LOCUS       NM_029573               2418 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus isocitrate dehydrogenase 3 (NAD+) alpha (Idh3a), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_029573
VERSION     NM_029573.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2418)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2418)
  AUTHORS   Su,H., Liang,Z., Weng,S., Sun,C., Huang,J., Zhang,T., Wang,X.,
            Wu,S., Zhang,Z., Zhang,Y., Gong,Q. and Xu,Y.
  TITLE     miR-9-5p regulates immunometabolic and epigenetic pathways in
            beta-glucan-trained immunity via IDH3alpha
  JOURNAL   JCI Insight 6 (9), 144260 (2021)
   PUBMED   33986196
  REMARK    GeneRIF: miR-9-5p regulates immunometabolic and epigenetic pathways
            in beta-glucan-trained immunity via IDH3alpha.
            Erratum:[JCI Insight. 2022 Mar 22;7(6):e159640. doi:
            10.1172/jci.insight.159640.. PMID: 35315365]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2418)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2418)
  AUTHORS   Findlay,A.S., Carter,R.N., Starbuck,B., McKie,L., Novakova,K.,
            Budd,P.S., Keighren,M.A., Marsh,J.A., Cross,S.H., Simon,M.M.,
            Potter,P.K., Morton,N.M. and Jackson,I.J.
  TITLE     Mouse Idh3a mutations cause retinal degeneration and reduced
            mitochondrial function
  JOURNAL   Dis Model Mech 11 (12) (2018)
   PUBMED   30478029
  REMARK    GeneRIF: the role of IDH3 in retinal disease and mitochondrial
            function, was investigated.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2418)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 2418)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   7  (bases 1 to 2418)
  AUTHORS   Cankaya,M., Hernandez,A.M., Ciftci,M., Beydemir,S., Ozdemir,H.,
            Budak,H., Gulcin,I., Comakli,V., Emircupani,T., Ekinci,D., Kuzu,M.,
            Jiang,Q., Eichele,G. and Kufrevioglu,O.I.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2418)
  AUTHORS   Soundar,S., Park,J.H., Huh,T.L. and Colman,R.F.
  TITLE     Evaluation by mutagenesis of the importance of 3 arginines in
            alpha, beta, and gamma subunits of human NAD-dependent isocitrate
            dehydrogenase
  JOURNAL   J Biol Chem 278 (52), 52146-52153 (2003)
   PUBMED   14555658
REFERENCE   9  (bases 1 to 2418)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2418)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC049956.1.
            
            On Jun 10, 2003 this sequence version replaced NM_029573.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049956.1, AK158646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.7 cM"
     gene            1..2418
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /note="isocitrate dehydrogenase 3 (NAD+) alpha"
                     /db_xref="GeneID:67834"
                     /db_xref="MGI:MGI:1915084"
     exon            1..33
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1107
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /EC_number="1.1.1.41"
                     /note="isocitrate dehydrogenase [NAD] subunit alpha,
                     mitochondrial; NAD(+)-specific ICDH subunit alpha;
                     isocitric dehydrogenase subunit alpha"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NAD] subunit alpha,
                     mitochondrial precursor"
                     /protein_id="NP_083849.1"
                     /db_xref="CCDS:CCDS23191.1"
                     /db_xref="GeneID:67834"
                     /db_xref="MGI:MGI:1915084"
                     /translation="MAGSAWVSKVSRLLGAFHNTKQVTRGFAGGVQTVTLIPGDGIGP
                     EISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTP
                     IAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVI
                     VDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREV
                     AENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSG
                     NIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFAT
