LOCUS       NM_173011               1718 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus isocitrate dehydrogenase 2 (NADP+), mitochondrial
            (Idh2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173011 NM_008322
VERSION     NM_173011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Bowman,R.L., Dunbar,A.J., Mishra,T., Xiao,W., Waarts,M.R.,
            Maestre,I.F., Eisman,S.E., Cai,L., Mowla,S., Shah,N., Youn,A.,
            Bennett,L., Fontenard,S., Gounder,S., Gandhi,A., Bowman,M.,
            O'Connor,K., Zaroogian,Z., Sanchez-Vela,P., Martinez Benitez,A.R.,
            Werewski,M., Park,Y., Csete,I.S., Krishnan,A., Lee,D., Boorady,N.,
            Potts,C.R., Jenkins,M.T., Cai,S.F., Carroll,M.P., Meyer,S.E.,
            Miles,L.A., Ferrell,P.B. Jr., Trowbridge,J.J. and Levine,R.L.
  TITLE     In vivo models of subclonal oncogenesis and dependency in
            hematopoietic malignancy
  JOURNAL   Cancer Cell 42 (11), 1955-1969 (2024)
   PUBMED   39532065
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Peng,Q., Li,B., Song,P., Wang,R., Jiang,J., Jin,X., Shen,J.,
            Bao,J., Ni,J., Han,X. and Hu,G.
  TITLE     IDH2-NADPH pathway protects against acute pancreatitis via
            suppressing acinar cell ferroptosis
  JOURNAL   Br J Pharmacol 181 (20), 4067-4084 (2024)
   PUBMED   39072736
  REMARK    GeneRIF: IDH2-NADPH pathway protects against acute pancreatitis via
            suppressing acinar cell ferroptosis.
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Lee,S.W., Kim,S., Kim,B., Seong,J.B., Park,Y.H., Lee,H.J.,
            Choi,D.K., Yeom,E. and Lee,D.S.
  TITLE     IDH2 regulates macrophage polarization and tumorigenesis by
            modulating mitochondrial metabolism in macrophages
  JOURNAL   Mol Med 30 (1), 143 (2024)
   PUBMED   39256649
  REMARK    GeneRIF: IDH2 regulates macrophage polarization and tumorigenesis
            by modulating mitochondrial metabolism in macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   He,Q., Yu,T., Chen,J., Liang,J., Lin,D., Yan,K., Xie,Z., Song,Y.
            and Chen,Z.
  TITLE     Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent
            reverse TCA cycle maintains the growth and angiogenic capacity of
            bone marrow-derived endothelial progenitor cells under hypoxia
  JOURNAL   Free Radic Biol Med 213, 327-342 (2024)
   PUBMED   38281628
  REMARK    GeneRIF: Enhancement of de novo lipogenesis by the IDH1 and
            IDH2-dependent reverse TCA cycle maintains the growth and
            angiogenic capacity of bone marrow-derived endothelial progenitor
            cells under hypoxia.
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Bonhomme,F., Catalan,J., Britton-Davidian,J., Chapman,V.M.,
            Moriwaki,K., Nevo,E. and Thaler,L.
  TITLE     Biochemical diversity and evolution in the genus Mus
  JOURNAL   Biochem Genet 22 (3-4), 275-303 (1984)
   PUBMED   6375655
  REMARK    Review article
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Comparative gene mapping in man and mouse: assignment of the genes
            for lactate dehydrogenase-A, peptidase-D, and isocitrate
            dehydrogenase-2 to mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 577-580 (1978)
   PUBMED   752544
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY311397.1, AK169395.1 and BQ747924.1.
