LOCUS       NM_021395               4375 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus hypoxia up-regulated 1 (Hyou1), transcript variant 1,
            mRNA.
ACCESSION   NM_021395
VERSION     NM_021395.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4375)
  AUTHORS   Mann,M.J., Melendez-Suchi,C., Vorndran,H.E., Sukhoplyasova,M.,
            Flory,A.R., Irvine,M.C., Iyer,A.R., Guerriero,C.J., Brodsky,J.L.,
            Hendershot,L.M. and Buck,T.M.
  TITLE     Loss of Grp170 results in catastrophic disruption of endoplasmic
            reticulum function
  JOURNAL   Mol Biol Cell 35 (4), ar59 (2024)
   PUBMED   38446639
  REMARK    GeneRIF: Loss of Grp170 results in catastrophic disruption of
            endoplasmic reticulum function.
REFERENCE   2  (bases 1 to 4375)
  AUTHORS   Wang,Z., Tan,C., Duan,C., Wu,J., Zhou,D., Hou,L., Qian,W., Han,C.
            and Hou,X.
  TITLE     FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells
            against inflammatory injury by regulating unfolded protein response
  JOURNAL   Redox Biol 60, 102618 (2023)
   PUBMED   36724577
  REMARK    GeneRIF: FUT2-dependent fucosylation of HYOU1 protects intestinal
            stem cells against inflammatory injury by regulating unfolded
            protein response.
REFERENCE   3  (bases 1 to 4375)
  AUTHORS   Sallais,J., Park,C., Alahari,S., Porter,T., Liu,R., Kurt,M.,
            Farrell,A., Post,M. and Caniggia,I.
  TITLE     HIF1 inhibitor acriflavine rescues early-onset preeclampsia
            phenotype in mice lacking placental prolyl hydroxylase domain
            protein 2
  JOURNAL   JCI Insight 7 (23), e158908 (2022)
   PUBMED   36227697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4375)
  AUTHORS   Porter,A.W., Nguyen,D.N., Clayton,D.R., Ruiz,W.G., Mutchler,S.M.,
            Ray,E.C., Marciszyn,A.L., Nkashama,L.J., Subramanya,A.R.,
            Gingras,S., Kleyman,T.R., Apodaca,G., Hendershot,L.M., Brodsky,J.L.
            and Buck,T.M.
  TITLE     The molecular chaperone GRP170 protects against ER stress and acute
            kidney injury in mice
  JOURNAL   JCI Insight 7 (5), e151869 (2022)
   PUBMED   35104250
  REMARK    GeneRIF: The molecular chaperone GRP170 protects against ER stress
            and acute kidney injury in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4375)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4375)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4375)
  AUTHORS   Tamatani,M., Matsuyama,T., Yamaguchi,A., Mitsuda,N., Tsukamoto,Y.,
            Taniguchi,M., Che,Y.H., Ozawa,K., Hori,O., Nishimura,H.,
            Yamashita,A., Okabe,M., Yanagi,H., Stern,D.M., Ogawa,S. and
            Tohyama,M.
  TITLE     ORP150 protects against hypoxia/ischemia-induced neuronal death
  JOURNAL   Nat Med 7 (3), 317-323 (2001)
   PUBMED   11231630
REFERENCE   8  (bases 1 to 4375)
  AUTHORS   Matsushita,K., Matsuyama,T., Nishimura,H., Takaoka,T., Kuwabara,K.,
            Tsukamoto,Y., Sugita,M. and Ogawa,S.
  TITLE     Marked, sustained expression of a novel 150-kDa oxygen-regulated
            stress protein, in severely ischemic mouse neurons
  JOURNAL   Brain Res Mol Brain Res 60 (1), 98-106 (1998)
   PUBMED   9748521
REFERENCE   9  (bases 1 to 4375)
  AUTHORS   Ikeda,J., Kaneda,S., Kuwabara,K., Ogawa,S., Kobayashi,T.,
            Matsumoto,M., Yura,T. and Yanagi,H.
  TITLE     Cloning and expression of cDNA encoding the human 150 kDa
            oxygen-regulated protein, ORP150
  JOURNAL   Biochem Biophys Res Commun 230 (1), 94-99 (1997)
   PUBMED   9020069
REFERENCE   10 (bases 1 to 4375)
  AUTHORS   Naved,A.F., Ozawa,M., Yu,S., Miyauchi,T., Muramatsu,H. and
            Muramatsu,T.
