LOCUS       NM_130884               1520 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus isocitrate dehydrogenase 3 (NAD+) beta (Idh3b),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_130884
VERSION     NM_130884.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Wang,X., Liu,Q., Yu,H.T., Xie,J.Z., Zhao,J.N., Fang,Z.T., Qu,M.,
            Zhang,Y., Yang,Y. and Wang,J.Z.
  TITLE     A positive feedback inhibition of isocitrate dehydrogenase 3beta on
            paired-box gene 6 promotes Alzheimer-like pathology
  JOURNAL   Signal Transduct Target Ther 9 (1), 105 (2024)
   PUBMED   38679634
  REMARK    GeneRIF: A positive feedback inhibition of isocitrate dehydrogenase
            3beta on paired-box gene 6 promotes Alzheimer-like pathology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Zhu,S., Huang,J., Xu,R., Wang,Y., Wan,Y., McNeel,R., Parker,E.,
            Kolson,D., Yam,M., Webb,B., Zhao,C., Sigado,J. and Du,J.
  TITLE     Isocitrate dehydrogenase 3b is required for spermiogenesis but
            dispensable for retinal viability
  JOURNAL   J Biol Chem 298 (9), 102387 (2022)
   PUBMED   35985423
  REMARK    GeneRIF: Isocitrate dehydrogenase 3b is required for spermiogenesis
            but dispensable for retinal viability.
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Findlay,A.S., Carter,R.N., Starbuck,B., McKie,L., Novakova,K.,
            Budd,P.S., Keighren,M.A., Marsh,J.A., Cross,S.H., Simon,M.M.,
            Potter,P.K., Morton,N.M. and Jackson,I.J.
  TITLE     Mouse Idh3a mutations cause retinal degeneration and reduced
            mitochondrial function
  JOURNAL   Dis Model Mech 11 (12) (2018)
   PUBMED   30478029
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 1520)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1520)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1520)
  AUTHORS   Soundar,S., Park,J.H., Huh,T.L. and Colman,R.F.
  TITLE     Evaluation by mutagenesis of the importance of 3 arginines in
            alpha, beta, and gamma subunits of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   J Biol Chem 278 (52), 52146-52153 (2003)
   PUBMED   14555658
REFERENCE   9  (bases 1 to 1520)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY336999.1, DN176034.1, CN456483.1, AW049896.1 and AL833804.16.
            
            On Apr 7, 2010 this sequence version replaced NM_130884.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009022.1, AY035212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY336999.1         1-34
            35-627              DN176034.1         1-593
            628-1157            CN456483.1         176-705
            1158-1517           AW049896.1         15-374              c
            1518-1520           AL833804.16        189508-189510       c
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.2 cM"
     gene            1..1520
                     /gene="Idh3b"
                     /note="isocitrate dehydrogenase 3 (NAD+) beta"
                     /db_xref="GeneID:170718"
                     /db_xref="MGI:MGI:2158650"
     exon            1..70
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1189
                     /gene="Idh3b"
                     /EC_number="1.1.1.41"
                     /note="isoform 1 is encoded by transcript variant 1; N14A
                     tumor-related protein; isocitrate dehydrogenase 3 beta"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NAD] subunit beta,
                     mitochondrial isoform 1"
                     /protein_id="NP_570954.1"
                     /db_xref="CCDS:CCDS16738.1"
                     /db_xref="GeneID:170718"
                     /db_xref="MGI:MGI:2158650"
                     /translation="MAALSNVRWLTRAVLAARNSGAWRGLGTSTAHAASQSQAQDVRV
                     EGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHHLSEVQNMASEEKLEQVLSS
                     MKENKVAIIGKIYTPMEYKGELASYDMQLRRKLDLFANVVHVKSLPGYKTRHNNLDLV
                     IIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYATKKGRSKVTAVHKA
                     NIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII
                     DNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRH
                     LNLEYHSSMIADAVKKVIKAGKVRTRDMGGYSTTTDFIKSVIGHLHPHGG"
     exon            71..148
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            149..247
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            248..368
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            369..429
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            430..562
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            563..696
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            697..799
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            800..946
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1041
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1102
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1520
                     /gene="Idh3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh3b"
                     /note="hexamer: AATAAA"
     polyA_site      1517
                     /gene="Idh3b"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcactt cccccgcgac ttcctcggcc gaacatggca gcgctgagca atgtccgctg
       61 gctgacccga gcggtgctcg ccgctcggaa ctccggggca tggagaggtc tcggaacatc
      121 tacggctcac gccgcttccc agagccaggc acaagatgtg agggtggagg gtgcctttcc
      181 tgtgaccatg ctgcctggag acggcgtggg gccagagctc atgcatgctg tcaaggaagt
      241 gttcaaggct gctgctgtcc ctgtggaatt taaggagcat catctgagcg aggtgcagaa
      301 tatggcttct gaggagaagc tggagcaggt gctgagttcc atgaaggaga acaaagttgc
      361 catcattgga aagatctata ccccaatgga gtataagggt gaactagcct cctatgatat
      421 gcagctgagg cgtaagttgg atttgtttgc caacgtagtc cacgtgaagt cacttcctgg
      481 atacaagact cggcacaaca atctagacct ggttatcatt cgagagcaga cagaagggga
      541 gtatagctct ctggaacatg agagcgccaa gggtgtcatt gagtgcctga agatcgtcac
      601 tcgcaccaag tctcagagga ttgcaaagtt tgcgttcgac tatgccacca agaaagggcg
      661 gagcaaggtc acagccgtcc ataaagccaa catcatgaaa ctaggggatg gcttgttctt
      721 gcagtgctgt gaggaagttg ctgaactgta ccctaaaatc aagtttgaaa ccatgatcat
      781 agacaactgc tgcatgcagc tggtgcagaa cccttaccag tttgatgtgc tcgtgatgcc
      841 caatctctat ggcaacataa ttgacaatct ggctgctggc cttgttgggg gagctggcgt
      901 ggttcctggg gagagctaca gtgcagagta tgcagttttt gagacgggtg ctcggcaccc
      961 atttgcccag gcagtgggca ggaatatagc caaccccaca gccatgctgc tgtcggccac
     1021 caacatgctg cggcatctca atcttgagta tcactccagc atgattgcag atgcagtgaa
     1081 gaaagtgatc aaagctggca aggtacggac tcgagacatg ggaggctaca gcaccacaac
     1141 tgacttcatc aagtctgtca tcggccacct gcacccccat gggggctaga gcccttactc
     1201 cctccaattt caaaaggacc atgcttcgta tacatccctt cagtacaatg gaccagaaga
     1261 gaacatctag acagtagact ataatagctt ttctgaggct aggctgtcct gggggctggt
     1321 gttaagggta tctcaaaggg tgggttgttg cgacaaggcc cagaccctaa gatgataact
     1381 ttttcccaca ggttcgaacc tcagatatgg gtggttatgc cacatgtcat gacttcactg
     1441 aagctgtcat tactgccctg tcataaatcc tatacatgcc catgaaaaaa atagtcaata
     1501 aacaaaatac acacatacta
//
