LOCUS       NM_026318                620 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus huntingtin interacting protein K (Hypk), mRNA.
ACCESSION   NM_026318
VERSION     NM_026318.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Das,S. and Bhattacharyya,N.P.
  TITLE     Huntingtin interacting protein HYPK is a negative regulator of heat
            shock response and is downregulated in models of Huntington's
            Disease
  JOURNAL   Exp Cell Res 343 (2), 107-117 (2016)
   PUBMED   27017930
  REMARK    GeneRIF: HYPK can act as negative regulator of heat shock response
            by repressing transcriptional activity of HSF1.
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Choudhury,K.R. and Bhattacharyya,N.P.
  TITLE     Chaperone protein HYPK interacts with the first 17 amino acid
            region of Huntingtin and modulates mutant HTT-mediated aggregation
            and cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 456 (1), 66-73 (2015)
   PUBMED   25446099
  REMARK    GeneRIF: specific interaction of HYPK with HTT-N17 is crucial for
            the chaperone activity of HYPK
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Choudhury,K.R., Raychaudhuri,S. and Bhattacharyya,N.P.
  TITLE     Identification of HYPK-interacting proteins reveals involvement of
            HYPK in regulating cell growth, cell cycle, unfolded protein
            response and cell death
  JOURNAL   PLoS One 7 (12), e51415 (2012)
   PUBMED   23272104
  REMARK    GeneRIF: HYPK has roles in regulating cell growth, cell cycle,
            unfolded protein response and cell death
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY165803.1 and AI847440.1.
            
            On Apr 25, 2009 this sequence version replaced NM_026318.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF738229.1, BC038469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               BY165803.1         3-386
            385-620             AI847440.1         1-236               c
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.39 cM"
     gene            1..620
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /note="huntingtin interacting protein K"
                     /db_xref="GeneID:67693"
                     /db_xref="MGI:MGI:1914943"
     exon            1..204
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..408
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /note="huntingtin yeast partner K"
                     /codon_start=1
                     /product="huntingtin-interacting protein K"
                     /protein_id="NP_080594.2"
                     /db_xref="CCDS:CCDS16647.1"
                     /db_xref="GeneID:67693"
                     /db_xref="MGI:MGI:1914943"
                     /translation="MRRRGEIEMATEGDVELELETETSGPERPPEKPRKHDSGAADLE
                     RVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEM
                     EISRAAAERSLREHMGNVVEALIALTN"
     exon            205..260
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     exon            261..312
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     exon            313..604
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /inference="alignment:Splign:2.1.0"
     regulatory      451..456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /note="hexamer: AATAAA"
     polyA_site      474
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /note="major polyA site"
     regulatory      576..581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /note="hexamer: TATAAA"
     polyA_site      600
                     /gene="Hypk"
                     /gene_synonym="2310003F16Rik; HSPC136"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgaagc ggcagcctat gcggcggcgc ggtgagatcg aaatggcgac cgagggagac
       61 gtggagttgg agttagagac cgagaccagc ggcccggagc ggcctcccga gaagccaagg
      121 aaacatgaca gtggtgctgc tgacctagag cgggttactg actatgcgga ggagaaggag
      181 atccagagtt cgaatcttga aacggctatg tccgtcattg gagacagacg gtccagggaa
      241 caaaaggcca aacaagagcg ggagaaggaa ctggcgaagg tcactatcaa gaaggaagat
      301 ctggagttga taatgacgga aatggagatc tctcgagcag cagcagaaag gagcttgagg
      361 gaacacatgg gcaatgtggt ggaggctctt attgccctaa ccaactgata atgtgctttt
      421 ttagacattc tggactgact gactgactga aataaagtgt tctgttttgc tgtttttttt
      481 ttttcttcag tttcatctca gatcaaatgc attatatatt ctattttatt gtcagtttct
      541 atgttggacc ttgatgaaac tgtgtgaaca atcagtataa agaagtacct aatgttcaaa
      601 tgcaaaaaaa aaaaaaaaaa
//
