LOCUS       NM_031166               3963 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus inhibitor of DNA binding 4 (Id4), mRNA.
ACCESSION   NM_031166 XM_993031
VERSION     NM_031166.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3963)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 3963)
  AUTHORS   Xu,Z., Qin,Q., Wang,Y., Zhang,H., Liu,S., Li,X., Chen,Y., Wang,Y.,
            Ruan,H., He,W., Zhang,T., Yan,X., Wang,C., Xu,D. and Jiang,X.
  TITLE     Deubiquitinase Mysm1 regulates neural stem cell proliferation and
            differentiation by controlling Id4 expression
  JOURNAL   Cell Death Dis 15 (2), 129 (2024)
   PUBMED   38342917
  REMARK    GeneRIF: Deubiquitinase Mysm1 regulates neural stem cell
            proliferation and differentiation by controlling Id4 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3963)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3963)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3963)
  AUTHORS   Hayashi,Y., Kimura,S., Yano,E., Yoshimoto,S., Saeki,A.,
            Yasukochi,A., Hatakeyama,Y., Moriyama,M., Nakamura,S., Jimi,E. and
            Kawakubo-Yasukochi,T.
  TITLE     Id4 modulates salivary gland homeostasis and its expression is
            downregulated in IgG4-related disease via miR-486-5p
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (2), 119404 (2023)
   PUBMED   36535369
  REMARK    GeneRIF: Id4 modulates salivary gland homeostasis and its
            expression is downregulated in IgG4-related disease via miR-486-5p.
REFERENCE   6  (bases 1 to 3963)
  AUTHORS   Jen,Y., Manova,K. and Benezra,R.
  TITLE     Each member of the Id gene family exhibits a unique expression
            pattern in mouse gastrulation and neurogenesis
  JOURNAL   Dev Dyn 208 (1), 92-106 (1997)
   PUBMED   8989524
REFERENCE   7  (bases 1 to 3963)
  AUTHORS   Jen,Y., Manova,K. and Benezra,R.
  TITLE     Expression patterns of Id1, Id2, and Id3 are highly related but
            distinct from that of Id4 during mouse embryogenesis
  JOURNAL   Dev Dyn 207 (3), 235-252 (1996)
   PUBMED   8922523
REFERENCE   8  (bases 1 to 3963)
  AUTHORS   Loveys,D.A., Streiff,M.B. and Kato,G.J.
  TITLE     E2A basic-helix-loop-helix transcription factors are negatively
            regulated by serum growth factors and by the Id3 protein
  JOURNAL   Nucleic Acids Res 24 (14), 2813-2820 (1996)
   PUBMED   8759016
REFERENCE   9  (bases 1 to 3963)
  AUTHORS   Riechmann,V. and Sablitzky,F.
  TITLE     Mutually exclusive expression of two dominant-negative
            helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing
            brain of the mouse suggests distinct regulatory roles of these
            dnHLH proteins during cellular proliferation and differentiation of
            the nervous system
  JOURNAL   Cell Growth Differ 6 (7), 837-843 (1995)
   PUBMED   7547505
REFERENCE   10 (bases 1 to 3963)
  AUTHORS   Riechmann,V., van Cruchten,I. and Sablitzky,F.
  TITLE     The expression pattern of Id4, a novel dominant negative
            helix-loop-helix protein, is distinct from Id1, Id2 and Id3
  JOURNAL   Nucleic Acids Res 22 (5), 749-755 (1994)
   PUBMED   8139914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123857.4.
