LOCUS       NM_008321                964 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Mus musculus inhibitor of DNA binding 3 (Id3), mRNA.
ACCESSION   NM_008321
VERSION     NM_008321.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Deng,Z., Loyher,P.L., Lazarov,T., Li,L., Shen,Z., Bhinder,B.,
            Yang,H., Zhong,Y., Alberdi,A., Massague,J., Sun,J.C., Benezra,R.,
            Glass,C.K., Elemento,O., Iacobuzio-Donahue,C.A. and Geissmann,F.
  TITLE     The nuclear factor ID3 endows macrophages with a potent anti-tumour
            activity
  JOURNAL   Nature 626 (8000), 864-873 (2024)
   PUBMED   38326607
  REMARK    GeneRIF: The nuclear factor ID3 endows macrophages with a potent
            anti-tumour activity.
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Wang,Y., He,S., Calendo,G., Bui,T., Tian,Y., Lee,C.Y., Zhou,Y.,
            Zhao,X., Abraham,C., Mo,W., Chen,M., Sanders-Braggs,R., Madzo,J.,
            Issa,J.P., Hexner,E.O., Wiest,D.L., Reshef,R., Xue,H.H. and
            Zhang,Y.
  TITLE     Tissue-infiltrating alloreactive T cells require Id3 to deflect
            PD-1-mediated immune suppression during GVHD
  JOURNAL   Blood 143 (2), 166-177 (2024)
   PUBMED   37871574
  REMARK    GeneRIF: Tissue-infiltrating alloreactive T cells require Id3 to
            deflect PD-1-mediated immune suppression during GVHD.
REFERENCE   3  (bases 1 to 964)
  AUTHORS   Lu,D., Cai,H., Li,Y., Chang,W., Liu,X., Dai,Q., Yu,W., Chen,W.,
            Qiao,G., Xie,H., Xiao,X. and Li,Z.
  TITLE     Investigating the ID3/SLC22A4 as immune-related signatures in
            ischemic stroke
  JOURNAL   Aging (Albany NY) 15 (24), 14803-14829 (2023)
   PUBMED   38112574
  REMARK    GeneRIF: Investigating the ID3/SLC22A4 as immune-related signatures
            in ischemic stroke.
REFERENCE   4  (bases 1 to 964)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Liu,H., Lu,P., He,S., Luo,Y., Fang,Y., Benkaci,S., Wu,B., Wang,Y.
            and Zhou,B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 964)
  AUTHORS   Riechmann,V. and Sablitzky,F.
  TITLE     Mutually exclusive expression of two dominant-negative
            helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing
            brain of the mouse suggests distinct regulatory roles of these
            dnHLH proteins during cellular proliferation and differentiation of
            the nervous system
  JOURNAL   Cell Growth Differ 6 (7), 837-843 (1995)
   PUBMED   7547505
REFERENCE   7  (bases 1 to 964)
  AUTHORS   Ellmeier,W. and Weith,A.
  TITLE     Expression of the helix-loop-helix gene Id3 during murine embryonic
            development
  JOURNAL   Dev Dyn 203 (2), 163-173 (1995)
   PUBMED   7655079
REFERENCE   8  (bases 1 to 964)
  AUTHORS   Menezes,J.R. and Luskin,M.B.
  TITLE     Expression of neuron-specific tubulin defines a novel population in
            the proliferative layers of the developing telencephalon
  JOURNAL   J Neurosci 14 (9), 5399-5416 (1994)
   PUBMED   8083744
REFERENCE   9  (bases 1 to 964)
  AUTHORS   Ellmeier,W., Aguzzi,A., Kleiner,E., Kurzbauer,R. and Weith,A.
  TITLE     Mutually exclusive expression of a helix-loop-helix gene and N-myc
            in human neuroblastomas and in normal development
  JOURNAL   EMBO J 11 (7), 2563-2571 (1992)
   PUBMED   1628620
REFERENCE   10 (bases 1 to 964)
  AUTHORS   Christy,B.A., Sanders,L.K., Lau,L.F., Copeland,N.G., Jenkins,N.A.
            and Nathans,D.
  TITLE     An Id-related helix-loop-helix protein encoded by a growth
            factor-inducible gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1815-1819 (1991)
   PUBMED   2000388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC145873.1 and AI173823.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_008321.3.
            
            On Dec 13, 2007 this sequence version replaced NM_008321.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145871.1, AK002820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               BC145873.1         1-706
            707-964             AI173823.1         1-258               c
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     gene            1..964
                     /gene="Id3"
                     /gene_synonym="bHLHb25; Hlh462; Idb3"
                     /note="inhibitor of DNA binding 3"
                     /db_xref="GeneID:15903"
                     /db_xref="MGI:MGI:96398"
     exon            1..357
                     /gene="Id3"
                     /gene_synonym="bHLHb25; Hlh462; Idb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..417
                     /gene="Id3"
                     /gene_synonym="bHLHb25; Hlh462; Idb3"
                     /note="ID-like protein inhibitor HLH 462; inhibitor of
                     differentiation 3"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-3"
                     /protein_id="NP_032347.1"
                     /db_xref="CCDS:CCDS18800.1"
                     /db_xref="GeneID:15903"
                     /db_xref="MGI:MGI:96398"
                     /translation="MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSTEEPLSLLDDM
                     NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTA
                     ELTPELVISKDKRSFCH"
     exon            358..440
                     /gene="Id3"
                     /gene_synonym="bHLHb25; Hlh462; Idb3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..953
                     /gene="Id3"
                     /gene_synonym="bHLHb25; Hlh462; Idb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactgtttg ctgctttagg tgtctctttt cctccctctc tatctctact ctccaacatg
       61 aaggcgctga gcccggtgcg cggctgctac gaggcggtgt gctgcctgtc ggaacgtagc
      121 ctggccattg cgcgaggccg cggtaagagc ccgtcgaccg aggagcctct tagcctcttg
      181 gacgacatga accactgcta ctcgcgcctg cgggaactgg tgccgggagt cccgcgaggc
      241 actcagctta gccaggtgga aatcctgcag cgtgtcatag actacatcct cgaccttcag
      301 gtggtcctgg cagagccggc gcctggaccc ccggacggtc cgcatctccc gatccagaca
      361 gctgagctca ctccggaact tgtgatctcc aaggacaaga ggagcttttg ccactgaccc
      421 ggtcgtcctg gcacctcccg aacgcaggtg ctggcgcccg ttccgcttgg gaccctggga
      481 ctctgggacc ctctctccag ccggaagcct gagggcatgg atgagcttcg atcttaaccc
      541 agccctcttc acttaccctg aactcaacgc ctcgaggctg gacctggagc ccgagagaag
      601 gactgaactt gggtggcctg aagagctagc acacgctggt cagcagctgg gcaacgtcac
      661 tctgtcccca ccctgactca agtctaaaag actggctttt ccgagaatgg ggtgtcgaga
      721 gggtgtgggg ggatgcgagt ggctgccctg cgcactctgc caaggcagca taagagctgt
      781 tcttctggtt tccttggaga aaagctctgc tgccctgatt atgaactcta taatagagta
      841 tatagctttt gtaccttttt tacaggaagg tgactttctg taatcatgtg atgtatatta
      901 aactttttat aaaagttaac attttgcata ataaaccatt tttgaacact ttgaaaaaaa
      961 aaaa
//
