LOCUS       NM_001410044            1923 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus islet cell autoantigen 1 (Ica1), transcript variant 4,
            mRNA.
ACCESSION   NM_001410044 XM_006504994
VERSION     NM_001410044.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Ji,L., Meng,Z., Dong,X., Wang,Q., Jiang,Y., Zhang,J., Hu,D.,
            Guo,S., Zhou,W. and Song,W.
  TITLE     ICA1 affects APP processing through the PICK1-PKCalpha signaling
            pathway
  JOURNAL   CNS Neurosci Ther 30 (6), e14754 (2024)
   PUBMED   38884369
  REMARK    GeneRIF: ICA1 affects APP processing through the PICK1-PKCalpha
            signaling pathway.
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Chiu,S.L., Chen,C.M. and Huganir,R.L.
  TITLE     ICA69 regulates activity-dependent synaptic strengthening and
            learning and memory
  JOURNAL   Front Mol Neurosci 16, 1171432 (2023)
   PUBMED   37251649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Chen,L., Tao,F., Zhang,Y., Shu,C., Xiang,W., Yang,L., Chen,X.,
            Hong,Y., Chen,B., Li,K., Zhang,W., Hao,K., Ge,F., Wang,Z. and
            Lyu,J.
  TITLE     Islet-cell autoantigen 69 accelerates liver regeneration by
            downregulating Tgfbr1 and attenuating Tgfbeta signaling in mice
  JOURNAL   FEBS Lett 594 (17), 2881-2893 (2020)
   PUBMED   32531799
  REMARK    GeneRIF: Islet-cell autoantigen 69 accelerates liver regeneration
            by downregulating Tgfbr1 and attenuating Tgfbeta signaling in mice.
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Karges,W., Gaedigk,R., Hui,M.F., Cheung,R. and Dosch,H.M.
  TITLE     Molecular cloning of murine ICA69: diabetes-prone mice recognize
            the human autoimmune-epitope, Tep69, conserved in splice variants
            from both species
  JOURNAL   Biochim Biophys Acta 1360 (2), 97-101 (1997)
   PUBMED   9128175
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Gaedigk,R., Karges,W., Hui,M.F., Scherer,S.W. and Dosch,H.M.
  TITLE     Genomic organization and transcript analysis of ICAp69, a target
            antigen in diabetic autoimmunity
  JOURNAL   Genomics 38 (3), 382-391 (1996)
   PUBMED   8975715
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Karges,W., Pietropaolo,M., Ackerley,C.A. and Dosch,H.M.
  TITLE     Gene expression of islet cell antigen p69 in human, mouse, and rat
  JOURNAL   Diabetes 45 (4), 513-521 (1996)
   PUBMED   8603775
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Pietropaolo,M., Castano,L., Babu,S., Buelow,R., Kuo,Y.L.,
            Martin,S., Martin,A., Powers,A.C., Prochazka,M., Naggert,J. et al.
  TITLE     Islet cell autoantigen 69 kD (ICA69). Molecular cloning and
            characterization of a novel diabetes-associated autoantigen
  JOURNAL   J Clin Invest 92 (1), 359-371 (1993)
   PUBMED   8326004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158670.5.
