LOCUS       NM_008319               2943 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus intercellular adhesion molecule 5, telencephalin
            (Icam5), transcript variant 1, mRNA.
ACCESSION   NM_008319
VERSION     NM_008319.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2943)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2943)
  AUTHORS   Bertrand,J.A., Woodward,D.F., Sherwood,J.M., Spenlehauer,A.,
            Silvestri,C., Piscitelli,F., Marzo,V.D., Yamazaki,M., Sakimura,K.,
            Inoue,Y., Watanabe,K. and Overby,D.R.
  TITLE     Deletion of the gene encoding prostamide/prostaglandin F synthase
            reveals an important role in regulating intraocular pressure
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 165, 102235 (2021)
   PUBMED   33418484
REFERENCE   3  (bases 1 to 2943)
  AUTHORS   Pei,Y.P., Wang,Y.Y., Liu,D., Lei,H.Y., Yang,Z.H., Zhang,Z.W.,
            Han,M., Cheng,K., Chen,Y.S., Li,J.Q., Cheng,G.R., Xu,L., Wu,Q.M.,
            McClintock,S.M., Yang,Y., Zhang,Y. and Zeng,Y.
  TITLE     ICAM5 as a Novel Target for Treating Cognitive Impairment in
            Fragile X Syndrome
  JOURNAL   J Neurosci 40 (6), 1355-1365 (2020)
   PUBMED   31882402
  REMARK    GeneRIF: ICAM5 as a Novel Target for Treating Cognitive Impairment
            in Fragile X Syndrome.
REFERENCE   4  (bases 1 to 2943)
  AUTHORS   Birkner,K., Loos,J., Gollan,R., Steffen,F., Wasser,B., Ruck,T.,
            Meuth,S.G., Zipp,F. and Bittner,S.
  TITLE     Neuronal ICAM-5 Plays a Neuroprotective Role in Progressive
            Neurodegeneration
  JOURNAL   Front Neurol 10, 205 (2019)
   PUBMED   30915022
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2943)
  AUTHORS   Katano,T., Takao,K., Abe,M., Yamazaki,M., Watanabe,M., Miyakawa,T.,
            Sakimura,K. and Ito,S.
  TITLE     Distribution of Caskin1 protein and phenotypic characterization of
            its knockout mice using a comprehensive behavioral test battery
  JOURNAL   Mol Brain 11 (1), 63 (2018)
   PUBMED   30359304
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2943)
  AUTHORS   Annaert,W.G., Esselens,C., Baert,V., Boeve,C., Snellings,G.,
            Cupers,P., Craessaerts,K. and De Strooper,B.
  TITLE     Interaction with telencephalin and the amyloid precursor protein
            predicts a ring structure for presenilins
  JOURNAL   Neuron 32 (4), 579-589 (2001)
   PUBMED   11719200
REFERENCE   7  (bases 1 to 2943)
  AUTHORS   Nakamura,K., Manabe,T., Watanabe,M., Mamiya,T., Ichikawa,R.,
            Kiyama,Y., Sanbo,M., Yagi,T., Inoue,Y., Nabeshima,T., Mori,H. and
            Mishina,M.
  TITLE     Enhancement of hippocampal LTP, reference memory and sensorimotor
            gating in mutant mice lacking a telencephalon-specific cell
            adhesion molecule
  JOURNAL   Eur J Neurosci 13 (1), 179-189 (2001)
   PUBMED   11135016
REFERENCE   8  (bases 1 to 2943)
  AUTHORS   Desai,S.B. and Libutti,S.K.
  TITLE     Tumor angiogenesis and endothelial cell modulatory factors
  JOURNAL   J Immunother 22 (3), 186-211 (1999)
   PUBMED   10335479
  REMARK    Review article
REFERENCE   9  (bases 1 to 2943)
  AUTHORS   Sugino,H., Yoshihara,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Mori,K.
  TITLE     Genomic organization and chromosomal localization of the mouse
            telencephalin gene, a neuronal member of the ICAM family
  JOURNAL   Genomics 43 (2), 209-215 (1997)
   PUBMED   9244438
REFERENCE   10 (bases 1 to 2943)
  AUTHORS   Yoshihara,Y., Oka,S., Nemoto,Y., Watanabe,Y., Nagata,S.,
            Kagamiyama,H. and Mori,K.
  TITLE     An ICAM-related neuronal glycoprotein, telencephalin, with brain
            segment-specific expression
  JOURNAL   Neuron 12 (3), 541-553 (1994)
   PUBMED   7794412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159314.3.
