LOCUS       NM_010493               2593 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus intercellular adhesion molecule 1 (Icam1), mRNA.
ACCESSION   NM_010493
VERSION     NM_010493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39667932
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2593)
  AUTHORS   Zhang,F., Pan,L., Lian,C., Xu,Z., Chen,H., Lai,W., Liang,X.,
            Liu,Q., Wu,H., Wang,Y., Zhang,P., Zhang,G. and Liu,Z.
  TITLE     ICAM-1 may promote the loss of dopaminergic neurons by regulating
            inflammation in MPTP-induced Parkinson's disease mouse models
  JOURNAL   Brain Res Bull 214, 110989 (2024)
   PUBMED   38825252
  REMARK    GeneRIF: ICAM-1 may promote the loss of dopaminergic neurons by
            regulating inflammation in MPTP-induced Parkinson's disease mouse
            models.
REFERENCE   3  (bases 1 to 2593)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   4  (bases 1 to 2593)
  AUTHORS   Chang,R.Q., Dai,J.C., Qiu,Y.H., Liang,Y., Hu,X.Y., Li,M.Q. and
            He,F.
  TITLE     Accumulation of gammadeltaT cells in the decidua is promoted by
            RANKL which upregulates ICAM-1 via NF-kappaB
  JOURNAL   Reproduction 167 (6), e230262 (2024)
   PUBMED   38614129
  REMARK    GeneRIF: Accumulation of gammadeltaT cells in the decidua is
            promoted by RANKL which upregulates ICAM-1 via NF-kappaB.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2593)
  AUTHORS   Ballantyne,C.M., Sligh,J.E. Jr., Dai,X.Y. and Beaudet,A.L.
  TITLE     Characterization of the murine Icam-1 gene
  JOURNAL   Genomics 14 (4), 1076-1080 (1992)
   PUBMED   1362180
REFERENCE   6  (bases 1 to 2593)
  AUTHORS   Prieto,J., Kaaya,E.E., Juntti-Berggren,L., Berggren,P.O.,
            Sandler,S., Biberfeld,P. and Patarroyo,M.
  TITLE     Induction of intercellular adhesion molecule-1 (CD54) on isolated
            mouse pancreatic beta cells by inflammatory cytokines
  JOURNAL   Clin Immunol Immunopathol 65 (3), 247-253 (1992)
   PUBMED   1360342
REFERENCE   7  (bases 1 to 2593)
  AUTHORS   Harning,R., Pelletier,J., Van,G., Takei,F. and Merluzzi,V.J.
  TITLE     Monoclonal antibody to MALA-2 (ICAM-1) reduces acute autoimmune
            nephritis in kdkd mice
  JOURNAL   Clin Immunol Immunopathol 64 (2), 129-134 (1992)
   PUBMED   1353711
REFERENCE   8  (bases 1 to 2593)
  AUTHORS   Siu,G., Hedrick,S.M. and Brian,A.A.
  TITLE     Isolation of the murine intercellular adhesion molecule 1 (ICAM-1)
            gene. ICAM-1 enhances antigen-specific T cell activation
  JOURNAL   J Immunol 143 (11), 3813-3820 (1989)
   PUBMED   2479693
REFERENCE   9  (bases 1 to 2593)
  AUTHORS   Horley,K.J., Carpenito,C., Baker,B. and Takei,F.
  TITLE     Molecular cloning of murine intercellular adhesion molecule
            (ICAM-1)
  JOURNAL   EMBO J 8 (10), 2889-2896 (1989)
   PUBMED   2573511
REFERENCE   10 (bases 1 to 2593)
  AUTHORS   Ballantyne,C.M., O'Brien,W.E. and Beaudet,A.L.
  TITLE     Nucleotide sequence of the cDNA for murine intercellular adhesion
            molecule-1 (ICAM-1)
  JOURNAL   Nucleic Acids Res 17 (14), 5853 (1989)
   PUBMED   2762164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY777078.1, AK151681.1 and
            AW491621.1.
            
            On Aug 4, 2016 this sequence version replaced NM_010493.2.
