LOCUS       NM_173785               4027 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus IBA57 homolog, iron-sulfur cluster assembly (Iba57),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173785 XR_035351
VERSION     NM_173785.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4027)
  AUTHORS   Waller,J.C., Alvarez,S., Naponelli,V., Lara-Nunez,A., Blaby,I.K.,
            Da Silva,V., Ziemak,M.J., Vickers,T.J., Beverley,S.M., Edison,A.S.,
            Rocca,J.R., Gregory,J.F. 3rd, de Crecy-Lagard,V. and Hanson,A.D.
  TITLE     A role for tetrahydrofolates in the metabolism of iron-sulfur
            clusters in all domains of life
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10412-10417 (2010)
   PUBMED   20489182
  REMARK    GeneRIF: Mouse COG0354 represents an ancient, folate-dependent
            protein family involved in the metabolism of Fe/S cluster
            containing enzymes
REFERENCE   2  (bases 1 to 4027)
  AUTHORS   Nilsson,R., Schultz,I.J., Pierce,E.L., Soltis,K.A.,
            Naranuntarat,A., Ward,D.M., Baughman,J.M., Paradkar,P.N.,
            Kingsley,P.D., Culotta,V.C., Kaplan,J., Palis,J., Paw,B.H. and
            Mootha,V.K.
  TITLE     Discovery of genes essential for heme biosynthesis through
            large-scale gene expression analysis
  JOURNAL   Cell Metab 10 (2), 119-130 (2009)
   PUBMED   19656490
  REMARK    GeneRIF: Required for functional heme biosynthesis in erythroid
            cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645854.10 and AK133203.1.
            
            On Aug 1, 2012 this sequence version replaced NM_173785.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133203.1, BC094909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL645854.10        147086-147088       c
            4-3451              AK133203.1         2-3449
            3452-3452           AL645854.10        139287-139287       c
            3453-4027           AK133203.1         3451-4025
FEATURES             Location/Qualifiers
     source          1..4027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.97 cM"
     gene            1..4027
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /note="IBA57 homolog, iron-sulfur cluster assembly"
                     /db_xref="GeneID:216792"
                     /db_xref="MGI:MGI:3041174"
     exon            1..395
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1131
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; putative transferase C1orf69 homolog,
                     mitochondrial; putative transferase CAF17 homolog,
                     mitochondrial; iron-sulfur cluster assembly factor
                     homolog; IBA57, iron-sulfur cluster assembly homolog"
                     /codon_start=1
                     /product="putative transferase CAF17 homolog,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_776146.1"
                     /db_xref="CCDS:CCDS24758.1"
                     /db_xref="GeneID:216792"
                     /db_xref="MGI:MGI:3041174"
