LOCUS       NM_053090               5669 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus hyccin PI4KA lipid kinase complex subunit 1 (Hycc1),
            transcript variant 1, mRNA.
ACCESSION   NM_053090
VERSION     NM_053090.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5669)
  AUTHORS   Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E,
            Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C,
            Raimondi A, Simons M, Walther TC, Reinisch KM and De Camilli P.
  TITLE     The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P
            synthesis at the plasma membrane
  JOURNAL   Nat Cell Biol 18 (1), 132-138 (2016)
   PUBMED   26571211
REFERENCE   2  (bases 1 to 5669)
  AUTHORS   Gazzerro E, Baldassari S, Giacomini C, Musante V, Fruscione F, La
            Padula V, Biancheri R, Scarfi S, Prada V, Sotgia F, Duncan ID, Zara
            F, Werner HB, Lisanti MP, Nobbio L, Corradi A and Minetti C.
  TITLE     Hyccin, the molecule mutated in the leukodystrophy hypomyelination
            and congenital cataract (HCC), is a neuronal protein
  JOURNAL   PLoS One 7 (3), e32180 (2012)
   PUBMED   22461884
  REMARK    GeneRIF: Data show that in the brain, Hyccin transcript levels were
            higher in early postnatal development (postnatal days 2 and 10) and
            then declined in adult mice.
REFERENCE   3  (bases 1 to 5669)
  AUTHORS   Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai
            N, Franklin RJ and Rowitch DH.
  TITLE     Dysregulation of the Wnt pathway inhibits timely myelination and
            remyelination in the mammalian CNS
  JOURNAL   Genes Dev 23 (13), 1571-1585 (2009)
   PUBMED   19515974
REFERENCE   4  (bases 1 to 5669)
  AUTHORS   Kawasoe T, Furukawa Y, Daigo Y, Nishiwaki T, Ishiguro H, Fujita M,
            Satoh S, Miwa N, Nagasawa Y, Miyoshi Y, Ogawa M and Nakamura Y.
  TITLE     Isolation and characterization of a novel human gene, DRCTNNB1A,
            the expression of which is down-regulated by beta-catenin
  JOURNAL   Cancer Res 60 (13), 3354-3358 (2000)
   PUBMED   10910037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115786.8, CJ102951.1, BC060692.1, BG081564.2, CJ244220.1 and
            AW046748.1.
            
            [WARNING] On Nov 24, 2023 this sequence was replaced by
            NM_053090.4.
            
            On Jul 14, 2015 this sequence version replaced NM_053090.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060692.1, SRR9219381.11175.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC115786.8         139462-139466       c
            6-20                CJ102951.1         7-21
            21-4777             BC060692.1         1-4757
            4778-5225           BG081564.2         135-582
            5226-5231           CJ244220.1         15-20
            5232-5669           AW046748.1         1-438               c
FEATURES             Location/Qualifiers
     source          1..5669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.53 cM"
     gene            1..5669
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /note="hyccin PI4KA lipid kinase complex subunit 1"
                     /db_xref="GeneID:84652"
                     /db_xref="MGI:MGI:2149839"
     exon            1..212
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            213..291
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1806
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hyccin; down-regulated by CTNNB1 protein A; family with
                     sequence similarity 126, member A"
                     /codon_start=1
                     /product="hyccin isoform 1"
                     /protein_id="NP_444320.2"
                     /db_xref="CCDS:CCDS19113.1"
                     /db_xref="GeneID:84652"
                     /db_xref="MGI:MGI:2149839"
                     /translation="MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVTSLYKV
                     IQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELMWCYLAVSASRDVHSSGCIE
                     ALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKV
                     VYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQ
                     HVRKYRGVSSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPL
                     LVANAIKASLPHGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTE
                     LTGQEELMDITEVDEGFYSRAASSTSQSGLSNSSHNCSNKTSVGKNQRRSGGSKAGAK
                     ERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSQGLAKTAATVF
                     SKSFEQVSGAPVPRSPSPAIGCVAGADANRFSACSLQEEKLIYVSERTELAVKCQAGQ
                     QGPPSISVTLSAE"
     exon            292..393
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            394..573
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            574..654
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            655..770
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            771..866
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            867..983
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1071
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1231
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..5659
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctgtc agagaggctg gcggcagtgg cggctgtccg ggctgggttg tcagtcagag
       61 agaggaggga agatggctcg cccggactcg tgctgctaga aggagagggg caggtggcgc
      121 ggctgccggc ggagcgcagt cgcccggtcg ccgtggtcgc cgtggtcgcc gtggtcgtgg
      181 ggggaggccg cggtaggtcc ggagctgctc tggttgaagg tttgaaacaa atgtggaaag
      241 atgttcacct cagagatagg agttgtggaa gaatggctgt cagaatttaa gacactccca
      301 gaaacatctt tgccaaatta tgccacaaat ttgaaagaca agagttcttt agttacatct
      361 ctctataaag ttatccagga gccacagagt gagttactag agcccgtgtg tcaccagctc
      421 tttgagttct accgcagtgg ggaggagcag ctgctgcgct tcactctgca gttcctcccg
      481 gagctgatgt ggtgctacct cgccgtgtcg gccagcagag atgtgcacag cagcggctgc
      541 attgaggctc tcctgctggg ggtttacaac ctggaaatag ttgacaaaca cggacatagt
      601 aaagtattga gttttacaat tccatcttta tccaaaccat ctgtatatca tgaaccttcc
      661 agcattgggt ctatggcgct gacggagagt gcgctgtccc agcatggctt atcaaaagtc
      721 gtgtacagtg gaccccatcc tcaacgggag atgctgacag cacagaacag gtttgaagta
      781 ttgacattcc ttctgctgtg ttacaatgct gccttaacct acatgcccag tgtctctctt
      841 cagtcactgt gtcagatttg ttcaagaata tgtgtctgtg gctatccccg acaacatgta
      901 agaaaataca gaggtgtgag cagcaggata ccgatttcat ccggcttcat ggtgcagatg
      961 ctaacaggag tgtattttgc catatacaat ggagaatggg atctagctca gaaagcactg
     1021 gatgacatta tatacagagc ccagctagaa ttgtatccag agcctctgct ggttgctaat
     1081 gcaataaagg cttcattgcc tcatggtgcc atgaaatcta gtaaggaagg tacaaggtgt
     1141 attcaagtgg agatcacacc aacctcctct agaatatcaa gaaatgcagt taccagcatg
     1201 tcaatacgag gtcacaggtg gaaaagacat ggagatacag aattaacagg tcaagaagaa
     1261 ctgatggaca taactgaagt tgacgaggga ttttattcca gggctgcgtc tagcaccagc
     1321 cagtcgggtc tatcaaacag tagtcacaat tgtagtaaca agacaagtgt aggaaagaac
     1381 cagagacggt cgggaggaag caaagctgga gcgaaggaga gagaaactgc aggggagtct
     1441 tgcagagatc actttgctcg caagcaaacc cagagagccc agagcgagaa ccttgagctt
     1501 ctctctctga agagactgac cttaacctcc agccagtccc tgcccaagcc cagcagccaa
     1561 ggcctggcta agactgcggc cactgtattt agtaaatcct ttgaacaagt cagtggtgcc
     1621 ccagtcccac gtagcccttc tcccgccatt ggctgtgttg ctggagcaga tgccaataga
     1681 ttttctgcct gtagtctcca agaagaaaag cttatttatg tgtcagaaag gactgaactt
     1741 gcagtgaagt gtcaagccgg ccagcaggga cctcctagta ttagcgtcac tctgtctgca
     1801 gagtaactgt cacttcgctc ctggagccag tgaagctgga aagacggctc tgctccctta
     1861 tgaaagcact gagtcttcat gcctggtcct ggcaggagcc tggggtcttg aattctgaag
     1921 gccccccttt gactatgaag ggaataatgt ctagtttgca gtaagctgag atgtggtcgt
     1981 gttatttctt gggaactctt ttcccctggg tttaagttct ttattcttgt attctccttt
     2041 cctgttactt gttactgtta acgtcctcag tgaggttatt tttaatacct tgttttttag
     2101 tggttgtgta tttgccctgg gaagtcaaag agagtctgtg agaggactgg gctgtagagc
     2161 ccagggggag gagcgagtcc atgaagccat gctgctccac aggcatgtga gaaaacagcc
     2221 tcacgtgaga gcagtgggga tgctacgagc tgtgaccaca tcatgcttag gatgggacag
     2281 tgtgctccac accgcaagtt gcctggcagg acagttgcaa ggggaagctg ggagaatttc
     2341 tgttgcagtc cttagaacat taaatagcaa aagtgagatt gctggtaggt gaccttctga