  TITLE     CBP-140, a novel endoplasmic reticulum resident Ca(2+)-binding
            protein with a carboxy-terminal NDEL sequence showed partial
            homology with 70-kDa heat shock protein (hsp70)
  JOURNAL   Cell Struct Funct 20 (2), 133-141 (1995)
   PUBMED   7641295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122428.4.
            
            On Aug 30, 2022 this sequence version replaced NM_021395.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128937.1, AK145857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC122428.4         105180-105232       c
            54-151              AC122428.4         104165-104262       c
            152-245             AC122428.4         103866-103959       c
            246-324             AC122428.4         103643-103721       c
            325-479             AC122428.4         103367-103521       c
            480-556             AC122428.4         103185-103261       c
            557-738             AC122428.4         102752-102933       c
            739-854             AC122428.4         102207-102322       c
            855-1047            AC122428.4         100474-100666       c
            1048-1182           AC122428.4         100204-100338       c
            1183-1265           AC122428.4         100031-100113       c
            1266-1398           AC122428.4         99813-99945         c
            1399-1586           AC122428.4         99470-99657         c
            1587-1725           AC122428.4         99070-99208         c
            1726-1786           AC122428.4         97683-97743         c
            1787-1866           AC122428.4         97446-97525         c
            1867-2052           AC122428.4         96902-97087         c
            2053-2225           AC122428.4         96597-96769         c
            2226-2313           AC122428.4         96410-96497         c
            2314-2436           AC122428.4         96171-96293         c
            2437-2570           AC122428.4         95850-95983         c
            2571-2655           AC122428.4         95653-95737         c
            2656-2896           AC122428.4         95304-95544         c
            2897-2947           AC122428.4         95148-95198         c
            2948-2998           AC122428.4         93889-93939         c
            2999-4375           AC122428.4         92410-93786         c
FEATURES             Location/Qualifiers
     source          1..4375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..4375
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /note="hypoxia up-regulated 1"
                     /db_xref="GeneID:12282"
                     /db_xref="MGI:MGI:108030"
     exon            1..53
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            54..151
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..3060
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; calcium binding protein 140; 170 kDa glucose
                     regulated protein GRP170; hypoxia up-regulated protein 1;
                     GRP-170; 140 kDa Ca(2+)-binding protein; calcium binding
                     protein, 140 kDa; 150-kDa oxygen regulated protein"
                     /codon_start=1
                     /product="hypoxia up-regulated protein 1 isoform 1
                     precursor"
                     /protein_id="NP_067370.3"
                     /db_xref="CCDS:CCDS23107.1"
                     /db_xref="GeneID:12282"
                     /db_xref="MGI:MGI:108030"
                     /translation="MAATVRRQRPRRLLCWALVAVLLADLLALSDTLAVMSVDLGSES
                     MKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATLRYFQH
                     LLGKQADNPHVALYRSRFPEHELIVDPQRQTVRFQISPQLQFSPEEVLGMVLNYSRSL
                     AEDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRR
                     KDINSTAQNVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEME
                     LRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLM
                     DDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKV
