LOCUS       NM_017480               3272 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus inducible T cell co-stimulator (Icos), mRNA.
ACCESSION   NM_017480 XM_001479117
VERSION     NM_017480.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3272)
  AUTHORS   Verma,S., Dufort,M.J., Olsen,T.M., Kimmel,S., Labuda,J.C.,
            Scharffenberger,S., McGuire,A.T. and Harrison,O.J.
  TITLE     Antigen-level resolution of commensal-specific B cell responses can
            be enabled by phage display screening coupled with B cell tetramers
  JOURNAL   Immunity 57 (6), 1428-1441 (2024)
   PUBMED   38723638
REFERENCE   2  (bases 1 to 3272)
  AUTHORS   Geels,S.N., Moshensky,A., Sousa,R.S., Murat,C., Bustos,M.A.,
            Walker,B.L., Singh,R., Harbour,S.N., Gutierrez,G., Hwang,M.,
            Mempel,T.R., Weaver,C.T., Nie,Q., Hoon,D.S.B., Ganesan,A.K.,
            Othy,S. and Marangoni,F.
  TITLE     Interruption of the intratumor CD8+ T cell:Treg crosstalk improves
            the efficacy of PD-1 immunotherapy
  JOURNAL   Cancer Cell 42 (6), 1051-1066 (2024)
   PUBMED   38861924
REFERENCE   3  (bases 1 to 3272)
  AUTHORS   Cao,Q., Wang,R., Niu,Z., Chen,T., Azmi,F., Read,S.A., Chen,J.,
            Lee,V.W.S., Zhou,C., Julovi,S., Huang,Q., Wang,Y.M., Starkey,M.R.,
            Zheng,G., Alexander,S.I., George,J., Wang,Y. and Harris,D.C.H.
  TITLE     Type 2 innate lymphoid cells are protective against hepatic
            ischaemia/reperfusion injury
  JOURNAL   JHEP Rep 5 (10), 100837 (2023)
   PUBMED   37691688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3272)
  AUTHORS   Cruz-Morales,E., Hart,A.P., Fossett,G.M. and Laufer,T.M.
  TITLE     Helios+ and RORgammat+ Treg populations are differentially
            regulated by MHCII, CD28, and ICOS to shape the intestinal Treg
            pool
  JOURNAL   Mucosal Immunol 16 (3), 264-274 (2023)
   PUBMED   36935092
  REMARK    GeneRIF: Helios[+] and RORgammat[+] Treg populations are
            differentially regulated by MHCII, CD28, and ICOS to shape the
            intestinal Treg pool.
REFERENCE   5  (bases 1 to 3272)
  AUTHORS   Panneton,V., Mindt,B.C., Bouklouch,Y., Bouchard,A., Mohammaei,S.,
            Chang,J., Diamantopoulos,N., Witalis,M., Li,J., Stancescu,A.,
            Bradley,J.E., Randall,T.D., Fritz,J.H. and Suh,W.K.
  TITLE     ICOS costimulation is indispensable for the differentiation of T
            follicular regulatory cells
  JOURNAL   Life Sci Alliance 6 (4), e202201615 (2023)
   PUBMED   36754569
  REMARK    GeneRIF: ICOS costimulation is indispensable for the
            differentiation of T follicular regulatory cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3272)
  AUTHORS   Tezuka,K., Tsuji,T., Hirano,D., Tamatani,T., Sakamaki,K.,
            Kobayashi,Y. and Kamada,M.
  TITLE     Identification and characterization of rat AILIM/ICOS, a novel
            T-cell costimulatory molecule, related to the CD28/CTLA4 family
  JOURNAL   Biochem Biophys Res Commun 276 (1), 335-345 (2000)
   PUBMED   11006126
REFERENCE   7  (bases 1 to 3272)
  AUTHORS   Kopf,M., Coyle,A.J., Schmitz,N., Barner,M., Oxenius,A.,
            Gallimore,A., Gutierrez-Ramos,J.C. and Bachmann,M.F.
  TITLE     Inducible costimulator protein (ICOS) controls T helper cell subset
            polarization after virus and parasite infection
  JOURNAL   J Exp Med 192 (1), 53-61 (2000)
   PUBMED   10880526
REFERENCE   8  (bases 1 to 3272)
  AUTHORS   Mages,H.W., Hutloff,A., Heuck,C., Buchner,K., Himmelbauer,H.,
            Oliveri,F. and Kroczek,R.A.
  TITLE     Molecular cloning and characterization of murine ICOS and
            identification of B7h as ICOS ligand
  JOURNAL   Eur J Immunol 30 (4), 1040-1047 (2000)
   PUBMED   10760791
REFERENCE   9  (bases 1 to 3272)
  AUTHORS   Ling,V., Wu,P.W., Finnerty,H.F., Bean,K.M., Spaulding,V.,
            Fouser,L.A., Leonard,J.P., Hunter,S.E., Zollner,R., Thomas,J.L.,
            Miyashiro,J.S., Jacobs,K.A. and Collins,M.
