LOCUS       NM_015790               2748 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus icos ligand (Icosl), mRNA.
ACCESSION   NM_015790
VERSION     NM_015790.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2748)
  AUTHORS   Huang,P., Xu,J., Jiang,S., Zhang,Y., Wang,X., Xiong,C. and Xia,C.
  TITLE     The impact of ICOSL/ICOS pathway-regulated long non-coding RNAs on
            liver fibrosis in mice infected with Schistosoma japonicum
  JOURNAL   Parasit Vectors 17 (1), 317 (2024)
   PUBMED   39044218
  REMARK    GeneRIF: The impact of ICOSL/ICOS pathway-regulated long non-coding
            RNAs on liver fibrosis in mice infected with Schistosoma japonicum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2748)
  AUTHORS   Tili,E., Otsu,H., Commisso,T.L., Palamarchuk,A., Balatti,V.,
            Michaille,J.J., Nuovo,G.J. and Croce,C.M.
  TITLE     MiR-155-targeted IcosL controls tumor rejection
  JOURNAL   Proc Natl Acad Sci U S A 121 (29), e2408649121 (2024)
   PUBMED   38980909
  REMARK    GeneRIF: MiR-155-targeted IcosL controls tumor rejection.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Sep 17;121(38):e2416854121.
            doi: 10.1073/pnas.2416854121.. PMID: 39250674]
REFERENCE   3  (bases 1 to 2748)
  AUTHORS   Johann,L., Soldati,S., Muller,K., Lampe,J., Marini,F., Klein,M.,
            Schramm,E., Ries,N., Schelmbauer,C., Palagi,I., Karram,K.,
            Assmann,J.C., Khan,M.A., Wenzel,J., Schmidt,M.H., Korbelin,J.,
            Schluter,D., van Loo,G., Bopp,T., Engelhardt,B., Schwaninger,M. and
            Waisman,A.
  TITLE     A20 regulates lymphocyte adhesion in murine neuroinflammation by
            restricting endothelial ICOSL expression in the CNS
  JOURNAL   J Clin Invest 133 (24), e168314 (2023)
   PUBMED   37856217
  REMARK    GeneRIF: A20 regulates lymphocyte adhesion in murine
            neuroinflammation by restricting endothelial ICOSL expression in
            the CNS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2748)
  AUTHORS   Provera,A., Ramavath,N.N., Gadipudi,L.L., Gigliotti,C.L.,
            Boggio,E., Vecchio,C., Stoppa,I., Rolla,R., Boldorini,R.,
            Pirisi,M., Smirne,C., Albano,E., Dianzani,U. and Sutti,S.
  TITLE     Role of the co-stimulatory molecule inducible T-cell co-stimulator
            ligand (ICOSL) in the progression of experimental metabolic
            dysfunction-associated steatohepatitis
  JOURNAL   Front Immunol 14, 1290391 (2023)
   PUBMED   38077334
  REMARK    GeneRIF: Role of the co-stimulatory molecule inducible T-cell
            co-stimulator ligand (ICOSL) in the progression of experimental
            metabolic dysfunction-associated steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2748)
  AUTHORS   Alves,G.F., Stoppa,I., Aimaretti,E., Monge,C., Mastrocola,R.,
            Porchietto,E., Einaudi,G., Collotta,D., Bertocchi,I., Boggio,E.,
            Gigliotti,C.L., Clemente,N., Aragno,M., Fernandes,D., Cifani,C.,
            Thiemermann,C., Dianzani,C., Dianzani,U. and Collino,M.
  TITLE     ICOS-Fc as innovative immunomodulatory approach to counteract
            inflammation and organ injury in sepsis
  JOURNAL   Front Immunol 13, 992614 (2022)
   PUBMED   36119089
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2748)
  AUTHORS   Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T.,
            Nishimura,H., Fitz,L.J., Malenkovich,N., Okazaki,T., Byrne,M.C.,
            Horton,H.F., Fouser,L., Carter,L., Ling,V., Bowman,M.R.,
            Carreno,B.M., Collins,M., Wood,C.R. and Honjo,T.
  TITLE     Engagement of the PD-1 immunoinhibitory receptor by a novel B7
            family member leads to negative regulation of lymphocyte activation
  JOURNAL   J Exp Med 192 (7), 1027-1034 (2000)
   PUBMED   11015443
REFERENCE   7  (bases 1 to 2748)
  AUTHORS   Mages,H.W., Hutloff,A., Heuck,C., Buchner,K., Himmelbauer,H.,
            Oliveri,F. and Kroczek,R.A.
