   37955350
  REMARK    GeneRIF: BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification.
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   He,N., Lim,S.J., Moreira de Mello,J.C., Navarro,I., Bialecka,M.,
            Salvatori,D.C.F., van der Westerlaken,L.A.J., Pereira,L.V. and
            Chuva de Sousa Lopes,S.M.
  TITLE     At Term, XmO and XpO Mouse Placentas Show Differences in Glucose
            Metabolism in the Trophectoderm-Derived Outer Zone
  JOURNAL   Front Cell Dev Biol 5, 63 (2017)
   PUBMED   28680878
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Ma,T., Peng,Y., Huang,W., Liu,Y. and Ding,J.
  TITLE     The beta and gamma subunits play distinct functional roles in the
            alpha2betagamma heterotetramer of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   Sci Rep 7, 41882 (2017)
   PUBMED   28139779
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Leduc,M.S., Savage,H.S., Stearns,T.M., Cario,C.L., Walsh,K.A.,
            Paigen,B. and Berndt,A.
  TITLE     A major X-linked locus affects kidney function in mice
  JOURNAL   Mol Genet Genomics 287 (11-12), 845-854 (2012)
   PUBMED   23011808
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Soundar,S., Park,J.H., Huh,T.L. and Colman,R.F.
  TITLE     Evaluation by mutagenesis of the importance of 3 arginines in
            alpha, beta, and gamma subunits of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   J Biol Chem 278 (52), 52146-52153 (2003)
   PUBMED   14555658
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Kuroiwa,A., Watanabe,T., Hishigaki,H., Takahashi,E., Namikawa,T.
            and Matsuda,Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Brenner,V., Nyakatura,G., Rosenthal,A. and Platzer,M.
  TITLE     Genomic organization of two novel genes on human Xq28: compact head
            to head arrangement of IDH gamma and TRAP delta is conserved in rat
            and mouse
  JOURNAL   Genomics 44 (1), 8-14 (1997)
   PUBMED   9286695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672094.11.
            
            On Aug 26, 2022 this sequence version replaced NM_008323.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085179.1, U68564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL672094.11        50254-50344         c
            92-133              AL672094.11        46154-46195         c
            134-145             AL672094.11        45777-45788         c
            146-243             AL672094.11        45485-45582         c
            244-356             AL672094.11        45156-45268         c
            357-417             AL672094.11        44631-44691         c
            418-550             AL672094.11        44377-44509         c
            551-684             AL672094.11        44053-44186         c
            685-787             AL672094.11        43692-43794         c
            788-934             AL672094.11        43456-43602         c
            935-1029            AL672094.11        43093-43187         c
            1030-1090           AL672094.11        42945-43005         c
            1091-1299           AL672094.11        42442-42650         c
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.41 cM"
     gene            1..1299
                     /gene="Idh3g"
                     /note="isocitrate dehydrogenase 3 (NAD+), gamma"
                     /db_xref="GeneID:15929"
                     /db_xref="MGI:MGI:1099463"
     exon            1..91
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1192
                     /gene="Idh3g"
                     /EC_number="1.1.1.41"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; isocitrate dehydrogenase [NAD] subunit gamma 1,
                     mitochondrial; NAD(+)-specific ICDH subunit gamma;
                     isocitric dehydrogenase subunit gamma"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NAD] subunit gamma 1,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_032349.1"
                     /db_xref="CCDS:CCDS30212.1"
                     /db_xref="GeneID:15929"
                     /db_xref="MGI:MGI:1099463"
                     /translation="MALKVAIAAGGAAKAMLKPTLLCRPWEVLAAHVAPRRSISSQQT
                     IPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRN
                     AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKD
                     IDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTA
                     VHKANIMKLGDGLFLQCCREVAAHYPQITFDSMIVDNTTMQLVSRPQQFDVMVMPNLY
                     GNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCM
                     MLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSQAIQDIIRHIRIINGRAVE
                     A"
     exon            92..133
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            134..145
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            146..243
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            244..356
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            357..417
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            418..550
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            551..684
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            685..787
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            788..934
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1029
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1090
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1299
                     /gene="Idh3g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1276..1281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh3g"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="Idh3g"
                     /note="major polyA site"
ORIGIN      
        1 acttttcgtc atggcgctga aggtggcgat agctgctggc ggtgctgcaa aggcaatgct
       61 caagccaact ctcctctgcc gtccttggga ggttctggct gcccatgtgg ccccccgaag
      121 gagcatttcc tcacaacaaa caattcctcc atctgctaag tatggtgggc ggcatacagt
      181 gactatgatc ccaggggatg gcatcggccc agagctcatg ttgcatgtta agtctgtatt
      241 caggcatgca tgtgtgccgg tggactttga agaggtgcat gtaagctcca acgctgatga
      301 ggaggacatc cgcaatgcca tcatggccat ccgccggaac cgtgtggccc tgaagggcaa
      361 cattgaaaca aatcataacc tgccaccatc ccacaaatct cgaaacaaca tccttcgcac
      421 cagcctagac ctctatgcca acgtcatcca ctgtaagagc ctgccaggag tggtgacccg
      481 gcacaaggac atagacatcc tcattgtacg ggaaaacaca gaaggcgagt acagcagcct
      541 ggagcatgag agcgtagcag gagtggtgga gagcttgaag attatcacca aagccaagtc
      601 cctgcgcatt gctgaatatg ctttcaagct ggcccaggag agtgggcgta agaaagtgac
      661 ggctgtgcac aaggccaaca tcatgaaact gggtgatgga ctcttcctcc agtgctgcag
      721 ggaagtagca gcccactacc ctcagatcac ctttgacagc atgattgtag acaacacaac
      781 aatgcagctg gtatcccggc ctcagcagtt tgatgtcatg gtgatgccta atctctatgg
      841 taacattgtc aacaacgtct gtgcagggct agttggaggc ccaggccttg tggctggggc
      901 caactatggc catgtgtatg cagtattcga gacagctaca aggaacacag gcaaaagtat
      961 tgccaataag aacattgcta acccgactgc cacactgcta gcaagctgca tgatgctaga
     1021 ccacctcaag ctccactcct atgccacttc catccgcaaa gctgtcttag catccatgga
     1081 caatgaaaat atgcataccc cagatattgg aggccagggc accacatccc aagccatcca
     1141 ggacatcatt cgtcatatcc gcatcattaa tggacgggct gtggaggctt agctatccct
     1201 acagttttgc tcagcttgtc tgtaggactc tcttctcact ttagcactcc agctagcttg
     1261 ggggacagga cccagaataa agccacttct gttccagaa
//