            
            On Feb 4, 2019 this sequence version replaced NM_031166.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.187679.1, X75018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-823               AC123857.4         90088-90910
            824-886             AC123857.4         91257-91319
            887-3963            AC123857.4         91924-95000
FEATURES             Location/Qualifiers
     source          1..3963
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 24.71 cM"
     gene            1..3963
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="inhibitor of DNA binding 4"
                     /db_xref="GeneID:15904"
                     /db_xref="MGI:MGI:99414"
     exon            1..823
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..868
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="inhibitor of differentiation 4"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-4"
                     /protein_id="NP_112443.1"
                     /db_xref="CCDS:CCDS26492.1"
                     /db_xref="GeneID:15904"
                     /db_xref="MGI:MGI:99414"
                     /translation="MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAA
                     AAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYIL
                     DLQLALETHPALLRQPPPPAPPLHPAGACPVAPPRTPLTALNTDPAGAVNKQGDSILC
                     R"
     exon            824..886
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /inference="alignment:Splign:2.1.0"
     exon            887..3963
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="hexamer: ATTAAA"
     polyA_site      1547
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="major polyA site"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="hexamer: ATTAAA"
     polyA_site      2448
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="major polyA site"
     regulatory      2727..2732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
     regulatory      3942..3947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="hexamer: AATAAA"
     polyA_site      3961
                     /gene="Id4"
                     /gene_synonym="bHLHb27; Idb4"
                     /note="major polyA site"
ORIGIN      
        1 gctgttgagc tgggaggcgc ggttggaagt cgttactttg agggggggca gtcaccgggc
       61 gatccacctt agtcgaagct cagaagggaa cggctcaggg accagggtgg gctacttttt
      121 ttattttccg gggcttttga tttttcttgt cttttgcttc gggccgattg tcgctcacaa
      181 aaaaagaaaa aaaacaaaaa aacaaaaacc tgagataccc tttccaaaac cccgagcagc
      241 tctccggtcg atttctggag ctcggagccg ccgggtgctg cgagcgccgg acgcgcagga
      301 gaggggagca aagcaaattg cgggcgggga cccggagctc gctctaccgc ttgtcgcggt
      361 cctctcgcgc aggaagcgcg cgatgaaggc ggtgagcccg gtgcgcccct cgggccgcaa
      421 ggcgccgtcg ggctgcggcg gcggggagct ggcgctacgc tgcctggcgg agcacggcca
      481 cagcctgggt ggctcggcag ccgccgccgc cgctgcggcg gccgcgcgct gcaaggcggc
      541 cgaggcggcg gccgatgagc cggcgctgtg cctgcagtgc gatatgaacg actgctacag
      601 tcgcctgcgg aggctcgtgc ctaccatccc gcccaacaag aaagtcagca aagtggagat
      661 cctgcagcac gttatcgact acatcctgga cctgcagctg gcgctggaga ctcaccctgc
      721 tttgctgaga cagccgccac cgcccgcgcc acctctccac ccggccgggg cttgtccggt
      781 cgcgccgccg cggaccccac tcaccgcgct caacactgac ccggccggcg ccgtgaacaa
      841 gcagggtgac agcattctct gccgctgagc tgcgatggat ggccaggtgt gcggccgcct
      901 gagcaccagc gagccaggag ccctaggaag ggagggccag agcagaaatt aagagaaaca
      961 agccaccgga ggaaaggggg ggaaatcttc agcaaatcta gaaacgtcgt ctcgtcttgt
     1021 cattccaaga gagagagaga gagagagaga gaaggggaaa aataaaactt aaattcactt