            
            Summary: This gene encodes an integral membrane protein that binds
            leukocyte adhesion protein LFA-1. It participates in the innate
            immune response. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008626.1, AK152155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BY777078.1         2-99
            99-2209             AK151681.1         55-2165
            2210-2593           AW491621.1         1-384               c
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.69 cM"
     gene            1..2593
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /note="intercellular adhesion molecule 1"
                     /db_xref="GeneID:15894"
                     /db_xref="MGI:MGI:96392"
     exon            1..162
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1709
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /note="myD10"
                     /codon_start=1
                     /product="intercellular adhesion molecule 1 precursor"
                     /protein_id="NP_034623.1"
                     /db_xref="CCDS:CCDS22889.1"
                     /db_xref="GeneID:15894"
                     /db_xref="MGI:MGI:96392"
                     /translation="MASTRAKPTLPLLLALVTVVIPGPGDAQVSIHPREAFLPQGGSV
                     QVNCSSSCKEDLSLGLETQWLKDELESGPNWKLFELSEIGEDSSPLCFENCGTVQSSA
                     SATITVYSFPESVELRPLPAWQQVGKDLTLRCHVDGGAPRTQLSAVLLRGEEILSRQP
                     VGGHPKDPKEITFTVLASRGDHGANFSCRTELDLRPQGLALFSNVSEARSLRTFDLPA
                     TIPKLDTPDLLEVGTQQKLFCSLEGLFPASEARIYLELGGQMPTQESTNSSDSVSATA
                     LVEVTEEFDRTLPLRCVLELADQILETQRTLTVYNFSAPVLTLSQLEVSEGSQVTVKC
                     EAHSGSKVVLLSGVEPRPPTPQVQFTLNASSEDHKRSFFCSAALEVAGKFLFKNQTLE
                     LHVLYGPRLDETDCLGNWTWQEGSQQTLKCQAWGNPSPKMTCRRKADGALLPIGVVKS
                     VKQEMNGTYVCHAFSSHGNVTRNVYLTVLYHSQNNWTIIILVPVLLVIVGLVMAASYV
                     YNRQRKIRIYKLQKAQEEAIKLKGQAPPP"
     exon            163..423
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..738
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1026
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1284
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1533
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..2577
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2555..2560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /note="hexamer: AATAAA"
     polyA_site      2577
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /note="major polyA site"
ORIGIN      
        1 gtgagccaga gactataaaa gcgccgcccg cctcagtctg cacccagtgc tagtgctgag
       61 ctccgctgct acctgcactt tgccctggcc ctgcaatggc ttcaacccgt gccaagccca
      121 cgctacctct gctcctggcc ctggtcaccg ttgtgatccc tgggcctggt gatgctcagg
      181 tatccatcca tcccagagaa gccttcctgc cccagggtgg gtccgtgcag gtgaactgtt
      241 cttcctcatg caaggaggac ctcagcctgg gcttggagac tcagtggctg aaagatgagc
      301 tcgagagtgg acccaactgg aagctgtttg agctgagcga gatcggggag gacagcagtc
      361 cgctgtgctt tgagaactgt ggcaccgtgc agtcgtccgc ttccgctacc atcaccgtgt
      421 attcgtttcc ggagagtgtg gagctgagac ctctgccagc ctggcagcaa gtaggcaagg
      481 acctcaccct gcgctgccac gtggatggtg gagcaccgcg gacccagctc tcagcagtgc
      541 tgctccgtgg ggaggagata ctgagccgcc agccagtggg tgggcacccc aaggacccca
      601 aggagatcac attcacggtg ctggctagca gaggggacca cggagccaat ttctcatgcc
      661 gcacagaact ggatctcagg ccgcaagggc tggcattgtt ctctaatgtc tccgaggcca
      721 ggagcctccg gactttcgat cttccagcta ccatcccaaa gctcgacacc cctgacctcc
      781 tggaggtggg cacccagcag aagttgtttt gctccctgga aggcctgttt cctgcctctg
      841 aagctcggat atacctggag ctgggaggcc agatgccgac ccaggagagc acaaacagca
      901 gtgactctgt gtcagccact gccttggtag aggtgactga ggagttcgac agaaccctgc
      961 cgctgcgctg cgttttggag ctagcggacc agatcctgga gacgcagagg accttaacag
     1021 tctacaactt ttcagctccg gtcctgaccc tgagccagct ggaggtctcg gaagggagcc
     1081 aagtaactgt gaagtgtgaa gcccacagtg ggtcgaaggt ggttcttctg agcggcgtcg
     1141 agcctaggcc acccaccccg caggtccaat tcacactgaa tgccagctcg gaggatcaca
     1201 aacgaagctt cttttgctct gccgctctgg aggtggcggg aaagttcctg tttaaaaacc
     1261 agaccctgga actgcacgtg ctgtatggtc ctcggctgga cgagacggac tgcttgggga
     1321 actggacctg gcaagagggg tctcagcaga ctctgaaatg ccaggcctgg gggaacccat
     1381 ctcctaagat gacctgcaga cggaaggcag atggtgccct gctgcccatc ggggtggtga
     1441 agtctgtcaa acaggagatg aatggtacat acgtgtgcca tgcctttagc tcccatggga
     1501 atgtcaccag gaatgtgtac ctgacagtac tgtaccactc tcaaaataac tggactataa
     1561 tcattctggt gccagtactg ctggtcattg tgggcctcgt gatggcagcc tcttatgttt
     1621 ataaccgcca gagaaagatc aggatataca agttacagaa ggctcaggag gaggccataa
     1681 aactcaaggg acaagcccca cctccctgag cctgctggat gagactcctg cctggacccc
     1741 ctgcagggca acagctgctg ctgcttttga acagaatggt agacagcatt taccctcagc
     1801 cacttcctct ggctgtcaca gaacaggatg gtggcctggg ggatgcacac ttgtagcctc
     1861 agagctaaga ggactcggtg gatggagcaa gactgtgaac acgtgtgacc cggacccacc
     1921 tacagcccgg tggaccttca gccaagaaac gctgacttca ttctctattg cccctgctga
     1981 ggggctcctg cctaaggaag acatgatatc cagtagacac aagcaagaag accacacttc
     2041 cccccgacac aggaaagctg agacattgtc cccaactctt cttgatgtat ttattaattt
     2101 agagttttac cagctattta ttgagtaccc tgtatatagt agatcagtga ggaggtgaat
     2161 gtataagtta tggcctggac cctgctgcag atgctgtgag agtctgggga aagatcacat
     2221 gggtcgaggg tttctctact ggtcaggatg cttttctcat aagggtcgac ttttttcacc
     2281 agtcacataa acactatgtg gactggcagt ggttctctgc tcctccacat cctggagcgt
     2341 cccagcacct ccccacctac ttttgttccc aatgtcagcc accatgcctt agcagctgaa
     2401 caatcgagcc tcatgctcat gaaatcatgg tcccaggcgg ctccacctca aagagaaagc
     2461 ctggaaggaa atgttccaac tccttagaag ggtcgtgcaa gctgctgtgg gagggtaagc
     2521 acccctccca gcacagaaac ctttcctttg aatcaataaa gttttatgtc ggcctgaaaa
     2581 aaaaaaaaaa aaa
//