                     QEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVEFT
                     REVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDL
                     RVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVED
                     SPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKE
                     EAEPPAEETSQPPPSEPKGDAAREGEKPDEKESGDKPEAQKPNEKGQAGPEGAAPAPE
                     EDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEELTLRDLEKQEREKAA
                     NSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKL
                     AELRKLCQGLFFRVEERRKWPERLSALDNLLNHSSIFLKGARLIPEMDQVFTEVEMTT
                     LEKVINDTWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKP
                     RPRPKDKNGTRAEPPLNASAGDQEEKVIPPAGQTEEAKPILEPDKEETGTEPADSEPL
                     ELGGPGAGPEQEEQSAGQKRPSKNDEL"
     exon            152..245
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            246..324
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            325..479
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            480..556
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            557..738
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            739..854
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1047
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1182
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1265
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1398
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1586
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1725
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1786
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1866
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2052
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2225
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2313
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2436
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2570
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2655
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2896
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2947
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..2998
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..4375
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4352..4357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /note="hexamer: AATAAA"
     polyA_site      4375
                     /gene="Hyou1"
                     /gene_synonym="Cab140; CBP-140; Grp170; Orp150"
                     /note="major polyA site"
ORIGIN      
        1 aatgagcgtg cgccgcgtcc ggggccggct ggtgcgcgag acgccgctga gagggtcaca
       61 atggcagcca cagtaagaag gcagaggcca aggaggctac tctgttgggc cttggtggct
      121 gtcctcttgg cagacctgtt ggcactgagc gacacattgg ctgtgatgtc tgtagacctg
      181 ggcagtgaat ccatgaaggt ggccattgtc aagcctggag tgcccatgga gattgtattg
      241 aacaaggaat ctcggaggaa aactccagtg actgtgacct tgaaagaaaa tgaaaggttt
      301 ttaggtgata gtgcagccgg catggccatc aagaacccaa aggctacgct ccgttatttc
      361 cagcacctcc ttggaaaaca ggcggataac cctcatgtgg ccctttaccg gtcccgtttc
      421 ccagaacatg agctaattgt tgacccacag aggcagactg tgcgcttcca gatcagtccg
      481 cagctgcagt tctctcccga ggaggtactg ggcatggttc tgaactactc ccgttccttg
      541 gctgaagatt ttgctgaaca acccattaag gatgcagtga tcaccgtgcc agcctttttc
      601 aaccaggctg agcgccgagc tgtgctgcag gctgctcgga tggctggcct caaggtgctg
      661 cagctcatca atgacaacac tgccacagcc ctcagctacg gtgtcttccg ccggaaagat
      721 atcaattcca ctgcacagaa cgtcatgttc tatgacatgg gctcgggcag cactgtgtgc
      781 accatcgtca cctaccagac agtgaagact aaggaggctg ggatgcaacc acagctgcag
      841 atccggggcg tgggatttga ccgcaccctg ggtggcctgg agatggagct tcggcttcga
      901 gaacacctgg ctaagctctt caatgagcag cgcaagggcc agaaagccaa ggatgttcgg
      961 gaaaaccccc gggccatggc caaactgctt cgggaagcca accggcttaa aaccgtcctg
     1021 agtgccaacg ctgatcacat ggcacagatt gagggcttga tggatgatgt ggacttcaag
     1081 gccaaagtaa ctcgggtgga attcgaggag ctgtgtgcag atttgtttga ccgtgtgcct
