LOCUS       NM_001081282            5679 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus inhibitor of Bruton agammaglobulinemia tyrosine kinase
            (Ibtk), transcript variant 1, mRNA.
ACCESSION   NM_001081282 XM_884665
VERSION     NM_001081282.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5679)
  AUTHORS   Vecchio,E., Fiume,G., Mignogna,C., Iaccino,E., Mimmi,S.,
            Maisano,D., Trapasso,F. and Quinto,I.
  TITLE     IBTK Haploinsufficiency Affects the Tumor Microenvironment of
            Myc-Driven Lymphoma in E-myc Mice
  JOURNAL   Int J Mol Sci 21 (3), 885 (2020)
   PUBMED   32019112
  REMARK    GeneRIF: IBTK Haploinsufficiency Affects the Tumor Microenvironment
            of Myc-Driven Lymphoma in E-myc Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5679)
  AUTHORS   Vecchio,E., Golino,G., Pisano,A., Albano,F., Falcone,C., Ceglia,S.,
            Iaccino,E., Mimmi,S., Fiume,G., Giurato,G., Britti,D., Scala,G. and
            Quinto,I.
  TITLE     IBTK contributes to B-cell lymphomagenesis in Emu-myc transgenic
            mice conferring resistance to apoptosis
  JOURNAL   Cell Death Dis 10 (4), 320 (2019)
   PUBMED   30975981
  REMARK    GeneRIF: Ibtk sustains the oncogenic activity of Myc by inhibiting
            apoptosis of murine pre-cancerous B cells, as a cell-specific
            mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5679)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5679)
  AUTHORS   Janda,E., Palmieri,C., Pisano,A., Pontoriero,M., Iaccino,E.,
            Falcone,C., Fiume,G., Gaspari,M., Nevolo,M., Di Salle,E., Rossi,A.,
            De Laurentiis,A., Greco,A., Di Napoli,D., Verheij,E., Britti,D.,
            Lavecchia,L., Quinto,I. and Scala,G.
  TITLE     Btk regulation in human and mouse B cells via protein kinase C
            phosphorylation of IBtkgamma
  JOURNAL   Blood 117 (24), 6520-6531 (2011)
   PUBMED   21482705
REFERENCE   6  (bases 1 to 5679)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 5679)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   8  (bases 1 to 5679)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 5679)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 5679)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB639555.1, BC137798.1, AK031796.1 and BP760552.1.
            
            On Dec 9, 2010 this sequence version replaced NM_001081282.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137798.1, SRR10223971.9530.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BB639555.1         3-113
            112-4482            BC137798.1         1-4371
            4483-5453           AK031796.1         2284-3254
            5454-5679           BP760552.1         28-253              c
FEATURES             Location/Qualifiers
     source          1..5679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.34 cM"
     gene            1..5679
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /note="inhibitor of Bruton agammaglobulinemia tyrosine
                     kinase"
                     /db_xref="GeneID:108837"
                     /db_xref="MGI:MGI:1918677"
     exon            1..204
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            205..889
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..4627
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of Bruton tyrosine kinase"
                     /codon_start=1
                     /product="inhibitor of Bruton tyrosine kinase isoform 1"
                     /protein_id="NP_001074751.1"
                     /db_xref="CCDS:CCDS40712.1"
                     /db_xref="GeneID:108837"
                     /db_xref="MGI:MGI:1918677"