  TITLE     Cutting edge: identification of GL50, a novel B7-like protein that
            functionally binds to ICOS receptor
  JOURNAL   J Immunol 164 (4), 1653-1657 (2000)
   PUBMED   10657606
REFERENCE   10 (bases 1 to 3272)
  AUTHORS   Yoshinaga,S.K., Whoriskey,J.S., Khare,S.D., Sarmiento,U., Guo,J.,
            Horan,T., Shih,G., Zhang,M., Coccia,M.A., Kohno,T.,
            Tafuri-Bladt,A., Brankow,D., Campbell,P., Chang,D., Chiu,L.,
            Dai,T., Duncan,G., Elliott,G.S., Hui,A., McCabe,S.M., Scully,S.,
            Shahinian,A., Shaklee,C.L., Van,G., Mak,T.W. and Senaldi,G.
  TITLE     T-cell co-stimulation through B7RP-1 and ICOS
  JOURNAL   Nature 402 (6763), 827-832 (1999)
   PUBMED   10617205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850356.1, BC034852.1, AK030827.1 and AI451625.1.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_017480.3.
            
            On or before Nov 17, 2010 this sequence version replaced
            XM_001479117.2, NM_017480.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030827.1, AJ250559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BB850356.1         2-14
            14-1005             BC034852.1         1-992
            1006-3248           AK030827.1         999-3241
            3249-3272           AI451625.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..3272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.6 cM"
     gene            1..3272
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /note="inducible T cell co-stimulator"
                     /db_xref="GeneID:54167"
                     /db_xref="MGI:MGI:1858745"
     exon            1..103
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..648
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /note="inducible T-cell costimulator; CD28-related protein
                     1; CD28 and CTLA-4-like protein; activation-inducible
                     lymphocyte immunomediatory molecule"
                     /codon_start=1
                     /product="inducible T-cell costimulator precursor"
                     /protein_id="NP_059508.2"
                     /db_xref="CCDS:CCDS14994.1"
                     /db_xref="GeneID:54167"
                     /db_xref="MGI:MGI:1858745"
                     /translation="MKPYFCRVFVFCFLIRLLTGEINGSADHRMFSFHNGGVQISCKY
                     PETVQQLKMRLFREREVLCELTKTKGSGNAVSIKNPMLCLYHLSNNSVSFFLNNPDSS
                     QGSYYFCSLSIFDPPPFQERNLSGGYLHIYESQLCCQLKLWLPVGCAAFVVVLLFGCI
                     LIIWFSKKKYGSSVHDPNSEYMFMAAVNTNKKSRLAGVTS"
     exon            104..442
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /inference="alignment:Splign:2.1.0"
     exon            443..549
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /inference="alignment:Splign:2.1.0"
     exon            550..634
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /inference="alignment:Splign:2.1.0"
     exon            635..3254
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /note="hexamer: AGTAAA"
     polyA_site      1512
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /note="major polyA site"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /note="hexamer: AATAAA"
     polyA_site      3233
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
     polyA_site      3254
                     /gene="Icos"
                     /gene_synonym="AILIM; CCLP; CRP-1; H4; Ly115"
                     /note="major polyA site"
ORIGIN      
        1 acttttgagc actggaggag aagactgcaa ctgctcctgg cagacatgaa gccgtacttc
       61 tgccgtgtct ttgtcttctg cttcctaatc agacttttaa caggagaaat caatggctcg
      121 gccgatcata ggatgttttc atttcacaat ggaggtgtac agatttcttg taaataccct
      181 gagactgtcc agcagttaaa aatgcgattg ttcagagaga gagaagtcct ctgcgaactc
