LOCUS       NM_010496               1289 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus inhibitor of DNA binding 2 (Id2), mRNA.
ACCESSION   NM_010496
VERSION     NM_010496.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Ren,G., Zhang,Y., Liu,J., Cheng,W., Wu,D., Han,M., Zeng,Y.,
            Zhao,X., Hu,L., Zeng,M., Gurram,R.K., Hu,X., Zhou,B., Hou,Z.,
            Zhu,J., Jin,W. and Zhong,C.
  TITLE     Decreased GATA3 levels cause changed mouse cutaneous innate
            lymphoid cell fate, facilitating hair follicle recycling
  JOURNAL   Dev Cell 59 (14), 1809-1823 (2024)
   PUBMED   38723629
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Van Der Byl,W., Nussing,S., Peters,T.J., Ahn,A., Li,H.,
            Ledergor,G., David,E., Koh,A.S., Wagle,M.V., Deguit,C.D.T., de
            Menezes,M.N., Travers,A., Sampurno,S., Ramsbottom,K.M., Li,R.,
            Kallies,A., Beavis,P.A., Jungmann,R., Bastings,M.M.C., Belz,G.T.,
            Goel,S., Trapani,J.A., Crabtree,G.R., Chang,H.Y., Amit,I.,
            Goodnow,C.C., Luciani,F. and Parish,I.A.
  TITLE     The CD8+ T cell tolerance checkpoint triggers a distinct
            differentiation state defined by protein translation defects
  JOURNAL   Immunity 57 (6), 1324-1344 (2024)
   PUBMED   38776918
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Sun,J., Zhang,Y., Zhang,Q., Hu,L., Zhao,L., Wang,H., Yuan,Y.,
            Niu,H., Wang,D., Zhang,H., Liu,J., Feng,X., Su,X., Qiu,J., Sun,J.,
            Xu,H., Zhang,C., Wang,K., Bi,Y., Engleman,E.G. and Shen,L.
  TITLE     Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1
            expression and mitochondrial homeostasis to prevent insulin
            resistance
  JOURNAL   Immunity 57 (6), 1289-1305 (2024)
   PUBMED   38772366
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Niu,H., Zhang,H., Wang,D., Zhao,L., Zhang,Y., Zhou,W., Zhang,J.,
            Su,X., Sun,J., Su,B., Qiu,J. and Shen,L.
  TITLE     LKB1 prevents ILC2 exhaustion to enhance antitumor immunity
  JOURNAL   Cell Rep 43 (5), 113579 (2024)
   PUBMED   38670109
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Bulfone,A., Smiga,S.M., Shimamura,K., Peterson,A., Puelles,L. and
            Rubenstein,J.L.
  TITLE     T-brain-1: a homolog of Brachyury whose expression defines
            molecularly distinct domains within the cerebral cortex
  JOURNAL   Neuron 15 (1), 63-78 (1995)
   PUBMED   7619531
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Zhu,W., Dahmen,J., Bulfone,A., Rigolet,M., Hernandez,M.C.,
            Kuo,W.L., Puelles,L., Rubenstein,J.L. and Israel,M.A.
  TITLE     Id gene expression during development and molecular cloning of the
            human Id-1 gene
  JOURNAL   Brain Res Mol Brain Res 30 (2), 312-326 (1995)
   PUBMED   7637581
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   Riechmann,V., van Cruchten,I. and Sablitzky,F.
  TITLE     The expression pattern of Id4, a novel dominant negative
            helix-loop-helix protein, is distinct from Id1, Id2 and Id3
  JOURNAL   Nucleic Acids Res 22 (5), 749-755 (1994)
   PUBMED   8139914
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Ceci,J.D., Matsuda,Y., Grubber,J.M., Jenkins,N.A., Copeland,N.G.
            and Chapman,V.M.
  TITLE     Interspecific backcrosses provide an important new tool for
            centromere mapping of mouse chromosomes
  JOURNAL   Genomics 19 (3), 515-524 (1994)
   PUBMED   8188294
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Sun,X.H., Copeland,N.G., Jenkins,N.A. and Baltimore,D.
