LOCUS       NM_023892                913 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus intercellular adhesion molecule 4, Landsteiner-Wiener
            blood group (Icam4), transcript variant 1, mRNA.
ACCESSION   NM_023892
VERSION     NM_023892.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Maynard,T.M., Horvath,A., Bernot,J.P., Karpinski,B.A.,
            Tavares,A.L.P., Shah,A., Zheng,Q., Spurr,L., Olender,J.,
            Moody,S.A., Fraser,C.M., LaMantia,A.S. and Lee,N.H.
  TITLE     Transcriptional dysregulation in developing trigeminal sensory
            neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion
            syndrome
  JOURNAL   Hum Mol Genet 29 (6), 1002-1017 (2020)
   PUBMED   32047912
  REMARK    Erratum:[Hum Mol Genet. 2020 Jun 3;29(9):1580. doi:
            10.1093/hmg/ddaa067.. PMID: 32358605]
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Wang,L., Yu,H., Cheng,H., He,K., Fang,Z., Ge,L., Cheng,T. and
            Jin,Y.
  TITLE     Deletion of Stk40 impairs definitive erythropoiesis in the mouse
            fetal liver
  JOURNAL   Cell Death Dis 8 (3), e2722 (2017)
   PUBMED   28358362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Mitsui,S., Saito,M., Mori,K. and Yoshihara,Y.
  TITLE     A transcriptional enhancer that directs telencephalon-specific
            transgene expression in mouse brain
  JOURNAL   Cereb Cortex 17 (3), 522-530 (2007)
   PUBMED   16581979
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Lee,G., Lo,A., Short,S.A., Mankelow,T.J., Spring,F., Parsons,S.F.,
            Yazdanbakhsh,K., Mohandas,N., Anstee,D.J. and Chasis,J.A.
  TITLE     Targeted gene deletion demonstrates that the cell adhesion molecule
            ICAM-4 is critical for erythroblastic island formation
  JOURNAL   Blood 108 (6), 2064-2071 (2006)
   PUBMED   16690966
  REMARK    GeneRIF: ICAM-4 is critical in erythroblastic island formation via
            ICAM-4/alpha(V) adhesion
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Sugino,H.
  TITLE     ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in
            mammalian evolution, but was lost in the rodent genome
  JOURNAL   FEBS Lett 579 (13), 2901-2906 (2005)
   PUBMED   15890347
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Leeb,T. and Muller,M.
  TITLE     Comparative human-mouse-rat sequence analysis of the ICAM gene
            cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q
  JOURNAL   Gene 343 (2), 239-244 (2004)
   PUBMED   15588578
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Lee,G., Spring,F.A., Parsons,S.F., Mankelow,T.J., Peters,L.L.,
            Koury,M.J., Mohandas,N., Anstee,D.J. and Chasis,J.A.
  TITLE     Novel secreted isoform of adhesion molecule ICAM-4: potential
            regulator of membrane-associated ICAM-4 interactions
  JOURNAL   Blood 101 (5), 1790-1797 (2003)
   PUBMED   12406883
  REMARK    GeneRIF: A novel second splice cDNA encodes an ICAM-4 isoform
            lacking the membrane-spanning domain. Erythroblasts express both
            isoforms. This new isoform, ICAM-4S, may modulate
            membrane-associated ICAM-4 binding & regulate erythroblast
            molecular attachments.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC116909.1 and D19050.1.
            
            On Jun 20, 2018 this sequence version replaced NM_023892.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116909.1, AF296282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               BC116909.1         60-907
            849-913             D19050.1           33-97
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.69 cM"
     gene            1..913
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /note="intercellular adhesion molecule 4,
                     Landsteiner-Wiener blood group"
                     /db_xref="GeneID:78369"
                     /db_xref="MGI:MGI:1925619"
     exon            1..392
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..811
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LW glycoprotein"
                     /codon_start=1
                     /product="intercellular adhesion molecule 4 isoform 1
                     precursor"
                     /protein_id="NP_076381.1"
                     /db_xref="CCDS:CCDS22890.1"
                     /db_xref="GeneID:78369"
                     /db_xref="MGI:MGI:1925619"
                     /translation="MESALLLPSLLLVAAYPRGGSPQQEWMQSPPAPSVTSAPFWVRL
                     NPELEAVPPGGSAWLNCSHNCPLPVHSSLRTQLRQGKIVNGSGWVSYQLLDVRAWNSK
                     VRCVVTCAGETREATARITAYKRPRSVILEPPVLVGHKYTLRCYVTHVFPVGFLVVSL
                     RRGGRVIYHESLERFTGSDLANVTLTYVMRAGLNDLWQPLTCHARLNLDGLVVRSSSA
                     PVMLTVLALSPASIALASTSIATLVGILLAVGAVYVRKYLAVQT"
     exon            393..698
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /inference="alignment:Splign:2.1.0"
     exon            699..913
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      893..898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /note="hexamer: AATAAA"
     polyA_site      911
                     /gene="Icam4"
                     /gene_synonym="1810015M19Rik; Cd242; ICAM-4"
                     /note="major polyA site"
ORIGIN      
        1 acttcagcgc gggctttgtg ccatggagtc tgcccttctg ctcccgtcgc ttttgctggt
       61 ggctgcctat ccgaggggtg ggagccccca gcaagagtgg atgcaaagtc ctcccgcgcc
      121 ttccgtgacc tcagcacctt tctgggtgcg tcttaatcca gagctagagg ccgtgcctcc
      181 cgggggctca gcgtggctta actgcagcca caactgcccc ctgccggtgc attccagcct
      241 gcgcacccaa ctgcggcagg gaaagatagt taatggatcc ggctgggtat cttaccagct
      301 actggatgtg agggcctgga attccaaggt gcgctgcgtc gtcacttgcg caggagaaac
      361 ccgagaggcc accgccagga tcactgctta caaacggccc agaagcgtga tcttggagcc
      421 tccggtccta gtgggccaca agtacactct gcgatgctat gtgacacacg tgttcccagt
      481 gggattcttg gtggtgagcc tgagaagagg tggccgagtg atttatcatg aaagcctgga
      541 gcgcttcacc ggttcagatt tggctaatgt cactttgacc tacgtgatgc gggccggact
      601 caacgacctc tggcagccac tcacctgcca tgcgcgcctc aatctcgacg ggctagtggt
      661 gcgcagcagc tcggcacctg ttatgttgac agtcctcgct ttaagcccag cctctatagc
      721 cttggcctct acctccatcg caaccctggt ggggatcctc ctggctgtgg gggctgtcta
      781 cgtgcgcaag tacctggctg tgcagactta gttatagatc tgttttcgat gcctgacaag
      841 agggagggga aaagaacttc agagtaatta attcagagac tcttattgaa acaataaagt
      901 cttcctcctc agt
//