                     /translation="MAAVALLRGAAVGRRSPAWHWRLSGTASHCLARGFGLLGSNPAD
                     GVAWTCFRLDGRALVRVRGPDAAPFLLGLSTNELPLSGPPTGAAQPSARAAYAHFLNV
                     QGRTLYDVILYGLPECTEGAPSFLLECDSSVLGALQKHLSMYKIRRKVTVEPSPELHV
                     WAVLPCVPQTSETAPLEERVEGTTMLIRDPRTARMGWRLLTQDDGPALVPRGQLGDLQ
                     DYHKYRYQQGIPEGVCDLPPGMALPLESNLVFMNGVSFTKGCYIGQELTARTHHTGVI
                     RKRLFPVKLEGPLPASGVSPGAIVTVTATGQAAGKFRAGQGHVGLALLRSETIKGPLH
                     IKTSESQLVAVTAVVPDWWPTAAK"
     exon            396..736
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /inference="alignment:Splign:2.1.0"
     exon            737..4027
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1713
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /note="hexamer: AGTAAA"
     polyA_site      1970
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
                     /note="major polyA site"
     polyA_site      2178
                     /gene="Iba57"
                     /gene_synonym="4930543L23Rik; A230051G13Rik; C1orf69"
ORIGIN      
        1 gccgccgccg ccgcccgggg ccgctgtggt gcccgccttc acttagcgcc caagatggca
       61 gcggtggcgc tgcttcgggg cgcggctgtg gggcgcagaa gcccagcttg gcactggcgg
      121 ctgagcggga ccgcgagtca ctgcctagcc cgtggctttg gccttcttgg cagcaacccc
      181 gcggacggtg tggcctggac ttgcttccgg ctggacgggc gcgccttagt gcgcgtgcgc
      241 ggcccggacg ctgcaccctt cctgttggga ctatcgacca atgagctgcc gctttcgggg
      301 cctccgaccg gcgcggctca gccctctgcg cgtgcggcgt atgcccattt cctgaatgtg
      361 cagggacgca cgctctatga cgtcattctg tatggactcc cagagtgtac ggagggggca
      421 ccaagctttc tcctggagtg tgacagctcc gtgctgggcg ccctacagaa gcacctctcc
      481 atgtacaaga tccggcggaa ggtcaccgtg gagccaagtc cggagctcca cgtgtgggct
      541 gtgctaccct gtgtccccca aacctctgag actgcacctc tagaagagag ggtagaaggc
      601 accaccatgc ttatccgtga cccccggact gcacgtatgg ggtggcggct tctcacccag
      661 gatgatggcc cagccctggt gcccagggga cagcttgggg atctccaaga ttatcacaag
      721 taccggtacc agcaaggcat ccccgaggga gtctgtgatc ttcccccagg gatggccctc
      781 cccctggagt ccaacctggt cttcatgaat ggcgtgagct tcacgaaggg ctgctacatt
      841 gggcaggagc tgacggcccg gacccaccat acaggtgtca tccgcaagcg cctcttccca
      901 gtgaagcttg aaggccccct gcctgcaagt ggcgtcagcc ctggcgccat agtgacggtg
      961 actgccacag gccaggcagc gggcaagttc agggctggcc agggacacgt gggactggct
     1021 ttgctgcggt cagagacaat caagggtcct ctccacatca agacctccga gagccagttg
     1081 gtggctgtga ctgccgtggt gccggactgg tggcccacag ctgccaagta gcttggatgc
     1141 tctggagccc cactggcctt agagtttcca gatgcctttg agcctctgcc caaggttgtc
     1201 tactctctgt gctgcgcctg ttgggtatga gttcctcctc ccgtggtgcc ttctggagca
     1261 catcctctag gaaagttcca tgggttccag gctacagatc ggctcatgct tcctacagag
     1321 agcctactct tatgggctgt cttctctcga gaagtctgac tgagagcaga gtgaccacct
     1381 gaggctggga gagagaaggg tctgagctcc catttggacc agcttctgaa caagatttga
     1441 gacagtccat atgccaggtc tacaggccta tgttgacata ggcctgtgtc agacgccagg
     1501 tccctgacct tgtttcccct tggaggaagg gactctgtgt gcctgcagag ttgctgggcc
     1561 tggcttcgtg ttctcttgaa actcatctca gggcagagat tgtataggtt gtgtgcaggg