            
            On Jul 26, 2022 this sequence version replaced XM_006504994.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4097393.1,
                                           SRR13948564.2771072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC158670.5         214864-214946       c
            84-261              AC158670.5         213839-214016       c
            262-354             AC158670.5         195158-195250       c
            355-517             AC158670.5         191381-191543       c
            518-590             AC158670.5         186487-186559       c
            591-714             AC158670.5         179047-179170       c
            715-913             AC158670.5         173809-174007       c
            914-1039            AC158670.5         109090-109215       c
            1040-1138           AC158670.5         107486-107584       c
            1139-1233           AC158670.5         95012-95106         c
            1234-1280           AC158670.5         93154-93200         c
            1281-1343           AC158670.5         90422-90484         c
            1344-1382           AC158670.5         90289-90327         c
            1383-1652           AC158670.5         80765-81034         c
            1653-1923           AC158670.5         67319-67589         c
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 4.38 cM"
     gene            1..1923
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /note="islet cell autoantigen 1"
                     /db_xref="GeneID:15893"
                     /db_xref="MGI:MGI:96391"
     exon            1..83
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            84..261
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            262..354
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1774
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /note="isoform 1 is encoded by transcript variant 4; p69;
                     ICAp69; islet cell autoantigen p69; 69 kDa islet cell
                     autoantigen; islet cell autoantigen 1, 69 kDa"
                     /codon_start=1
                     /product="islet cell autoantigen 1 isoform 1"
                     /protein_id="NP_001396973.1"
                     /db_xref="GeneID:15893"
                     /db_xref="MGI:MGI:96391"
                     /translation="MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKE
                     DEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGF
                     QDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQ
                     YRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLL
                     GASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKL
                     VEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTC
                     SGPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAV
                     FGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAW
                     FSLFADLDPLSNPDAVGKTDKEHELLNA"
     exon            355..517
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            518..590
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            591..714
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            715..913
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1039
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1138
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1233
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1280
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1343
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1382
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1652
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1923
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /note="hexamer: AATAAA"
     polyA_site      1923
                     /gene="Ica1"
                     /gene_synonym="69kDa; ICA69"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgacg ctgacgtcgg cgcagggagc tggagggacg ctaggatctc cgccgggagg
       61 ctcctggggg ccggagcacc aagatagcat tgaatctagc acaagaaggg tttatccatc
      121 aacctgagca gctgctaact aaacattcca tggacctgga aaagacatca ccagctggtt
      181 tgaaaatggt tatgaatgga ggaagacaca tggagtattt gctgaccatt atggttcttt
      241 aagcgataac ttactgcatg tgtttaatat aacatatcct atcatgattt ttctctgccc
      301 cttctcaaat catcggcagt agaaaagaga agaaaacatg tcaggacaca aatgttattc
      361 ctgggagttg caggaccggt ttgctcaaga taagtcagtt gtcaataaga tgcagcagaa
      421 atattgggag accaagcagg cctttatcaa agccacgggg aagaaggaag atgaacatgt
      481 ggttgcttct gatgcagacc tggatgccaa gctggagctg tttcactcaa tccagagaac
      541 ctgcctggac ttgtctaaag caatcgtgct ctatcaaaag agaatatgtt tcttgtctca
      601 agaggaaaat gaactgggaa agtttcttcg atctcaaggc ttccaagaca aaacccgagc
      661 aggaaaaatg atgcaagcca cgggcaaggc cctctgcttt tcctcccagc aaaggttggc
      721 cttgagaaac cctttgtgtc gatttcacca agaagtagaa acttttagac atcgggccat
      781 ctctgatacc tggctgacag tgaaccgcat ggagcagtac aggacagaat acagaggagc
      841 gttgttgtgg atgaaggatg tgtctcagga acttgatcca gacctctaca agcaaatgga
      901 gaagttcagg aaggtgcaga cacaagtccg ccttgcgaaa aaaaactttg acaagttgaa
      961 gatggatgtg tgtcaaaagg tggatcttct tggagcaagc agatgtaacc tcttatctca
     1021 catgctagca acataccaga ccactctgct ccacttttgg gagaaaactt ctcacaccat
     1081 ggcagccatt catgagagct tcaaaggtta tcaaccatat gaattcacaa cgttaaagag
     1141 cttacaagac cccatgaaga agctagttga gaaagaaggg aagaagacct cctggaggga
     1201 aaaccgggag gctgtggcac cagagccgag gcagttaatt tctttggagg atgagcacaa
     1261 agattcatct gcttataaga ctgaagaggg aacaagcgtt ttgtcttccg tagacaaagg
     1321 ttctgtacat gacacatgct caggacccat agatgaacta ttagacggga aacccgagga
     1381 agcgtgcctg ggtcccacgg cagggacccc agaacctgaa agtggggaca aggatgacct
     1441 cttgctgttg aatgagatct tcagcacttc ctgcctggat gagggagagt tcagcagaga
     1501 gtgggctgca gtgtttggag atgaccagct aaaggagcca gcacccatgg gggcccaagg
     1561 agagccagac cccaagcccc agataggctc cggattcctt ccgtcacagc ttttagacca
     1621 aaatatgaaa gatctccagg cctctctgca agagcctgcc aaggctgcct cggacctgac
     1681 tgcctggttc agcctctttg ctgacctcga ccccttatca aaccctgatg ctgttgggaa
     1741 aactgataaa gaacacgaat tgctcaatgc atgagtctgc aaccttcaac agggagccct
     1801 cgggccactc cgcggcacct catccagggc ttgcagaagt ctaatatgct cagtgtgctg
     1861 ttttaatatt tacatgccat tttaataaaa tgagagggtc aaggccctgt ttctatcgct
     1921 ata
//