  TITLE     Molecular cloning and characterization of murine ICOS and
            identification of B7h as ICOS ligand
  JOURNAL   Eur J Immunol 30 (4), 1040-1047 (2000)
   PUBMED   10760791
REFERENCE   8  (bases 1 to 2748)
  AUTHORS   Ling,V., Wu,P.W., Finnerty,H.F., Bean,K.M., Spaulding,V.,
            Fouser,L.A., Leonard,J.P., Hunter,S.E., Zollner,R., Thomas,J.L.,
            Miyashiro,J.S., Jacobs,K.A. and Collins,M.
  TITLE     Cutting edge: identification of GL50, a novel B7-like protein that
            functionally binds to ICOS receptor
  JOURNAL   J Immunol 164 (4), 1653-1657 (2000)
   PUBMED   10657606
REFERENCE   9  (bases 1 to 2748)
  AUTHORS   Yoshinaga,S.K., Whoriskey,J.S., Khare,S.D., Sarmiento,U., Guo,J.,
            Horan,T., Shih,G., Zhang,M., Coccia,M.A., Kohno,T.,
            Tafuri-Bladt,A., Brankow,D., Campbell,P., Chang,D., Chiu,L.,
            Dai,T., Duncan,G., Elliott,G.S., Hui,A., McCabe,S.M., Scully,S.,
            Shahinian,A., Shaklee,C.L., Van,G., Mak,T.W. and Senaldi,G.
  TITLE     T-cell co-stimulation through B7RP-1 and ICOS
  JOURNAL   Nature 402 (6763), 827-832 (1999)
   PUBMED   10617205
REFERENCE   10 (bases 1 to 2748)
  AUTHORS   Swallow,M.M., Wallin,J.J. and Sha,W.C.
  TITLE     B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by
            TNFalpha
  JOURNAL   Immunity 11 (4), 423-432 (1999)
   PUBMED   10549624
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153507.11.
            
            On Nov 17, 2006 this sequence version replaced NM_015790.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029227.1, AF199027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC153507.11        59391-59558         c
            169-287             AC153507.11        57647-57765         c
            288-641             AC153507.11        56835-57188         c
            642-935             AC153507.11        54926-55219         c
            936-1085            AC153507.11        53572-53721         c
            1086-1115           AC153507.11        51753-51782         c
            1116-2748           AC153507.11        49401-51033         c
FEATURES             Location/Qualifiers
     source          1..2748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2748
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /note="icos ligand"
                     /db_xref="GeneID:50723"
                     /db_xref="MGI:MGI:1354701"
     exon            1..168
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1126
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /note="B7 homolog 2; B7-like protein Gl50; B7-related
                     protein 1"
                     /codon_start=1
                     /product="ICOS ligand precursor"
                     /protein_id="NP_056605.1"
                     /db_xref="CCDS:CCDS35956.1"
                     /db_xref="GeneID:50723"
                     /db_xref="MGI:MGI:1354701"
                     /translation="MQLKCPCFVSLGTRQPVWKKLHVSSGFFSGLGLFLLLLSSLCAA
                     SAETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVD
                     SSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRV
                     AANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYL
                     NKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTGNNTKNPQETHNN
                     ELKVLVPVLAVLAAAAFVSFIIYRRTRPHRSYTGPKTVQLELTDHA"
     exon            169..287
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     exon            288..641
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     exon            642..935
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1085
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1115
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..2748