     1621 tcgggaggtt ggatcccctg ggttgagaga tgtgttctgt gagccacagg gactacatgc
     1681 ctactgtccc aagagctctt ttcacgcctc aaagtgagct gctgtctttt catgttcccc
     1741 tggaagctct aggaggggtg gagcccaggg ctcaggtcca tctggggggg aggggagggc
     1801 ttctgctcgg ctaacgtttt tgctggcttg ggcttttaga agggagttac ttgctggcca
     1861 ctggtggggt gcatacctcc ctctgaacca ctttttctaa cctttgtaat gtgaactgag
     1921 ggtctcgcca caaagcccaa ggactagtaa agtgtggtct gagaacagcc ctttcagacc
     1981 tcttgtttca tttgggtcag gtttggtagg acagaccgtg ggacagctgt ccccagagac
     2041 cacccaccag atggaagcag cccactgtta tagccctggt tggtcttgaa cttgaaattc
     2101 tcctgcctca gctttgtgag tgttagattg ataggcaagc cccagtgggc tcacacgata
     2161 cacctatgtc tctctcaaga gatgtatttt gtttttatgt ctttatgtgt gtgtttatgg
     2221 atgaatgtct gggtgcctag agaggacaaa aggagggtat cacataccct ggagttggag
     2281 ttacaggtga ctctgagttg ctgaacatgc gtgtgatggg aactgaactt gtatcccctg
     2341 caagagcagc agtattcttt gttgtttgtt tgtttgtttc tttgtttatt tgaggcagga
     2401 tttttctgtg tagccctggc tatcctggaa ctcactctgt agaacaggct ggcctcgaac
     2461 tcacataggt ctgcctgcct ctgccttcca agcactgagg ttaaaggcaa gtgtcaccac
     2521 tatgcctggc tagatccaat aggtttattt cagcagagtt ctactgaact ggtccatact
     2581 aggttggcag gaagtgggga ggccgctgtg agcctaggca aggcaatggg tgctcagggt
     2641 tctggggtgg ggggatgggg acatctctga aactgttttc tacagtgccc ccaaggtaaa
     2701 tccacagagg cctggggtgt gggcagcctg gcagtcactc tggtgccagg ggcagtgagg
     2761 acttctaaga actgtgactt tggaggctgc ttaggctagg gctcaaggtg ctctctgaat
     2821 tgaggtgcag tttgccgcag cttagaagga ggcacggggg gttgggagtg ccctccttct
     2881 tcagcaagaa gaaggcacct tgagtgacct cctctctatg gtactgagtg ggtagacagt
     2941 gctggggaca gggacctggc agagacaacc tgaaggatgg attaccctgg ctggcgattt
     3001 cagggggttc atggcagtgg gagtgtggct gagcccctca catggtaagg caccaggaag
     3061 cagagaaagg gcatctaaag gcaggtacat ccttcaagca gaaggacaga cttcacattc
     3121 cacaggttcc actgccttcc aagcagcacc agctgctggg gaccacagtg aggtcaaagg
     3181 tgagttcatg gaggacggtt cacaaccaaa gcacaatact tgaagcacac acataggctg
     3241 tgcaggtcct agcatggcgg acagacccag ctgtcctgct tggatggttg cctggcctgg
     3301 cctatgacag ccttgtctcc gtggctgttt tgcctctgcc tgcctgccca ctcaggagca
     3361 atactgcggt tgcgttggat gttggggttc cagctgtgct ctggaaggct gtgactgatg
     3421 ggctcctgcc aaccccacct ggcagccttt tagattgaca gaggaacctc taagggttcc
     3481 aggcagctta ctttagggtt gcagtcatgt gactggcttt tgccctctca aacctgatgg
     3541 gggcgtgccc acacagaggt tggtgcttct gggcctgctt cacatacatt ctagccttca
     3601 gaaggaaggc agaaaggtcc aaggcaggcc cgttgggtaa ggaaaggaca agtccgaaaa
     3661 gaggcaggat gctgctttgg gcagaagacc cgctttgtga gtcacccatt gcctgctgtt
     3721 gggctcttcc agtgttgggg gcttgaacag atccacagtt gccatgatgt gtctccacag
     3781 tttagaaagg cagcaccgca cattaaaatc gccagtgagt ggagccagtg ggcactgggc
     3841 tgatcttcag ggacctcagg gccattctta gtgatgcagg catgtgttgg tattcacatt
     3901 ctcacaggga tctgtataga ccccagtgtg gacacttgaa aacccctaac tgtttttcag
     3961 tgtgttttgt aaacagtaca aagctttgaa aaataaacca atcaaggggg gaaagggtgt
     4021 agatctt
//