  TITLE     Id proteins Id1 and Id2 selectively inhibit DNA binding by one
            class of helix-loop-helix proteins
  JOURNAL   Mol Cell Biol 11 (11), 5603-5611 (1991)
   PUBMED   1922066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135547.1 and BQ044638.1.
            
            [WARNING] On Feb 10, 2025 this sequence was replaced by
            NM_010496.4.
            
            On Dec 11, 2007 this sequence version replaced NM_010496.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M69293.1, AK146606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1133              AK135547.1         3-1135
            1134-1289           BQ044638.1         392-547
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.57 cM"
     gene            1..1289
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /note="inhibitor of DNA binding 2"
                     /db_xref="GeneID:15902"
                     /db_xref="MGI:MGI:96397"
     exon            1..430
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..487
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /note="inhibitor of differentiation 2"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-2"
                     /protein_id="NP_034626.1"
                     /db_xref="CCDS:CCDS25846.1"
                     /db_xref="GeneID:15902"
                     /db_xref="MGI:MGI:96397"
                     /translation="MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYS
                     KLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTP
                     LTTLNTDISILSLQASEFPSELMSNDSKVLCG"
     exon            431..494
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1272
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1251..1256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /note="hexamer: AATAAA"
     polyA_site      1272
                     /gene="Id2"
                     /gene_synonym="bHLHb26; Idb2"
                     /note="major polyA site"
ORIGIN      
        1 tcattctgaa ccgagcctgg tgccgcgcag tcagctcagc cccctgtggc ggctccctcc
       61 cggtcttcct cctacgagca gcatgaaagc cttcagtccg gtgaggtccg ttaggaaaaa
      121 cagcctgtcg gaccacagct tgggcatctc ccggagcaaa accccggtgg acgacccgat
      181 gagtctgctc tacaacatga acgactgcta ctccaagctc aaggaactgg tgcccagcat
      241 cccccagaac aagaaggtga ccaagatgga aatcctgcag cacgtcatcg attacatctt
      301 ggacctgcag atcgccctgg actcgcatcc cactatcgtc agcctgcatc accagagacc
      361 tggacagaac caggcgtcca ggacgccgct gaccaccctg aacacggaca tcagcatcct
      421 gtccttgcag gcatctgaat tcccttctga gcttatgtcg aatgatagca aagtactctg
      481 tggctaaata aatggcattt ggggactttt ttttttcttt ttactttctc tttttctttt
      541 gcacaagaag aagtctacaa gatcttttaa gacttttgtt atcagccatt tcaccaggag
      601 aacacgttga atggaccttt ttaaaaagaa agcggaagga aaactaagga tgatcgtctt
      661 gcccaggtgt cgttctccgg cctggactgt gataccgtta tttatgagag actttcagtg
      721 ccctttctac agttggaagg ttttctttat atactattcc caccatgggg agcgaaaacg
      781 ttaaaaaaaa aagaaaaaaa tcacaaggaa ttgcccaatg taagcagact ttgccttttc
      841 acaaaggtgg agcgtgaata ccagaaggac ccagtattcg gttacttaaa tgaagtcttc
      901 ggtcagaaat ggcctttttg acacgagcct actgaatgct gtgtatatat ttatatataa
      961 atatatatat attgagtgaa ccttgtggac tctttaatta gagttttctt gtatagtggc
     1021 agaaataacc tatttctgca ttaaaatgta atgacgtact tatgctaaac tttttataaa
     1081 agtttagttg taaacttaac ccttttatac aaaataaatc aagtgtgttt attgaatgtt
     1141 gattgcttgc tttatttcag acaaccagtg ctttgatttt ttttatgcta tgttataact
     1201 gaacccaaat aaataccagt tcaaatttat gtagactgta ttaagattat aataaaatgt
     1261 gtctgacatc aaaaaaaaaa aaaaaaaaa
//
