LOCUS       NM_010497               2270 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus isocitrate dehydrogenase 1 (NADP+), soluble (Idh1),
            transcript variant 2, mRNA.
ACCESSION   NM_010497
VERSION     NM_010497.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2270)
  AUTHORS   Wu,M.J., Kondo,H., Kammula,A.V., Shi,L., Xiao,Y., Dhiab,S., Xu,Q.,
            Slater,C.J., Avila,O.I., Merritt,J., Kato,H., Kattel,P.,
            Sussman,J., Gritti,I., Eccleston,J., Sun,Y., Cho,H.M., Olander,K.,
            Katsuda,T., Shi,D.D., Savani,M.R., Smith,B.C., Cleary,J.M.,
            Mostoslavsky,R., Vijay,V., Kitagawa,Y., Wakimoto,H., Jenkins,R.W.,
            Yates,K.B., Paik,J., Tassinari,A., Saatcioglu,D.H., Tron,A.E.,
            Haas,W., Cahill,D., McBrayer,S.K., Manguso,R.T. and Bardeesy,N.
  TITLE     Mutant IDH1 inhibition induces dsDNA sensing to activate tumor
            immunity
  JOURNAL   Science 385 (6705), eadl6173 (2024)
   PUBMED   38991060
  REMARK    GeneRIF: Mutant IDH1 inhibition induces dsDNA sensing to activate
            tumor immunity.
REFERENCE   2  (bases 1 to 2270)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   3  (bases 1 to 2270)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2270)
  AUTHORS   He,Q., Yu,T., Chen,J., Liang,J., Lin,D., Yan,K., Xie,Z., Song,Y.
            and Chen,Z.
  TITLE     Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent
            reverse TCA cycle maintains the growth and angiogenic capacity of
            bone marrow-derived endothelial progenitor cells under hypoxia
  JOURNAL   Free Radic Biol Med 213, 327-342 (2024)
   PUBMED   38281628
  REMARK    GeneRIF: Enhancement of de novo lipogenesis by the IDH1 and
            IDH2-dependent reverse TCA cycle maintains the growth and
            angiogenic capacity of bone marrow-derived endothelial progenitor
            cells under hypoxia.
REFERENCE   5  (bases 1 to 2270)
  AUTHORS   Chen,X., Liu,J., Li,Y., Zeng,Y., Wang,F., Cheng,Z., Duan,H.,
            Pan,G., Yang,S., Chen,Y., Li,Q., Shen,X., Li,Y., Qin,Z., Chen,J.,
            Huang,Y., Wang,X., Lu,Y., Shu,M., Zhang,Y., Wang,G., Li,K., Lin,X.,
            Xing,F. and Zhang,H.
  TITLE     IDH1 mutation impairs antiviral response and potentiates oncolytic
            virotherapy in glioma
  JOURNAL   Nat Commun 14 (1), 6781 (2023)
   PUBMED   37880243
  REMARK    GeneRIF: IDH1 mutation impairs antiviral response and potentiates
            oncolytic virotherapy in glioma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2270)
  AUTHORS   Bradley,D.J., Taylor,B.A., Blackwell,J., Evans,E.P. and Freeman,J.
  TITLE     Regulation of Leishmania populations within the host. III. Mapping
            of the locus controlling susceptibility to visceral leishmaniasis
            in the mouse
  JOURNAL   Clin Exp Immunol 37 (1), 7-14 (1979)
   PUBMED   290436
REFERENCE   7  (bases 1 to 2270)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics, ontogeny, and testosterone inducibility of aldehyde
            oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I
            and Aox-2) closely linked on chromosome 1
  JOURNAL   Biochem Genet 17 (5-6), 517-527 (1979)
   PUBMED   518535
REFERENCE   8  (bases 1 to 2270)
  AUTHORS   Wilcox,F.H., Womack,J.E. and Roderick,T.H.
  TITLE     Linkage of the locus for conversion of albumin (Acf-1) in the house
            mouse, Mus musculus
  JOURNAL   Biochem Genet 17 (1-2), 159-162 (1979)
   PUBMED   454356
REFERENCE   9  (bases 1 to 2270)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 2270)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868400.1, AK167158.1 and CF379827.1.
