LOCUS       NM_008318               1955 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus integrin binding sialoprotein (Ibsp), mRNA.
ACCESSION   NM_008318 XM_003689386 XM_006543982 XM_908826
VERSION     NM_008318.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Xu,Z., Wang,W., Yang,T., Li,L., Ma,X., Chen,J., Wang,J., Huang,Y.,
            Gould,J., Lu,H., Du,W., Sahu,S.K., Yang,F., Li,Z., Hu,Q., Hua,C.,
            Hu,S., Liu,Y., Cai,J., You,L., Zhang,Y., Li,Y., Zeng,W., Chen,A.,
            Wang,B., Liu,L., Chen,F., Ma,K., Xu,X. and Wei,X.
  TITLE     STOmicsDB: a comprehensive database for spatial transcriptomics
            data sharing, analysis and visualization
  JOURNAL   Nucleic Acids Res 52 (D1), D1053-D1061 (2024)
   PUBMED   37953328
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Roth,C.E., Niederau,C., Radermacher,C., Rizk,M., Neuss,S.,
            Jankowski,J., Apel,C., Craveiro,R.B. and Wolf,M.
  TITLE     Knockout of bone sialoprotein in cementoblasts cell lines affects
            specific gene expression in unstimulated and mechanically
            stimulated conditions
  JOURNAL   Ann Anat 249, 152102 (2023)
   PUBMED   37150306
  REMARK    GeneRIF: Knockout of bone sialoprotein in cementoblasts cell lines
            affects specific gene expression in unstimulated and mechanically
            stimulated conditions.
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Suh,J., Kim,N.K., Shim,W., Lee,S.H., Kim,H.J., Moon,E., Sesaki,H.,
            Jang,J.H., Kim,J.E. and Lee,Y.S.
  TITLE     Mitochondrial fragmentation and donut formation enhance
            mitochondrial secretion to promote osteogenesis
  JOURNAL   Cell Metab 35 (2), 345-360 (2023)
   PUBMED   36754021
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Gorski,J.L., Estrada,L., Hu,C. and Liu,Z.
  TITLE     Skeletal-specific expression of Fgd1 during bone formation and
            skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome)
  JOURNAL   Dev Dyn 218 (4), 573-586 (2000)
   PUBMED   10906777
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Satokata,I., Ma,L., Ohshima,H., Bei,M., Woo,I., Nishizawa,K.,
            Maeda,T., Takano,Y., Uchiyama,M., Heaney,S., Peters,H., Tang,Z.,
            Maxson,R. and Maas,R.
  TITLE     Msx2 deficiency in mice causes pleiotropic defects in bone growth
            and ectodermal organ formation
  JOURNAL   Nat Genet 24 (4), 391-395 (2000)
   PUBMED   10742104
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Rice,D.P., Kim,H.J. and Thesleff,I.
  TITLE     Apoptosis in murine calvarial bone and suture development
  JOURNAL   Eur J Oral Sci 107 (4), 265-275 (1999)
   PUBMED   10467942
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Crosby,A.H., Lyu,M.S., Lin,K., McBride,O.W., Kerr,J.M., Aplin,H.M.,
            Fisher,L.W., Young,M.F., Kozak,C.A. and Dixon,M.J.
  TITLE     Mapping of the human and mouse bone sialoprotein and osteopontin
            loci
  JOURNAL   Mamm Genome 7 (2), 149-151 (1996)
   PUBMED   8835534
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   Begue-Kirn,C., Smith,A.J., Loriot,M., Kupferle,C., Ruch,J.V. and
            Lesot,H.
  TITLE     Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin,
            osteonectin and bone sialoprotein gene expression during normal and
            in vitro-induced odontoblast differentiation
  JOURNAL   Int J Dev Biol 38 (3), 405-420 (1994)
   PUBMED   7848824
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Young,M.F., Ibaraki,K., Kerr,J.M., Lyu,M.S. and Kozak,C.A.
  TITLE     Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and
            genetic mapping
  JOURNAL   Mamm Genome 5 (2), 108-111 (1994)
   PUBMED   8180469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122775.15, AK132371.1 and BB373876.1.
