LOCUS       NM_178020               1830 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hyaluronoglucosaminidase 3 (Hyal3), mRNA.
ACCESSION   NM_178020
VERSION     NM_178020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Dumaresq-Doiron,K., Edjekouane,L., Orimoto,A.M., Yoffou,P.H.,
            Gushulak,L., Triggs-Raine,B. and Carmona,E.
  TITLE     Hyal-1 but not Hyal-3 deficiency has an impact on ovarian
            folliculogenesis and female fertility by altering the
            follistatin/activin/Smad3 pathway and the apoptotic process
  JOURNAL   J Cell Physiol 227 (5), 1911-1922 (2012)
   PUBMED   21732362
  REMARK    GeneRIF: Data show that Hyal-1, but not Hyal-3,is an ovarian
            regulator factor for follicle development, and show an
            interrelationship between this enzyme and the
            follistatin/activin/Smad3 pathway.
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Reese,K.L., Aravindan,R.G., Griffiths,G.S., Shao,M., Wang,Y.,
            Galileo,D.S., Atmuri,V., Triggs-Raine,B.L. and Martin-Deleon,P.A.
  TITLE     Acidic hyaluronidase activity is present in mouse sperm and is
            reduced in the absence of SPAM1: evidence for a role for
            hyaluronidase 3 in mouse and human sperm
  JOURNAL   Mol Reprod Dev 77 (9), 759-772 (2010)
   PUBMED   20586096
  REMARK    GeneRIF: Hyal3 null sperm showed delayed cumulus penetration and
            reduced acrosomal exocytosis.
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Jadin,L., Wu,X., Ding,H., Frost,G.I., Onclinx,C., Triggs-Raine,B.
            and Flamion,B.
  TITLE     Skeletal and hematological anomalies in HYAL2-deficient mice: a
            second type of mucopolysaccharidosis IX?
  JOURNAL   FASEB J 22 (12), 4316-4326 (2008)
   PUBMED   18772348
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Hemming,R., Martin,D.C., Slominski,E., Nagy,J.I., Halayko,A.J.,
            Pind,S. and Triggs-Raine,B.
  TITLE     Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose
            overexpression increases hyaluronidase 1 activity in cultured cells
  JOURNAL   Glycobiology 18 (4), 280-289 (2008)
   PUBMED   18234732
  REMARK    GeneRIF: Hyal3 may contribute to hyaluronan metabolism by
            augmenting the activity of Hyal1.
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Stankunas,K., Hang,C.T., Tsun,Z.Y., Chen,H., Lee,N.V., Wu,J.I.,
            Shang,C., Bayle,J.H., Shou,W., Iruela-Arispe,M.L. and Chang,C.P.
  TITLE     Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
            for myocardial morphogenesis
  JOURNAL   Dev Cell 14 (2), 298-311 (2008)
   PUBMED   18267097
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Shuttleworth,T.L., Wilson,M.D., Wicklow,B.A., Wilkins,J.A. and
            Triggs-Raine,B.L.
  TITLE     Characterization of the murine hyaluronidase gene region reveals
            complex organization and cotranscription of Hyal1 with downstream
            genes, Fus2 and Hyal3
  JOURNAL   J Biol Chem 277 (25), 23008-23018 (2002)
   PUBMED   11929860
  REMARK    GeneRIF: Characterization of the murine hyaluronidase gene region
            reveals complex organization and cotranscription of Hyal1 with
            downstream genes, Fus2 and Hyal3.
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Rai,S.K., Duh,F.M., Vigdorovich,V., Danilkovitch-Miagkova,A.,
            Lerman,M.I. and Miller,A.D.
  TITLE     Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
            (GPI)-anchored cell-surface receptor for jaagsiekte sheep
            retrovirus, the envelope protein of which mediates oncogenic
            transformation
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
   PUBMED   11296287
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Strobl,B., Wechselberger,C., Beier,D.R. and Lepperdinger,G.
  TITLE     Structural organization and chromosomal localization of Hyal2, a
            gene encoding a lysosomal hyaluronidase
  JOURNAL   Genomics 53 (2), 214-219 (1998)
   PUBMED   9790770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672219.7.