                     IKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD"
     exon            34..96
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            97..180
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            181..295
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            296..483
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            484..617
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..720
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            721..785
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            786..870
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1023
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..2404
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1684
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /note="major polyA site"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2404
                     /gene="Idh3a"
                     /gene_synonym="1110003P10Rik; 1500012E04Rik"
ORIGIN      
        1 gacgcgatgg ccgggtccgc gtgggtgtcc aaggtctctc ggctgctggg tgcattccac
       61 aacacaaaac aggtgacaag aggttttgct ggtggtgttc agacagtaac tttaattcct
      121 ggagatggaa ttggcccaga aatttcagcc tcagtcatga agatttttga tgctgccaaa
      181 gcacctattc agtgggagga gcgcaatgtc acagcaattc aaggaccagg aggaaagtgg
      241 atgatccctc cagaagccaa ggagtccatg gataagaaca agatgggctt gaaaggccca
      301 ctaaagaccc caatagccgc tggccatcca tctatgaatc tgttgcttcg taagacattt
      361 gacctttatg ccaatgtccg gccatgtgtc tcaattgaag gttataaaac cccttacacg
      421 gatgtaaata tcgtcaccat ccgagagaac acggaaggag aatacagtgg aattgagcat
      481 gtgatcgttg atggggttgt gcagagcatc aagctcatca ccgaagaagc aagcaagcgc
      541 attgcagagt ttgccttcga gtacgctcgg aacaaccacc ggagcaacgt cacagctgtg
      601 cacaaagcta acatcatgag gatgtcagat gggctctttc tgcaaaaatg cagggaagtt
      661 gcggagaact gtaaagacat taaatttaac gagatgtacc ttgatactgt atgtttaaat
      721 atggtacaag acccatccca gtttgatgtt cttgtcatgc caaatttata cggagacatc
      781 cttagtgatc tgtgtgcagg actgattgga ggtcttgggg tgactccaag tggcaatatt
      841 ggagccaacg gtgttgccat ctttgaatcg gttcatggaa cagccccgga cattgcaggc
      901 aaggacatgg ccaaccccac ggccctcctg cttagtgctg tgatgatgct tcgccacatg
      961 ggactttttg accatgcagc aaaaatcgag gctgcatgtt ttgctacaat taaggatgga
     1021 aagagcttaa caaaagatct gggaggcaac gcgaagtgct ctgacttcac agaagaaatc
     1081 tgtcgtagag tcaaagactt agattagcac tcctgctggt ggatttgctg cagtcagtca
     1141 atcactccaa aaggataccc tgtaatcctc cttgagggcg cccaccattg gtttgcttgc
     1201 ttcttgacag agtacgtttt ttgaatctgg ccttttctta acaaaaccct tgcaatggat
     1261 gcacatgatg gccccaggcc ttcattcaaa gggttttccc aagtgctggt tgtatttatt
     1321 gtccgtctgg taaaccttat tttgtaaact gtaagtgaac tgtatcattt atcattgtta
     1381 acccatttta cacttcaggc aaaatcattt tcctcaactg taaatattct gatacagaat
     1441 taataagaga agatatttaa ctttttaaca aaagccctgg atttttggtt tatgaaaaac
     1501 aaactgggaa taaaacaggg ttttaacaat cgcacaagat aacattattc taatactaat
     1561 gggtacaaaa gaaatttact gggaaagttc acagcaaaaa aatggtatat ttcttaaaaa
     1621 tatggaaata aagtatttgt cctatacatg aattactatt aataaaaatg taagctccaa
     1681 gaaatccata atgaatgatg taattttgtt actacatcgg taatccttgt caaggccccg
     1741 gatgctctct gtgtatttga ttcttttgtt accttgagat tcactatttt gggggaagag
     1801 ctttcagata agggagatca ctcctcacta gacagatcgt cagcattgcg agctgtcagc
     1861 catgagagcc agccactgca gatcccctcc cacgtggcca cactccagcc agtgctgcag
     1921 gtgaccctgg aaaggcctgg ctgccccttg actttcccta aagcaaccag tcactgcctt
     1981 ctgccccagt agcacccatt acagacttaa ttgccgaggt ggagctgact cagcccacgc
     2041 tcatacaaat caggccaagc gggggcctgt gttaccagct gctgaccatc aggttctgcc
     2101 cctcattctt cccacagcct ctgctccaca gcatgaacct agcctttggc ccacaccaaa
     2161 gccaagctgt cttcccttag cccttgcact agtttgcaaa ctcgtggctt tgcataatgt
     2221 accctggtcc caaggggatt tcttaacaac agatgtccct gtctgggtca tttttttaaa
     2281 gcttttattt ggacttacaa tcttctgtgt attttacttt aaaactgctg ctttccctgt
     2341 ctcactggat tgttctggtt agcagtggct ttgggttcac agtaataaag aacttaagaa
     2401 ctgaaaaaaa aaaaaaaa
//
