LOCUS       NM_027407               3727 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus islet cell autoantigen 1-like (Ica1l), transcript
            variant 1, mRNA.
ACCESSION   NM_027407 XM_203766
VERSION     NM_027407.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   He,J., Xia,M., Tsang,W.H., Chow,K.L. and Xia,J.
  TITLE     ICA1L forms BAR-domain complexes with PICK1 and is crucial for
            acrosome formation in spermiogenesis
  JOURNAL   J Cell Sci 128 (20), 3822-3836 (2015)
   PUBMED   26306493
  REMARK    GeneRIF: ICA1L forms BAR-domain complexes with PICK1 and is crucial
            for acrosome formation in spermiogenesis.
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125377.5.
            
            On Oct 18, 2022 this sequence version replaced NM_027407.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079669.1, AK158859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               AC125377.5         217399-217766       c
            369-537             AC125377.5         202670-202838       c
            538-610             AC125377.5         197180-197252       c
            611-734             AC125377.5         190314-190437       c
            735-933             AC125377.5         188422-188620       c
            934-1059            AC125377.5         184711-184836       c
            1060-1158           AC125377.5         182410-182508       c
            1159-1244           AC125377.5         180836-180921       c
            1245-1294           AC125377.5         178258-178307       c
            1295-1555           AC125377.5         172053-172313       c
            1556-3727           AC125377.5         163670-165841       c
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.45 cM"
     gene            1..3727
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /note="islet cell autoantigen 1-like"
                     /db_xref="GeneID:70375"
                     /db_xref="MGI:MGI:1917625"
     exon            1..368
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            369..537
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1671
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /note="isoform a is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 15; islet cell autoantigen 1-like
                     protein; Ica69-related protein; amyotrophic lateral
                     sclerosis 2 chromosomal region candidate gene 15 protein
                     homolog"
                     /codon_start=1
                     /product="islet cell autoantigen 1-like protein isoform a"
                     /protein_id="NP_081683.3"
                     /db_xref="CCDS:CCDS14987.1"
                     /db_xref="GeneID:70375"
                     /db_xref="MGI:MGI:1917625"
                     /translation="MDSSEQLRAEDNQSVVSRMQKNYWRTKQVFIKATGKKEDEHVVA
                     SDAELDAKLEVFHSIQETCNELVKIVEKYQLRLNVISEEENELGLFLKFQAERDSTQA
                     GEMMDAAGKALCSSAKQRLALCTPLSRLKQEVATFSQRAISDTLVTINRMERARTEYR
                     GALLWMKDASQELDPDTFKQMEKFRKVQNQVRNSKDSFDKLKKDVCQKVDLLGASRCN
                     MLSHSLTTYQRTLLGFWEKTAQMMTQIQEACAGFHPYDFLALKRLQDTPGNLTADCTE
                     GQTEGSCLTTDLNKVALSEEEEEERFEREPAVARALPRDSLEGDDFEKEFSFLNSLLS
                     PTSSSASEFTQECQPACGSPCTGLTSQEPSVGPGSLTSSSQFLPSQLFDLGLHADGAF
                     NTPNNGNQDMSAWFNLFADLGPLSNPDAIGHSDDELLNA"
     exon            538..610
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            611..734
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            735..933
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1059
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1158
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1244
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1294
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1555
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..3727
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /note="hexamer: GATAAA"
     polyA_site      1978
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
     regulatory      2194..2199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /note="hexamer: ATTAAA"
     polyA_site      2216
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /note="hexamer: AATAAA"
     polyA_site      3723
                     /gene="Ica1l"
                     /gene_synonym="1700030B17Rik; Als2cr15; b2b3465Clo"
                     /note="major polyA site"
ORIGIN      
        1 gcgggctcgc gggctcgcgg gcggcggctg ggccggtgcg cggaagagct cagcgcggcc