     2401 agtgtgtgat ctggactgca ggcatgaaag tccctttcgg tgtctaaagt gtaaccagcc
     2461 acaaagctgt tgggctgtgc tgctctggaa atcctagtta gtttgtatct tagtggtcag
     2521 agcacacatc atagaagacg tcctgaaaac ccctgtaaat cttgtagcac agctaccgag
     2581 ataccagaat gaagcattta tttaatagta aatgtctgtg aatgaaggaa accaggtcat
     2641 gtttcatcca caaaatgtgg tgaaagaaaa cagtaggtgt gggcagagga catttgtgca
     2701 ttagcttgtg tttgttcttg aatttaacat aagaaagagt gcacttcttg tttgtgagct
     2761 ttaagtattc ttgttatgtt gtagaaagaa ttcagctatc acccattcct gccaaccaag
     2821 cagtaagaaa tgtggtaagg cagaagctaa actctgcgtc ctctagatgg acgcccaggc
     2881 ttggtgcctg tggtctgctc agttggctga cgctcctgtg aggtgcacgt gctgtggtgc
     2941 tacactgggg catgagagga gcagggtcag tggggaggcc tgggactctg tctacttctc
     3001 agctttcctg acttagcaca ctgaggcctc cttaccggtg gcctctcgct gtgctcacag
     3061 aacatgctag tggtcctgtc tcaaaccacg tgggtccagc tcatggagat gagaaagctg
     3121 catgggttgc agagtgcaaa gcatttttac acttgagata cattttttaa atgcttacct
     3181 cctagtttaa acctgattat ccaaggccta tgctttttag cataaatgag cttaacattt
     3241 tattttagtt tcagtaacag aacgaactgc tggcttaaat tgtcctcatc aattttaagg
     3301 taactagata gtaaaattga taattggaat aatctaatag taatctttta tacagttgaa
     3361 atgtttgtaa aatgtcactg tgaatttcct gttgtctttt tgtaattcct taagaacttt
     3421 tcttaaacat agttactaac agtgttgata ttattaagaa gaaatttaaa gattgtcact
     3481 aggcaagttg aagtgcttac ttaagcatag agtaagttta aagaaacatt agctggcaca
     3541 aacaagagat cagaataatg ttcagccacc atattgaaac ctcattttga tattgttgta
     3601 gacatttgct acttgtgtgg tccaaagacc actggtatca cctagtatct taataaaact
     3661 tcaaaatttc gggggcagac ctagtaaatc agagctgacc ttgttaaact agggatgcta
     3721 gtatccatct gtctttgtga agacagtttc agagtgctaa ctgctggtct aatgtagggt
     3781 cctcagtggt ctcacagccc tcaagcatgg gcattagatt ctaggtcgtc acaattgtca
     3841 taggttttga taaccaagta gcttttttaa taacattgac atgtgacttc ttagagactc
     3901 tcatttcaaa tccccacttc tcatttgttt ctgtaataaa aatgcagcac cttttgcctc
     3961 tcttgttggc aataaatgag cccagcgctg cagacacttc gggtttaagc aggaaagccc
     4021 tctttgctct tgagctgtta gatgagacac agaggaacag ttgcacacac gtccatcctc
     4081 ttacaaattc tgtaacagct tgcacagtgc aatgagtctc aagtttgctc caaatgattt
     4141 acatcaattg atttcctggg gtgtggtgtt acatgaacag taaagttctt ttatactact
     4201 tttgatacta tttcaagtaa ggattgtgta catcaggggc tttcatacca gctgccaagg
     4261 ccggatgctg tcacctgtgg caacagctgt tctagtcact ttcctactca tctttcaaag
     4321 gtgagaagtt gtgtggcttt gtaggcttgt ttctattaag atgctagtgt agtcatctca
     4381 tggatccaga ggaatagctt ttaccaagag gattccacac agaactgggg tctggcaccc
     4441 catagttagc tctagatagg ggctttggat tgactcaacc cttgcacgcc tctgacactg
     4501 ggcctggcat gaacctcggc aatccaagtg aagagagaag cagaggatcc agctgcccgg
     4561 gtgctgctac ccttccactt cctggagcct cgagaaagcc ccttggcatg gctgggacac
     4621 ggcctgaccc ctttaagccc atctctgtag cacagaacag caggaattcc agaatgactg
     4681 gcttgttttg aaaaggtagt gtttcattgc cctttcgatt gtaaagcagc aactctgcaa
     4741 atagcactct gctgttaaaa aaaaaaaaaa aaaaaaagtt gaattaaagg gaaatctgtc
     4801 tttaaatcaa aatagatttt taaaaatccc ggtttaaagg gattgtgcct attttgaagt
     4861 atcatagtta aaatgttgaa tggtaaatta tggaggaaaa tatatacact ctaaaacatg
     4921 attttaagca aagagttaga gtaagacagc tcaatgttta cacccgtggg cacatgagac
     4981 ctcagtaaag gagagcacgc tgaggaagcc tgtgctaagt attgtaactg acagacaatg
     5041 cgaaaacgca caatgttggc actaaggcac tgtagataga aattaatgta caatagtgtc
     5101 ttcccaaccc gagtgaaagg ctaaaacccc agtcctttag tgagcacgag tttacacttg
     5161 cacatttgct gctgagtggt agaacattgg gaaatggaga tgtgtgcttt ttaatactgc
     5221 tcgtcttcac agagagcact cgtgggctgc cttctgtact ttgtaacttg cacatatcca
     5281 aaaagactga gcgtgaacaa tttgaagatg ttttgtattt ttgcagaagc gtgctagtgg
     5341 acatgggcct cagttgtgtt ttttgggccc caagttgtct gtcttgttgg aactggccat
     5401 ctgcctctgg cctttccttc tgatcatgtg atgctaaact cttctcacaa atacacgtgt
     5461 cattgtatgc ctagtgttta cattcctaag aataaatctt ggatatcatt atgtgctctt
     5521 tacattttta aggtttgaaa taaactggag ttgagttctt tgaagttttg tacatttgta
     5581 taaatgttct ccatatgcag tactttatac atcaagtgtt tcctcttgtt ttgttgaaat
     5641 aaaaactaaa agaaaaaaaa aaaaaaaaa
//
