LOCUS       NM_029762               1643 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus HYLS1, centriolar and ciliogenesis associated (Hyls1),
            mRNA.
ACCESSION   NM_029762
VERSION     NM_029762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Mee,L., Honkala,H., Kopra,O., Vesa,J., Finnila,S., Visapaa,I.,
            Sang,T.K., Jackson,G.R., Salonen,R., Kestila,M. and Peltonen,L.
  TITLE     Hydrolethalus syndrome is caused by a missense mutation in a novel
            gene HYLS1
  JOURNAL   Hum Mol Genet 14 (11), 1475-1488 (2005)
   PUBMED   15843405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY109268.1, AK131639.1 and AK013896.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131639.1, BC035953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY109268.1         12-48
            38-1478             AK131639.1         2-1442
            1479-1495           AK013896.1         1513-1529
            1496-1643           AK131639.1         1460-1607
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.32 cM"
     gene            1..1643
                     /gene="Hyls1"
                     /gene_synonym="3010015K02Rik"
                     /note="HYLS1, centriolar and ciliogenesis associated"
                     /db_xref="GeneID:76832"
                     /db_xref="MGI:MGI:1924082"
     exon            1..193
                     /gene="Hyls1"
                     /gene_synonym="3010015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            194..244
                     /gene="Hyls1"
                     /gene_synonym="3010015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            245..359
                     /gene="Hyls1"
                     /gene_synonym="3010015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1290
                     /gene="Hyls1"
                     /gene_synonym="3010015K02Rik"
                     /note="hydrolethalus syndrome protein 1 homolog;
                     hydrolethalus syndrome 1"
                     /codon_start=1
                     /product="centriolar and ciliogenesis-associated protein
                     HYLS1"
                     /protein_id="NP_084038.1"
                     /db_xref="CCDS:CCDS52754.1"
                     /db_xref="GeneID:76832"
                     /db_xref="MGI:MGI:1924082"
                     /translation="MAEKRQAYSVPEAMKQLIGPGGQKWANMDPEERMLAAATAFTRI
                     CAGQGEGDSRREAQAGQYDPYSKASVTPGKRPALPMHLHFPHTASRVTSSTVSETSQK
                     CRKPVMKRKVLRRKPDGEVLVTDESVISECESGTESDLGLWDLRHRFMNLQFQEGTES
                     PVVTSQKFNLPCEYQGISQEDQLICYLQREEMDPPVYEQDLIVASRPKSFILPRLDQL
                     SRNRGKIDRVARYFEYKRDWDSMRFPGEDHRKELRWSVRGQMLSRTEPPSKPQHVYVP
                     NNYLVPTEKKRSALRWGVRCDLANGVMPKKLPFPLSPS"
     exon            360..1643
                     /gene="Hyls1"
                     /gene_synonym="3010015K02Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagtggga aacagcgttc cggggtgagc cgcgactgct agaccctggg cagcggcggc
       61 cgaggctggt gaggatcacg gagccggagc ggtggacctt tcctgggaca gggtgcagcg
      121 gagcccacgc tctttccctc ggccgctgcg cgtggattcg cgttttcttc cctgccaggt
      181 tctggcgttc aaggtttcct ttttgttaac tcaaatacag ccagtcaagg aaaaacaaaa
      241 taaggtggca caatagaagc tatcttaatt gaagaaatac tatccatgat tatatttctc
      301 attgggaata gaacctggag acagattttc ctttaagcag ttttaatggc agaaaaaaga
      361 caagcttata gtgtaccgga agcaatgaag caactgatag gacctggtgg acaaaaatgg
      421 gccaatatgg atcctgaaga acgaatgtta gctgctgcta cagcatttac acggatctgt
      481 gcagggcagg gtgaaggaga ttcacggaga gaagcccagg ctggccagta tgatccctac
      541 agtaaagcct cagtaacccc aggaaagaga ccggctcttc ctatgcacct gcacttccca
      601 catacagcaa gccgtgtcac ttcatccacg gtgtcagaga cttcccaaaa atgcagaaaa
      661 ccagtgatga agaggaaggt gctgcgaaga aagccagacg gggaagtgct agtgacagat
      721 gagtctgtta tcagtgaatg tgaatctgga acagaaagtg atttgggtct ctgggacttg
      781 agacacaggt tcatgaactt acagttccaa gaaggtacag aatccccagt tgtcacttca
      841 caaaaattta acctaccatg tgaataccaa ggaatttcac aagaagatca gctcatttgc
      901 tatctacaaa gagaagaaat ggaccctcct gtttatgaac aagacttgat tgttgccagc
      961 agacccaagt cctttattct ccccagactg gatcagttaa gccgaaaccg gggcaagata
     1021 gaccgagtag ccagatattt tgagtacaaa agagactggg attcaatgcg gtttcctggt
     1081 gaagatcata gaaaggagtt acgctggagt gtccgagggc aaatgctttc ccgaacagaa
     1141 cctccgtcca agcctcaaca tgtgtatgtt ccaaacaatt acctggtgcc aactgagaag
     1201 aaaagatctg cccttcggtg gggtgtgcgt tgtgaccttg caaatggtgt catgcccaag
     1261 aagcttccct tcccgctttc tccttcttaa gtctttaaaa aacatgtctc tcctaccaaa
     1321 agagttagga taacctagtt ctttatctct ccttcaaata taattgcctt gaaaagcagg
     1381 cagaacacag aataaggact tcactggttc ttccgagggt tgttggtatg tcacatagat
     1441 ataatacacc acttgaattt ctaattctca aatacagcaa ttgtgagggg ggtggaaaac
     1501 tactggaatt tggattttgt caaagtaagt gccattttga aacaacttgt aaactgtggt
     1561 ttgttttttg ggttttgttt tttttttttt ttttttttct ttttttagga ttaagctaat
     1621 ctattaaaga attttggaaa atg
//
