LOCUS       NM_010495                934 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus inhibitor of DNA binding 1, HLH protein (Id1),
            transcript variant 2, mRNA.
ACCESSION   NM_010495
VERSION     NM_010495.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 934)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Yao,Y., Kim,I.M.,
            Zhou,J., Li,J. and Su,H.
  TITLE     Inhibition of cardiomyocyte neddylation impairs embryonic cardiac
            morphogenesis
  JOURNAL   J Mol Cell Cardiol 197, 40-44 (2024)
   PUBMED   39437885
REFERENCE   3  (bases 1 to 934)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   4  (bases 1 to 934)
  AUTHORS   Liu,C., Zeng,X., Xiong,Z., Bahabayi,A., Hasimu,A., Liu,T.,
            Zheng,M., Ren,L., Alimu,X. and Lu,S.
  TITLE     Id1 expression in CD4 T cells promotes differentiation and function
            of follicular helper T cells and upregulation of related functional
            molecules
  JOURNAL   Immunology 172 (3), 408-419 (2024)
   PUBMED   38501859
  REMARK    GeneRIF: Id1 expression in CD4 T cells promotes differentiation and
            function of follicular helper T cells and upregulation of related
            functional molecules.
REFERENCE   5  (bases 1 to 934)
  AUTHORS   Liang,X.G., Hoang,K., Meyerink,B.L., Kc,P., Paraiso,K., Wang,L.,
            Jones,I.R., Zhang,Y., Katzman,S., Finn,T.S., Tsyporin,J., Qu,F.,
            Chen,Z., Visel,A., Kriegstein,A., Shen,Y., Pilaz,L.J. and Chen,B.
  TITLE     A conserved molecular logic for neurogenesis to gliogenesis switch
            in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 121 (20), e2321711121 (2024)
   PUBMED   38713624
REFERENCE   6  (bases 1 to 934)
  AUTHORS   Duncan,M., DiCicco-Bloom,E.M., Xiang,X., Benezra,R. and Chada,K.
  TITLE     The gene for the helix-loop-helix protein, Id, is specifically
            expressed in neural precursors
  JOURNAL   Dev Biol 154 (1), 1-10 (1992)
   PUBMED   1426618
REFERENCE   7  (bases 1 to 934)
  AUTHORS   Jen,Y., Weintraub,H. and Benezra,R.
  TITLE     Overexpression of Id protein inhibits the muscle differentiation
            program: in vivo association of Id with E2A proteins
  JOURNAL   Genes Dev 6 (8), 1466-1479 (1992)
   PUBMED   1644289
REFERENCE   8  (bases 1 to 934)
  AUTHORS   Wang,Y., Benezra,R. and Sassoon,D.A.
  TITLE     Id expression during mouse development: a role in morphogenesis
  JOURNAL   Dev Dyn 194 (3), 222-230 (1992)
   PUBMED   1361374
REFERENCE   9  (bases 1 to 934)
  AUTHORS   Sun,X.H., Copeland,N.G., Jenkins,N.A. and Baltimore,D.
  TITLE     Id proteins Id1 and Id2 selectively inhibit DNA binding by one
            class of helix-loop-helix proteins
  JOURNAL   Mol Cell Biol 11 (11), 5603-5611 (1991)
   PUBMED   1922066
REFERENCE   10 (bases 1 to 934)
  AUTHORS   Benezra,R., Davis,R.L., Lockshon,D., Turner,D.L. and Weintraub,H.
  TITLE     The protein Id: a negative regulator of helix-loop-helix DNA
            binding proteins
  JOURNAL   Cell 61 (1), 49-59 (1990)
   PUBMED   2156629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731857.9.
            
            On Aug 13, 2013 this sequence version replaced NM_010495.2.
            
            Transcript Variant: This variant (2) uses a splice site in the 3'
            region, compared to variant 3. This results in a shorter protein
            (isoform 2), compared to isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025073.1, AI323524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               AL731857.9         127584-128078       c
            496-934             AL731857.9         126919-127357       c
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..934
                     /gene="Id1"
                     /gene_synonym="bHLHb24; D2Wsu140e; Idb1"
                     /note="inhibitor of DNA binding 1, HLH protein"
                     /db_xref="GeneID:15901"
                     /db_xref="MGI:MGI:96396"
     exon            1..495
                     /gene="Id1"
                     /gene_synonym="bHLHb24; D2Wsu140e; Idb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..537
                     /gene="Id1"
                     /gene_synonym="bHLHb24; D2Wsu140e; Idb1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DNA-binding protein inhibitor ID-1; inhibitor of
                     differentiation 1"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-1 isoform 2"
                     /protein_id="NP_034625.1"
                     /db_xref="CCDS:CCDS16897.1"
                     /db_xref="GeneID:15901"
                     /db_xref="MGI:MGI:96396"
                     /translation="MKVASGSAAAAAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGT
                     RLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL
                     NSESEVGTTGGRGLPVRAPLSTLNGEISALAAEAACVPADDRILCR"
     exon            496..934
                     /gene="Id1"
                     /gene_synonym="bHLHb24; D2Wsu140e; Idb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      917..922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Id1"
                     /gene_synonym="bHLHb24; D2Wsu140e; Idb1"
                     /note="hexamer: AACAAA"
     polyA_site      934
                     /gene="Id1"
                     /gene_synonym="bHLHb24; D2Wsu140e; Idb1"
                     /note="major polyA site"
ORIGIN      
        1 tctcattgta caacctttct tcaacttctt gttctcttcc cacactctgt tctcagcctc
       61 ctccgctccc ctccgcctgt tctcaggatc atgaaggtcg ccagtggcag tgccgcagcc
      121 gctgcaggcc ctagctgttc gctgaaggcg ggcaggacag cgggcgaggt ggtacttggt
      181 ctgtcggagc aaagcgtggc catctcgcgc tgcgctggga cgcgcctgcc cgccttgctg
      241 gacgagcagc aggtgaacgt cctgctctac gacatgaacg gctgctactc acgcctcaag
      301 gagctggtgc ccaccctgcc ccagaaccgc aaagtgagca aggtggagat cctgcagcat
      361 gtaatcgact acatcaggga cctgcagctg gagctgaact cggagtctga agtcgggacc
      421 accggaggcc ggggactgcc tgtccgcgcc ccgctcagca ccctgaacgg cgagatcagt
      481 gccttggcgg ccgaggcggc atgtgttcca gccgacgatc gcatcttgtg tcgctgaggc
      541 ggcgcactga gggaccagat ggactccagc ccttcaggag gcaagaggaa aaaagtgctc
      601 tcggttcccc aggggatctc tgggaaagac actaccgcag ccaccggact cttggcggat
      661 cggtccagtg ggtagagggt ttgatcaaca gagcctcacc ctctccacct ttcagcctcc
      721 agagactttg gggagggggt taatcaaccc cgcgtgtttc tgttttattg aaaaagcaga
      781 catttttttt taaatggtca catttcgtgc ttctcggatt tctgaggaaa tattttgtat
      841 tgtatattac aatgatcact ggctgaaaat attgttttac aatagttcta tgggggtgag
      901 ttttttgttg ttattaaaca aacactttag ataa
//