            
            On or before Jan 5, 2014 this sequence version replaced
            XM_006543982.1, XM_003689386.2, NM_008318.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045143.1, AK132371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC122775.15        109444-109445
            3-1948              AK132371.1         2-1947
            1949-1955           BB373876.1         255-261
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..1955
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /note="integrin binding sialoprotein"
                     /db_xref="GeneID:15891"
                     /db_xref="MGI:MGI:96389"
     exon            1..68
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     exon            69..135
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1056
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /note="bone sialoprotein 2; cell-binding sialoprotein;
                     bone sialoprotein II"
                     /codon_start=1
                     /product="integrin-binding sialoprotein precursor"
                     /protein_id="NP_032344.2"
                     /db_xref="CCDS:CCDS19485.1"
                     /db_xref="GeneID:15891"
                     /db_xref="MGI:MGI:96389"
                     /translation="MKTALILLSILGMACAFSMKNFHRRIKAEDSEENGVFKYRPRYF
                     LYKHAYFYPPLKRFPVQGGSDSSEENGDGDSSEEEGEEEETSNEEENNEDSEGNEDQE
                     AEAENSTLSTLSGVTASYGAETTPQAQTFELAALQLPKKAGDAESRAPKVKESDEEEE
                     EEEEEEENENEEAEVDENELAVNGTSTNSTEVDGGNGSSGGDNGEEAEAEEASVTEAG
                     AEGTTGGRELTSVGTQTAVLLNGFQQTTPPPEAYGTTSPPIRKSSTVEYGGEYEQTGN
                     EYNNEYEVYDNENGEPRGDTYRAYEDEYSYYKGHGYEGYEGQNYYYHQ"
     exon            136..186
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     exon            187..264
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     exon            265..330
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     exon            331..504
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1955
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /note="hexamer: AATAAA"
     polyA_site      1947
                     /gene="Ibsp"
                     /gene_synonym="BSP; BSP II; Bsp2; BSPII"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtgaca gccgggagaa caatccgtgc cactcactcg agccaggact gccgaaagga
       61 aggttaagaa gaaattgcaa aatgaagact gctttaattt tgctcagcat tttgggaatg
      121 gcctgtgctt tctcgatgaa aaatttccat cgaagaatca aagcagagga ttctgaagaa
      181 aacggggtct ttaagtaccg gccacgctac tttctttata agcatgccta cttttatcct
      241 cctctgaaac ggtttccagt ccagggaggc agtgactctt cagaagaaaa tggagacggc
      301 gatagttccg aagaggaggg ggaggaagag gagacttcaa acgaagagga aaacaatgaa
      361 gattctgagg ggaatgaaga ccaggaggcg gaggcagaga actccacact ttccacactc
      421 tcgggtgtaa cagctagcta cggagcagag accacacccc aagcacagac ttttgagtta
      481 gcggcactcc aactgcccaa gaaggctgga gatgcagaaa gcagggctcc aaaagtgaag
      541 gaaagcgacg aggaagaaga agaagaagag gaagaggaag aaaatgagaa cgaagaagca
      601 gaagtggatg aaaacgagct ggcggtcaac ggcaccagca ccaactccac ggaggtggat
      661 ggcgggaatg gcagcagcgg aggagacaac ggagaagaag ccgaagcaga ggaggcaagc
      721 gtcactgaag caggtgcaga aggaaccaca gggggcaggg aactgaccag tgttggcacc
      781 cagacagctg tccttctgaa cgggtttcag cagacaaccc caccgcccga agcctatggg
      841 accacctcgc caccgatcag aaaaagcagc accgttgagt atgggggaga atacgaacaa
      901 acaggcaacg aatacaacaa tgagtatgaa gtctatgaca acgagaacgg ggagcctcgt
      961 ggcgacactt accgagctta tgaggatgaa tacagctact acaaggggca tggctatgaa
     1021 ggctacgagg gtcagaatta ttactaccat cagtgaagcc ccctccccgg ggggaatttc
     1081 cccatttgaa ttccccattc tgtcttatca tctggctacc attttcaaaa ttcaactcag
     1141 gaaggtgcaa tataacagat gtgcatttta tagtgtggaa tggtgctaca gccccagagt
     1201 gatttccgca aatgcttttg tttgtagtgg gcttcttctt taaaaaaaac aaatttccca
     1261 ggtgtgtcat tgaagagtct tagtaaatca gggctattga tcaagcagca cacagatcta
     1321 tgagctggga ctagatggat actttgggat tatagctcta tagtgtttgt gctattgcta
     1381 actgcgcaaa cataccctgt ataagaaggc tcctaatgag agatttatta acaacactat
     1441 atatgatgtg tgacgttcct ttatcacacc ccctatctaa tactgtatta ggtttaattt
     1501 gcatcctcat gtattttatg taacctgtgc acatgcattt ttatcacaaa taaatatgca
     1561 atctttcaca tgtgttataa ttaagaagaa agagatttag aatgagtgtg ggtttaagga
     1621 gcagggaaca attcagctaa aaagcaacac ttatttccat cagggtttta aactcagagg
     1681 atctggaagc attctttctt caatacatct gaatggctaa ggtttgacta aggagggcac
     1741 agtcactgta tacaggagga agtaaatgtc tccccttaaa gttgccagat ttaacaagca
     1801 tgaatacatg ttataagatg cccacttcag tttgaattcc agataaacaa taagtggctt
     1861 ttaatacaac ccctcccccc atgaatgatt tgtctctgtg aaacatctgg aacaaactta
     1921 tgctaaataa atgacttatt ctttatctaa tattc
//