            
            On Jul 31, 2009 this sequence version replaced NM_178020.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY048681.1, BC018457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AL672219.7         154445-154485
            42-955              AL672219.7         157901-158814
            956-1045            AL672219.7         159531-159620
            1046-1830           AL672219.7         159724-160508
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.19 cM"
     gene            1..1830
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /note="hyaluronoglucosaminidase 3"
                     /db_xref="GeneID:109685"
                     /db_xref="MGI:MGI:1330288"
     exon            1..41
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /inference="alignment:Splign:2.1.0"
     exon            42..955
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1297
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /EC_number="3.2.1.35"
                     /note="hyaluronidase-3; hyal-3"
                     /codon_start=1
                     /product="hyaluronidase-3 precursor"
                     /protein_id="NP_821139.2"
                     /db_xref="CCDS:CCDS23499.1"
                     /db_xref="GeneID:109685"
                     /db_xref="MGI:MGI:1330288"
                     /translation="MIMHLGLMMVVGLTLCLMHGQALLQVPEHPFSVVWNVPSARCKA
                     HFGVHLPLDALGIVANHGQHFHGQNISIFYKNQFGLYPYFGPRGTAHNGGIPQAVSLD
                     HHLARAAHQILHSLGSSFAGLAVLDWEEWYPLWAGNWGPHRQVYLAASWVWTQQMFPG
                     LDPQEQLHKAHTSFEQAARALMEYTLQLGRTLRPSGLWGFYRYPACGNGWHKMASNYT
                     GHCHAAITTRNTQLRWLWAASSALFPSIYLPPRLPLAYRQAFVRHRLEEAFRVALLEH
                     SHPLPVLAYSRLTHRSSGRFLSLDDLMQTIGVSAALGTAGVVLWGDLSFSSSEEKCWR
                     LHDYLVGTLGPYVINVTKAAMACSHQRCHGHGRCARKDPGQMEAFLHLQPDDSLGAWN
                     SFRCHCYSGWAGPTCLEPKP"
     exon            956..1045
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1830
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /note="hexamer: CATAAA"
     polyA_site      1824
                     /gene="Hyal3"
                     /gene_synonym="Hyl3"
                     /note="major polyA site"
ORIGIN      
        1 ctggggaggg agtactgtgt ctgcggagcc acctgagcca ggtctccatc tctgtggcat
       61 gatcatgcac ctaggcctaa tgatggtggt ggggttaacc ctgtgcctga tgcatggcca
      121 agctttgctg caggttcctg aacatccttt ttctgtggta tggaatgtac cctcagcaag
      181 atgtaaggcc cattttggtg tgcatctgcc tctcgatgcc ctcggcattg tagccaacca
      241 cggccaacat tttcacggcc aaaacatctc catcttctac aagaaccagt ttggtcttta
      301 tccttacttt ggacctagag gtacagccca caatggggga atccctcagg ctgtgtcctt
      361 agaccaccac ttggcacgag ctgcccacca gatcctacac agcctaggat ctagctttgc
      421 tggcttggca gtgctggact gggaagaatg gtacccactc tgggctggga actggggccc
      481 ccatcgacaa gtctacctgg cagcctcctg ggtttggaca cagcagatgt tccctggctt
      541 ggatcctcag gaacagctcc acaaagccca tactagcttt gagcaggctg cccgtgcact
      601 catggaatac actctgcagc tgggccggac acttcgcccg agtggcctct ggggctttta
      661 cagatatcca gcctgtggca atggctggca taagatggct tccaactaca caggccactg
      721 ccatgcagcc atcaccaccc gaaacaccca actgcgttgg ctctgggctg cctccagtgc
      781 tctcttccct agcatctacc tcccacccag actgccactt gcctaccgtc aggcctttgt
      841 ccgacaccgc ctggaggaag ccttccgtgt agcccttttg gagcattcac accctctacc
      901 tgttctggct tattctcgcc tcacacaccg gagctctggg agattcctgt ctctggacga
      961 cctgatgcag actattggag tgagtgccgc actgggaaca gctggagtgg tactctgggg
     1021 ggacctgagc ttctctagct ctgaggaaaa gtgctggcgt ctccatgact acttagtggg
     1081 cactttaggc ccctatgtga tcaatgtgac caaggctgcc atggcttgca gtcaccagcg
     1141 atgtcatggc catggtcgat gtgcccggaa agacccagga caaatggaag cctttctaca
     1201 tctgcagcca gatgacagtc ttggagcttg gaattccttc agatgccatt gttattcggg
     1261 ttgggctggc cctacctgcc tggagcctaa accctgagcc caacatagag tcaggagtcc
     1321 ctgcctttgc tacttgaccc tgctgtcatt ttcccagtcc tagaggaatt cccctttatg
     1381 ctttgtttag cttatgggac tttcccaagt acatatccca cttccaccaa tacaacttcc
     1441 atagaaattc ctgaggagcc gggcatggtg gcgcacgcct ttaatcccag cactcgggag
     1501 gcagaggcag gccgatttct gagttcgagg ccagcctgat ctacaaagtg agttccagga
     1561 cagccagggc tatacagaga aaccctgtct cagaaaaaaa aaaaaaaaaa aaaaagaagc
     1621 ttccgggtca gttccaggca tttaaggtga ctagcctagg actttgttcc tataccccag
     1681 cgtatctata gagaagtaaa atctaggttc agacaacccc tacatgcctc ccaacacaca
     1741 tcccccccaa aaaaaattaa gctaaggtct gttaaacgct aagctattat ctgtattttt
     1801 atccataaag tcactctttc attacttgaa
//