                     /translation="MDAATPDCTSKCRSLKHALDVLSVVTKGSESQIKSFLARYCYNA
                     ATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKESGWTALHRSVFYGHIDCV
                     WSLLKHGVSLYMQDKEGLSPLDLLMKDRPTHVVFKDTDPTEVYTWGDNTNFTLGHGSQ
                     NSKHHPELLDLFSRSGVYVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCL
                     VPRLVEGLSGHNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPASCNVPRQI
                     QAKYLKGRTIIGVAAGRFHTVLWTREAVYTLGLNGGQLGHLLDPNGEKCVTTPRQVSA
                     LHHKDIAVSLVAASDGATVCVTTRGDIYLLADYQCKKMATKQLNLKKVLVSGGCMEYK
                     VDPEHLTENGGQKICVLAMDGAGRVFCWRSISSSLKQCRWAYPRQVSISDIALNRNEI
                     LFVTQDGEGFKGKWFEDKRKNSEKKADILPNLHHSSSDVSCVPDTNSVYERIRLEKLP
                     FAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPVVSSSSFFEEFGKLLRETDEMDSFHD
                     VTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGCHLFVVEKV
                     HPDLFEYLLQFMYTDTCDLLTHGFKPRMIVKRKAEDCEGSPDSHLHTVNCHVDDKQKS
                     AFEVYRSNQAHTLSERQKSKPKSSKKGKGVGDDDPVRMLQSVAKKFGLSNLSSRLEGV
                     RLENEKINVIAKKTGNKLKLSQKKCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSM
                     LSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVDFVCSVLVVADQLL
                     ITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLD
                     VLSEDVLKDLSIFYRKMIPAMERRVITPYQDGPDISSMQVEDGEVFFKEEINMEPNYS
                     ETMFKKAKTRAKKKPRKRSDSSGGYTLSDVIQSPPSAGLLKSAKTNSVESLPELLTSD
                     SEGSYAGVASPRDLQSPDFTAGFHSDKVEGKAKPYVNGIPPPCTREDVKPWEKSPTTK
                     SAPQFIPSNRVDTAASSSWLAGSCSPVSPPVVDLRTIMETEENRQKYGAAPKSNLGKI
                     ISHGIKLSQKQRKMIALTTKENNSGTNSMEAILTAPSKSPKPANAWAPLHSPLSRSFR
                     DFLLEEKKPVPGYGSGDHVKKVCFKGTENSPALNVARCSTHGTPGLESNHVSDFPLLD
                     SPNPWQSSSLAASPAVAPVTFASIVEEERQQEAALIRSREKPLALIQVEEHAIQDLLV
                     FYEAFGNPEEFVVVERAPQGPLAVPMWNKHGC"
     exon            890..986
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1111
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1222
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1393
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1511
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1692
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1816
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1994
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2172
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2775
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2862
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2945
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..2983
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3080
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3182
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3300
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3361
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3483
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3596
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3745
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3906
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..3999
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4143
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4290
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4362
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4495
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..5650
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5630..5635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /note="hexamer: AATAAA"