            
            On Aug 1, 2022 this sequence version replaced NM_008319.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113140.1, AK135040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC159314.3         182166-182301
            137-406             AC159314.3         183177-183446
            407-727             AC159314.3         183585-183905
            728-1015            AC159314.3         184637-184924
            1016-1270           AC159314.3         185134-185388
            1271-1519           AC159314.3         185484-185732
            1520-1762           AC159314.3         186284-186526
            1763-2041           AC159314.3         186606-186884
            2042-2281           AC159314.3         186975-187214
            2282-2545           AC159314.3         187671-187934
            2546-2943           AC159314.3         188728-189125
FEATURES             Location/Qualifiers
     source          1..2943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.7 cM"
     gene            1..2943
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /note="intercellular adhesion molecule 5, telencephalin"
                     /db_xref="GeneID:15898"
                     /db_xref="MGI:MGI:109430"
     exon            1..136
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2808
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; intercellular adhesion molecule 3;
                     telencephalin"
                     /codon_start=1
                     /product="intercellular adhesion molecule 5 isoform 1
                     precursor"
                     /protein_id="NP_032345.2"
                     /db_xref="CCDS:CCDS22891.1"
                     /db_xref="GeneID:15898"
                     /db_xref="MGI:MGI:109430"
                     /translation="MPGPSPGLRRALLGLWAALGLGILGISAVALEPFWADLQPRVAL
                     VERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFR
                     CARRTLQARGLIRTFQRPDRVELVPLPSWQPVGENFTLSCRVPGAGPRASLTLTLLRG
                     GQELIRRSFVGEPPRARGAMLTARVLARREDHRVNFSCLAELDLRPHGLGLFANSSAP
                     RQLRTFAMPPHSPSLIAPRVLEVDSERPVTCTLDGLFPAPEAGVYLSLGDQRLNPNVT
                     LDGDSLVATATATASAEQEGTKQLMCVVTLGGESRETQENLTVYSFPTPLLTLSEPEA
                     PEGKMVTISCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCDAALDVDGE
                     TLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPEGGA
                     VLALGLLGPVTRALAGTYRCTAVNGQGQAVKDVTLTVEYAPALDSVGCPEHITWLEGT
                     EASLSCVAHGVPPPSVSCVRSGKEEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAV
                     TVEYGPSFEELGCPSNWTWVEGSGKLFSCEVDGKPEPRVECVGSEGASEGIVLPLVSS
                     NSGPRNSMTPGNLSPGIYLCNATNRHGSTVKTVVVSAESPPQMDESSCPSHQTWLEGA
                     EATALACSARGRPSPRVHCSREGAARLERLQVSREDAGTYRCVATNAHGTDSRTVTVG
                     VEYRPVVAELAASPPSVRPGGNFTLTCRAEAWPPAQISWRAPPGALNLGLSSNNSTLS
                     VAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAF
                     YVQSTACKKGEYNVQEAESSGEAVCLNGAGGTPGAEGGAETPGTAESPADGEVFAIQL
                     TSS"
     exon            137..406
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            407..727
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1015
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1270
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1519
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1762
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..2041
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2281
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2545
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2943
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2924..2929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /note="hexamer: AATAAA"
     polyA_site      2943
                     /gene="Icam5"
