LOCUS       NM_010491                725 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus islet amyloid polypeptide (Iapp), mRNA.
ACCESSION   NM_010491
VERSION     NM_010491.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 725)
  AUTHORS   Iglesias-Fortes,S., Gonzalez-Blanco,C., Garcia-Carrasco,A.,
            Izquierdo-Lahuerta,A., Garcia,G., Garcia-Aguilar,A., Lockwood,A.,
            Palomino,O., Medina-Gomez,G., Benito,M. and Guillen,C.
  TITLE     The overexpression of human amylin in pancreatic beta cells
            facilitate the appearance of amylin aggregates in the kidney
            contributing to diabetic nephropathy
  JOURNAL   Sci Rep 14 (1), 24729 (2024)
   PUBMED   39433955
  REMARK    GeneRIF: The overexpression of human amylin in pancreatic beta
            cells facilitate the appearance of amylin aggregates in the kidney
            contributing to diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 725)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   3  (bases 1 to 725)
  AUTHORS   Wenzlau,J.M., Peterson,O.J., Vomund,A.N., DiLisio,J.E.,
            Hohenstein,A., Haskins,K. and Wan,X.
  TITLE     Mapping of a hybrid insulin peptide in the inflamed islet
            beta-cells from NOD mice
  JOURNAL   Front Immunol 15, 1348131 (2024)
   PUBMED   38455055
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 725)
  AUTHORS   Taylor,A.J., Panzhinskiy,E., Orban,P.C., Lynn,F.C., Schaeffer,D.F.,
            Johnson,J.D., Kopp,J.L. and Verchere,C.B.
  TITLE     Islet amyloid polypeptide does not suppress pancreatic cancer
  JOURNAL   Mol Metab 68, 101667 (2023)
   PUBMED   36621763
REFERENCE   5  (bases 1 to 725)
  AUTHORS   Meier,D.T., Rachid,L., Wiedemann,S.J., Traub,S., Trimigliozzi,K.,
            Stawiski,M., Sauteur,L., Winter,D.V., Le Foll,C., Bregere,C.,
            Guzman,R., Odermatt,A., Boni-Schnetzler,M. and Donath,M.Y.
  TITLE     Prohormone convertase 1/3 deficiency causes obesity due to impaired
            proinsulin processing
  JOURNAL   Nat Commun 13 (1), 4761 (2022)
   PUBMED   35963866
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 725)
  AUTHORS   Mulder,H., Lindh,A.C., Ekblad,E., Westermark,P. and Sundler,F.
  TITLE     Islet amyloid polypeptide is expressed in endocrine cells of the
            gastric mucosa in the rat and mouse
  JOURNAL   Gastroenterology 107 (3), 712-719 (1994)
   PUBMED   8076756
REFERENCE   7  (bases 1 to 725)
  AUTHORS   Fox,N., Schrementi,J., Nishi,M., Ohagi,S., Chan,S.J.,
            Heisserman,J.A., Westermark,G.T., Leckstrom,A., Westermark,P. and
            Steiner,D.F.
  TITLE     Human islet amyloid polypeptide transgenic mice as a model of
            non-insulin-dependent diabetes mellitus (NIDDM)
  JOURNAL   FEBS Lett 323 (1-2), 40-44 (1993)
   PUBMED   8495745
REFERENCE   8  (bases 1 to 725)
  AUTHORS   Ahren,B. and Sundler,F.
  TITLE     Localization of calcitonin gene-related peptide and islet amyloid
            polypeptide in the rat and mouse pancreas
  JOURNAL   Cell Tissue Res 269 (2), 315-322 (1992)
   PUBMED   1423499
REFERENCE   9  (bases 1 to 725)
  AUTHORS   Nishi,M., Chan,S.J., Nagamatsu,S., Bell,G.I. and Steiner,D.F.
  TITLE     Conservation of the sequence of islet amyloid polypeptide in five
            mammals is consistent with its putative role as an islet hormone
  JOURNAL   Proc Natl Acad Sci U S A 86 (15), 5738-5742 (1989)
   PUBMED   2668946
REFERENCE   10 (bases 1 to 725)
  AUTHORS   Betsholtz,C., Christmansson,L., Engstrom,U., Rorsman,F.,
            Svensson,V., Johnson,K.H. and Westermark,P.
  TITLE     Sequence divergence in a specific region of islet amyloid
            polypeptide (IAPP) explains differences in islet amyloid formation
            between species
  JOURNAL   FEBS Lett 251 (1-2), 261-264 (1989)
   PUBMED   2666169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ042995.1 and BC027527.1.
            
            On Dec 7, 2007 this sequence version replaced NM_010491.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027527.1, BP766052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CJ042995.1         4-32
            30-725              BC027527.1         1-696
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 73.81 cM"
     gene            1..725
                     /gene="Iapp"
                     /gene_synonym="DAP"
                     /note="islet amyloid polypeptide"
                     /db_xref="GeneID:15874"
                     /db_xref="MGI:MGI:96382"
     exon            1..86
                     /gene="Iapp"
                     /gene_synonym="DAP"
                     /inference="alignment:Splign:2.1.0"
     exon            87..181
                     /gene="Iapp"
                     /gene_synonym="DAP"
                     /inference="alignment:Splign:2.1.0"
     exon            182..696
                     /gene="Iapp"
                     /gene_synonym="DAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgtgcatg cagacttggg ctgtagttcc tgaagcttca ggctgtcaaa gcattttctg
       61 atattgctgc ctcggaccac tgaaagggat cttgagaaat gatgtgcatc tccaaactgc
      121 cagctgtcct cctcatcctc tctgtggcac tgaaccactt gagagctaca cctgtcagaa
      181 gtggtagcaa ccctcagatg gacaaacgga agtgcaacac ggccacgtgt gccacacaac
      241 gcctggcaaa ctttttggtt cgttccagca acaaccttgg tccagtcctc ccaccaacca
      301 acgtgggatc gaatacatat ggcaagagga atgcggcagg ggatccaaat agggaatcct
      361 tggatttctt actcgtttaa agtcaatgta cttctgcagc acttaatact ttatgtgtaa
      421 atgctctggt gatttcctga atattaacag tacctttttc attcccccct cagtgagaat
      481 gcacaatgtg cttgtgcttg atgactgtgt gtgtaaattc tcatgctaag aattgcttta
      541 aactgagtat tgatcaagtt cagagtgaag tcaatgtctc taatcacaca tgttcttgct
      601 atacatttat attttaggga cacttaaaat ttctgttttt accttgtacc tctatgactc
      661 aagtttaaca ataaagaaga ccatgggatg atgaaaaaaa aaaaaaaaaa aaaaaaaaaa
      721 aaaaa
//
