LOCUS       NM_145618               4070 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus interactor of little elongation complex ELL subunit 2
            (Ice2), mRNA.
ACCESSION   NM_145618 NM_177046 XM_981034
VERSION     NM_145618.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   2  (bases 1 to 4070)
  AUTHORS   Sugiura,N., Dadashev,V. and Corriveau,R.A.
  TITLE     NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is
            expressed during development
  JOURNAL   Eur J Biochem 271 (23-24), 4629-4637 (2004)
   PUBMED   15606750
REFERENCE   3  (bases 1 to 4070)
  AUTHORS   Sugiura,N., Patel,R.G. and Corriveau,R.A.
  TITLE     N-methyl-D-aspartate receptors regulate a group of transiently
            expressed genes in the developing brain
  JOURNAL   J Biol Chem 276 (17), 14257-14263 (2001)
   PUBMED   11297529
REFERENCE   4  (bases 1 to 4070)
  AUTHORS   Yamamoto,M., Lin,X.H., Kominato,Y., Hata,Y., Noda,R., Saitou,N. and
            Yamamoto,F.
  TITLE     Murine equivalent of the human histo-blood group ABO gene is a
            cis-AB gene and encodes a glycosyltransferase with both A and B
            transferase activity
  JOURNAL   J Biol Chem 276 (17), 13701-13708 (2001)
   PUBMED   11278752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068183.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_981034.1, NM_145618.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068183.1, AY244558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 38.58 cM"
     gene            1..4070
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /note="interactor of little elongation complex ELL subunit
                     2"
                     /db_xref="GeneID:93697"
                     /db_xref="MGI:MGI:2135947"
     exon            1..56
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            57..198
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3124
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /note="NMDA receptor-regulated protein 2; NMDA
                     receptor-regulated gene 2; interactor of little elongator
                     complex ELL subunit 2"
                     /codon_start=1
                     /product="little elongation complex subunit 2"
                     /protein_id="NP_663593.2"
                     /db_xref="CCDS:CCDS23315.1"
                     /db_xref="GeneID:93697"
                     /db_xref="MGI:MGI:2135947"
                     /translation="MSSSITMSEPRLNWDVTPKNGLKAFFSPENYKDHSMAPSLKELY
                     ILSNRRIGENLSVSASSVENEPAVSSATQAKEKVGMILLPKPRVPYPRFSRFSQREQR
                     TYVDLLAKYAKLPSSSKTVGTNTNEYLQYLDMKKHVNEEVNEFLKFLQNSAKKCAQDY
                     NMLSDEARLFTEQLLRACIEQVKKYPEFYTLHEVTSLMGFFPFKTEMGLKLEKTLLVL
                     GSAKFVKTAFPSMPVKLQLSKEDMSSIETPQQKAEVMHCDISKDPNAEKLVSRYHPQI
                     ALTSQALFTLLNNHGPSYKEQWEIPVCVEMIAVEGSKPVKVIYINSPLPRKQMTMRER
                     NQIFHEVPLKHIISKNTSVPVSAVFMDKPEEYTSEVDMPTEAGECRKIETLENLDMDF
                     DGDVTELETFGVTTTSPPRSPSSESDSSAPLMTDVHAVPKIAAVPLAPATPVAPTMPV
                     APATPVTPTMPMAPATPEASATPNITDDSRSLCQILMKQLQKEKQLFSGVEGGPEGCK
                     NKDDQGLEPCGEEVPSANAKSLTQDNEVHRTEGISKESDVGVLCTNDERQGGQGNANN
                     PNNTATASEAAESEKGIPCGSDTDEDCLIIDTESRSCDGKTADLGSRPNSSAQASAGN
                     QATTTVSEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPVSRKVPELPLTNSEESKQ