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2727..2732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="Icosl"
                     /gene_synonym="B7-H2; B7h; B7RP-1; GI50; GL50; GL50-B;
                     ICOS-L; Icoslg; LICOS; Ly115l; mKIAA0653"
                     /note="major polyA site"
ORIGIN      
        1 agcgggtctc ctgccgccaa agcctcaaga accccagatt tcagcgcccc aagcctggaa
       61 gctccccagt tcttcgtggc ccccaacagc tccggaaccc cagccgctgc aactctccgc
      121 gtccgaaatc cagcaccccg cagtctgcgc tcgcaccatg cagctaaagt gtccctgttt
      181 tgtgtccttg ggaaccaggc agcctgtttg gaagaagctc catgtttcta gcgggttctt
      241 ttctggtctt ggtctgttct tgctgctgtt gagcagcctc tgtgctgcct ctgcagagac
      301 tgaagtcggt gcaatggtgg gcagcaatgt ggtgctcagc tgcattgacc cccacagacg
      361 ccatttcaac ttgagtggtc tgtatgtcta ttggcaaatc gaaaacccag aagtttcggt
      421 gacttactac ctgccttaca agtctccagg gatcaatgtg gacagttcct acaagaacag
      481 gggccatctg tccctggact ccatgaagca gggtaacttc tctctgtacc tgaagaatgt
      541 cacccctcag gatacccagg agttcacatg ccgggtattt atgaatacag ccacagagtt
      601 agtcaagatc ttggaagagg tggtcaggct gcgtgtggca gcaaacttca gtacacctgt
      661 catcagcacc tctgatagct ccaacccggg ccaggaacgt acctacacct gcatgtccaa
      721 gaatggctac ccagagccca acctgtattg gatcaacaca acggacaata gcctaataga
      781 cacggctctg cagaataaca ctgtctactt gaacaagttg ggcctgtatg atgtaatcag
      841 cacattaagg ctcccttgga catctcgtgg ggatgttctg tgctgcgtag agaatgtggc
      901 tctccaccag aacatcacta gcattagcca ggcagaaagt ttcactggaa ataacacaaa
      961 gaacccacag gaaacccaca ataatgagtt aaaagtcctt gtccccgtcc ttgctgtact
     1021 ggcggcagcg gcattcgttt ccttcatcat atacagacgc acgcgtcccc accgaagcta
     1081 tacaggaccc aagactgtac agcttgaact tacagaccac gcctgacagg actctgccca
     1141 ggatatggac agggtttctg tgagttgcca ccaggtggat gtcagacaca acttcagagt
     1201 ggacccccac aggcctggtg acagaggaca acgagctgtc tgcttatggg ctgtgatgga
     1261 ggccaggaat ccctggcttt acgaggcaca gagacttcat cccagaaacc ccgagggaga
     1321 tctctccagt gggcagcagc aacatcatcg gaatatggag cctccggtga gctgtcggca
     1381 cagagagcag cagcttgtga gaagatcctt ccttggcacg ttactactca ggcctaggag
     1441 ctttataaaa gagcgtttga gccactctga aagccctaca gagtctactg gagactttcc
     1501 ctgcaggacc ttcagttggg gaggaagcct gactttattt aggtctcagg ctacttgggc
     1561 ctcttcgagg atatgtggga ttttgtctac tgcaaacctg tttctggctg acaatggttg
     1621 ggctcagagg cactcagctt cacaacatca atgggacacg cctcatcctt gacttcctgt
     1681 ggctacagaa gctttccgaa agccttgagc tctttcagac tgaacagctc tgcccagtct
     1741 cagcagccca tgaagatctc aactccagct tcctgggtct ccgtgttgct ggccagaata
     1801 gagctagctc ttttgtttca agatggttct gcaaagttgg ctgcttggaa acctagggat
     1861 gtatgtacaa gctccaggct gatgcagtag ggggcacgga ctccccgatg gaacacagta
     1921 tctgacccta ggtgagggca agctccttcc cacgcagagg actggaaatt ctggaccgtc
     1981 aaggcctgtc tgctatgtgg ctggggctca gtgctgatgg atgtgtgaga tctcaggaat
     2041 gaggagtgag aaccctgggc tcaggactag gaagacctgt ccattttttt ttttttttaa
     2101 tgcccacatg gactttttat tcttcacacc gatgtattca atgagtgtag agagaactac
     2161 ttaagtcctt cccgagtaca aagcattacc tacctgcaga atagcaactg ttgttatggg
     2221 tcttgagttg gcagctacag caaacaagca caaggagcag ttggggtgca agaagatggg
     2281 gtgcagcgcc cccaaggaca gacatttggg aattagtggt ctccctgatg cccatagttc
     2341 cccaggaact caggtgggtc tgcggcagca cagtaggagt attcctccta ctttaacttt
     2401 tcttgtcaga cgtagtttag gttcagaaag aggtcaactc agcaagccag ctagccgcct
     2461 tggggcacca gacacactgc cccccacccc ctgcttatgt aggcattggg aacccttcac
     2521 agaccactgg ctgtacagtc accatcacct gctgattcca gcaggccccc accttcttgt
     2581 ggaatcctgg gagcactccc ctcttacccc tcactgcccc ccaccccctg cacatcagca
     2641 ttcattagat ttgccctgta acgtctgatt cctcctttat ctgggttgta gatggggcat
     2701 agtgacttct agaaacctaa caagggaata aatgtaagat gtgctttc
//