     1081 ttactttttt tgcacgttca cgagcattca ccgtacgtat tctctttcgt ttcttctttt
     1141 atgaccgctg tgaattgtac gtttctgtgg ttatttttat cacccttttg aaggtgcagt
     1201 taaacttcga agcttaagtg ttgtcgacca gactgctaag tagaagagca atcgtgaatc
     1261 caaccttaga ggctacattg tgacaaggga actgtttttg tttttgaagc tttactaata
     1321 taccagagca ctgtagatat gttgttttac atctattgtt taaaatagat gattataaca
     1381 gggcggggaa ctttttctct gcaagaatgt tacatattgt atagataagt gagtgacatt
     1441 tcataccctg tatatataga gatgttctat aagtgtgaga aagtatatgc gctttaatag
     1501 actactgtaa ttataagata tttttaatta aatatttttt gtaaatatta tgtgtctgtt
     1561 tttttaaaat cgatgggaat atttcttttg gaaaattatt tttcagctcc cttgcagagc
     1621 ttttgctatc tggatgtttt ctgtttggcc aggctgttga tttggttttt ttgttttgtt
     1681 ttgcccagta tccagtttct gaggctcaga ggtaacagct ctctggtact ggtcttgcat
     1741 gattgcatga ggtgttcaat cacaaaataa accagttacg agtcctttca aatgtgcttt
     1801 ctttaaccta gatggaaacc tttgtatttg acgtgtacat ggtaaaaacc taccttctcg
     1861 ggttttaagt acagggtttt atagtgtaat atataaagaa ttaagtgtgt ggggttttta
     1921 ttattattat tctttttgaa ctgaggtcaa aaatagattc tgagtgaatt cgcatatagg
     1981 atggagaaat gcttggacct ttaagaagtc tacagaactg ctgtcttttc aaagtgaaaa
     2041 tgctcgccct tcattttaca ctaaagcata atgtcatgaa gtttcatatc tgtacagatt
     2101 atttaaatca tagaaatgaa aaatgttctc tgcttgctac caaaggacaa actcttggaa
     2161 acggacattt tctgccctct tccctccaaa gaatattaat aggcatcagt aggagaaaaa
     2221 aaaaagaaaa aaaaaacata ctggaaaatc cttcaagcag ggataaaagt cgatcttcaa
     2281 atattaactt aagtagacca aaaattctga tgaccacatc tagattattt ttctataaaa
     2341 aaatgatttt cactatagcg atgtcagtca ccactaagct actgtccaat tccatgtgat
     2401 gtgtaacttt tacatgtgaa aattaaaagt agatttatct gtcttgtact gtgacttctg
     2461 atgtgatttc ttaacgctat aggattgact aaggaccctt cttcccttcc gggaaaaatc
     2521 atatattcta ggtgagctga gaactccagg gtttatgaac atcacacatt taatgtaatg
     2581 ggtattttac ataccagtta gatggaattt ttaagagtgg gagaattaag tgggatttaa
     2641 ttgggtgctt tgtaaatagt gaactgtgtg taaacgtgct ctgtttgatt tttaaaagga
     2701 aaaggatttg tttcagatta tacaagaata aaagtattat agacccaagg gactttttat
     2761 gaagtcaaag tcaaatattt atggggatct gaaatgtcac agttcctagc tgtcagctag
     2821 gggggataac tcaacgaaaa gggtcaaaat gagtgcgagg ttaaaaattc atggagggtt
     2881 tctataaaac ctgtgcgatt ctgtccacct cccaccccag ggcttgcccc tcatctcctt
     2941 ccctggtctc cagtctattt agaatttggt gttgaacctt ataaagtcaa agggccgctt
     3001 ttggatgagg tttgtgcttg gttgttttat attgctcata ctactcgtgc atcaggaaga
     3061 aagcactaga tcactgatgg aattccggat ctcaaggatt ctaaggactg cattctttgt
     3121 tattaaaaag ggcacttttt gccttttggc agtttaattt cagagggatt gtgtcacgtg
     3181 tgtgcccttc cctgggacta tgcgcttggc atgcctgact gctgaaccct acctaagctg
     3241 ttaggcagag tttaaaacgg cattgctaga ctctgaatct ttttaaaaag tttggatgtt
     3301 tctgctgtta gagatattgg catataaatt tatatctgag catacaaaaa ccactgaaag
     3361 aaatgtggag atcctgttgt ttgagagttg atactttttc cttggccctc tgaagcagca
     3421 gttgacatct ctaaagaaat acaaccactg ctgattaaat gacaagacaa caagtatcct
     3481 atgtagttgt agaagatgct actttctatg aggatattgc ctgtgtccta accaggcaac
     3541 cagataataa aaacatgtta agtcttttat ccagattgtt atacttatgc aaatatttag
     3601 cttaacaaaa gaaaatatcc tgacctggtt ttggtaattt gtagtttcat tgtataggca
     3661 aaaccaaaga ataaggttca tttaaaacct tggaaggaaa agaaatacac ccccccccca
     3721 cccccacaca cacaatggat gttatttcta aagttgttac aaaatcctgg catctcagac
     3781 atcttaggat aaaacagtat ataccctttg gtttgaaaga actgactttg gtattgtaca
     3841 attcctactc aagttcgttg tcaactttaa cggcattttt aaaactttaa aaaaacttaa
     3901 ttcatccttc cctaactgtt gtattagatg cctcctgtac taataaatca atcttcactg
     3961 aga
//
