LOCUS       NM_010494               1308 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus intercellular adhesion molecule 2 (Icam2), mRNA.
ACCESSION   NM_010494
VERSION     NM_010494.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   da Silva,S.F., Murta,E.F. and Michelin,M.A.
  TITLE     ICAM2 is related to good prognosis in dendritic cell immunotherapy
            for cancer
  JOURNAL   Immunotherapy 16 (3), 173-185 (2024)
   PUBMED   38126167
  REMARK    GeneRIF: ICAM2 is related to good prognosis in dendritic cell
            immunotherapy for cancer.
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Li,S.Y., Bhandary,B., Gu,X. and DeFalco,T.
  TITLE     Perivascular cells support folliculogenesis in the developing ovary
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2213026119 (2022)
   PUBMED   36194632
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Tian,A., Wang,S., Wang,H., Li,N., Liu,H., Zhou,H., Chen,X., Liu,X.,
            Deng,J., Xiao,J. and Liu,C.
  TITLE     Over-expression of Fgf8 in cardiac neural crest cells leads to
            persistent truncus arteriosus
  JOURNAL   J Mol Histol 52 (2), 351-361 (2021)
   PUBMED   33547543
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Zindel,J., Peiseler,M., Hossain,M., Deppermann,C., Lee,W.Y.,
            Haenni,B., Zuber,B., Deniset,J.F., Surewaard,B.G.J., Candinas,D.
            and Kubes,P.
  TITLE     Primordial GATA6 macrophages function as extravascular platelets in
            sterile injury
  JOURNAL   Science 371 (6533) (2021)
   PUBMED   33674464
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Buck,C.A., Edelman,J.M., Buck,C.E., Kennedy,G. and Baldwin,H.S.
  TITLE     Expression patterns of adhesion receptors in the developing mouse
            lung: functional implications
  JOURNAL   Cell Adhes Commun 4 (2), 69-87 (1996)
   PUBMED   8937744
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Xu,H., Bickford,J.K., Luther,E., Carpenito,C., Takei,F. and
            Springer,T.A.
  TITLE     Characterization of murine intercellular adhesion molecule-2
  JOURNAL   J Immunol 156 (12), 4909-4914 (1996)
   PUBMED   8648141
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Ohh,M., Smith,C.A., Carpenito,C. and Takei,F.
  TITLE     Regulation of intercellular adhesion molecule-1 gene expression
            involves multiple mRNA stabilization mechanisms: effects of
            interferon-gamma and phorbol myristate acetate
  JOURNAL   Blood 84 (8), 2632-2639 (1994)
   PUBMED   7919377
REFERENCE   9  (bases 1 to 1308)
  AUTHORS   Kuramoto,T., Mashimo,T., Koike,R., Miyawaki,S., Yamada,J.,
            Miyasaka,M. and Serikawa,T.
  TITLE     The alymphoplasia (aly) mutation co-segregates with the
            intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11
  JOURNAL   Int Immunol 6 (7), 991-994 (1994)
   PUBMED   7947467
REFERENCE   10 (bases 1 to 1308)
  AUTHORS   Xu,H., Tong,I.L., De Fougerolles,A.R. and Springer,T.A.
  TITLE     Isolation, characterization, and expression of mouse ICAM-2
            complementary and genomic DNA
  JOURNAL   J Immunol 149 (8), 2650-2655 (1992)
   PUBMED   1401904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604045.7 and X65493.1.
            
            On Jun 29, 2016 this sequence version replaced NM_010494.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X65493.1, BC039128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL604045.7         164691-164830       c
            141-1308            X65493.1           1-1168
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 69.09 cM"
     gene            1..1308
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /note="intercellular adhesion molecule 2"
                     /db_xref="GeneID:15896"
                     /db_xref="MGI:MGI:96394"
     exon            1..352
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1131
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /note="lymphocyte function-associated AG-1
                     counter-receptor"
                     /codon_start=1
                     /product="intercellular adhesion molecule 2 precursor"
                     /protein_id="NP_034624.1"
                     /db_xref="CCDS:CCDS25555.1"
                     /db_xref="GeneID:15896"
                     /db_xref="MGI:MGI:96394"
                     /translation="MSSFACWSLSLLILFYSPGSGEKAFEVYIWSEKQIVEATESWKI
                     NCSTNCAAPDMGGLETPTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSE
                     SLNIRVYQPPAQVTLKLQPPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQT
                     FGGAETVPQEATATFNSTALKKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPM
                     QDNQMVIIIVVVSILLFLFVTSVLLCFIFGQHWHRRRTGTYGVLAAWRRLPRAFRARP
                     V"
     exon            353..625
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /inference="alignment:Splign:2.1.0"
     exon            626..943
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1282
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1262..1267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /note="hexamer: AATACA"
     polyA_site      1282
                     /gene="Icam2"
                     /gene_synonym="CD102; Icam-2; Ly-60"
                     /note="major polyA site"
ORIGIN      
        1 agcatgcaac gtgagagaac cctgttacac ccctgcttat ctgctgcttc ctggcttcct
       61 ctgcatgaat tcttgaggcc ctaaaggctt gggagctggt ctgtgcatat tgtttcctga
      121 tctcagataa ttagaggaaa tgagctcact ggcacagagg agattgtgga tttcagttgg
      181 gagcgccagg cttcactccc cgacctgtag cagacatctc tccctaaccc tccaggcagc
      241 cgtcagctgt gcccctgaag cccatagact ccacagaccc cacagacccc acctgagatg
      301 tcttcttttg cttgctggag cctgtctctt cttatcctgt tctacagccc agggtctggt
      361 gagaaggcct ttgaggtcta catatggtcc gagaagcaga tagtagaagc cacagagtct
      421 tggaaaatca actgcagcac caactgcgca gccccagaca tgggcggcct ggagacgccc
      481 acgaataaaa taatgttgga agagcatcct caagggaagt ggaaacagtt cttagtctca
      541 aacgtctcca aagacacggt cttcttttgc catttcacgt gttcgggaaa gcagcactcg
      601 gagagtctca acatcagggt gtaccagcct ccagctcaag tcacactgaa gctgcagccg
      661 cctcgggtgt ttgtgggtga agacttcacc attgagtgca cggtgtcccc tgtgcagccc
      721 cttgagaggc tcaccctctc tctgctccgt ggcagagaga ccctgaagaa tcagaccttt
      781 gggggagcag aaactgtccc ccaagaggcc acagccacgt tcaacagcac agctctgaaa
      841 aaggacggtc tcaacttttc ctgccaggct gagctggatc tacggcccca tggtgggtat
      901 atcatccgca gcatctcgga gtaccagatc cttgaagtct atgagccgat gcaggacaac
      961 caaatggtca tcatcatcgt ggtggtgtca atactgctgt tcttatttgt gacatctgtc
     1021 ctgctatgct ttatctttgg ccagcactgg cacagaagac ggacaggcac ctacggggtg
     1081 ctagctgcct ggaggaggct gccccgagcc tttcgggcac gtcccgtgtg agcccacgtt
     1141 gccaggcccc tggtggttac cagaactcaa catggcacct tcaaggtgtg gttcggcact
     1201 ggctgaagga ctgtggcggc agcagcagat gcgggggaca tttcctctcc tttttagcct
     1261 caatacaaat atctggattt caaaaaaaaa aaaaaaaaaa aaaaaaaa
//
