LOCUS       NM_029848               2088 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus hyaluronoglucosaminidase 4 (Hyal4), mRNA.
ACCESSION   NM_029848 XM_132998 XM_912735 XM_990875
VERSION     NM_029848.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Kaneiwa,T., Miyazaki,A., Kogawa,R., Mizumoto,S., Sugahara,K. and
            Yamada,S.
  TITLE     Identification of amino acid residues required for the substrate
            specificity of human and mouse chondroitin sulfate hydrolase
            (conventional hyaluronidase-4)
  JOURNAL   J Biol Chem 287 (50), 42119-42128 (2012)
   PUBMED   23086929
  REMARK    GeneRIF: Identification of amino acid residues required for the
            substrate specificity of human and mouse chondroitin sulfate
            hydrolase (conventional hyaluronidase-4).
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Kaneiwa,T., Mizumoto,S., Sugahara,K. and Yamada,S.
  TITLE     Identification of human hyaluronidase-4 as a novel chondroitin
            sulfate hydrolase that preferentially cleaves the galactosaminidic
            linkage in the trisulfated tetrasaccharide sequence
  JOURNAL   Glycobiology 20 (3), 300-309 (2010)
   PUBMED   19889881
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Kim,E., Baba,D., Kimura,M., Yamashita,M., Kashiwabara,S. and
            Baba,T.
  TITLE     Identification of a hyaluronidase, Hyal5, involved in penetration
            of mouse sperm through cumulus mass
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 18028-18033 (2005)
   PUBMED   16330764
REFERENCE   7  (bases 1 to 2088)
  AUTHORS   Zhang,H., Shertok,S., Miller,K., Taylor,L. and Martin-Deleon,P.A.
  TITLE     Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice
            revisited: involvement of Hyalp1 and Hyal5
  JOURNAL   Mol Reprod Dev 72 (3), 404-410 (2005)
   PUBMED   16078272
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC125402.1.
            
            On or before Oct 30, 2006 this sequence version replaced
            XM_132998.3, XM_912735.2, XM_990875.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125402.1, AK014599.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.28 cM"
     gene            1..2088
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /note="hyaluronoglucosaminidase 4"
                     /db_xref="GeneID:77042"
                     /db_xref="MGI:MGI:1924292"
     exon            1..26
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /inference="alignment:Splign:2.1.0"
     exon            27..169
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /inference="alignment:Splign:2.1.0"
     exon            170..1171
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1663
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /EC_number="3.2.1.35"
                     /note="hyal-4; chondroitin sulfate hydrolase; chondroitin
                     sulfate endo-beta-N-acetylgalactosaminidase"
                     /codon_start=1
                     /product="hyaluronidase-4"
                     /protein_id="NP_084124.1"
                     /db_xref="CCDS:CCDS39441.1"
                     /db_xref="GeneID:77042"
                     /db_xref="MGI:MGI:1924292"
                     /translation="MQLLPEGQLRLCVFQPVHLTSGLLILFILKSISSLKPARLPVYQ
                     RKPFIAAWNAPTDLCLIKYNLTLNLKVFQMVGSPRLKDRGQNVVIFYANRLGYYPWYT