            
            On Mar 24, 2009 this sequence version replaced NM_173011.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060030.1, AK169395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY311397.1         10-13
            5-1699              AK169395.1         2-1696
            1700-1718           BQ747924.1         450-468
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.43 cM"
     gene            1..1718
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /note="isocitrate dehydrogenase 2 (NADP+), mitochondrial"
                     /db_xref="GeneID:269951"
                     /db_xref="MGI:MGI:96414"
     exon            1..189
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1433
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /EC_number="1.1.1.42"
                     /note="isocitrate dehydrogenase [NADP], mitochondrial;
                     IDH; IDP; ICD-M; NADP(+)-specific ICDH; oxalosuccinate
                     decarboxylase; NADP+-specific isocitrate dehydrogenase"
                     /codon_start=1
                     /product="isocitrate dehydrogenase [NADP], mitochondrial
                     precursor"
                     /protein_id="NP_766599.2"
                     /db_xref="CCDS:CCDS39994.1"
                     /db_xref="GeneID:269951"
                     /db_xref="MGI:MGI:96414"
                     /translation="MAGYLRAVSSLCRASGSARTWAPAALTVPSWPEQPRRHYAEKRI
                     KVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSAL
                     ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL
                     VPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPAGGVG
                     MGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKT
                     DFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVL
                     VCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLI
                     RFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALG
                     KQ"
     exon            190..281
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            282..447
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            448..608
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            609..752
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            753..889
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1041
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1154
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1252
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1345
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1703
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /note="hexamer: ACTAAA"
     polyA_site      1703
                     /gene="Idh2"
                     /gene_synonym="E430004F23; Idh-2; IDPm"
                     /note="major polyA site"
ORIGIN      
        1 agccaccagg gccagcctag agtccccacc gcacagcccg gtgcagcggc gtgctcggac
       61 ctcgcgtgct cgggatggcc ggctacctgc gggctgtgag ctcgctctgc agagcctcgg
      121 gctcagcgcg gacctgggca ccggcagcac tgactgtccc cagctggccg gagcagccgc
      181 ggcgccacta tgctgagaag aggatcaagg tggagaagcc ggtagtggag atggacggtg
      241 acgagatgac ccggatcatc tggcagttca tcaaggagaa gctcatcctg cctcacgtgg
      301 atgttcagct caagtatttt gaccttgggc ttccaaaccg tgaccagacc aatgaccagg
      361 tcaccattga ctctgctctg gccacccaga agtacagtgt ggctgtcaag tgtgccacaa
      421 tcacccctga tgaggcccgt gtggaagagt tcaagctgaa gaaaatgtgg aagagcccta
      481 acggaacgat ccggaacatc cttgggggaa ccgtcttcag agagccaatc atctgcaaaa
      541 acatcccccg ccttgtccct ggctggacca agcccatcac cattggcagg cacgcccatg
      601 gcgaccagta caaggccaca gattttgtgg tagatcgagc tggcacgttc aagttggtct
      661 tcaccccaaa ggatggcagc agtgccaagg agtgggaggt gtataacttc cctgccggag
      721 gcgttgggat ggggatgtac aacaccgacg agtccatttc gggcttcgcg cacagctgct
      781 tccagtactc tatccagaag aaatggccgc tctacttgag caccaagaac accattctga
      841 aggcctatga cgggcgtttc aaggacatct tccaggagat ctttgacaag cactataaga
      901 ctgacttcga caagaataag atctggtatg aacatcggct catcgacgac atggtggccc
      961 aggtgctcaa gtcttccggt ggctttgtgt gggcttgcaa aaactatgat ggagacgtgc
     1021 agtctgacat cctggctcaa ggctttggct ccctcggcct gatgacatct gtgctggtct
     1081 gccctgatgg gaagacaatt gaggctgagg ctgctcatgg gacagtcacc cgccattacc
     1141 gagaacacca gaagggccgg cccaccagta ccaaccctat tgccagcatc tttgcctgga
     1201 cacggggtct ggagcatcgt gggaagctgg atgggaacca ggaccttatc aggtttgcac
     1261 agacgctgga gaaggtgtgc gtgcagactg tggagagcgg agcgatgacc aaggacctgg
     1321 ctggctgtat ccatggcctc agcaatgtga agctgaacga gcacttcctg aacaccacag
     1381 acttcctgga caccattaag agcaacctgg acagagctct gggcaagcag taggggtgga
     1441 cactactcag ctccagtggg tactctgtac atggcagagg gtgggcctca cagcccctct
     1501 ctggtggcct ttctagggga cattttttta catatatata tgatggagat gttttttaaa
     1561 gtatatgagc attttccctc acggtggaca tgaggcagga acgtgtgctt tacctcagac
     1621 agtcagtgtt ctgcatactg taatttatat tgctctggaa tcacatggtg ccatatttag
     1681 ctactaaaaa gctcttcgca aaaaaaaaaa aaaaaaaa
//