     polyA_site      5650
                     /gene="Ibtk"
                     /gene_synonym="5430411K16Rik; BTKI; mKIAA1417"
                     /note="major polyA site"
ORIGIN      
        1 gctctagctc aggtttcccc gaacccggtc ccggcgccga cagtcgcggc tgtcgctttc
       61 cgtgcagccg tccccggagc tgactcgggc gtcccggctc ctggctccct tcgttgtccc
      121 cggtagcttt cactaaggat gagtccctgc gcggccgcgc gcctgccccg cggagaccgc
      181 cggcgcacct tcatctagcg actggtcacc ctcgcaatta tggctatttg aaaggctcag
      241 acagtgtgga gggggagttc ccctcctcac tcccccttgg tgcttgactc caggaataat
      301 ttataaactg ggattatttt ttaaatgaag aacttgtatt tgatatgaac tttatagaat
      361 tatttataaa tttttgattt aagtgccaaa agattataca gagatatata gttttatata
      421 attgttgtga ctacttaaat tataaccccc aaagggccat ctcttcttga aattcttcct
      481 gaatagtacc tttgcgtctt ggctttttca cttttaaaat ttacttcggt gactgttctg
      541 aaggagtaag caatataaag cagttaggat ggatgctgcc acccccgact gcacgtcaaa
      601 atgcagatcc ctgaagcatg cgctggatgt cctttctgtg gtgacaaagg ggagtgagag
      661 ccagatcaag tccttcctcg ccaggtactg ctacaatgct gcaactgtca aggatgcctt
      721 tggcaggaac gccggccacc tggcttcctc ctgcgggaag aaaggagtgt tggactggct
      781 gattgagaaa ggagtggact tgctggtgaa agacaaggag tccggctgga cagcactgca
      841 cagaagcgtt ttttatggac atatcgattg tgtttggtct ctgttgaagc atggtgttag
      901 cttgtatatg caagataaag aaggattgtc acctttggat cttcttatga aggacaggcc
      961 aactcatgtt gtatttaagg acactgatcc cacagaagtc tatacttggg gagataacac
     1021 aaacttcact ctgggccacg gaagccagaa tagcaaacat caccccgagc tgctggacct
     1081 gttctccagg agtggggttt atgtcaagca ggtggtgctt tgcaaatttc attcggtgtt
     1141 tctgtcccag aaagggcagg tttacacctg tggccatggt cgcggaggac ggttaggcca
     1201 tggagatgaa cagacatgct tggttcccag gcttgtggaa ggactgtctg gtcacaattg
     1261 ttcgcaagtg gcagctgcta aggatcacac tgttgtgtta actgatgatg gatgtgtcta
     1321 tacatttggt ctcaacatgt ttcaccaatt aggaattatt cctccacctg ctagttgtaa
     1381 tgtacccaga cagatacagg caaaatatct gaaaggaagg actatcattg gagtagcagc
     1441 gggcaggttt catacggtgc tgtggactcg agaagccgtt tacacactgg gactgaatgg
     1501 tggacagttg ggtcacttac tggatcccaa tggtgaaaag tgtgtcacaa cccctcgcca
     1561 agtctctgcc cttcatcaca aggatatcgc tgtgtctttg gtagctgcaa gtgatggtgc
     1621 cacagtctgt gtcaccacaa ggggagacat ttacttactt gcagactatc agtgcaagaa
     1681 gatggcaact aaacaactga acttgaaaaa ggttcttgtc tctggaggtt gtatggaata
     1741 caaggttgat cctgaacatt tgacagaaaa tggaggtcag aaaatatgtg tcctcgctat
     1801 ggatggagct ggaagggtgt tttgctggag atcaatcagc agttctctga agcagtgccg
     1861 atgggcctat cctcgccagg tgtcaatctc cgatattgct ttaaatagaa atgaaattct
     1921 gtttgtcaca caggatgggg aaggatttaa agggaaatgg tttgaagaca aaagaaagaa
     1981 ttctgaaaag aaagcagaca ttttaccaaa cctccatcat tcctcatcag atgtgtcttg
     2041 tgtccctgat acaaatagtg tgtatgaaag aattcgactt gagaaacttc cttttgccca
     2101 tagagctgtt agtgtcagca cagatccaag tgggtgcaac tttgcaatcc tacagtcaga
     2161 ccctaaaaca agcctttatg agattccagt tgtgtcttca tcatcttttt ttgaagaatt
     2221 tggcaagctc ctgagggaga cagatgaaat ggacagcttc cacgatgtga cctttcaagt
     2281 tggcaataga cacttccccg cacataaata cattttggcc gtgcgctctg acttcttcca
     2341 gaagttgttt ctttcagatg gctcttcttt agagctgacg gatgtttacc agaaagacga
     2401 agatgctgct ggctgccatc tctttgtggt ggagaaagtc catcctgact tgttcgaata
     2461 cctcttacag ttcatgtaca cagatacctg tgacttgtta actcatggct tcaaaccaag
     2521 aatgatcgtg aagagaaagg cagaagactg tgagggctcc ccagattctc atctgcacac
     2581 tgtgaattgc catgtggatg ataaacagaa gtcagcattt gaggtgtaca gaagcaacca
     2641 ggcccacaca cttagtgaac ggcagaagag caaacccaaa tcttctaaga agggaaaagg
     2701 tgttggggac gacgaccctg taaggatgtt gcaaagtgtt gctaagaagt ttggcctcag