                     SEGVPINGGLPQNTSLQVHLKKAAQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTK
                     DIYRQKSRTLISDMKENISAADIEYSAKATFEKSAKAFMEETIKLGSKSRPKGLWGYY
                     LYPDCHNYNVYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLH
                     FSRFRVRESLRISTMTSQDYALPVFVYTQLGYKEEPLLFLSKQDLISTIGESAALGAA
                     GIVVWGDMNLTSSEENCTKVNRFVNSDFGSYIINVTRAAEVCSRHLCKNNGRCVRKTW
                     KAAHYLHLNPASYHIEASEDGEFIVRGRASDTDLAVMAENFLCHCYEGYEGADCREMT
                     EASGPSGLSLSSSSVITLCLLVLAGYQSIQL"
     exon            1172..1261
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..2088
                     /gene="Hyal4"
                     /gene_synonym="4632428M18Rik; CSHY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccagcag gcaaacaaaa gcaaaggttt ttaaacatag tttatcacag ctgttctgct
       61 gagaggagag tggctttttc actaactcca gtctatatgt ggcaaacctg tctccaccca
      121 aggaatagct attcaccttt ttcgctaact ggaagagtga accaaagagg ccttttggat
      181 tacgttgaag aaaaggtagt gaaggttcta tcttatcatg caactattgc ctgaaggaca
      241 attaagactc tgtgtttttc aaccagtaca tcttacatcg gggctgctca tactttttat
      301 cctgaagtct atctcatccc taaaacctgc ccgacttcca gtttatcaaa ggaaaccttt
      361 tattgctgct tggaatgctc caacagacct gtgtttgata aaatataatt taacactgaa
      421 cttaaaagtg tttcagatgg ttggaagccc tcggctcaaa gacagggggc aaaatgttgt
      481 tatattttat gccaacagat tgggatatta cccatggtat acatcagaag gggtacccat
      541 caatggtggt cttccccaaa acacaagctt acaagtacac ctgaaaaaag ctgcccagga
      601 tattaattat tacatccctt ctgaaaattt cagtggactt gctgttatag actgggaata
      661 ttggcgccca cagtgggccc ggaactggaa cacaaaggat atctacagac agaagtcaag
      721 aactcttatt tctgatatga aagagaacat atctgctgct gatattgaat attcagccaa
      781 ggcaactttt gagaaaagtg caaaagcttt catggaggaa actatcaaat tgggaagtaa
      841 gagcagaccc aagggccttt ggggttatta tttatatcct gattgccaca attataatgt
      901 ttatgccaca aactatactg ggtcatgccc agaagaggaa gttttgagga acaatgacct
      961 ctcttggctc tggaacagca gtacagccct gtatcctgct gtcagtatta ggaaatcctt
     1021 tgcagacagt gaaaacactt tgcacttctc acgatttcgg gtgcgtgaat cactgaggat
     1081 ttccaccatg acatcacagg attatgctct gcctgtattt gtctacacac agctgggcta
     1141 caaagaggaa cctttacttt tcctttctaa gcaagatcta attagtacca taggagaaag
     1201 tgctgcgttg ggagcggcag gcattgttgt ttggggagac atgaatttaa cttcatctga
     1261 ggagaactgt acgaaagtga accgctttgt gaattctgat tttggcagct acataatcaa
     1321 tgtgaccaga gcagctgagg tgtgcagtcg tcacctttgc aagaataatg ggaggtgtgt
     1381 acggaagaca tggaaagcag ctcattacct ccatttgaac cctgcaagtt accacataga
     1441 ggcctctgag gatggagaat tcatagtgag gggaagagca tcagacactg acctagctgt
     1501 gatggcagag aatttcctat gtcactgtta tgagggatat gagggggctg actgtagaga
     1561 aatgacagag gccagtggcc cctcggggct ttccctttcc tctagctctg taataacact
     1621 gtgtctgcta gttctagcag gttatcaaag cattcagttg tgacataatt gactttaaag
     1681 ggaatcgcat ccttttaaaa agggtgttag ggaacagata gacactcttc tctcttagga
     1741 gttcctctga gaggccttat aaatcaacat atgtgtcaca acataaatag aacctgttac
     1801 cttatttgct acactttgtt tagagccagc tttaaaagaa caaagcaatg cacaccattt
     1861 tcttacttga gtatttcaat tacacttaaa ttgaatttta ttctctttct aattatataa
     1921 acaccagtgt atacatgaat actaagtttg ttatttcaag cacattttct aggtagcagt
     1981 ttaaggactg gttacaatgt aaccacctca ttcaacagat ggatcaactc agccatgacc
     2041 cagtcaacta attcatcaga gaaggtgaaa tgcagggcta ctgtgcca
//