                     /gene_synonym="CD50; ICAM-3; ICAM-5; Icam3; Tlcn; TLN"
                     /note="major polyA site"
ORIGIN      
        1 atcactcgcg ctcccctcgc cttctgtgct ctcccctccc cggcagcggc ggcaatgccg
       61 gggccttcgc cagggctgcg ccgagcgctc ctcggcctct gggctgccct gggcctgggg
      121 atcctaggca tctcagcggt cgcgctagaa cctttctggg cggaccttca gccccgcgtg
      181 gcgctcgtgg agcgcggggg ctcgctgtgg ctcaactgca gcactaactg tccgcggccg
      241 gagcgcggtg gcctggagac ctcgctacgc cgaaacggga cccagagggg tctgcgctgg
      301 ctggctcggc agctggtgga catccgagag cctgagaccc agccggtctg cttcttccgc
      361 tgcgcgcgcc gcacactcca agcgcgtgga ctcatccgaa ctttccagcg accggatcgg
      421 gtagagctgg tgccgctccc ttcttggcag ccagtgggcg agaacttcac cttgagctgc
      481 agggtcccgg gagcaggacc ccgagcgagc ctcacattga ccctgctgcg gggcggccag
      541 gagctgattc gccgcagttt cgtaggcgag ccaccccgag cgcggggtgc gatgctcacc
      601 gccagggtcc tggcacgcag ggaggaccac agggtcaatt tctcatgcct cgccgagctt
      661 gacctgcggc cacacggctt gggactgttt gcaaatagct cggcccccag acagctccgt
      721 acctttgcca tgcctccaca ttccccgagt cttattgctc cccgagtctt agaagtggac
      781 tcagaaaggc cggtgacttg cacgttggat ggactgtttc ctgccccaga agccggggtt
      841 tacctctctc tgggagatca gaggctcaat cctaatgtga ccctcgatgg ggacagcctt
      901 gtggccactg ccacagctac agcaagcgca gaacaggaag gcaccaaaca gctgatgtgc
      961 gtcgtgaccc tcgggggcga aagcagggag acccaggaaa acctgactgt ttacagcttc
     1021 ccgactcctc ttctgacttt gagtgagcca gaagcccccg agggaaaaat ggtgaccata
     1081 agctgctggg caggggctcg agcccttgtc accctggagg gaattccagc tgcggtcccg
     1141 gggcagcccg ctgagctcca gttaaatgtt acaaagaacg atgacaagcg gggcttcttc
     1201 tgcgacgccg ccctcgatgt ggacggggaa actctaagaa aaaaccagag ctctgagctt
     1261 cgtgtcctgt atgcacctcg cctggatgac ttggattgtc ccagaagctg gacgtggcca
     1321 gagggtccag agcagaccct ccactgcgag gcccgcggaa accctgagcc ctcggtgcac
     1381 tgtgcaaggc ctgagggcgg ggcggtgcta gcgctgggcc tattgggtcc agtgacccgt
     1441 gccctcgcag gcacttaccg atgcacagca gtcaatgggc aaggccaggc ggtcaaagat
     1501 gtgaccctga ccgtggaata tgccccagcg ctggacagtg taggctgccc agaacatatt
     1561 acttggctgg agggaacgga ggcatcgctt agctgtgtgg cacacggggt cccaccacct
     1621 agcgtgagtt gtgtgcgctc tggaaaggag gaagtcatgg aagggcctct gcgcgtggcc
     1681 cgggagcacg ccggcactta ccgatgcgaa gccatcaacg ccagaggatc agcggccaaa
     1741 aatgtggccg tcacggtgga atatggtccc agttttgagg agttgggctg ccccagcaac
     1801 tggacgtggg tagagggatc tggaaagctg ttttcctgtg aagttgatgg gaagccagaa
     1861 ccacgtgtgg agtgcgtagg ctcggagggt gcaagcgaag ggatagtgtt gcccttggtg
     1921 tcctcaaact ctggtcctag aaactctatg acccctggta acctgtcacc gggcatttac
     1981 ctctgcaacg ccaccaaccg gcacggctcc acagtcaaaa cagtcgtcgt gagcgcggag
     2041 tcgccgccac agatggatga atccagttgc ccgagtcacc agacctggct ggaaggagct
     2101 gaggctaccg cgctggcctg cagtgccagg ggccgcccct ctccacgggt gcattgctcc
     2161 agggagggtg ccgccaggct ggagaggcta caggtgtccc gagaggatgc ggggacctac
     2221 cgctgtgtgg ccaccaatgc gcatggcacg gattcacgga cggtcactgt gggtgtggaa
     2281 taccggcctg tggtggctga gctggcagcc tcgcccccaa gcgtgcggcc gggcggtaac
     2341 ttcactctga cctgccgcgc agaggcttgg cctccagccc agatcagctg gcgcgcgccc
     2401 ccgggggctc tcaacctcgg cctctccagc aacaatagca ctctgagcgt ggcgggagcc
     2461 atgggcagcc atggcggcga gtatgagtgt gcagcgacca atgcgcatgg gcgccacgca
     2521 cggcgcatca cagtgcgcgt ggccggtcca tggctgtggg tcgctgtggg cggtgcggca
     2581 gggggcgcgg cgctgctggc cgctggggcc ggcctggcct tctacgtgca atccaccgct
     2641 tgcaagaagg gcgagtacaa cgtccaggag gctgagagct caggcgaggc cgtgtgtctc
     2701 aatggcgcgg gcgggacacc gggtgcagaa ggcggagcag agaccccagg cactgcagag
     2761 tcacctgcag atggcgaggt tttcgctatc cagctgacat cttcctgagc ctatacccag
     2821 ctcccacagg ggcctcgcaa gcacagaggt ggacgtatgt attgttcgct ctctatttat
     2881 tcaactccag gggcgtcacc cccattttct acccattccc ttcaataaag tttttataaa
     2941 gga
//