                     PPASEQPSAALDAAPWPKSSWPSAFQKPKGRLPYELQDYVEDTSEYIAPQEGNFVYKL
                     FSLQDLLLLVRCSIQRVETRPRSKKRKKIRRQFPVYVLPKVEYQGCYGVEALTESELC
                     RFWTESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILK
                     KLCSLQEGSYLLSHAAEDSSLLIYKTSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVP
                     LDPSYLLPYHIHHGRVPCTFPPKPLRPAAQAKVGGTRMPTRNHRNPVSMETKSSCLPV
                     QQVENEGVARNKRKIM"
     exon            199..303
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..553
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..673
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..811
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..928
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1088
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1270
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..2294
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2470
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2600
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2685
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2736
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2995
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..4029
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /note="hexamer: ATTAAA"
     polyA_site      3593
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
     regulatory      4010..4015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /note="hexamer: AATAAA"
     polyA_site      4029
                     /gene="Ice2"
                     /gene_synonym="B230343B06Rik; Narg2"
                     /note="major polyA site"
ORIGIN      
        1 aacgtgtgtg gaagcgtcgg cttttctcgg gggccagagc cgcttgggac cctgagttaa
       61 ctgtagactc taggaaggat ccgaccctca ctctctggga gccttcactg cccagctgaa
      121 ataattgtgg gctagagtga aggagaattc taggaagatg agctctagca taaccatgag
      181 tgaaccaagg ctgaactggg atgttacacc caaaaatggc cttaaagcat ttttctctcc
      241 agaaaattat aaagaccatt ccatggctcc aagtttaaaa gaactctata ttttgtctaa
      301 cagacgtata ggagaaaatt tgagtgtctc agcaagttct gtagaaaatg agcctgcagt
      361 tagttcagca actcaagcaa aggaaaaagt tgggatgatt ctccttccaa aaccacgagt
      421 tccttatcct cgtttctctc ggttctcaca gagggagcag agaacttatg tggatttgtt
      481 ggctaaatat gcaaagctcc cctcaagttc caagactgtc ggaacaaata ccaatgaata
      541 tctgcagtat ctggatatga aaaaacatgt gaatgaagaa gttaatgaat ttctaaagtt
      601 tttacaaaat tctgcaaaga aatgtgcaca ggattataat atgctctctg atgaggcccg
      661 actcttcacg gagcaactcc taagagcttg cattgaacaa gtgaaaaagt acccagaatt
      721 ttatactctt catgaagtta ccagcctaat gggattcttc cccttcaaaa cagagatggg
      781 actgaagttg gaaaagactc ttcttgtttt gggcagtgca aagtttgtaa aaacagcatt
      841 tccctcaatg cctgtgaaat tacagctctc aaaagaggac atgtcttcca ttgagacccc
      901 acaacaaaaa gctgaagtta tgcactgtga tattagtaaa gacccgaacg cagagaagct
      961 tgtttcaaga taccacccgc agatagctct gactagccaa gcattattca ccttgctcaa
     1021 taaccatgga ccaagctaca aggagcagtg ggaaattcca gtgtgtgttg agatgatagc
     1081 tgtggaaggt tccaaaccag ttaaagtaat ttatatcaat tctccacttc ctcgaaagca
     1141 aatgacaatg agagaaagaa atcaaatctt ccatgaagtt ccattaaaac atataatatc
     1201 aaaaaacaca tctgttccag tctctgctgt ctttatggac aaacctgaag agtacacctc
     1261 tgaggtggac atgcccactg aagctggtga gtgccgaaaa attgaaactc tggaaaattt
     1321 ggatatggac ttcgatggtg atgtcacaga acttgaaacc tttggagtaa ctactactag
