LOCUS       NP_032349                393 aa            linear   ROD 01-MAY-2025
DEFINITION  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
            isoform 1 precursor [Mus musculus].
ACCESSION   NP_032349
VERSION     NP_032349.1
DBSOURCE    REFSEQ: accession NM_008323.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 393)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 393)
  AUTHORS   Wang,M., He,T., Meng,D., Lv,W., Ye,J., Cheng,L. and Hu,J.
  TITLE     BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification
  JOURNAL   J Proteome Res 22 (12), 3854-3865 (2023)
   PUBMED   37955350
  REMARK    GeneRIF: BZW2 Modulates Lung Adenocarcinoma Progression through
            Glycolysis-Mediated IDH3G Lactylation Modification.
REFERENCE   3  (residues 1 to 393)
  AUTHORS   He,N., Lim,S.J., Moreira de Mello,J.C., Navarro,I., Bialecka,M.,
            Salvatori,D.C.F., van der Westerlaken,L.A.J., Pereira,L.V. and
            Chuva de Sousa Lopes,S.M.
  TITLE     At Term, XmO and XpO Mouse Placentas Show Differences in Glucose
            Metabolism in the Trophectoderm-Derived Outer Zone
  JOURNAL   Front Cell Dev Biol 5, 63 (2017)
   PUBMED   28680878
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 393)
  AUTHORS   Ma,T., Peng,Y., Huang,W., Liu,Y. and Ding,J.
  TITLE     The beta and gamma subunits play distinct functional roles in the
            alpha2betagamma heterotetramer of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   Sci Rep 7, 41882 (2017)
   PUBMED   28139779
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 393)
  AUTHORS   Leduc,M.S., Savage,H.S., Stearns,T.M., Cario,C.L., Walsh,K.A.,
            Paigen,B. and Berndt,A.
  TITLE     A major X-linked locus affects kidney function in mice
  JOURNAL   Mol Genet Genomics 287 (11-12), 845-854 (2012)
   PUBMED   23011808
REFERENCE   6  (residues 1 to 393)
  AUTHORS   Soundar,S., Park,J.H., Huh,T.L. and Colman,R.F.
  TITLE     Evaluation by mutagenesis of the importance of 3 arginines in
            alpha, beta, and gamma subunits of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   J Biol Chem 278 (52), 52146-52153 (2003)
   PUBMED   14555658
REFERENCE   7  (residues 1 to 393)
  AUTHORS   Kuroiwa,A., Watanabe,T., Hishigaki,H., Takahashi,E., Namikawa,T.
            and Matsuda,Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
REFERENCE   8  (residues 1 to 393)
  AUTHORS   Brenner,V., Nyakatura,G., Rosenthal,A. and Platzer,M.
  TITLE     Genomic organization of two novel genes on human Xq28: compact head
            to head arrangement of IDH gamma and TRAP delta is conserved in rat
            and mouse
  JOURNAL   Genomics 44 (1), 8-14 (1997)
   PUBMED   9286695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672094.11.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085179.1, U68564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.41 cM"
     Protein         1..393
                     /product="isocitrate dehydrogenase [NAD] subunit gamma 1,
                     mitochondrial isoform 1 precursor"
                     /EC_number="1.1.1.41"
                     /note="isocitrate dehydrogenase [NAD] subunit gamma 1,
                     mitochondrial; NAD(+)-specific ICDH subunit gamma;
                     isocitric dehydrogenase subunit gamma"
                     /calculated_mol_wt=38721
     transit_peptide 1..39
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P70404.1)"
                     /calculated_mol_wt=4083
     mat_peptide     40..393
                     /product="Isocitrate dehydrogenase [NAD] subunit gamma 1,
                     mitochondrial. /id=PRO_0000014451"
                     /note="propagated from UniProtKB/Swiss-Prot (P70404.1)"
                     /calculated_mol_wt=38721
     Region          52..383
                     /region_name="mito_nad_idh"
                     /note="isocitrate dehydrogenase, NAD-dependent,
                     mitochondrial type; TIGR00175"
                     /db_xref="CDD:272942"
     Site            130
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P41565; propagated from
                     UniProtKB/Swiss-Prot (P70404.1)"
     Site            206
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P70404.1)"
     CDS             1..393
                     /gene="Idh3g"
                     /coded_by="NM_008323.2:11..1192"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS30212.1"
                     /db_xref="GeneID:15929"
                     /db_xref="MGI:MGI:1099463"
ORIGIN      
        1 malkvaiaag gaakamlkpt llcrpwevla ahvaprrsis sqqtippsak yggrhtvtmi
       61 pgdgigpelm lhvksvfrha cvpvdfeevh vssnadeedi rnaimairrn rvalkgniet
      121 nhnlppshks rnnilrtsld lyanvihcks lpgvvtrhkd idilivrent egeysslehe
      181 svagvveslk iitkakslri aeyafklaqe sgrkkvtavh kanimklgdg lflqccreva
      241 ahypqitfds mivdnttmql vsrpqqfdvm vmpnlygniv nnvcaglvgg pglvaganyg
      301 hvyavfetat rntgksiank nianptatll ascmmldhlk lhsyatsirk avlasmdnen
      361 mhtpdiggqg ttsqaiqdii rhiriingra vea
//