      241 accaagacca agggaagcgg aaatgcggtg tccatcaaga atccaatgct ctgtctatat
      301 catctgtcaa acaacagcgt ctcttttttc ctaaacaacc cagacagctc ccagggaagc
      361 tattacttct gcagcctgtc catttttgac ccacctcctt ttcaagaaag gaaccttagt
      421 ggaggatatt tgcatattta tgaatcccag ctctgctgcc agctgaagct ctggctaccc
      481 gtagggtgtg cagctttcgt tgtggtactc ctttttggat gcatacttat catctggttt
      541 tcaaaaaaga aatacggatc cagtgtgcat gaccctaata gtgaatacat gttcatggcg
      601 gcagtcaaca caaacaaaaa gtctagactt gcaggtgtga cctcataagc tggaacaccc
      661 ggacccacag aggaaacgca tggactagtt cccctgaaac ttgaatggag aaattcttct
      721 attttctgga ccacagggca cctgacttga tttaactaca gacaacattc tgctggtgtt
      781 ttgtttgtct ggatcagtga ctatcagtca ttcagaattt cagcagactg ccctgggttt
      841 gctgagtcct tttaagatga accccttctt aaggaagacc cagctcatat atattcaaca
      901 aacagacctc actgggatag aatgcccctc tctccgtgcc tgattctagc tatgcactgg
      961 ccaggaaaac aaacatatct ccagcatttt tttacaaaaa atgccaaggg tatgaatctg
     1021 taaagcacac aggcagccaa tggccaccat ctgtcctcat ttttcagatt ccattttctt
     1081 tccatggaga tcagcattct ttctagaatc agacagtaga gggagatgct tcacaacaga
     1141 agcgcttgtg tttctgcgat tttgatgtat atactttatc gaactcatgc attagaacca
     1201 acatgctctc ttccaattcc tagactctag ctgatcactg cttcagggct tagatgcctg
     1261 ctcttgcctt caaatttccc cttaaagata tgtccacatg tctacttggc agcctgctgc
     1321 cactccaaat aggaagctca gcctacattc cctcccaccc ctgttgctca aaaaaaaaaa
     1381 aaaaaattag tagatatgat gttcccatat tctccctgcc aaagtaattt tttccagaaa
     1441 agacatctaa attcagttaa tatggtttac tatgttgata ttagtggtag taaacatttc
     1501 tcagaaacaa aagcaaatta attttgctgt ggtgttttct actattatct gtgtttccat
     1561 ggtgctatta atcacaagct tagctatttt tgtagatcat attaaagttg caagcaagga
     1621 aagcaaccct ctgttaatgg gcaaacattc tcctggggta gaatgaatta tctatttagc
     1681 ctgaaagctg cggtttctgg gtggtggctg ccagactaca gccacacttt gctctctctg
     1741 ggtttgacag gttgaagtag tccccctgga gcagcactcc aggctacgct ggagtcccag
     1801 agttgggaga tgcctgggac aagctgctgc tttggtctct gggatctggg aagtacagta
     1861 gggccaagac agaattccct ctcctagaaa ctatgcagcc tggaagtcag ccctagcact
     1921 ttaagatagc cttctttaga atatgagtta gttggaagga ttctgaagtg taaagagcat
     1981 atgactgctc tgagctggac cattttctct actttcctgt ctgtatgcct aagacttctg
     2041 gagcagccaa tgtgtatgca acataaaaaa acaaaaaaca aaaaaactca caaactttaa
     2101 gtaaaatatg gctgcatcat agttttaagt tatagttgct tacttacagt ttactttaaa
     2161 agtgagctgt gcatcagtat atagttatta cgttaagcat gtgtaatgct ggctatgtac
     2221 agtacagtac tgaacgtgta atttgaatca agtatggtgt tctctctctt cagatgaccc
     2281 gggcagtctg actggctttg ttagggcatt ccccaagttg gacggtcctt tctgtgtgag
     2341 ggtgaaggtg ctttactctg ttccttgaag gatccccatt cccaacacga acacctaaca
     2401 atgacttctt gaagaacaaa atttctgtga aataaaatct ggcttaaaga ggagccactt
     2461 gctaaaagat gttagcaata atacaaagta aaggctaagc acttgtgtgc agcaatgggc
     2521 tataaccttg ctgtgttttc tgggggtgaa gaagtgatga ccttagctac catatgcaaa
     2581 ttagcccttg ctctccaatg acctttcgtg ctacataaga tagttgctcc ctttgtctcg
     2641 tttttcccct tttagactct gaaatattca caagcttata aaagagtcag aagcacagga
     2701 aacagcacgc tctgtgcctg agttagtttc tgcgttgacc tcctggcccc acagaatggt
     2761 gcctatttcc tatggaaatg aagactgcac tcttgataac ttgacagtca ccaatatcag
     2821 aaaattaaca ctgatatgtc actaccctct agtctttggt ctgcattcaa gatcttcccc
     2881 tggcttctag gatgtatgta ggagctgtaa gttctgctgg ggatgtccct ttgtgttcga
     2941 ttgacctgtc tcgggagtgt tcttcagtct agacagttct cttcagcctg tagcctgggc
     3001 ccttttgcag atcacacacc attattttgt agaatgttcc ttttgtgggg ggtcacgctg
     3061 atgtttcttc atgaatgaaa tgaggttact cgtctttagc agaaataaca cagaagtggt
     3121 gttgtgccct atagggcggc tcacattttg gtttgccaag taactgccag tgtttgtttt
     3181 catctcctgt caagcttctc cattgtaaag ggattctgct cctgaacagc caataaatat
     3241 gctttgtgag agaaaaaaaa aaaaaaaaaa aa
//