     1141 ggacctgtgc agcaggcctt gcagagtgca gagatgagct tggatcaaat tgagcaggtg
     1201 atcctggtgg gcggggccac tcgtgttccc aaagttcaag aagtgctgct caaggccgtg
     1261 ggcaaggagg aactaggaaa gaacatcaat gcggacgaag ctgctgccat gggggctgtg
     1321 taccaggcag cggcgctcag caaggccttc aaagtgaagc catttgttgt gcgggatgct
     1381 gtcatttacc caatcctggt ggagttcaca agggaggtgg aggaggagcc tgggctccga
     1441 agcctgaaac acaataagcg tgtgctcttc tcccgaatgg ggccctaccc tcagcgcaaa
     1501 gtcatcacct ttaaccgcta cagccatgat ttcaacttcc acatcaacta cggtgacctg
     1561 ggcttcctgg ggcctgagga tcttcgggta tttggctccc agaatctgac cacagtaaaa
     1621 ctaaaaggcg tgggagagag cttcaagaaa tatcccgact atgagtccaa aggcatcaag
     1681 gcccacttta acctggatga gagtggcgtg ctcagtttag acagggtgga gtccgtattt
     1741 gagaccctgg tggaggatag cccagaggaa gaatctactc ttaccaaact tggcaacacc
     1801 atatccagcc tgtttggagg tggtacctca tcagatgcca aagagaatgg tactgatgct
     1861 gtacaggagg aagaggagag ccccgctgag gggagcaagg atgagcctgc agagcagggg
     1921 gaactcaagg aagaagctga acccccagca gaggagacct ctcagcctcc accctctgag
     1981 cctaaggggg atgcagcccg tgagggagag aaacctgatg aaaaagagag tggggacaag
     2041 cctgaggccc agaagcccaa tgagaagggg caagcagggc ctgagggtgc tgctccagct
     2101 cctgaggagg acaaaaagcc gaaacctgcc cggaagcaga aaatggtgga ggagataggt
     2161 gtggagctgg ctgtcttgga cctgcctgac ttgccagagg atgagctggc ccgttctgtg
     2221 cagaaacttg aagaactgac cctgcgcgac ctagagaagc aggagaggga gaaagctgcc
     2281 aacagcttgg aggctttcat ctttgagacc caggacaagc tgtaccagcc tgagtaccag
     2341 gaagtgtcca ctgaggaaca gcgggaggag atctcgggga aactcagcgc cacttctacc
     2401 tggctggagg atgagggatt tggagccacc actgtgatgc tgaaggacaa gctggctgag
     2461 ctgagaaagc tgtgccaagg gctgtttttt cgggtggaag aacgcaggaa atggccagag
     2521 cggctttcag ctctggataa tctcctcaac cattccagca ttttcctcaa gggtgcccgg
     2581 ctcatcccgg agatggacca ggtcttcact gaagtggaga tgacgacatt agagaaagtc
     2641 atcaatgaca cctgggcctg gaagaatgca actctggccg aacaagccaa gcttcctgcc
     2701 acagagaagc ctgtgctgct ttcaaaagac attgaggcca aaatgatggc cctggaccgg
     2761 gaggtacagt atctactcaa taaggccaag tttaccaagc cacggccacg gcccaaagac
     2821 aagaatggca cccgggcaga acctcccctc aatgccagtg ctggtgacca agaggagaag
     2881 gtcattccac ctgcaggcca gactgaagag gcgaaaccca ttttagaacc tgacaaagaa
     2941 gagactggta cggaaccagc agactcggag cctctggaat taggaggtcc tggagctgga
     3001 cctgaacagg aagagcagtc agcaggacag aagcggcctt caaagaacga tgaactataa
     3061 ccccagctcc tgccttccga cttggctcca gccccttctc ctaccacctc tatttattat
     3121 acatcagggt tggagtgggg gttggtccct caggggctca agttccttct ctcagctggg
     3181 acaggaggtg gctgctcagt cctagagtag ctctatgggt gaaaccggct ctagttctgt
     3241 ccccagcccc accctctggt ctcctactct ctggccctgt gtttgggaaa aatcactatt
     3301 atgtcttaat tctttgcctg tgggtaagtg agagaatggc tgccagtagt tgttggagac
     3361 ctggtagtgg gaaggatgtt atgggtcact ggaaagtggc cagtcttcac agcatccttt
     3421 catcttttcc tcttccacaa aatcagtgtc ctgtttgggc cagtgtctac agagcctcag
     3481 tcccacttgg tttctgagtg cctcttttct cttctgtgtc ttctcttccc ttgtccttcc
     3541 tccttggctc ttctgtcctt tccttccctg tgcagacagg actatggtct tcttgcccaa
     3601 agactttcat ctggactgtc tatagagtaa atatgctctc atggttcatg cgacccctgg
     3661 tggctggagt aagcggggag caggcaagaa gggaaagccc tgtagccctg aatgggttgt
     3721 tggacccagg acagtacagg tccggagagt ggctggcaag gatgcaagta tactgcaggc
     3781 actcgacatc cttgtcagcc ccagttcctg tgacacctac cccttcatgc tctttcctcc
     3841 ttccccctgg gctgaccaaa aatgtgctat ctactgtgag cccctttccc aagaccctgg
     3901 gggacggaga gaccatggag tgaatgtaaa aatgccacct cactctcagg caagctttgt
     3961 gggtaaagac gaggggtcag ggttcaactt gacagtgtac ttcgctagga aggagaggcc
     4021 cttgcctgct ataaccatgc ctagagtgcc tgtcctccag tattgcacct gtagccggag
     4081 ctagggccac cccagtgcag gggcaaagca aacctgatgt cagtcgtttt gtcttttcta
     4141 ccccaacctc accctctcac cctactttcc accccccacc ccgccttttt tttttttttt
     4201 tttttttttt tgtgccacat tggcagaggg gcctataggt ccttcactgt tccctcctgt
     4261 gtgttggagt tctttagtta gcagttcagg ctggttggac aggtttgaat caaattgtac
     4321 tttgttccat tgttaattga gaaactgttt caataaaata ttcttttcta taggt
//