     2761 taatttgagt agcaggttag aaggagtcag attggaaaat gaaaaaatta atgttattgc
     2821 gaagaaaact ggcaataaac tgaagctaag tcagaaaaaa tgttcgtttc tgtatgatgt
     2881 caccatgaag tctgtggatg gaaaggagtt ctcctgccat aagtgtgtgc tctgtgcgag
     2941 acttgagtat ttccacagca tgcttagcag atcgtggatt gaggcctcca gctgtgcagc
     3001 tctggaaatg ccaatccagt ctgagattct gaaagtgatt ttggactacc tctacactga
     3061 tgaggctgtg gtgataaaag agtctcaaaa cgtggacttt gtttgtagtg ttcttgtcgt
     3121 ggctgatcag cttctcataa ctcggttaaa ggagatttgt gaagtagcat tgactgaaaa
     3181 ccttaccctt aagaatgctg cgatgctgct ggagtttgca gccttgtaca atgctgggca
     3241 gttgaagctc tcttgtttac agttcatagg actgaatatg gcagctttac ttgaagcaag
     3301 gtctctggat gttttaagtg aggatgtttt gaaggacctt tccatattct acagaaaaat
     3361 gattccagca atggagagaa gagtcattac accgtatcaa gatgggccag atattagctc
     3421 tatgcaagta gaagacggag aggtcttttt taaagaagaa ataaacatgg aaccaaatta
     3481 ctcggaaact atgttcaaga aggcgaaaac aagagctaaa aagaagccac ggaagcgctc
     3541 agacagttca ggaggctaca ccctttcaga tgttatccag agtccaccgt ctgcaggatt
     3601 attaaagtct gcaaagacca attctgtgga gtctcttcca gaattgttga cctcagattc
     3661 ggaaggaagc tatgcaggag tggcgagtcc cagagacctc cagtcgcccg acttcacagc
     3721 aggattccat tcggataagg tcgaggggaa agctaagcca tacgtgaatg gtatacctcc
     3781 tccatgtact agggaagatg taaagccgtg ggagaaatca ccaacaacta agtctgctcc
     3841 ccagttcatc cccagtaaca gagtggacac tgcagcctct tccagttggc ttgccggctc
     3901 ttgcagtcct gtgagtcctc ctgttgtgga tcttagaacc atcatggaaa cagaagaaaa
     3961 cagacagaaa tatggcgcag caccaaagtc aaacttagga aagattattt ctcacggaat
     4021 caaactttct cagaagcaac ggaaaatgat tgcattgacc accaaagaaa acaattcagg
     4081 aacgaacagc atggaagcca ttttgacagc tccttccaag tcccccaagc ctgcgaatgc
     4141 atgggcacct ctgcactcac ctttatccag gtcattccgg gattttttac tagaagaaaa
     4201 aaaacccgtt cctggctatg gttcaggaga tcatgtcaaa aaagtttgtt ttaaaggaac
     4261 tgaaaactct ccagccctaa atgttgcaag atgttcaacc catggaactc caggattaga
     4321 aagcaatcat gtttctgatt ttccacttct agacagtccc aacccctggc agtcttcctc
     4381 cctggcggct tctcccgcag ttgctccagt cacatttgca tccattgtag aagaagagcg
     4441 gcaacaagaa gctgccctca tcagaagccg ggagaaaccc ttggctctca ttcaggtcga
     4501 ggagcatgca atacaagact tgctggtttt ctatgaggca tttggcaacc ccgaggagtt
     4561 tgtcgtcgtt gaaagggcac cacaggggcc tctggcagtg cctatgtgga acaagcatgg
     4621 ctgctagctc cctggagagg gtgctgctcc ccgaatgtgg ttgctccacc cacatgaaga
     4681 aaacgcatgt gcaagcgttc ttacagattt gttagcacat tgttgtagtc agagcaagaa
     4741 tggatatgat ttttttttcc tgtagtttat aatgtttgta tgactaatga gaaatttatc
     4801 agaattgtga ttttagaact ttcatgtgaa aatgtgtcag gaaaaatgtt aggctaaggt
     4861 tggttggatt gtttcttcta aattacctaa gaaaaatgtg agtgaaagat gaagcttagg
     4921 aataattcat gaaacataca tttttcactt gagactgtgg ggtgattatt ctagaagagc
     4981 ttgccgcata agatgttatg ttaaataaga cgttgatgaa cttaaggcag gagcctcaat
     5041 cattacttct gatcactgat ggccagaatg ttgtgtttgc ctgaggagat gtgtctctgt
     5101 tgttgctttg tcactgggct gctaacttct taggcctctt tacagttgct ggacagttta
     5161 tggccatagc gtctgtggga tatttggatt cgtagatttt cttttgttgg gctgggaagg
     5221 tagcaagaga ggacagacct ttgaattcct aattgtgaaa gaatcggttt cttaaggttt
     5281 ctacaaacaa gcgtaagatt actgaagagt ttaccacagt ggttgtttat aattactttt
     5341 tagtctgtgt aatcagaatt tctgtgagcc tgcattatat gtatacatgg acattttgat
     5401 tattccttta tagtatgctg tttggtttga ttttgaatgt ttaaaattaa aggaaaaaaa
     5461 atttaaaatg tgtgtttcag tctgtagagc aaatgagaat gtgaatgctt aagttctggg
     5521 aaagaatcca tggcgatagg ttggcagctt gacttgagct gatgggaaat tgttgaaagt
     5581 aacaaactca gtgtttcagt tcagttccac ccacaagcag cagacgtgca ataaaagtaa
     5641 agtcaatcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