            
            On Dec 13, 2007 this sequence version replaced NM_010497.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.184210.1,
                                           SRR1660817.185662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB868400.1         2-31
            31-2257             AK167158.1         3-2229
            2258-2270           CF379827.1         500-512
FEATURES             Location/Qualifiers
     source          1..2270
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.91 cM"
     gene            1..2270
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /note="isocitrate dehydrogenase 1 (NADP+), soluble"
                     /db_xref="GeneID:15926"
                     /db_xref="MGI:MGI:96413"
     exon            1..153
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            154..291
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            292..583
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            584..689
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            690..867
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1019
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1160
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1323
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..2263
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /note="hexamer: ATTAAA"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /note="hexamer: AATGAA"
     polyA_site      2251
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
                     /note="major polyA site"
     polyA_site      2263
                     /gene="Idh1"
                     /gene_synonym="E030024J03Rik; Id-1; Idh-1; Idpc"
ORIGIN      
        1 gggctgaggg ggtggggcct gggaggagac aaagccggga agagttaaac agccttgacc
       61 ctgccgctgg gcttccgagc gaaggttgtg gcagatgctg atctaactgg ggccggctta
      121 ttacagcttg tgtgtacgcg cgggtgtgag ccgggttatt gaagtaaaaa tgtccagaaa
      181 aatccaagga ggttctgtgg tggagatgca aggagatgaa atgacacgaa tcatttggga
      241 attgattaag gaaaaactta ttcttcccta tgtggaactg gatctgcata gctatgattt
      301 aggcatagag aatcgtgatg ccaccaatga ccaggtcacc aaagatgctg cagaggctat
      361 aaagaaatac aacgtgggcg tcaagtgtgc taccatcacc cccgatgaga agagggttga
      421 agaattcaag ttgaaacaaa tgtggaaatc cccaaatggc accatccgaa acattctggg
      481 tggcactgtc ttcagggaag ctattatctg caaaaatatc ccccggctag tgacaggctg
      541 ggtaaaaccc atcatcattg gccgacatgc atatggggac caatacagag caactgattt
      601 tgttgttcct gggcctggaa aagtagagat aacctacaca ccaaaagatg gaactcagaa
      661 ggtgacatac atggtacatg actttgaaga aggtggtggt gttgccatgg gcatgtacaa
      721 ccaggataag tcaattgaag actttgcaca cagttccttc caaatggctc tgtccaaggg
      781 ctggcctttg tatctcagca ccaagaacac tattctgaag aagtatgatg ggcgtttcaa
      841 agacatcttc caggagatct atgacaagaa atacaagtcc cagtttgaag ctcagaagat
      901 ctgctatgaa cacaggctca tagatgacat ggtggcccaa gctatgaagt ccgagggagg
      961 cttcatctgg gcctgtaaga attacgatgg ggatgtgcag tcagactcag tcgcccaagg
     1021 ttatggctcc cttggcatga tgaccagtgt gctgatttgt ccagatggta agacggtaga
     1081 agcagaggct gcccatggca ctgtcacacg tcactaccgc atgtaccaga aagggcaaga
     1141 gacgtccacc aaccccattg cttccatttt tgcctggtcc cgagggttag cccacagagc
     1201 aaagcttgat aacaatactg agctcagctt cttcgcaaag gctttggaag acgtctgcat
     1261 tgagaccatt gaggctggct ttatgactaa ggacttggct gcttgcatta aaggcttacc
     1321 caatgtacaa cgttctgact acttgaatac atttgagttt atggacaaac ttggagaaaa
     1381 cttgaaggcc aaattagctc aggccaaact ttaaggtcaa acctgggctt agaatgagtc
     1441 tttgcggtaa ctaggtccac aggtttacgt attttttttt tttttttagt aacactcaag
     1501 attaaaaaca aaaatcattt tgtaatttgt ttagaagaca aagttgaact tttatatatg
     1561 tttacagtct tttttctttt tcatacagtt attgccacct taatgaatgt ggtggggaaa
     1621 tttttttaat tgtattttat tgtgtagtag cagtgtagga attatgttag tacctgttca
     1681 caattaactg tcatgttttc tcatgctcta atgtaaatga ccaaaatcag aagtgctcca
     1741 agggtgaaca atagctacag tatggttccc cataagggga aaagagaaac tcacttcccc
     1801 tgttgtccat gagtgtgaac actggggcct ttgtacgcaa atgttgtact gtgtgtggga
     1861 gagctataca gtaagctcac ataagactgg aacagatagg atgtgtgtag ctaaaatgca
     1921 tggcagacgt gtttataaag agcatgtatg tgtccaatat actagttata ttttaagacc
     1981 actggagaat tccaagtcta gaataaatgc agactggagg attctgctct ttgatttctc
     2041 ttctcctgtg acccagccta agtattatcc taccccaagc agtacatttc acccatgggc
     2101 aataatggga gctgtaccgt ttggatttct gctgacctgc tgcatttctt ttatataaat
     2161 gtgacttttt tttcccagaa gttgatatta aacactattc cagtctagtc cttctaaact
     2221 gttaatttta attaaaatga agtactaatg actcttcttt gaaaaaaaaa
//