     1381 tccacctagg tcaccaagtt cagaaagtga ctcctctgca cccctcatga cagatgtcca
     1441 cgcagtcccc aaaatagcag ctgtgcctct ggcaccagct acgcctgtgg cacccactat
     1501 gcctgtggca ccagctacac ctgtcacacc cactatgccc atggcaccag ctacacctga
     1561 ggcatcagct acacctaaca ttactgatga ttctagaagt ttatgtcaga ttctgatgaa
     1621 acaattacag aaggagaaac agctattctc tggtgtggaa ggtggtcctg aagggtgcaa
     1681 aaataaagat gatcaaggac ttgaaccatg tggtgaagag gtccccagtg ccaatgcaaa
     1741 atctctaaca caagataatg aagtccacag aactgaggga atttctaagg aaagtgatgt
     1801 aggtgtgctg tgtaccaatg atgaaagaca gggtggtcag gggaatgcaa acaatcccaa
     1861 caacacagct actgcatcag aagcagctga aagtgagaaa gggattcctt gtggcagtga
     1921 tacagatgag gactgcttaa tcattgatac agagagtaga agttgtgatg ggaagacagc
     1981 tgatttaggt tctaggccaa attcttcagc acaggcttct gcagggaatc aggccactac
     2041 cactgtttct gaggaatctt gtgttttaaa gaaacctatc aaaagagtct acaaaaaatt
     2101 tgatccagtt ggagaaattc taaaaatgca ggatgagctt ttaaaaccag tttccaggaa
     2161 agtacctgag ttgcccttga ctaattcaga agaatctaaa cagccgcctg cttctgagca
     2221 accctctgct gctttggatg ccgctccctg gccaaaatcc agttggccct ctgcatttca
     2281 gaagcctaaa ggacgattgc catatgaact tcaagactat gtggaagata catcagaata
     2341 tatagctcct caagaaggaa actttgtcta caagttgttc agcctacaag acctgttgtt
     2401 acttgtgcgg tgcagcatcc agagggtaga aacgagacca cgctccaaaa aacggaagaa
     2461 gatcagaaga caatttccag tttacgtgct accaaaagta gagtatcaag gttgttatgg
     2521 agttgaagct ctgactgaaa gcgagctctg tcgcttctgg actgaaagtt tattgcattc
     2581 caactgctcg ttttatgttg ggcatattga tgcatttact tcaaagcttt tcatgctaga
     2641 agaaatcgct tcagaagaat taaaagaaaa acttgcagca ctcaagattt caagcttatt
     2701 taacattctc cagcacattc taaagaaatt atgtagcttg caggaagggt cctacttgct
     2761 gtctcatgca gcagaagatt cttcactcct gatctacaag acctcagatg gaaaagttac
     2821 tagaacggca tataatttgc ataaggcaca ttgtgacctt cctggcgtac cctccagtct
     2881 ctcggttcct tgggtcccat tagatcccag ttacctgtta ccatatcata tccatcatgg
     2941 acgagtacct tgcacttttc cacctaaacc actgcgccct gcagcacaag caaaggttgg
     3001 tgggacaaga atgcctaccc gtaaccacag gaatcctgtc tccatggaaa ccaaaagcag
     3061 ttgcctgcct gttcagcaag ttgaaaatga aggagtggct cggaataaaa ggaaaataat
     3121 gtaagggctg gaccatagaa aatgaagttt cagaaaaccc agttataaca gtgtttaatg
     3181 ttgaacttta aggggaaaca tacccagaag atcagctagt gagaagagtg tctcccctcg
     3241 ctatcctgga gttcttacaa agtgccttgg aaacctactg actgcaggaa tggcggtgac
     3301 agcaggagtt agtcactcct cagccctggt gcacggagaa tgtagaatgc tccattagca
     3361 tggcagcaaa ctgaataaga aaaatatttt tatagcattc ttttctaaag atcataggta
     3421 ggaaaaccac ttgctgattt aggaactgtc atgtattacg ttatcaattt gattatattg
     3481 ccactcaaat gagactggcc caatagttaa atattgccaa tgttagaaac agctctgtgc
     3541 attgtttctg acccattttt gtcagtatta aaactgctgt tgatgtttga aaacttgttg
     3601 aaattccttt gtggacgccg aaagtgaaaa caagaaaaat cttcatctct gaaaagtggc
     3661 aaattaatat tttcttacta ggcaaccacc cttgtgtttt ataaaaacaa aaagcattct
     3721 gtggtgtgac agctttggtg acaatatctc tactactttg cacaaattcc atgtaaatgt
     3781 ggtaagatac tacccaaagc agaaataacc atgaggatgc aggaaaaaca aaaaaaacaa
     3841 aaaaaaacac ttgatgatcc tatcagacat ggtgaaggtg ccattaagcc taggattgtt
     3901 tctttcttct catgtattgt ggttaattca gaaagcagca tcagcagtgg gtttggccag
     3961 tttgcatttg aggggacaga atatgtttac tttttgttac ctgtttttta ataaacacta
     4021 aaagcttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