       61 cgagcggcga ggagcggcgc ggctccggcg gcgcggtgag ggtccggggt ctggccctcc
      121 gctccctcag ggcggcgggc ggcggtggcc aaacctggtt cccatgacga cggcgggcgg
      181 gggcgcgggc cgcgcgctct ccgtgggccg gcctcaggcg gcggcctcgg cggacccgac
      241 ccgtccgcgg cgggggcgtc tcctgcgctc cctccagggg aaggaagccg cggcctgagg
      301 ccggcctggg cgctcccgat acggggcaga tgctcacagc cctgcgtgct ttcctgctgg
      361 ctgcctattt actccatgga ttcctctgag caactcagag cagaagataa ccagtcagta
      421 gtgagcagaa tgcagaagaa ctactggaga actaaacaag tctttatcaa agcgacggga
      481 aagaaggagg acgagcatgt ggttgcatcc gatgcagaac tggacgctaa gttggaggtt
      541 tttcactcca tccaggagac atgcaatgaa cttgtgaaga tagttgagaa ataccagcta
      601 agactcaacg ttatatcaga ggaagaaaat gaactaggac tctttttaaa gtttcaagca
      661 gagcgggatt cgactcaagc tggcgaaatg atggatgctg ctggcaaggc cctctgttct
      721 tcagccaagc aaagattggc cttgtgtact cccctgtctc gtcttaagca agaagtggca
      781 acattcagtc agagggccat ttctgacacc ttggtgacca ttaaccgcat ggagcgggcc
      841 cgcacagagt acagaggagc cctgctgtgg atgaaagatg catcgcagga acttgaccca
      901 gacaccttca aacaaatgga aaagttcaga aaagtacaga atcaagtgag aaacagcaaa
      961 gattcttttg acaagttaaa gaaggatgtc tgccagaaag tggacttgct gggagctagt
     1021 cgctgcaata tgctgtctca ctcactcact acctaccaga gaacactgct tgggttctgg
     1081 gagaaaacag ctcagatgat gacccaaatc caagaggcct gcgctggctt tcatccgtac
     1141 gacttcctgg ctctcaagcg actacaagac actccaggaa atctcactgc agactgcaca
     1201 gagggacaaa cagaaggcag ttgtctcact acagacctca ataaggtagc tttgtctgaa
     1261 gaggaagagg aagagagatt tgaaagagaa ccagcagttg caagagctct gcctagagac
     1321 tcactagaag gagatgattt tgagaaagaa ttctcatttc tgaacagcct cctaagcccc
     1381 acttcttcaa gtgctagtga gtttacacag gaatgccagc ccgcgtgtgg gagcccctgc
     1441 actggcctca catcccagga gccttcagta ggacccgggt ctctcacttc ctcctcacag
     1501 ttccttcctt cacagctctt tgaccttggc cttcacgctg atggagcttt caacaccccc
     1561 aacaatggta accaagacat gtcagcctgg ttcaatctat ttgcagactt gggtccgctc
     1621 tcaaacccag atgccattgg acactcagat gacgagcttc tgaatgcctg attgatgtca
     1681 tggtgactga tgtcacaggt tcaggggtct tgaggctcca accgtgcaac atttaccttt
     1741 ctgaagagaa gttcccactg tgacctcaca cagaagcgtg tatccaagat agaagtctgc
     1801 cagccaactc gtcagattgg tggagcagac tgttgtacat ggataatttt acaaactctt
     1861 gagtctgcag tactgagaaa ccagatttat gtcggaatca cagaagcatg gtgtgtttct
     1921 ttggaaggct ttatacttgt tactttgctg taaggggata aaaacaggat ataaagtggc
     1981 tctggtttgg ggtttttcct tggtagtgtc gggtgttttc tgttgtggag aacagcacta
     2041 gatgtagaaa gtttctcctc aagtacaaca tggaacaaga ttagacaact gtctgtttta
     2101 ctgaaatcag agaaacttgt ttgcttttct gtatctggaa actaaatgca atgttacctt
     2161 tcatacgcaa tcatggatac acttagttcc atcattaaat ttttatgggg aagatagcag
     2221 gatgtaaaat ccattgtttg tagaaactgg aaaaggaatc tacaggcctg ttttcacaaa
     2281 cttcggcagc gcagaacaat gaggaccagc actggcagcc tgaggagcaa ccttgccgaa
     2341 acctgcagaa acttctatgt gaacggcaag acttctgaac acctgtcttt actgcgtatt
     2401 ctaactcatc acatgcttaa cgcagaaggc tggcagacat ggaaaattcc agacagttaa
     2461 ggagcatcct gggttcgtcc ttaaggtcta actctcacgg cgccttctga ttgctaagca
     2521 aaagctactg gcagaggaca tagtttggag ggaaggcagt ggcagttggg tgagctggaa
     2581 atcggctcat ggattgccgc tctctcactt cctgtccttt cttgtccacc ctttaagtca
     2641 ggggtggttt cccacgtgtt cggtcatcca ggccattgtg gctgatgtcc cacaagggac
     2701 attttaatta agttgtttac tgtggttttt atgggcttct agttattagc aggttgattc
     2761 agattgaaat tacatgtaat gtccaagtca tggaatatat agtgagctat ttttaaggag
     2821 taaaccagag tgggtgaatg ctatccactc cacacgccca gcaacctggc ctaaccctgt
     2881 gaactgcccc tgcggtctct agaaagccag tttcaggtca ctggtgcatg ggctgcagat
     2941 tcacttgagg gtcaaaaaca aattcagact tgttcctgaa tatcttagcc ttaatgaact
     3001 attatctctt cagaagcact ttctgtctgt tgagttaaaa tttccagtac acggtacttt
     3061 cattgtgttg ccaagattta tcaccaggat tactattacg agtcacagtc taaggctagt
     3121 gccagtgcaa ccactgccat caacctcaag aaatgatagc ttaggtcgtc tgtgctactc
     3181 ttctttgtga gggtgttctt ccagtgagtt agttcacagt tgtgagaata cagtcagagc
     3241 acttaccaga aagacagatg ctgggaaggc acacattatc ctaggaacaa ctttctcaaa
     3301 gtgggtatct tttatactga gcggggaaac acctatatcc tactttattt tatcccagat
     3361 agcacttcac acaaagttag acaagctcca gcaagccacc tgtcttcttc tcaagagatg
     3421 caagaatgga aggctatgct atcatgtgta atttgtattt tctgagattt taattataca
     3481 atatagctct aatatcatta gaaacaaatt gtatttcaaa aaattagatt tcattattta
     3541 cacatcgaaa ggaatttcca ctttgaatat tcacttcaca ttacctattg ttctggatat
     3601 ttatctcatc cttcctatct cataggtcta gaaatataca gagcttacag cattaagatg
     3661 gtaacttaag tgtgctcttg ctctctcttg agcatctata ataaagacta cagatagcat
     3721 aaagcaa
//
